DK355486A - Fusionsproteiner, deres fremstilling og anvendelse - Google Patents
Fusionsproteiner, deres fremstilling og anvendelse Download PDFInfo
- Publication number
- DK355486A DK355486A DK355486A DK355486A DK355486A DK 355486 A DK355486 A DK 355486A DK 355486 A DK355486 A DK 355486A DK 355486 A DK355486 A DK 355486A DK 355486 A DK355486 A DK 355486A
- Authority
- DK
- Denmark
- Prior art keywords
- sequence
- amino acids
- genetically codable
- genetically
- fusion protein
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 5
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 10
- 241000588724 Escherichia coli Species 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3526995 | 1985-07-27 | ||
| DE19853526995 DE3526995A1 (de) | 1985-07-27 | 1985-07-27 | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK355486D0 DK355486D0 (da) | 1986-07-25 |
| DK355486A true DK355486A (da) | 1987-01-28 |
| DK172618B1 DK172618B1 (da) | 1999-03-01 |
Family
ID=6276985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198603554A DK172618B1 (da) | 1985-07-27 | 1986-07-25 | Fusionsproteiner, deres fremstilling og anvendelse |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0211299B1 (da) |
| JP (1) | JPH07113040B2 (da) |
| KR (1) | KR950000299B1 (da) |
| AT (1) | ATE50596T1 (da) |
| AU (1) | AU595221B2 (da) |
| CA (1) | CA1336329C (da) |
| DE (2) | DE3526995A1 (da) |
| DK (1) | DK172618B1 (da) |
| ES (1) | ES2000278A6 (da) |
| FI (1) | FI86887C (da) |
| GR (1) | GR861957B (da) |
| HU (1) | HU197356B (da) |
| IE (1) | IE59127B1 (da) |
| IL (1) | IL79522A (da) |
| NO (1) | NO175640C (da) |
| NZ (1) | NZ216967A (da) |
| PT (1) | PT83065B (da) |
| ZA (1) | ZA865556B (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
| DE3541856A1 (de) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
| ATE80913T1 (de) * | 1986-03-12 | 1992-10-15 | Int Minerals & Chem Corp | Hybride expressionsvektoren, deren herstellung und verwendungen. |
| JPH03503596A (ja) * | 1987-06-24 | 1991-08-15 | ノボ・ノルディスク エー／エス | 蛋白質若しくはポリペプチドの調製方法、該ポリペプチドをコードするｄｎａ配列、該ｄｎａ配列およびポリペプチドを有する微生物および該ポリペプチドの薬学的製剤としての利用 |
| US5179196A (en) * | 1989-05-04 | 1993-01-12 | Sri International | Purification of proteins employing ctap-iii fusions |
| US5358857A (en) * | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
| US5227293A (en) * | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
| IL95495A (en) * | 1989-08-29 | 1996-10-16 | Hoechst Ag | Fusion proteins their preparation and use |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| DE3942580A1 (de) * | 1989-12-22 | 1991-06-27 | Basf Ag | Verfahren zur herstellung von hirudin |
| ATE264871T1 (de) | 1996-07-26 | 2004-05-15 | Aventis Pharma Gmbh | Insulinderivate mit erhöhter zinkbindung |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| AU2008327513B2 (en) | 2007-09-21 | 2012-05-03 | Cadila Healthcare Limited | GCSF fusion protein systems suitable for high expression of peptides |
| PT2349324T (pt) | 2008-10-17 | 2017-12-06 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| WO2011058083A1 (de) | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin |
| SG10201500871TA (en) | 2009-11-13 | 2015-04-29 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| RS55378B1 (sr) | 2010-08-30 | 2017-03-31 | Sanofi Aventis Deutschland | Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| HRP20151068T1 (hr) | 2011-08-29 | 2016-01-01 | Sanofi-Aventis Deutschland Gmbh | Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| TWI758239B (zh) | 2014-12-12 | 2022-03-21 | 德商賽諾菲阿凡提斯德意志有限公司 | 甘精胰島素/利司那肽固定比率配製劑 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| KR20200080748A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법 |
