AP2719A - Method of producing 2'-deoxy -5- azacytidine (Decitabine) - Google Patents

Method of producing 2'-deoxy -5- azacytidine (Decitabine)

Info

Publication number: AP2719A
Authority: AP; ARIPO
Prior art keywords: azacytidine; decitabine; deoxy; producing
Prior art date: 2007-10-10

Application number

AP2010005226A

Other languages

English (en)

Other versions

AP2010005226A0 (en

Inventor

Oliver Jungmann

Norbert Kraut

Original Assignee

Cilag Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-10

Filing date

2008-10-10

Publication date

2013-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39496166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2719(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-10 Application filed by Cilag Ag filed Critical Cilag Ag

2010-04-30 Publication of AP2010005226A0 publication Critical patent/AP2010005226A0/xx

2013-07-31 Application granted granted Critical

2013-07-31 Publication of AP2719A publication Critical patent/AP2719A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AP2010005226A 2007-10-10 2008-10-10 Method of producing 2'-deoxy -5- azacytidine (Decitabine) AP2719A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07019826A EP2050757A1 (en)	2007-10-10	2007-10-10	Method of producing 2' -deoxy-5-azacytidine (Decitabine)
PCT/EP2008/063581 WO2009047313A2 (en)	2007-10-10	2008-10-10	Method of producing 2' -deoxy-5-azacytidine (decitabine)

Publications (2)

Publication Number	Publication Date
AP2010005226A0 AP2010005226A0 (en)	2010-04-30
AP2719A true AP2719A (en)	2013-07-31

Family

ID=39496166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2010005226A AP2719A (en)	2007-10-10	2008-10-10	Method of producing 2'-deoxy -5- azacytidine (Decitabine)

Country Status (31)

Country	Link
US (1)	US20100222565A1 (xx)
EP (2)	EP2050757A1 (xx)
JP (1)	JP5453279B2 (xx)
KR (1)	KR101551779B1 (xx)
CN (1)	CN102037003B (xx)
AP (1)	AP2719A (xx)
AU (1)	AU2008309552B2 (xx)
BR (1)	BRPI0818595B1 (xx)
CA (1)	CA2703560C (xx)
CO (1)	CO6270260A2 (xx)
CY (1)	CY1116540T1 (xx)
DK (1)	DK2201020T3 (xx)
EA (1)	EA018924B1 (xx)
EC (1)	ECSP10010091A (xx)
ES (1)	ES2512591T3 (xx)
GT (1)	GT201000076A (xx)
HN (1)	HN2010000654A (xx)
HR (1)	HRP20140856T1 (xx)
IL (1)	IL204918A0 (xx)
MX (1)	MX2010003887A (xx)
MY (1)	MY150047A (xx)
NI (1)	NI201000049A (xx)
NZ (1)	NZ584373A (xx)
PL (1)	PL2201020T3 (xx)
PT (1)	PT2201020E (xx)
SI (1)	SI2201020T1 (xx)
SV (1)	SV2010003523A (xx)
UA (1)	UA101482C2 (xx)
UY (1)	UY31388A1 (xx)
WO (1)	WO2009047313A2 (xx)
ZA (1)	ZA201002517B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2048151A1 (en) *	2007-10-10	2009-04-15	Cilag AG	Method for producing nucleosides by direct glycosylation of the nucleoside base
US8586729B2 (en)	2008-10-03	2013-11-19	Scinopharm Taiwan Ltd.	Synthesis of decitabine
EP2424845A4 (en) *	2009-04-27	2014-03-05	Reddys Lab Ltd Dr	PREPARATION OF DECITABIN
IT1399195B1 (it) *	2010-03-30	2013-04-11	Chemi Spa	Processo per la sintesi di azacitidina e decitabina
CN101948493A (zh) *	2010-06-28	2011-01-19	江苏奥赛康药业有限公司	一种高纯度地西他滨的工业化生产方法
KR101241321B1 (ko) *	2010-08-05	2013-03-11	케이피엑스 라이프사이언스 주식회사	수율 및 순도가 개선된 데시타빈의 제조방법
CN102391338A (zh) *	2011-09-30	2012-03-28	重庆泰濠制药有限公司	一种地西他滨中间体粗品的纯化方法
CN104211743A (zh) *	2013-05-29	2014-12-17	南京工业大学	一种地西他宾的合成
CN103601768B (zh) *	2013-11-13	2015-09-30	齐鲁天和惠世制药有限公司	一种阿米卡星的制备方法
MX383757B (es)	2015-12-03	2025-03-04	Epidestiny Inc	Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos
CN109912672B (zh) *	2019-04-02	2021-07-27	江西师范大学	一种以邻炔基苯酚醚作为离去基的碱基糖苷化的方法
CN112209976B (zh) *	2019-07-10	2023-05-26	鲁南制药集团股份有限公司	一种地西他滨中间体化合物ⅴ
CN112209977B (zh) *	2019-07-10	2023-05-26	鲁南制药集团股份有限公司	一种地西他滨中间体化合物ⅵ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3817980A (en) *	1970-03-14	1974-06-18	Schering Ag	5-azapyrimidine nucleosides
US4082911A (en) *	1975-02-24	1978-04-04	Schering Aktiengesellschaft	Process for the preparation of nucleosides
US4209613A (en) *	1977-12-20	1980-06-24	Schering Aktiengesellschaft	Process for the preparation of nucleosides

