DK227186D0 - Profylaktisk og terapeutisk middel - Google Patents
Profylaktisk og terapeutisk middelInfo
- Publication number
- DK227186D0 DK227186D0 DK227186A DK227186A DK227186D0 DK 227186 D0 DK227186 D0 DK 227186D0 DK 227186 A DK227186 A DK 227186A DK 227186 A DK227186 A DK 227186A DK 227186 D0 DK227186 D0 DK 227186D0
- Authority
- DK
- Denmark
- Prior art keywords
- prophylactic
- therapeutic agent
- therapeutic
- agent
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 230000000069 prophylactic effect Effects 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10579885A JPS61263917A (ja) | 1985-05-20 | 1985-05-20 | 脳機能正常化剤 |
| JP10579885 | 1985-05-20 | ||
| JP24805785A JPS62108814A (ja) | 1985-11-07 | 1985-11-07 | 過酸化脂質生成抑制剤 |
| JP24805785 | 1985-11-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK227186D0 true DK227186D0 (da) | 1986-05-16 |
| DK227186A DK227186A (da) | 1986-11-21 |
| DK169672B1 DK169672B1 (da) | 1995-01-09 |
Family
ID=26446032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK227186A DK169672B1 (da) | 1985-05-20 | 1986-05-16 | Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4857542A (da) |
| EP (1) | EP0208874B1 (da) |
| DE (1) | DE3673273T2 (da) |
| DK (1) | DK169672B1 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235567B1 (en) * | 1986-01-29 | 1994-01-12 | Sumitomo Chemical Company, Limited | Indazole compounds, their production, use and intermediates |
| EP0269030B1 (en) * | 1986-11-20 | 1994-05-04 | Mitsubishi Kasei Corporation | Lipid-peroxide formation inhibiting composition and novel compounds useful therefor |
| IL84944A (en) * | 1987-01-19 | 1992-02-16 | Ici Plc | Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation |
| US5233044A (en) * | 1989-06-08 | 1993-08-03 | Millipore Corporation | Active esters for solid phase peptide synthesis |
| US5264451A (en) * | 1992-04-07 | 1993-11-23 | American Home Products Corporation | Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones |
| JPH0725765A (ja) * | 1993-07-07 | 1995-01-27 | Mitsubishi Chem Corp | 眼疾患用薬剤 |
| JP3065506B2 (ja) * | 1995-04-03 | 2000-07-17 | 株式会社資生堂 | ピラゾリジン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤 |
| DE19518082A1 (de) * | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
| DE19756115A1 (de) * | 1997-12-17 | 1999-06-24 | Basf Ag | Substituierte Phenylpyrazolone, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen und tierischen Schädlingen |
| CA2414586C (en) * | 2000-06-29 | 2009-09-29 | Mitsubishi Pharma Corporation | Agent for therapeutic treatment of optic nerve diseases and the like |
| RU2192419C2 (ru) * | 2000-08-17 | 2002-11-10 | Открытое Акционерное Общество "Каустик" | Способ получения 1-фенил-3-метил-пиразолона-5 |
| JP3758164B2 (ja) | 2000-10-24 | 2006-03-22 | 三菱ウェルファーマ株式会社 | 筋萎縮性側索硬化症（ａｌｓ）治療剤 |
| US7211596B2 (en) | 2001-05-11 | 2007-05-01 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
| CN100398104C (zh) * | 2001-09-14 | 2008-07-02 | 三菱制药株式会社 | 抗血栓药和吡唑啉酮衍生物的组合药物 |
| JPWO2003064395A1 (ja) * | 2002-01-31 | 2005-05-26 | 国立精神・神経センター総長 | 神経変性疾患の予防又は治療剤 |
| AU2003207275A1 (en) * | 2002-02-06 | 2003-09-02 | Mitsubishi Pharma Corporation | Preventive and/or therapeutic agent for cardiac disorder |
| JP2005343789A (ja) * | 2002-03-15 | 2005-12-15 | Mitsubishi Pharma Corp | 低酸素性虚血性脳障害予防・治療剤 |
| JPWO2003105909A1 (ja) * | 2002-06-13 | 2005-10-13 | 三菱ウェルファーマ株式会社 | 肝虚血再灌流傷害の予防及び／又は治療のための医薬並びに移植肝臓の保護剤 |
| WO2004013107A1 (ja) * | 2002-08-05 | 2004-02-12 | Mitsubishi Pharma Corporation | 脊髄損傷による障害の予防及び／又は治療のための医薬 |
| US7312239B2 (en) * | 2002-09-04 | 2007-12-25 | Mitsubishi Pharma Corporation | Medicament for prevention and/or therapy of arterial wall disorder |
| CN1681794A (zh) * | 2002-09-09 | 2005-10-12 | 三菱制药株式会社 | 预防和/或治疗炎症性肠病的药物 |
| MXPA05003195A (es) * | 2002-09-26 | 2005-06-08 | Pfizer | Derivados de pirazol como inhibidores de la transcriptasa inversa. |
| US7230025B2 (en) | 2002-09-26 | 2007-06-12 | Pfizer, Inc. | Pyrazole derivatives |
| WO2004033431A2 (en) * | 2002-10-04 | 2004-04-22 | Arena Pharmaceuticals, Inc. | Hydroxypyrazoles for use against metabolic-related disorders |
| JP2006096664A (ja) * | 2002-10-18 | 2006-04-13 | Mitsubishi Pharma Corp | 肝繊維化抑制剤 |
| AU2003275707A1 (en) * | 2002-10-28 | 2004-05-13 | Mitsubishi Pharma Corporation | Agent for alleviation of functional disorder after cardiopulmonary resuscitation |
| EP1582517A4 (en) * | 2003-01-10 | 2008-11-12 | Mitsubishi Tanabe Pharma Corp | INHIBITORS OF THE BREAKDOWN OF THE BLOOD BRAIN BARRIER |
| EP1685837A4 (en) | 2003-11-12 | 2009-03-25 | Lead Chem Co Ltd | BRAIN PROTECTIVE AGENT OF THE TYPE ADMINISTERED BY PERCUTANEOUS ABSORPTION |
| PL1714960T3 (pl) | 2004-02-09 | 2018-08-31 | Mitsubishi Tanabe Pharma Corporation | Nowy środek terapeutyczny przeciwko stwardnieniu zanikowemu bocznemu (ALS) lub chorobie którą można przypisać ALS |
| WO2006016707A2 (en) | 2004-08-10 | 2006-02-16 | Mitsubishi Pharma Corporation | Pyrazolone compounds for treating cerebrovascular disorders |
| US7850723B1 (en) * | 2005-11-28 | 2010-12-14 | Innercool Therapies, Inc. | Method and apparatus for patient temperature control employing titration of therapy using EEG signals |
| CN101367763B (zh) * | 2007-08-17 | 2012-06-27 | 深圳泛胜塑胶助剂有限公司 | 1-苯基-3-甲基-5-吡唑酮的合成工艺 |
| WO2009066752A1 (ja) | 2007-11-22 | 2009-05-28 | Mitsubishi Tanabe Pharma Corporation | 環状ポリオレフィン層を含むプラスチック容器 |
| CN101524352A (zh) | 2008-03-04 | 2009-09-09 | 江苏先声药物研究有限公司 | 一种含有3-甲基-1-苯基-2-吡唑啉-5-酮的组合物 |
| CN101830852B (zh) * | 2010-03-22 | 2012-05-09 | 海南美兰史克制药有限公司 | 一种新路线的依达拉奉化合物 |
| CN102241631A (zh) * | 2010-05-13 | 2011-11-16 | 吉林省博大制药有限责任公司 | 依达拉奉原料的制备方法 |
| CN102180834B (zh) * | 2011-03-24 | 2012-09-26 | 江苏正大丰海制药有限公司 | 一种依达拉奉的制备方法 |
| ES2736007T3 (es) | 2011-09-05 | 2019-12-23 | Mitsubishi Tanabe Pharma Corp | Agente medicinal para el tratamiento de la esclerosis lateral amiotrófica o la prevención de la progresión de una fase de la esclerosis lateral amiotrófica |
| CN103588709B (zh) * | 2012-08-17 | 2015-09-09 | 上海医药工业研究院 | 一种依达拉奉的制备方法 |
| WO2014074218A1 (en) * | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| JP2017222575A (ja) | 2014-09-19 | 2017-12-21 | 田辺三菱製薬株式会社 | 眼科疾患予防治療剤 |
| CN104326984A (zh) * | 2014-10-10 | 2015-02-04 | 河南明德科润医药科技有限责任公司 | 一种高纯度药用注射级依达拉奉原料的合成方法 |
| CN106117144B (zh) * | 2016-06-24 | 2019-01-29 | 合肥久诺医药科技有限公司 | 一种高纯度依达拉奉的合成工艺 |
| CA3078320A1 (en) | 2017-10-04 | 2019-04-11 | Mitsubishi Tanabe Pharma Corporation | Method for treating amyotrophic lateral sclerosis and method for suppressing progress of amyotrophic lateral sclerosis |
| WO2019070932A1 (en) | 2017-10-04 | 2019-04-11 | Mitsubishi Tanabe Pharma Corporation | METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS AND METHOD OF PREVENTING THE PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS |
