DK422786A - Rekombinant-dna-sekvens til styring af den intracellulaere produktionaf metalloproteinase-inhibitorer og fremgangsmaade til fremstillingaf en saadan sekvens - Google Patents
Rekombinant-dna-sekvens til styring af den intracellulaere produktionaf metalloproteinase-inhibitorer og fremgangsmaade til fremstillingaf en saadan sekvens Download PDFInfo
- Publication number
- DK422786A DK422786A DK422786A DK422786A DK422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A
- Authority
- DK
- Denmark
- Prior art keywords
- sequence
- dna sequence
- preparing
- procedure
- control
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108020004511 Recombinant DNA Proteins 0.000 title abstract 2
- 230000003834 intracellular effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 2
- 101710170181 Metalloproteinase inhibitor Proteins 0.000 abstract 1
- 229940126170 metalloproteinase inhibitor Drugs 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69918185A | 1985-02-05 | 1985-02-05 | |
| US69918185 | 1985-02-05 | ||
| US78431985A | 1985-10-04 | 1985-10-04 | |
| US78431985 | 1985-10-04 | ||
| US8600302 | 1986-02-05 | ||
| PCT/US1986/000302 WO1986004608A1 (en) | 1985-02-05 | 1986-02-05 | Metalloproteinase inhibitor sequence recombinant vector system for using same and recombinant-dna method for the manufacture of same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK422786D0 DK422786D0 (da) | 1986-09-04 |
| DK422786A true DK422786A (da) | 1986-12-05 |
| DK175964B1 DK175964B1 (da) | 2005-09-26 |
Family
ID=27106361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198604227A DK175964B1 (da) | 1985-02-05 | 1986-09-04 | Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6090585A (da) |
| EP (1) | EP0211077B1 (da) |
| JP (1) | JPH088870B2 (da) |
| KR (1) | KR940010862B1 (da) |
| AT (1) | ATE89005T1 (da) |
| AU (2) | AU5549386A (da) |
| DE (1) | DE3688383T2 (da) |
| DK (1) | DK175964B1 (da) |
| WO (1) | WO1986004608A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62500424A (ja) * | 1984-10-01 | 1987-02-26 | サンド・リミテッド | 赤血球の増強活性を有する蛋白質のための遺伝子を含有するベクタ−および前記蛋白質を生産するための組み換えｄｎａ法 |
| GB2169295A (en) * | 1985-01-07 | 1986-07-09 | Celltech Ltd | Process for the production of a metalloproteinase inhibitor |
| JPH01213232A (ja) * | 1988-02-22 | 1989-08-28 | Fuji Yakuhin Kogyo Kk | 新規な皮膚潰瘍治療剤 |
| WO1990014363A1 (en) * | 1989-05-19 | 1990-11-29 | Amgen Inc. | Metalloproteinase inhibitor |
| US5714465A (en) | 1989-05-19 | 1998-02-03 | Amgen Inc. | Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor |
| NZ335864A (en) | 1996-11-06 | 2001-09-28 | Univ California | Isolated tumor necrosis factor receptor releasing enzyme (TRRE), compositions comprising the enzyme and methods of the use in modulation of TNF levels |
| US6916789B2 (en) * | 2001-07-02 | 2005-07-12 | Merrion Research I Limited | Peyer's patch and/or M-cell targeting ligands |
| JP2010502425A (ja) * | 2006-08-30 | 2010-01-28 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 膜を評価するシステム及び方法並びに膜濾過装置 |
| US8189753B1 (en) | 2007-04-12 | 2012-05-29 | Russound/Fmp Incorporated | Distributed intercom system with audio bus |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276284A (en) * | 1971-07-26 | 1981-06-30 | Brown Stuart I | Prevention of collagenase induced disease by treatment with collagenase inhibitors |