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US5606048A (en)	1992-06-22	1997-02-25	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) *	1992-06-22	1995-06-20	Eli Lilly And Company	Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
WO1995012593A1 (en) *	1993-11-05	1995-05-11	The Noguchi Institute	5-0-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, process for producing the same, and use thereof
ZA969220B (en) *	1995-11-02	1997-06-02	Chong Kun Dang Corp	Nucleoside derivatives and process for preparing the same
ATE282034T1 (de) *	1998-08-12	2004-11-15	Gilead Sciences Inc	Verfahren zur herstellung von 1,3- oxathiolannukleoside

2007
- 2007-10-10 EP EP07019826A patent/EP2050757A1/en not_active Withdrawn
2008
- 2008-10-10 HR HRP20140856AT patent/HRP20140856T1/hr unknown
- 2008-10-10 EA EA201070437A patent/EA018924B1/ru unknown
- 2008-10-10 ES ES08805203.0T patent/ES2512591T3/es active Active
- 2008-10-10 WO PCT/EP2008/063581 patent/WO2009047313A2/en not_active Ceased
- 2008-10-10 MX MX2010003887A patent/MX2010003887A/es active IP Right Grant
- 2008-10-10 EP EP08805203.0A patent/EP2201020B1/en active Active
- 2008-10-10 AP AP2010005226A patent/AP2719A/xx active
- 2008-10-10 UY UY31388A patent/UY31388A1/es active IP Right Grant
- 2008-10-10 KR KR1020107009760A patent/KR101551779B1/ko active Active
- 2008-10-10 UA UAA201004166A patent/UA101482C2/ru unknown
- 2008-10-10 US US12/682,293 patent/US20100222565A1/en not_active Abandoned
- 2008-10-10 DK DK08805203.0T patent/DK2201020T3/da active
- 2008-10-10 AU AU2008309552A patent/AU2008309552B2/en active Active
- 2008-10-10 SI SI200831289T patent/SI2201020T1/sl unknown
- 2008-10-10 JP JP2010528403A patent/JP5453279B2/ja active Active
- 2008-10-10 PL PL08805203T patent/PL2201020T3/pl unknown
- 2008-10-10 MY MYPI2010001611A patent/MY150047A/en unknown
- 2008-10-10 PT PT88052030T patent/PT2201020E/pt unknown
- 2008-10-10 BR BRPI0818595-6A patent/BRPI0818595B1/pt active IP Right Grant
- 2008-10-10 CA CA2703560A patent/CA2703560C/en active Active
- 2008-10-10 CN CN200880111108.0A patent/CN102037003B/zh active Active
- 2008-10-10 NZ NZ584373A patent/NZ584373A/en unknown
2010
- 2010-04-05 CO CO10037834A patent/CO6270260A2/es active IP Right Grant
- 2010-04-06 GT GT201000076A patent/GT201000076A/es unknown
- 2010-04-08 IL IL204918A patent/IL204918A0/en active IP Right Grant
- 2010-04-09 ZA ZA2010/02517A patent/ZA201002517B/en unknown
- 2010-04-09 EC EC2010010091A patent/ECSP10010091A/es unknown
- 2010-04-09 NI NI201000049A patent/NI201000049A/es unknown
- 2010-04-09 SV SV2010003523A patent/SV2010003523A/es unknown
- 2010-04-09 HN HN2010000654A patent/HN2010000654A/es unknown
2014
- 2014-10-15 CY CY20141100844T patent/CY1116540T1/el unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3817980A (en) *	1970-03-14	1974-06-18	Schering Ag	5-azapyrimidine nucleosides
US4082911A (en) *	1975-02-24	1978-04-04	Schering Aktiengesellschaft	Process for the preparation of nucleosides
US4209613A (en) *	1977-12-20	1980-06-24	Schering Aktiengesellschaft	Process for the preparation of nucleosides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEN-HATTAR, JEAN ET AL: "An improved synthesis of 2'-deoxy-5-azacytidine by condensation of an 9-fluorenylmethoxycarbonyl-protected sugar onto the silylated base" JOURNAL OF ORGANIC CHEMISTRY , 51(16), 3211-13 CODEN: JOCEAH; ISSN: 0022-3263, 1986, XP002484923 *
LU K-C ET AL: "Simple and efficient per-O-acetylation of carbohydrates by lithium perchlorate catalyst", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 60, no. 40, 27 September 2004 (2004-09-27), pages 8967-8973, XP004565047, ISSN: 0040-4020, DOI: 10.1016/J.TET.2004.06.138 *
WINKLEY, MICHAEL W. ET AL: "Direct glycosylation of 1,3,5-triazinones. New approach to the synthesis of the nucleoside antibiotic 5-azacytidine (4-amino-1-.beta.-D- ribofuranosyl-1,3,5-triazin-2-one) and related derivatives" JOURNAL OF ORGANIC CHEMISTRY , 35(2), 491-5 CODEN: JOCEAH; ISSN: 0022-3263, 1970, XP002484924 *

Also Published As

Publication number	Publication date
MY150047A (en)	2013-11-29
JP5453279B2 (ja)	2014-03-26
EP2201020B1 (en)	2014-07-16
ZA201002517B (en)	2012-07-25
AU2008309552A1 (en)	2009-04-16
IL204918A0 (en)	2010-11-30
HN2010000654A (es)	2012-12-03
CA2703560C (en)	2016-09-13
CO6270260A2 (es)	2011-04-20
DK2201020T3 (da)	2014-10-13
ECSP10010091A (es)	2010-06-29
EA201070437A3 (ru)	2011-02-28
KR101551779B1 (ko)	2015-09-09
NI201000049A (es)	2010-11-10
CA2703560A1 (en)	2009-04-16
WO2009047313A2 (en)	2009-04-16
ES2512591T3 (es)	2014-10-24
CN102037003B (zh)	2014-05-07
HRP20140856T1 (hr)	2014-10-24
UY31388A1 (es)	2009-04-30
UA101482C2 (ru)	2013-04-10
MX2010003887A (es)	2010-04-30
SV2010003523A (es)	2011-01-25
JP2011518759A (ja)	2011-06-30
AU2008309552B2 (en)	2013-01-17
BRPI0818595A2 (pt)	2015-04-22
AP2010005226A0 (en)	2010-04-30
KR20100064387A (ko)	2010-06-14
GT201000076A (es)	2012-03-12
CN102037003A (zh)	2011-04-27
WO2009047313A3 (en)	2012-03-01
EA201070437A2 (ru)	2010-08-30
US20100222565A1 (en)	2010-09-02
EP2050757A1 (en)	2009-04-22
SI2201020T1 (sl)	2014-11-28
EA018924B1 (ru)	2013-11-29
EP2201020A2 (en)	2010-06-30
PT2201020E (pt)	2014-09-23
PL2201020T3 (pl)	2014-12-31
CY1116540T1 (el)	2017-03-15
BRPI0818595B1 (pt)	2022-02-15
HK1152312A1 (en)	2012-02-24
NZ584373A (en)	2011-08-26

Publication	Publication Date	Title
AP2719A (en)	2013-07-31	Method of producing 2'-deoxy -5- azacytidine (Decitabine)
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