| WO2019167178A1 (ja) | 2018-02-28 | 2019-09-06 | 田辺三菱製薬株式会社 | ３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬の分析方法、筋萎縮性側索硬化症の治療および筋萎縮性側索硬化症の進行抑制、ならびに、３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬を含む薬剤の製造方法 |
| CN118632692A (zh) | 2022-02-03 | 2024-09-10 | 田边三菱制药株式会社 | 用于治疗肌萎缩侧索硬化症或抑制肌萎缩侧索硬化症进展的药剂 |
| WO2024005187A1 (ja) | 2022-07-01 | 2024-01-04 | 田辺三菱製薬株式会社 | 組成物、およびエダラボンの応答可能性の評価方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1723545A (en) * | 1925-10-21 | 1929-08-06 | Ig Farbenindustrie Ag | Process of preparing 1-phenyl-3-methyl-5-pyrazolone |
| DE1003215B (de) * | 1954-08-07 | 1957-02-28 | Hoechst Ag | Verfahren zur Herstellung von 1-Benzyl-3-methyl-pyrazolon-(5) |
| US3514465A (en) * | 1966-12-30 | 1970-05-26 | Degussa | Certain thiazolyl- and pyridinylaminoketones |
| US3479369A (en) * | 1967-04-05 | 1969-11-18 | Uniroyal Inc | Alkyl- or aryl-4-antipyrylmonosulfides and method for preparing same |
| IT1044784B (it) * | 1970-12-15 | 1980-04-21 | Italfarmaco Spa | Farmaco adnattivita analgesica e antiinfiammatoria |
| US4112227A (en) * | 1973-04-17 | 1978-09-05 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| US4005215A (en) * | 1973-04-17 | 1977-01-25 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| US4000294A (en) * | 1973-04-17 | 1976-12-28 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| DE2319278C2 (de) * | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmazeutisches Mittel |
| DE2427272C3 (de) * | 1974-06-06 | 1981-10-01 | Bayer Ag, 5090 Leverkusen | 1-(2-(β-Naphthyloxy)-äthyl)-3-methyl -pyrazolon-(5), Verfahren sowie Verwendung als Antithrombotikum |
| DE2461039A1 (de) * | 1974-12-23 | 1976-06-24 | Thiemann Chem Pharm Fab | Arzneimittel |
| JPS5813556B2 (ja) * | 1975-12-22 | 1983-03-14 | タイホウヤクヒンコウギヨウ カブシキガイシヤ | ピラノピラゾ−ル −３− カルボンサンユウドウタイノセイホウ |
| JPS5770871A (en) * | 1980-10-17 | 1982-05-01 | Konishiroku Photo Ind Co Ltd | Synthetic method of magneta coupler |
| DK143684A (da) * | 1983-03-12 | 1984-09-13 | Bayer Ag | Anvendelse af pyrazolonderivater som lipoxygenasehaemmer ved terapi af isaer ischaemi og hjerterytmeforstyrrelser |
| DE3312581A1 (de) * | 1983-04-08 | 1984-10-11 | Bayer Ag, 5090 Leverkusen | Verwendung von pyrazolonderivaten bei der bekaempfung des wachstums von tumorzellen und der metastasenbildung, arzneimittel hierfuer und verfahren zu deren herstellung |
| US4550119A (en) * | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| DE3443308A1 (de) * | 1984-11-28 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 1-heteroaryl-4-aryl-pyrazolin-5-one zur verwendung als arzneimittel |
-
1986
- 1986-05-16 DK DK227186A patent/DK169672B1/da not_active IP Right Cessation
- 1986-05-20 EP EP86106817A patent/EP0208874B1/en not_active Expired - Lifetime
- 1986-05-20 DE DE8686106817T patent/DE3673273T2/de not_active Expired - Fee Related
-
1987
- 1987-11-19 US US07/122,516 patent/US4857542A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE3673273D1 (de) | 1993-04-29 |
| EP0208874B1 (en) | 1993-03-24 |
| DK169672B1 (da) | 1995-01-09 |
| DE3673273T2 (de) | 1993-09-09 |
| US4857542A (en) | 1989-08-15 |
| DK227186A (da) | 1986-11-21 |
| EP0208874A1 (en) | 1987-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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