| US4530901A (en) * | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| ZA814375B (en) * | 1980-07-01 | 1982-07-28 | Hoffmann La Roche | Interferons and process for their preparation |
| US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
| US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
| US4382081A (en) * | 1981-06-12 | 1983-05-03 | E. R. Squibb & Sons, Inc. | Inhibitors of mammalian collagenase |
| US4361574A (en) * | 1981-10-02 | 1982-11-30 | American Home Products Corporation | Inhibitors of mammalian collagenase |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| GR79124B (da) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| JPH06102034B2 (ja) * | 1983-03-25 | 1994-12-14 | セルテク リミテツド | タンパク質の生産方法 |
| US4609667A (en) * | 1983-12-19 | 1986-09-02 | American Home Products Corporation | Inhibitor of mammalian collagenase and elastase |
| US4602006A (en) * | 1984-05-09 | 1986-07-22 | Syntex (U.S.A.) Inc. | Ynenolactone protease inhibitors |
| JPS62500424A (ja) * | 1984-10-01 | 1987-02-26 | サンド・リミテッド | 赤血球の増強活性を有する蛋白質のための遺伝子を含有するベクタ−および前記蛋白質を生産するための組み換えｄｎａ法 |
| GB8500341D0 (en) * | 1985-01-07 | 1985-02-13 | Celltech Ltd | Production of protein |
| GB2169295A (en) * | 1985-01-07 | 1986-07-09 | Celltech Ltd | Process for the production of a metalloproteinase inhibitor |
| EP0189784B1 (en) * | 1985-01-18 | 1989-11-08 | G.D. Searle & Co. | Human natural inhibitor of collagenases |
| US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
-
1986
- 1986-02-05 JP JP61501640A patent/JPH088870B2/ja not_active Expired - Lifetime
- 1986-02-05 WO PCT/US1986/000302 patent/WO1986004608A1/en not_active Ceased
- 1986-02-05 KR KR1019860700678A patent/KR940010862B1/ko not_active Expired - Lifetime
- 1986-02-05 AU AU55493/86A patent/AU5549386A/en not_active Abandoned
- 1986-02-05 EP EP86902087A patent/EP0211077B1/en not_active Expired - Lifetime
- 1986-02-05 DE DE8686902087T patent/DE3688383T2/de not_active Expired - Lifetime
- 1986-02-05 AT AT86902087T patent/ATE89005T1/de not_active IP Right Cessation
- 1986-09-04 DK DK198604227A patent/DK175964B1/da not_active IP Right Cessation
-
1990
- 1990-07-20 AU AU59710/90A patent/AU636370B2/en not_active Expired
-
1995
- 1995-06-07 US US08/474,553 patent/US6090585A/en not_active Expired - Fee Related
-
1999
- 1999-12-01 US US09/452,817 patent/US6342374B1/en not_active Expired - Fee Related
-
2001
- 2001-11-14 US US09/987,357 patent/US6800732B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR870700096A (ko) | 1987-02-28 |
| DK175964B1 (da) | 2005-09-26 |
| AU5971090A (en) | 1990-11-01 |
| US6342374B1 (en) | 2002-01-29 |
| ATE89005T1 (de) | 1993-05-15 |
| DE3688383D1 (de) | 1993-06-09 |
| KR940010862B1 (ko) | 1994-11-18 |
| AU5549386A (en) | 1986-08-26 |
| EP0211077B1 (en) | 1993-05-05 |
| EP0211077A1 (en) | 1987-02-25 |
| JPH088870B2 (ja) | 1996-01-31 |
| AU636370B2 (en) | 1993-04-29 |
| DE3688383T2 (de) | 1993-08-26 |
| WO1986004608A1 (en) | 1986-08-14 |
| US20030003556A1 (en) | 2003-01-02 |
| JPS62502101A (ja) | 1987-08-20 |
| US6090585A (en) | 2000-07-18 |
| EP0211077A4 (en) | 1987-11-23 |
| DK422786D0 (da) | 1986-09-04 |
| US6800732B2 (en) | 2004-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |