DK270789D0 - Hirudin-derivater, deres fremstilling og anvendelse - Google Patents

Hirudin-derivater, deres fremstilling og anvendelse

Info

Publication number: DK270789D0
Authority: DK; Denmark
Prior art keywords: preparation; hirudin derivatives; hirudin; derivatives; carrier
Prior art date: 1988-06-04

Application number

DK270789A

Other languages

English (en)

Other versions

DK270789A (da

DK175103B1 (da

Inventor

Peter Crause

Paul Habermann

Martin Kramer

Rainer Obermeier

Klaus Sauber

Dominique Tripier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-04

Filing date

1989-06-02

Publication date

1989-06-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6355879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK270789(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-06-02 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-06-02 Publication of DK270789D0 publication Critical patent/DK270789D0/da

1989-12-05 Publication of DK270789A publication Critical patent/DK270789A/da

2004-06-01 Application granted granted Critical

2004-06-01 Publication of DK175103B1 publication Critical patent/DK175103B1/da

Links

WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 3
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK198902707A 1988-06-04 1989-06-02 Hirudin-derivater, deres fremstilling og anvendelse DK175103B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3819079A DE3819079A1 (de)	1988-06-04	1988-06-04	Hirudin-derivate mit verzoegerter wirkung
DE3819079		1988-06-04

Publications (3)

Publication Number	Publication Date
DK270789D0 true DK270789D0 (da)	1989-06-02
DK270789A DK270789A (da)	1989-12-05
DK175103B1 DK175103B1 (da)	2004-06-01

Family

ID=6355879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198902707A DK175103B1 (da)	1988-06-04	1989-06-02	Hirudin-derivater, deres fremstilling og anvendelse

Country Status (20)

Country	Link
US (1)	US5538946A (da)
EP (1)	EP0345616B1 (da)
JP (1)	JP2804514B2 (da)
KR (1)	KR0140884B1 (da)
AT (1)	ATE130315T1 (da)
AU (1)	AU625215B2 (da)
CA (1)	CA1340197C (da)
CY (1)	CY2025A (da)
DE (2)	DE3819079A1 (da)
DK (1)	DK175103B1 (da)
ES (1)	ES2080732T3 (da)
FI (1)	FI98703C (da)
GR (1)	GR3018364T3 (da)
HU (1)	HU204851B (da)
IE (1)	IE72201B1 (da)
IL (1)	IL90507A0 (da)
NO (1)	NO177312C (da)
NZ (1)	NZ229402A (da)
PT (1)	PT90743B (da)
ZA (1)	ZA894180B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2000887A1 (en) *	1988-11-01	1990-05-01	Cecilia S.L. Ku	Thromboresistant materials and methods for making same
JP3187044B2 (ja) *	1989-12-01	2001-07-11	ビーエーエスエフアクチェンゲゼルシャフト	ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体
JP2975632B2 (ja) *	1990-03-30	1999-11-10	生化学工業株式会社	グリコサミノグリカン修飾プロテイン
GB2247239A (en) *	1990-08-22	1992-02-26	Ciba Geigy Ag	Hirudin conjugates with polyoxyethylene
DE4041185A1 (de) *	1990-12-21	1992-06-25	Knoll Ag	Verwendung von hirudin und dessen muteinen zur kombinationsbehandlung von tumoren
DE4437502A1 (de) *	1993-12-02	1995-06-08	Basf Ag	Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen
DE4342154A1 (de) *	1993-12-10	1995-06-14	Behringwerke Ag	Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19533817C2 (de) *	1995-09-13	1999-12-09	Max Planck Gesellschaft	Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
US6491965B1 (en)	1995-11-30	2002-12-10	Hamilton Civic Hospitals Research Development, Inc.	Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6562781B1 (en)	1995-11-30	2003-05-13	Hamilton Civic Hospitals Research Development Inc.	Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en)	1995-11-30	2006-05-16	Hamilton Civic Hospital Research Development Inc.	Methods of coating a device using anti-thrombin heparin
US5856452A (en) *	1996-12-16	1999-01-05	Sembiosys Genetics Inc.	Oil bodies and associated proteins as affinity matrices
DE19915862A1 (de) *	1999-04-08	2000-10-12	Max Planck Gesellschaft	Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
US6809076B2 (en) *	2000-03-20	2004-10-26	Abbott Gmbh & Co. Kg	Use of anticoagulant agents in the extracorporeal treatment of blood
US6818392B2 (en)	2000-12-06	2004-11-16	Abbott Laboratories	Monoclonal antibodies to human immunodeficiency virus and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1979000638A1 (en) *	1978-02-17	1979-09-06	Thin Conductive Coating Oester	A method of producing thrombosis-resistant surfaces
DE2930542A1 (de) *	1979-07-27	1981-02-12	Hoechst Ag	Neue insulinderivate und verfahren zu ihrer herstellung
ATE78294T1 (de) *	1984-03-27	1992-08-15	Transgene Sa	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
US4666884A (en) *	1984-04-10	1987-05-19	New England Deaconess Hospital	Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
EP0168342B1 (de) *	1984-06-14	1991-07-03	Ciba-Geigy Ag	Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3500268A1 (de) *	1985-01-05	1986-07-10	Hoechst Ag, 6230 Frankfurt	Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens

1988
- 1988-06-04 DE DE3819079A patent/DE3819079A1/de not_active Withdrawn
1989
- 1989-05-30 DE DE58909493T patent/DE58909493D1/de not_active Expired - Lifetime
- 1989-05-30 ES ES89109772T patent/ES2080732T3/es not_active Expired - Lifetime
- 1989-05-30 EP EP89109772A patent/EP0345616B1/de not_active Expired - Lifetime
- 1989-05-30 AT AT89109772T patent/ATE130315T1/de not_active IP Right Cessation
- 1989-06-01 FI FI892686A patent/FI98703C/fi active IP Right Grant
- 1989-06-01 AU AU35955/89A patent/AU625215B2/en not_active Expired
- 1989-06-01 HU HU892808A patent/HU204851B/hu unknown
- 1989-06-02 NZ NZ229402A patent/NZ229402A/en unknown
- 1989-06-02 PT PT90743A patent/PT90743B/pt not_active IP Right Cessation
- 1989-06-02 DK DK198902707A patent/DK175103B1/da not_active IP Right Cessation
- 1989-06-02 ZA ZA894180A patent/ZA894180B/xx unknown
- 1989-06-02 JP JP1139378A patent/JP2804514B2/ja not_active Expired - Lifetime
- 1989-06-02 KR KR1019890007560A patent/KR0140884B1/ko not_active Expired - Lifetime
- 1989-06-02 NO NO892267A patent/NO177312C/no not_active IP Right Cessation
- 1989-06-02 CA CA000601593A patent/CA1340197C/en not_active Expired - Lifetime
- 1989-06-02 IL IL90507A patent/IL90507A0/xx unknown
- 1989-06-12 IE IE181589A patent/IE72201B1/en not_active IP Right Cessation
1992
- 1992-06-05 US US07/895,436 patent/US5538946A/en not_active Expired - Lifetime
1995
- 1995-12-12 GR GR950403492T patent/GR3018364T3/el unknown
1998
- 1998-02-20 CY CY202598A patent/CY2025A/xx unknown

Also Published As

Publication number	Publication date
EP0345616A3 (de)	1991-03-20
NO892267D0 (no)	1989-06-02
IL90507A0 (en)	1990-01-18
US5538946A (en)	1996-07-23
ZA894180B (en)	1990-02-28
EP0345616B1 (de)	1995-11-15
NO892267L (no)	1989-12-05
FI98703C (fi)	1997-08-11
HK1006024A1 (en)	1999-02-05
EP0345616A2 (de)	1989-12-13
HU204851B (en)	1992-02-28
ATE130315T1 (de)	1995-12-15
AU3595589A (en)	1989-12-07
NZ229402A (en)	1992-05-26
FI892686A0 (fi)	1989-06-01
JP2804514B2 (ja)	1998-09-30
AU625215B2 (en)	1992-07-02
DE3819079A1 (de)	1989-12-07
DK270789A (da)	1989-12-05
FI892686L (fi)	1989-12-05
ES2080732T3 (es)	1996-02-16
FI98703B (fi)	1997-04-30
DE58909493D1 (de)	1995-12-21
CA1340197C (en)	1998-12-15
IE72201B1 (en)	1997-04-09
IE891815L (en)	1989-12-04
PT90743A (pt)	1989-12-29
HUT51298A (en)	1990-04-28
GR3018364T3 (en)	1996-03-31
CY2025A (en)	1998-02-20
KR0140884B1 (ko)	1998-06-15
PT90743B (pt)	1994-10-31
NO177312C (no)	1995-08-23
NO177312B (no)	1995-05-15
JPH0267300A (ja)	1990-03-07
KR910001041A (ko)	1991-01-30
DK175103B1 (da)	2004-06-01

Publication	Publication Date	Title
DK270789A (da)	1989-12-05	Hirudin-derivater, deres fremstilling og anvendelse
ATE269290T1 (de)	2004-07-15	Benzoylderivate
UA39099C2 (uk)	2001-06-15	Циклічні азотовмісні похідні, суміш їх ізомерів або окремі ізомери, або їх солі
AU8581991A (en)	1992-04-30	Mercaptoacetylamide derivatives as inhibitors of enkephalinase and ACE, and processes for their production
BR0012243A (pt)	2002-03-26	Triflúor butenos nematocidas
DK0400583T3 (da)	2000-03-13	Imidazoquinoxalinoner,deres azaanaloger og fremgangsmåde til fremstilling deraf
IL103263A0 (en)	1993-02-21	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
NO881697D0 (no)	1988-04-20	Verktoeyenhet, verktoeydeler og fremgangsmaate for sammensetting av delene.
ATE56211T1 (de)	1990-09-15	2-phenylbenzoxepin-derivat.
ES2063796T3 (es)	1995-01-16	Nuevos derivados de 2'-halometiliden, 2'-eteniliden- y 2'-etinil-adenosina.
NO883582D0 (no)	1988-08-12	Katodisk elektrodeponerbart belegningspreparat.
AU8032794A (en)	1995-06-15	Amidinophenylalanine derivatives, a process for their preparation, their use and compositions containing these as anticoagulants
HUT51295A (en)	1990-04-28	Process for producing peptidalcohol derivatives of anticoagulant activity
FI895844A0 (fi)	1989-12-07	Koagulation foerhindrande peptider.
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
FI891111A7 (fi)	1989-09-09	Menetelmä 1,4-dihydropyridiinijohdannaisten valmistamiseksi
IT8921657A0 (it)	1989-09-08	Procedimento per la produzione di cuoio morbido senza piombo.
NO894189D0 (no)	1989-10-20	4-amino-3-acylkinolonderivater og deres anvendelse som inhibitorer av mavesyresekresjon.
MX9203634A (es)	1992-07-01	Derivados de pirocatecol 3,5-disubstituidos.
ATE84794T1 (de)	1993-02-15	Aminosaeure-derivate als antihypertensive.
FI935707L (fi)	1993-12-17	Anvaendning av hirudinderivat som trombininhibitorer

Legal Events

Date	Code	Title	Description
2009-06-22	PUP	Patent expired