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DK2898914T3 - Inhalationsindretninger til lagring og levering af medikament - Google Patents

Inhalationsindretninger til lagring og levering af medikament Download PDF

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Publication number
DK2898914T3
DK2898914T3 DK15150445.3T DK15150445T DK2898914T3 DK 2898914 T3 DK2898914 T3 DK 2898914T3 DK 15150445 T DK15150445 T DK 15150445T DK 2898914 T3 DK2898914 T3 DK 2898914T3
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Denmark
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chamber
housing
drug
air
mouthpiece
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DK15150445.3T
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English (en)
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Andrew Jones
Richard L Miller
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Manta Devices Llc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/008—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised by squeezing, e.g. using a flexible bottle or a bulb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
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    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/005—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a cylindrical surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0061—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using pre-packed dosages having an insert inside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
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    • A—HUMAN NECESSITIES
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    • A61M15/00—Inhalators
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    • A61M15/00—Inhalators
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)

Claims (14)

1. Indretning til levering af medikament, hvilken indretning omfatter: en fluidstrømningsvej (103, 403, 503, 903, 1103, 1103', 1303, 1303', 1403, 1503, 2103, 3016) med et indløb (115, 415, 515, 915, 3022) og et udløb (116, 416, 516, 916, 3023); en indsnævring (107, 407, 507, 507', 907, 1107, 1107', 1107", 1307, 1507, 2107, 3019) positioneret i fluidstrømningsvejen mellem indløbet og udløbet; et oplukkeligt kammer (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007) konfigureret til levering af et medikament; og en udløbskanal (106, 406, 506, 906, 1106', 1306, 1506, 2106, 3017), som forbinder det oplukkelige kammer til fluidstrømningsvejen, hvilket kammer har en indre overflade, der er mindst delvist krum og en åbning i fluid forbindelse med fluidstrømningsvejen via udløbskanalen, hvilken indre overflade er konfigureret til at modtage fluidstrøm tilladt igennem åbningen og til at omdirigere mindst en del af fluidstrømmen tilbage mod åbningen således at mindst en del af den omdirigerede fluidstrøm indføres i fluidstrømningsvejen igennem åbningen og udløbskanalen.
2. Indretningen ifølge krav 1, hvor den indre overflade inkluderer et indløbsafsnit, et udløbsafsnit og et krumt afsnit, hvor indløbsafsnittet er konfigureret til at tilvejebringe fluidstrømmen til det krumme afsnit til cirkulation rundt i kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007) til udløbsafsnittet til indføring i fluidstrømningsvejen igennem åbningen og udløbskanalen.
3. Indretningen ifølge krav 1, hvor den indre overflade er konfigureret til at omdirigere fluidstrømmen således at fluidstrømmen recirkulerer og krydser fluidstrøm strømmende ind i kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007).
4. Indretningen ifølge et hvilket som helst af kravene 1-3, hvor fluidstrømningsvejen og det oplukkelige kammer er konfigureret således at fluid forbindelse er selektivt oplukkelig og lukkelig mellem fluidstrømningsvejen og kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007), hvor kammeret fortrinsvis forskydes i forhold til fluidstrømningsvejen til selektivt at åbne eller lukke fluid forbindelse mellem fluidstrømningsvejen og kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007), eller kammeret fortrinsvis roterer i forhold til fluidstrømningsvejen til selektivt at åbne eller lukke fluid forbindelse mellem fluidstrømningsvejen (103, 403, 503, 903, 1103, 1103', 1303, 1303', 1403, 1503, 2103) og kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007).
5. Indretningen ifølge et hvilket som helst af kravene 1-4, hvor fluidstrømmen igennem udløbskanalen møder fluidstrømningsvejen ved indsnævringen (107, 407, 507, 507', 907, 1107, 1107', 1107", 1307, 1507,2107,3019).
6. Indretningen ifølge et hvilket som helst af kravene 1-5, yderligere omfattende et hvirvelkammer positioneret nedstrøms af udløbskanalen.
7. Indretningen ifølge et hvilket som helst af kravene 1-6, yderligere omfattende en aktiv kilde (308, 1008, 3058) konfigureret til at tilvejebringe luftstrøm til fluidstrømningsvejen.
8. Indretningen ifølge krav 1, et volumen (138, 538) separeret fra en recirkuleringsfluidvej i kammeret afen forhindring (104, 504) og som tilvejebringer en fluidvej mellem kammeret og udløbskanalen, hvor volumenet (138, 538) er fortrinsvis formet til at styre levering af et medikament fra kammeret til udløbskanalen, eller kammeret er fortrinsvis defineret delvist af forhindringen (104, 504), og hvor forhindringen forårsager mindst en del af fluidstrømmen til at recirkulere i kammeret og separerer volumenet fra den recirkulerende fluidstrøm.
9. Indretningen ifølge et hvilket som helst af kravene 1-8, yderligere omfattende en indløbskanal konfigureret til at lede indkommende fluidstrøm til en væg af kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007), mod udløbskanalen, eller væk fra udløbskanalen.
10. Indretningen ifølge et hvilket som helst af kravene 1-9, yderligere omfattende et mundstykke koblet til fluidstrømningsvejen således at bevægelse af mundstykket åbner fluid forbindelse mellem fluidstrømningsvejen og kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007).
11. Indretningen ifølge et hvilket som helst af kravene 1-10, yderligere omfattende en dosis af medikamentet i kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007).
12. Indretningen ifølge et hvilket som helst af kravene 1-11, hvor kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007) har et U-formet tværsnit.
13. Indretningen ifølge krav 12, hvor den indre overflade er konfigureret til omdirigere fluidstrømmen i kammeret (101, 401, 501, 901, 1101, 1201, 1301, 1401, 1501, 3007) langs en U-formet vej fra indløbskanalen til udløbskanalen.
14. Indretningen ifølge et hvilket som helst af kravene 1-13, hvor mindst en del af den omdirigerede fluidstrøm indføres i fluidstrømningsvejen tværgående til fluidstrømningsvejen (103, 403, 503, 903, 1103, 1103', 1303, 1303', 1403, 1503, 2103).
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US20090013994A1 (en) 2009-01-15
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JP5651200B2 (ja) 2015-01-07
EP2898914A2 (en) 2015-07-29
CN101795723A (zh) 2010-08-04
US20130032144A1 (en) 2013-02-07
EP2898914B1 (en) 2018-06-20
US20140102451A1 (en) 2014-04-17
WO2009009013A3 (en) 2009-04-23
US20180207374A1 (en) 2018-07-26
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US8291901B2 (en) 2012-10-23
US9919115B2 (en) 2018-03-20
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US8607787B2 (en) 2013-12-17
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EP3453418A1 (en) 2019-03-13
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