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DK214090A - 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse - Google Patents

5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse Download PDF

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Publication number
DK214090A
DK214090A DK214090A DK214090A DK214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A DK 214090 A DK214090 A DK 214090A
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Prior art keywords
aminosulphonylalkyl
incidental
derivatives
procedure
preparation
Prior art date
Application number
DK214090A
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English (en)
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DK214090D0 (da
Inventor
Alexander William Oxford
Brian Evans
Michael Dennis Dowle
Ian Harold Coates
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Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK214090A publication Critical patent/DK214090A/da
Publication of DK214090D0 publication Critical patent/DK214090D0/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK214090A 1983-12-06 1990-09-06 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse DK214090D0 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (2)

Publication Number Publication Date
DK214090A true DK214090A (da) 1990-09-06
DK214090D0 DK214090D0 (da) 1990-09-06

Family

ID=10552845

Family Applications (2)

Application Number Title Priority Date Filing Date
DK583684A DK583684A (da) 1983-12-06 1984-12-06 Kemiske forbindelser
DK214090A DK214090D0 (da) 1983-12-06 1990-09-06 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK583684A DK583684A (da) 1983-12-06 1984-12-06 Kemiske forbindelser

Country Status (27)

Country Link
US (1) US4994483A (da)
JP (2) JPH062733B2 (da)
KR (1) KR850004459A (da)
CN (2) CN85104233A (da)
AT (1) AT381934B (da)
AU (1) AU575365B2 (da)
BE (1) BE901224A (da)
CA (1) CA1233183A (da)
CH (1) CH663411A5 (da)
CY (1) CY1562A (da)
DE (1) DE3444572C2 (da)
DK (2) DK583684A (da)
ES (2) ES8607234A1 (da)
FI (1) FI80260C (da)
FR (1) FR2555987B1 (da)
GB (2) GB8332435D0 (da)
HK (1) HK85690A (da)
HU (2) HU196752B (da)
IL (1) IL73756A (da)
IT (1) IT1178268B (da)
NL (1) NL8403719A (da)
NO (1) NO162764C (da)
NZ (1) NZ210469A (da)
PT (1) PT80572B (da)
SE (1) SE458446B (da)
SG (1) SG65790G (da)
ZA (1) ZA849498B (da)

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NL8503337A (nl) * 1984-12-04 1986-07-01 Glaxo Group Ltd Indoolderivaten.
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
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GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
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GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
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ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
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US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
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US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
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US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
TWI466879B (zh) 2005-04-13 2015-01-01 Neuraxon Inc 具有一氧化氮合成酶抑制活性之取代的吲哚化合物
US7989447B2 (en) * 2006-04-13 2011-08-02 Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
PT2425820E (pt) * 2007-02-11 2015-08-04 Map Pharmaceuticals Inc Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
EA201000808A1 (ru) 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли
EP2219449A4 (en) * 2007-11-16 2010-10-27 Univ Arizona State METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING
EP2220074A4 (en) * 2007-11-16 2012-01-04 Neuraxon Inc 3,5-SUBSTITUTED INDOL COMPOUNDS WITH NOS AND NOREPINEPHRINE RECOVERY-HEMDERING EFFECT
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
WO2011036521A2 (en) 2009-09-25 2011-03-31 Dr. Reddy's Laboratories Limited Formulations comprising triptan compounds
JPWO2012165262A1 (ja) * 2011-05-27 2015-02-23 国立大学法人徳島大学 ベンジルアミン誘導体
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NL8503337A (nl) * 1984-12-04 1986-07-01 Glaxo Group Ltd Indoolderivaten.

Also Published As

Publication number Publication date
GB2150932A (en) 1985-07-10
IL73756A0 (en) 1985-03-31
ES538336A0 (es) 1986-06-01
HK85690A (en) 1990-10-25
FI844789A0 (fi) 1984-12-05
FR2555987A1 (fr) 1985-06-07
AT381934B (de) 1986-12-10
PT80572B (en) 1986-12-22
CY1562A (en) 1991-05-17
IL73756A (en) 1988-02-29
IT1178268B (it) 1987-09-09
NO844879L (no) 1985-06-07
FI844789L (fi) 1985-06-07
AU575365B2 (en) 1988-07-28
DK583684D0 (da) 1984-12-06
FI80260B (fi) 1990-01-31
NO162764B (no) 1989-11-06
BE901224A (fr) 1985-06-06
CH663411A5 (fr) 1987-12-15
ZA849498B (en) 1986-09-24
CN85104233A (zh) 1987-01-07
NO162764C (no) 1990-02-14
ATA387384A (de) 1986-05-15
AU3636784A (en) 1985-06-13
SE8406200D0 (sv) 1984-12-06
US4994483A (en) 1991-02-19
HUT40624A (en) 1987-01-28
CN1015055B (zh) 1991-12-11
PT80572A (en) 1985-06-01
ES8607234A1 (es) 1986-06-01
NZ210469A (en) 1989-01-27
SE458446B (sv) 1989-04-03
FR2555987B1 (fr) 1987-07-17
ES546631A0 (es) 1987-10-16
NL8403719A (nl) 1985-07-01
ES8800150A1 (es) 1987-10-16
GB8430810D0 (en) 1985-01-16
DE3444572A1 (de) 1985-06-20
GB8332435D0 (en) 1984-01-11
IT8449265A0 (it) 1984-12-06
JPS60155156A (ja) 1985-08-15
SE8406200L (sv) 1985-06-07
JPH062733B2 (ja) 1994-01-12
KR850004459A (ko) 1985-07-15
GB2150932B (en) 1987-10-28
CN85106225A (zh) 1987-02-18
HUT36455A (en) 1985-09-30
DE3444572C2 (de) 1993-10-14
CA1233183A (en) 1988-02-23
SG65790G (en) 1990-10-26
DK583684A (da) 1985-06-07
DK214090D0 (da) 1990-09-06
JPH03184958A (ja) 1991-08-12
FI80260C (fi) 1990-05-10
HU196752B (en) 1989-01-30

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