EA200000527A3 - Новые бициклические амино-пиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их - Google Patents
Новые бициклические амино-пиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие ихInfo
- Publication number
- EA200000527A3 EA200000527A3 EA200000527A EA200000527A EA200000527A3 EA 200000527 A3 EA200000527 A3 EA 200000527A3 EA 200000527 A EA200000527 A EA 200000527A EA 200000527 A EA200000527 A EA 200000527A EA 200000527 A3 EA200000527 A3 EA 200000527A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- preparation
- pharmaceutical compositions
- compositions containing
- bicyclic amino
- Prior art date
Links
- -1 bicyclic amino-pyrazinone compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
(57) 1. Соединение формулы (I)где Rобозначает атом водорода, необязательно замещенную алкильную, циклоалкильную или гетероциклоалкильную группу или группу формулы (G)где Aобозначает одинарную связь, -СН-, -СН-СН- или -N(СН)-группу или атом кислорода или серы, и Xи Х, которые могут быть одинаковыми или могут различаться, обозначают, каждый, атом углерода или азота,R обозначает атом водорода или линейную или разветвленную (C-С) алкильную группу,обозначает насыщенное кольцо, содержащее от 4 до7 членов в кольце,n обозначает целое число, при этом 1≤ n ≤6,Ar обозначает арильную или гетероарильную группу,его изомеры, его N-оксиды и их соли присоединения фармацевтически приемлемых кислоты или основания.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9907538A FR2795072B1 (fr) | 1999-06-15 | 1999-06-15 | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA200000527A2 EA200000527A2 (ru) | 2000-12-25 |
| EA200000527A3 true EA200000527A3 (ru) | 2001-04-23 |
| EA003209B1 EA003209B1 (ru) | 2003-02-27 |
Family
ID=9546789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000527A EA003209B1 (ru) | 1999-06-15 | 2000-06-14 | Новые бициклические аминопиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6277851B1 (ru) |
| EP (1) | EP1069132B1 (ru) |
| JP (1) | JP3364472B2 (ru) |
| KR (1) | KR100456796B1 (ru) |
| CN (1) | CN1147489C (ru) |
| AT (1) | ATE251177T1 (ru) |
| AU (1) | AU766194B2 (ru) |
| BR (1) | BR0002643A (ru) |
| CA (1) | CA2312206C (ru) |
| DE (1) | DE60005609T2 (ru) |
| DK (1) | DK1069132T3 (ru) |
| EA (1) | EA003209B1 (ru) |
| ES (1) | ES2208239T3 (ru) |
| FR (1) | FR2795072B1 (ru) |
| HU (1) | HUP0002277A3 (ru) |
| NO (1) | NO316650B1 (ru) |
| NZ (1) | NZ505149A (ru) |
| PL (1) | PL199522B1 (ru) |
| PT (1) | PT1069132E (ru) |
| SE (1) | SE1069132T5 (ru) |
| SI (1) | SI1069132T1 (ru) |
| ZA (1) | ZA200003034B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003525294A (ja) * | 2000-02-29 | 2003-08-26 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害剤 |
| FR2818277B1 (fr) * | 2000-12-14 | 2003-01-24 | Servier Lab | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1523483A4 (en) * | 2002-06-26 | 2006-03-08 | Bristol Myers Squibb Co | AMINO-BICYCLIC PYRAZINONE AND PYRIDINONE FOR INHIBITING THE COOKING OF SERIN PROTEASE |
| FR2867780B1 (fr) * | 2004-03-19 | 2006-05-19 | Servier Lab | Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20140350034A1 (en) * | 2012-01-27 | 2014-11-27 | Novartis Ag | Aminopyridine derivatives as plasma kallikrein inhibitors |
| US20250122225A1 (en) * | 2023-10-06 | 2025-04-17 | Omeros Corporation | Masp-2 inhibitors and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な３環性キノキサリンジオン誘導体 |
| MD970253A (ru) * | 1994-12-22 | 1999-05-31 | Biochem Pharma Inc. | Низкомолекулярные бициклические ингибиторы тромбина |
| WO1996030396A1 (en) * | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
| CA2245811A1 (en) * | 1996-02-22 | 1997-08-28 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
| WO1997048706A1 (en) * | 1996-06-18 | 1997-12-24 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
| WO1998009987A1 (en) * | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
| ES2191830T3 (es) * | 1996-10-24 | 2003-09-16 | Merck & Co Inc | Inhibidores de trombina. |
| US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
| JP2001517623A (ja) * | 1997-09-23 | 2001-10-09 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害薬 |
-
1999
- 1999-06-15 FR FR9907538A patent/FR2795072B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-08 NO NO20002941A patent/NO316650B1/no not_active IP Right Cessation
- 2000-06-14 CA CA002312206A patent/CA2312206C/fr not_active Expired - Fee Related
- 2000-06-14 NZ NZ505149A patent/NZ505149A/xx not_active IP Right Cessation
- 2000-06-14 EA EA200000527A patent/EA003209B1/ru not_active IP Right Cessation
- 2000-06-15 SI SI200030218T patent/SI1069132T1/xx unknown
- 2000-06-15 AU AU40865/00A patent/AU766194B2/en not_active Ceased
- 2000-06-15 ZA ZA200003034A patent/ZA200003034B/xx unknown
- 2000-06-15 BR BR0002643-3A patent/BR0002643A/pt active Search and Examination
- 2000-06-15 AT AT00401686T patent/ATE251177T1/de active
- 2000-06-15 CN CNB001183745A patent/CN1147489C/zh not_active Expired - Fee Related
- 2000-06-15 EP EP00401686A patent/EP1069132B1/fr not_active Expired - Lifetime
- 2000-06-15 HU HU0002277A patent/HUP0002277A3/hu unknown
- 2000-06-15 US US09/594,852 patent/US6277851B1/en not_active Expired - Fee Related
- 2000-06-15 PT PT00401686T patent/PT1069132E/pt unknown
- 2000-06-15 DE DE60005609T patent/DE60005609T2/de not_active Expired - Lifetime
- 2000-06-15 PL PL340784A patent/PL199522B1/pl not_active IP Right Cessation
- 2000-06-15 JP JP2000179279A patent/JP3364472B2/ja not_active Expired - Fee Related
- 2000-06-15 KR KR10-2000-0032945A patent/KR100456796B1/ko not_active Expired - Fee Related
- 2000-06-15 ES ES00401686T patent/ES2208239T3/es not_active Expired - Lifetime
- 2000-06-15 DK DK00401686T patent/DK1069132T3/da active
- 2000-06-15 SE SE00401686T patent/SE1069132T5/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |