DK8685A - METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS - Google Patents
METHOD FOR PREPARING 1ALFA, 25-HYDROXYLERED VITAMIN D2 AND RELATED COMPOUNDS Download PDFInfo
- Publication number
- DK8685A DK8685A DK8685A DK8685A DK8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A DK 8685 A DK8685 A DK 8685A
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- preparing
- hydroxylered
- 1alfa
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 229930003231 vitamin Natural products 0.000 abstract 2
- 239000011782 vitamin Substances 0.000 abstract 2
- 229940088594 vitamin Drugs 0.000 abstract 2
- 235000013343 vitamin Nutrition 0.000 abstract 2
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 208000022458 calcium metabolism disease Diseases 0.000 abstract 1
- 229960002061 ergocalciferol Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 235000001892 vitamin D2 Nutrition 0.000 abstract 1
- 239000011653 vitamin D2 Substances 0.000 abstract 1
- 150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Previously unknown derivatives of vitamin D2 and, more especially, 1α,25-dihydroxylated compounds of the vitamin D series. A process is also provided for preparing these derivatives, as are certain intermediates for this. The invention provides 1α,25- dihydroxyvitamin D2 derivatives, and acylates thereof, which can be used as replacement for vitamin D3 or D2, or for various of the known vitamin metabolites of the vitamins, for their various purposes for remedying pathological states in connection with calcium metabolism and bone diseases which are associated therewith.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49286383A | 1983-05-09 | 1983-05-09 | |
| US49286383 | 1983-05-09 | ||
| US60732784A | 1984-05-04 | 1984-05-04 | |
| US60732784 | 1984-05-04 | ||
| US8400714 | 1984-05-09 | ||
| PCT/US1984/000714 WO1984004527A1 (en) | 1983-05-09 | 1984-05-09 | PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK8685A true DK8685A (en) | 1985-01-08 |
| DK8685D0 DK8685D0 (en) | 1985-01-08 |
| DK171397B1 DK171397B1 (en) | 1996-10-14 |
Family
ID=27050897
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK008685A DK171397B1 (en) | 1983-05-09 | 1985-01-08 | 24-Epi-1alpha,25-dihydroxylated vitamin D2 derivatives, and preparations for pharmaceutical use which comprises these derivatives |
| DK198801845A DK172567B1 (en) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
| DK199101832A DK172733B1 (en) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198801845A DK172567B1 (en) | 1983-05-09 | 1988-04-06 | 3,5-cyclovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
| DK199101832A DK172733B1 (en) | 1983-05-09 | 1991-11-07 | 25-oxovitamin D2 derivative intermediates for use in the preparation of 1alpha, 25-dihydroxylated vitamin D2 derivatives |
Country Status (7)
| Country | Link |
|---|---|
| JP (3) | JPH02288873A (en) |
| AU (1) | AU568549B2 (en) |
| CH (1) | CH665834A5 (en) |
| DE (4) | DE3490215T (en) |
| DK (3) | DK171397B1 (en) |
| NL (1) | NL193245C (en) |
| WO (1) | WO1984004527A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH672920A5 (en) * | 1984-10-04 | 1990-01-15 | Wisconsin Alumni Res Found | |
| EP0211863B1 (en) * | 1985-01-17 | 1992-12-30 | Wisconsin Alumni Research Foundation | Vitamin d derivatives and methods for preparing same |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
| US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| JP2645130B2 (en) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | Steroid derivatives |
| GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
| IN171449B (en) * | 1990-02-14 | 1992-10-17 | Wisconsin Alumni Res Found | |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| ES2170069T3 (en) * | 1992-06-22 | 2002-08-01 | Bone Care Int Inc | 1-ALFA-HYDROXIPREVITAMINE D FOR ORAL ADMINISTRATION. |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| HUP0002454A2 (en) | 1997-02-13 | 2000-12-28 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| WO2002006218A2 (en) | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| EP3026042B1 (en) | 2008-03-12 | 2019-10-09 | OPKO Ireland Global Holdings, Limited | Stabilized 1,25-dihydroxyvitamin d2 and method of making same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
| US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
-
1984
- 1984-05-09 WO PCT/US1984/000714 patent/WO1984004527A1/en not_active Ceased
- 1984-05-09 NL NL8420137A patent/NL193245C/en not_active IP Right Cessation
- 1984-05-09 DE DE19843490215 patent/DE3490215T/en active Pending
- 1984-05-09 DE DE3448412A patent/DE3448412C2/de not_active Expired - Lifetime
- 1984-05-09 DE DE3490215A patent/DE3490215C2/de not_active Expired - Lifetime
- 1984-05-09 CH CH145/85A patent/CH665834A5/en not_active IP Right Cessation
- 1984-05-09 DE DE3448360A patent/DE3448360C2/de not_active Expired - Lifetime
- 1984-05-09 AU AU30115/84A patent/AU568549B2/en not_active Ceased
-
1985
- 1985-01-08 DK DK008685A patent/DK171397B1/en not_active IP Right Cessation
-
1988
- 1988-04-06 DK DK198801845A patent/DK172567B1/en not_active IP Right Cessation
-
1989
- 1989-12-26 JP JP1338024A patent/JPH02288873A/en active Granted
- 1989-12-26 JP JP1338023A patent/JPH0651624B2/en not_active Expired - Lifetime
- 1989-12-26 JP JP1338025A patent/JPH0610188B2/en not_active Expired - Fee Related
-
1991
- 1991-11-07 DK DK199101832A patent/DK172733B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0339505B2 (en) | 1991-06-14 |
| JPH02288854A (en) | 1990-11-28 |
| DK172567B1 (en) | 1999-01-18 |
| CH665834A5 (en) | 1988-06-15 |
| DK171397B1 (en) | 1996-10-14 |
| JPH02288873A (en) | 1990-11-28 |
| DE3448412C2 (en) | 1991-12-12 |
| WO1984004527A1 (en) | 1984-11-22 |
| JPH02288829A (en) | 1990-11-28 |
| DE3448360C2 (en) | 1991-10-02 |
| DK183291D0 (en) | 1991-11-07 |
| NL8420137A (en) | 1985-04-01 |
| JPH0610188B2 (en) | 1994-02-09 |
| AU3011584A (en) | 1984-12-04 |
| DK172733B1 (en) | 1999-06-21 |
| DK184588D0 (en) | 1988-04-06 |
| AU568549B2 (en) | 1988-01-07 |
| JPH0651624B2 (en) | 1994-07-06 |
| NL193245B (en) | 1998-12-01 |
| DK184588A (en) | 1988-04-06 |
| DE3490215C2 (en) | 1991-07-25 |
| NL193245C (en) | 1999-04-02 |
| DE3490215T (en) | 1985-05-15 |
| DK183291A (en) | 1991-11-07 |
| DK8685D0 (en) | 1985-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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