EA200800920A1 - Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5) - Google Patents
Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5)Info
- Publication number
- EA200800920A1 EA200800920A1 EA200800920A EA200800920A EA200800920A1 EA 200800920 A1 EA200800920 A1 EA 200800920A1 EA 200800920 A EA200800920 A EA 200800920A EA 200800920 A EA200800920 A EA 200800920A EA 200800920 A1 EA200800920 A1 EA 200800920A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pde5
- pyrazolo
- phosphodiesterrase
- ila
- pyrimidine
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 2
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- IQZQWPRZFLHJFI-UHFFFAOYSA-N 1-[1-(2-ethoxyethyl)-3-ethyl-7-[(4-methylpyridin-2-yl)amino]pyrazolo[4,3-d]pyrimidin-5-yl]piperidine-4-carboxylic acid Chemical compound C=12N(CCOCC)N=C(CC)C2=NC(N2CCC(CC2)C(O)=O)=NC=1NC1=CC(C)=CC=N1 IQZQWPRZFLHJFI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
Настоящее изобретение включает (I) 1-(1-(2-этоксиэтил)-3-этил-7-(4-метилпиридин-2-иламино)-1Н-пиразоло[4,3-d]пиримидин-5-ил)пиперидин-4-карбоновую кислоту и ее соли. Изобретение также включает фармацевтические композиции, способы лечения и способы синтеза, относящиеся к соединениям формулы (I). Соединения формулы (I) применяют для ингибирования фермента фосфодиэстеразы 5 (PDE5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73532005P | 2005-11-10 | 2005-11-10 | |
| PCT/IB2006/003132 WO2007054778A1 (en) | 2005-11-10 | 2006-10-31 | Pyrazolo[4,3-d]pyrimidin-5-yl)derivative used as pde5 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200800920A1 true EA200800920A1 (ru) | 2008-10-30 |
Family
ID=37685872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800920A EA200800920A1 (ru) | 2005-11-10 | 2006-10-31 | Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5) |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20090156618A1 (ru) |
| EP (1) | EP1948661B1 (ru) |
| JP (1) | JP4208959B1 (ru) |
| KR (1) | KR101012592B1 (ru) |
| CN (1) | CN101305007B (ru) |
| AP (1) | AP2008004437A0 (ru) |
| AR (1) | AR057885A1 (ru) |
| AT (1) | ATE435865T1 (ru) |
| AU (1) | AU2006313486B2 (ru) |
| BR (1) | BRPI0618284A2 (ru) |
| CA (1) | CA2629339C (ru) |
| CR (1) | CR9966A (ru) |
| DE (1) | DE602006007728D1 (ru) |
| DK (1) | DK1948661T3 (ru) |
| DO (1) | DOP2006000248A (ru) |
| EA (1) | EA200800920A1 (ru) |
| EC (1) | ECSP088441A (ru) |
| ES (1) | ES2326919T3 (ru) |
| IL (1) | IL190456A (ru) |
| MA (1) | MA29943B1 (ru) |
| NL (1) | NL2000291C2 (ru) |
| NO (1) | NO20082593L (ru) |
| PE (1) | PE20070764A1 (ru) |
| RS (1) | RS20080197A (ru) |
| TN (1) | TNSN08209A1 (ru) |
| TW (1) | TW200738723A (ru) |
| UY (1) | UY29909A1 (ru) |
| WO (1) | WO2007054778A1 (ru) |
| ZA (1) | ZA200803173B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010014930A2 (en) * | 2008-08-01 | 2010-02-04 | Biocryst Pharmaceuticals, Inc. | Therapeutic agents |
| WO2010043633A1 (en) * | 2008-10-15 | 2010-04-22 | Palau Pharma, S. A. | 2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases |
| WO2011126250A2 (ko) * | 2010-04-05 | 2011-10-13 | 에스케이케미칼 주식회사 | Pde5 억제제를 함유하는 피부 주름 개선용 조성물 |
| CN107261119A (zh) * | 2011-02-28 | 2017-10-20 | 独立行政法人国立循环器病研究中心 | 恶性肿瘤转移抑制用药物 |
| TWI606049B (zh) | 2011-04-21 | 2017-11-21 | 原真股份有限公司 | 新穎激酶抑制劑 |
| WO2014060112A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| KR20150056853A (ko) * | 2012-10-23 | 2015-05-27 | 화이자 인코포레이티드 | 당뇨병성 신병증의 치료를 위한 사치환된 피라졸로[4,3-d]피리미딘 화합물의 용도 |
| BR112017002675A2 (pt) | 2014-08-12 | 2017-12-12 | Mezzion Pharma Co Ltd | métodos para aperfeiçoar desempenho miocárdico em pacientes de fontan com o uso de composições de udenafila |