| KR20200080747A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA802992B (en) * | 1979-06-01 | 1981-10-28 | Univ California | Human pre-growth hormone |
| ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| AU596585B2 (en) * | 1985-03-18 | 1990-05-10 | Genelabs Incorporated | Hybrid genes (eg. ig's & mhc proteins) via lambda library andplasmid casette vector |
| GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
| ES8706824A1 (es) * | 1985-04-08 | 1987-07-01 | Genetic Systems Corp | Un metodo para preparar proteinas que son inmunologicamente reactivas con anticuerpos para virus asociados con linfadenopatia. |
-
1985
- 1985-07-27 DE DE19853526995 patent/DE3526995A1/de not_active Withdrawn
-
1986
- 1986-07-19 DE DE8686109945T patent/DE3669175D1/de not_active Expired - Lifetime
- 1986-07-19 EP EP86109945A patent/EP0211299B1/de not_active Expired - Lifetime
- 1986-07-19 AT AT86109945T patent/ATE50596T1/de active
- 1986-07-24 FI FI863041A patent/FI86887C/fi not_active IP Right Cessation
- 1986-07-24 ES ES8600544A patent/ES2000278A6/es not_active Expired
- 1986-07-25 IL IL79522A patent/IL79522A/xx not_active IP Right Cessation
- 1986-07-25 ZA ZA865556A patent/ZA865556B/xx unknown
- 1986-07-25 HU HU863100A patent/HU197356B/hu unknown
- 1986-07-25 CA CA000514682A patent/CA1336329C/en not_active Expired - Lifetime
- 1986-07-25 AU AU60565/86A patent/AU595221B2/en not_active Expired
- 1986-07-25 GR GR861957A patent/GR861957B/el unknown
- 1986-07-25 DK DK198603554A patent/DK172618B1/da not_active IP Right Cessation
- 1986-07-25 PT PT83065A patent/PT83065B/pt unknown
- 1986-07-25 NO NO863000A patent/NO175640C/no unknown
- 1986-07-25 IE IE197786A patent/IE59127B1/en not_active IP Right Cessation
- 1986-07-25 NZ NZ216967A patent/NZ216967A/xx unknown
- 1986-07-26 JP JP61176558A patent/JPH07113040B2/ja not_active Expired - Lifetime
- 1986-07-26 KR KR1019860006142A patent/KR950000299B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR870001312A (ko) | 1987-03-13 |
| NO863000L (no) | 1987-01-28 |
| IE861977L (en) | 1987-01-27 |
| FI86887B (fi) | 1992-07-15 |
| EP0211299A2 (de) | 1987-02-25 |
| PT83065B (pt) | 1989-02-28 |
| FI863041L (fi) | 1987-01-28 |
| IL79522A0 (en) | 1986-10-31 |
| FI863041A0 (fi) | 1986-07-24 |
| GR861957B (en) | 1986-11-25 |
| AU595221B2 (en) | 1990-03-29 |
| KR950000299B1 (ko) | 1995-01-13 |
| HU197356B (en) | 1989-03-28 |
| NO175640B (da) | 1994-08-01 |
| IE59127B1 (en) | 1994-01-12 |
| PT83065A (de) | 1986-08-01 |
| IL79522A (en) | 1991-08-16 |
| DE3669175D1 (de) | 1990-04-05 |
| AU6056586A (en) | 1987-01-29 |
| NZ216967A (en) | 1988-08-30 |
| DK355486D0 (da) | 1986-07-25 |
| JPH07113040B2 (ja) | 1995-12-06 |
| DK172618B1 (da) | 1999-03-01 |
| FI86887C (fi) | 1992-10-26 |
| NO863000D0 (no) | 1986-07-25 |
| HUT43629A (en) | 1987-11-30 |
| ATE50596T1 (de) | 1990-03-15 |
| ES2000278A6 (es) | 1988-02-01 |
| DE3526995A1 (de) | 1987-02-05 |
| JPS6229600A (ja) | 1987-02-07 |
| ZA865556B (en) | 1987-03-25 |
| EP0211299B1 (de) | 1990-02-28 |
| CA1336329C (en) | 1995-07-18 |
| EP0211299A3 (en) | 1988-06-01 |
| NO175640C (no) | 1994-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |