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EA201000808A1 - Индольные соединения и способы лечения висцеральной боли - Google Patents

Индольные соединения и способы лечения висцеральной боли

Info

Publication number
EA201000808A1
EA201000808A1 EA201000808A EA201000808A EA201000808A1 EA 201000808 A1 EA201000808 A1 EA 201000808A1 EA 201000808 A EA201000808 A EA 201000808A EA 201000808 A EA201000808 A EA 201000808A EA 201000808 A1 EA201000808 A1 EA 201000808A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
treatment
visceral pain
indol
connections
Prior art date
Application number
EA201000808A
Other languages
English (en)
Inventor
Шон Мэддэфорд
Джейлолл Рэмноут
Суман Рахит
Джоанн Пэтмэн
Пол Рентон
Сабхэш С. Эннеди
Джон С. Эндрюс
Габриэла Младенова
Original Assignee
Ньюраксон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюраксон, Инк. filed Critical Ньюраксон, Инк.
Publication of EA201000808A1 publication Critical patent/EA201000808A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение представляет способы лечения висцеральной боли или состояния у млекопитающего, вызванного действием фермента NO-синтазы (NOS) или действием серотониновых 5HT1D/1B рецепторов, путем введения пациенту, нуждающемуся в лечении, терапевтически эффективного количества индольного соединения формулы (I) или его фармацевтически приемлемой соли или пролекарства. Способы изобретения могут, кроме того, включать введение дополнительных терапевтических агентов. Изобретение также обеспечивает новые соединения формулы (I), их фармацевтические композиции и способы разделения энантиомерных смесей.
EA201000808A 2007-11-16 2008-11-17 Индольные соединения и способы лечения висцеральной боли EA201000808A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98875707P 2007-11-16 2007-11-16
US13393008P 2008-07-03 2008-07-03
PCT/CA2008/002047 WO2009062319A1 (en) 2007-11-16 2008-11-17 Indole compounds and methods for treating visceral pain

Publications (1)

Publication Number Publication Date
EA201000808A1 true EA201000808A1 (ru) 2011-04-29

Family

ID=40638299

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000808A EA201000808A1 (ru) 2007-11-16 2008-11-17 Индольные соединения и способы лечения висцеральной боли

Country Status (13)

Country Link
US (1) US8673909B2 (ru)
EP (1) EP2220075A4 (ru)
JP (2) JP2011503120A (ru)
KR (1) KR20100103799A (ru)
CN (1) CN101910157B (ru)
AU (1) AU2008323526A1 (ru)
BR (1) BRPI0820632A2 (ru)
CA (1) CA2705835A1 (ru)
EA (1) EA201000808A1 (ru)
MX (1) MX356032B (ru)
NZ (1) NZ586082A (ru)
SG (1) SG185991A1 (ru)
WO (1) WO2009062319A1 (ru)

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