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| NZ333696A (en) | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
| HUP0102543A3 (en) | 1998-04-20 | 2002-01-28 | Pfizer | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction and medicaments containing them |
| GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
| JP2002528456A (ja) | 1998-10-23 | 2002-09-03 | ファイザー・インク | 性的機能障害の処置のためのピラゾロピリミジノン系ｃＧＭＰ阻害薬 |
| DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| CN1814596A (zh) | 2000-04-28 | 2006-08-09 | 阿卡蒂亚药品公司 | 毒蕈碱性激动剂 |
| DE10031584A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| WO2002016348A1 (en) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| EP1348707B1 (en) | 2002-03-28 | 2010-08-25 | Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy |
| AU2004234158B2 (en) * | 2003-04-29 | 2010-01-28 | Pfizer Inc. | 5,7-diaminopyrazolo[4,3-D]pyrimidines useful in the treatment of hypertension |
| JP2006528229A (ja) | 2003-05-22 | 2006-12-14 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４阻害剤及びｐｄｅ５阻害剤を含有する組成物 |
| US7615552B2 (en) | 2003-11-10 | 2009-11-10 | Synta Pharmaceuticals Corp. | Fused heterocyclic compounds |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
| WO2005097799A1 (en) * | 2004-04-07 | 2005-10-20 | Pfizer Limited | Pyrazolo`4,3-d! pyrimidines |
| EP1773826A4 (en) | 2004-07-02 | 2009-06-03 | Exelixis Inc | MODULATORS OF C-MET AND THEIR METHOD OF USE |
| CA2585557C (en) * | 2004-10-28 | 2009-08-18 | Pharmacia & Upjohn Company Llc | Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors |
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2006
- 2006-10-27 NL NL2000291A patent/NL2000291C2/nl not_active IP Right Cessation
- 2006-10-31 AU AU2006313486A patent/AU2006313486B2/en not_active Ceased
- 2006-10-31 AP AP2008004437A patent/AP2008004437A0/xx unknown
- 2006-10-31 CN CN2006800416985A patent/CN101305007B/zh not_active Expired - Fee Related
- 2006-10-31 CA CA2629339A patent/CA2629339C/en not_active Expired - Fee Related
- 2006-10-31 DK DK06809195T patent/DK1948661T3/da active
- 2006-10-31 RS RSP-2008/0197A patent/RS20080197A/sr unknown
- 2006-10-31 WO PCT/IB2006/003132 patent/WO2007054778A1/en not_active Ceased
- 2006-10-31 EP EP06809195A patent/EP1948661B1/en active Active
- 2006-10-31 BR BRPI0618284-4A patent/BRPI0618284A2/pt not_active Application Discontinuation
- 2006-10-31 JP JP2008539522A patent/JP4208959B1/ja not_active Expired - Fee Related
- 2006-10-31 AT AT06809195T patent/ATE435865T1/de not_active IP Right Cessation
- 2006-10-31 ES ES06809195T patent/ES2326919T3/es active Active
- 2006-10-31 DE DE602006007728T patent/DE602006007728D1/de active Active
- 2006-10-31 EA EA200800920A patent/EA200800920A1/ru unknown
- 2006-10-31 KR KR1020087011230A patent/KR101012592B1/ko not_active Expired - Fee Related
- 2006-11-07 PE PE2006001379A patent/PE20070764A1/es not_active Application Discontinuation
- 2006-11-08 AR ARP060104894A patent/AR057885A1/es unknown
- 2006-11-09 US US11/558,306 patent/US20090156618A1/en not_active Abandoned
- 2006-11-09 DO DO2006P000248A patent/DOP2006000248A/es unknown
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- 2006-11-09 UY UY29909A patent/UY29909A1/es not_active Application Discontinuation
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- 2008-03-26 IL IL190456A patent/IL190456A/en not_active IP Right Cessation
- 2008-04-10 ZA ZA200803173A patent/ZA200803173B/xx unknown
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- 2008-05-09 CR CR9966A patent/CR9966A/es not_active Application Discontinuation
- 2008-05-09 MA MA30918A patent/MA29943B1/fr unknown
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