DK200900016A - Stabiliserede insulinlignende vækstfaktorpolypeptider - Google Patents
Stabiliserede insulinlignende vækstfaktorpolypeptider Download PDFInfo
- Publication number
- DK200900016A DK200900016A DK200900016A DKPA200900016A DK200900016A DK 200900016 A DK200900016 A DK 200900016A DK 200900016 A DK200900016 A DK 200900016A DK PA200900016 A DKPA200900016 A DK PA200900016A DK 200900016 A DK200900016 A DK 200900016A
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptide
- precursor protein
- peptide
- deleted
- human animal
- Prior art date
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title claims 5
- 102000013275 Somatomedins Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 52
- 229920001184 polypeptide Polymers 0.000 claims 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims 39
- 239000002243 precursor Substances 0.000 claims 22
- 235000018102 proteins Nutrition 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 238000000034 method Methods 0.000 claims 11
- 241000283690 Bos taurus Species 0.000 claims 6
- 241001494479 Pecora Species 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 241000251468 Actinopterygii Species 0.000 claims 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 4
- 241000283707 Capra Species 0.000 claims 4
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 4
- 241000282887 Suidae Species 0.000 claims 4
- 241000282472 Canis lupus familiaris Species 0.000 claims 3
- 241000282326 Felis catus Species 0.000 claims 3
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 3
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 3
- 241000283073 Equus caballus Species 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 235000013365 dairy product Nutrition 0.000 claims 2
- 235000013372 meat Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical group 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 239000013589 supplement Substances 0.000 claims 2
- 125000003974 3-carbamimidamidopropyl group Chemical group C(N)(=N)NCCC* 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Claims (44)
1. Polypeptid omfattende et ikke-humant animalsk IGF-1-precursorprotein, hvor spaltningen af E-peptidet fra IGF-1 med en protease er formindsket ved modifikation af precursorproteinet.
2. Polypeptid ifølge krav 1, hvor det ikke-humane animalske IGF-1-precursorprotein stammer fra en ikke-human hvirveldyrsart.
3. Polypeptid ifølge krav 2, hvor den ikke-humane hvirveldyrsart er valgt blandt en mus, en rotte, en ko, en gris, en hest, et får, en ged, en fugl, en hund, en kat eller en fisk.
4. Polypeptid ifølge ethvert af kravene 1-3, hvor precursorproteinet omfatter Ea-peptidet.
5. Polypeptid ifølge krav 4, hvor Ea-peptidet er valgt fra en ikke-human animalsk sekvens i fig. 8A.
6. Polypeptid ifølge ethvert af kravene 1-3, hvor precursorproteinet omfatter Eb-peptidet.
7. Polypeptid ifølge krav 6, hvori Eb-peptidet er valgt fra en ikke-human animalsk sekvens i fig. 9a.
8. Polypeptid ifølge krav 6 eller 7, hvor de sidste syv C-terminale aminosyrer i Eb er detekteret.
9. Polypeptid ifølge ethvert af kravene 1-3, hvor precursorproteinet omfatter Ec-peptidet.
10. Polypeptid ifølge krav 9, hwor Ec er valgt fra en ikke-human animalsk sekvens i fig. 10a.
11. Polypeptid ifølge ethvert af de foregående krav, hvor G1 i precursorproteinet er deleteret eller muteret.
12. Polypeptid ifølge ethvert af de foregående krav, hvor P2 i precursorproteinet er deleteret eller muteret.
13. Polypeptid ifølge ethvert af de foregående krav, hvor E3 i precursorproteinet er deleteret eller muteret.
14. Polypeptid ifølge ethvert af de foregående krav, hvor R36 i precursorproteinet er deleteret eller muteret.
15. Polypeptid ifølge ethvert af de foregående krav, hvor R36 er muteret til alanin.
16. Polypeptid ifølge ethvert af de foregående krav, hvor R37 i precursorproteinet er deleteret eller muteret.
17. Polypeptid ifølge ethvert af de foregående krav, hvor R37 er muteret til alanin.
18. Polypeptid ifølge ethvert af de foregående krav, der yderligere omfatter den N-bundne glycosyleringskonsensussekvens NXS/T.
19. Eb-polypeptidet ifølge krav 6, der yderligere omfatter aminosyrer 93-102 i Ea indsat mellem aminosyrer N95 og T96 i Eb.
20. Polypeptid ifølge ethvert af de foregående krav, der yderligere omfatter et oligosaccharid covalent bundet til en aminosyresideksede i precursorproteinet.
21. Polypeptid ifølge krav 20, hvor oligosaccharidet er covalent bundet til en argininsidekæde i precursorproteinet.
22. Polypeptid ifølge ethvert af de foregående krav, hvor en rest af precursorproteinet er erstattet med en ikke-naturlig aminosyre.
23. Polypeptid ifølge krav 22, hvor den ikke-naturlige aminosyre omfatter en acetyleneller azidogruppe.
24. Polypeptid ifølge ethvert af de foregående krav, der yderligere omfatter en poly(ethylenglycol)/del covalent bundet til en sidekæde i precursorproteinet.
25. Polypeptid ifølge ethvert af de foregående krav, der yderligere omfatter et yderligere E-peptid forbundet til C-terminalen i precursorproteinet.
26. Polypeptid, derfra N-terminal til C-terminal omfatter et IGF-1-precursorprotein omfattende et første Eb-peptid, hvor G1, P1 og E1 erdeleteret, R36 og 37 er delete ret, R71 og S72 er deleteret, og de sidste syv C-terminale aminosyrer i det første Eb-peptid er deleteret, et andet Eb-peptid, hvor R71, S72 og de sidste syv C-terminale aminosyrer i det andet Eb-peptid er deleteret, et tredje Eb-peptid, hvor R71, S72 og de sidste syv C-terminale aminosyrer i det tredje Eb-peptid er deleteret, og et fjerde Eb-peptid, hvor R71 og S72 er deleteret.
27. Polypeptid ifølge ethvert af kravene 1-26, hvor R71 eller S72 i precursorproteinet er deleteret eller muteret.
28. Polypeptid indeholdende et ikke-humant animalsk IGF-2-precursorprotein, hvor spaltningen af E-peptidet fra IGF-2 med en protease er formindsket ved modifikation af precursorproteinet.
29. Polypeptid ifølge krav 28, hvor den ikke-humane hvirveldyrsart er valgt blandt en mus, en rotte, en ko, en gris, en hest, et får, en ged, en fugl, en hund, en kat eller en fisk.
30. Polypeptid ifølge ét af kravene 28-39, hvor precursorproteinet omfatter E-peptidet i IGF-2.
31. Polypeptid ifølge krav 30, hvor E-peptidet er valgt fra en sekvens fra fig. 12A.
32. Polypeptid ifølge ethvert af kravene 28-32, hwor R68 eller D69 i precursorproteinet er deleteret eller muteret.
33. Fremgangsmåde til forøgelse af graden og/eller udstrækningen af vækst i et ikke-humant dyr, omfattende indgivelse af en virksom mængde af et polypeptid ifølge opfindelsen ifølge ethvert af kravene 1-32.
34. Fremgangsmåde ifølge krav 33, hvor det ikke-humane dyr er et kødproducerende dyr, omfattende svin, kvæg, får, fjerkræ og fisk.
35. Fremgangsmåde til forøgelse af effektiviteten af omdannelse af foder i kropsvæv i en ikke-humant dyr, omfattende indgivelse af en virksom mængde af et polypeptid ifølge opfindelsen ifølge ethvert af kravene 1-32.
36. Fremgangsmåde ifølge krav 35, hvor det ikke-humane dyr er et kødproducerende dyr omfattende svin, kvæg, får, fjerkræ og fisk.
37. Fremgangsmåde til forøgelse af mælkeproduktion hos mælkegivende ikke-humane dyr, omfattende indgivelse af en virksom mængde af et polypeptid ifølge opfindelsen ifølge ethvert af kravene 1-32.
38. Fremgangsmåde ifølge krav 37, hvor det ikke humane dyr er et mælkegivende dyr omfattende malkekvæg, svin, får og geder,
39. Fremgangsmåde til behandling af et ikke-humant dyr for hentæringssymptomer forbundet med kachexi, traumer eller andre indtagelsessygdomme, omfattende indgivelse af en virksom mængde af et polypeptid ifølge ethvert af kravene 1-32.
40. Fremgangsmåde ifølge krav 39, hvor det ikke-humane dyr er et husdyr omfattende hunde, katte og heste.
41. Fremgangsmåde til behandling af mælkegivende ikke-humane dyr til forbedring af neonatal sundhed, omfattende indgivelse af en virksom mængde af et polypeptid ifølge opfindelsen ifølge ethvert af kravene 1-32.
42. Fremgangsmåde ifølge krav 41, hvor det ikke-humane dyr er et mælkegivende dyr omfattende malkekvæg, svin, får og geder.
43. Anvendelse af polypeptidet ifølge ethvert af kravene 1-32 til fremstilling af en veterinær sammensætning til anvendelse ved en fremgangsmåde ifølge ethvert af kravene 33-42.
44. Anvendelse af polypeptidet ifølge krav 43, hvor den veterinære sammensætning er en stor oral dosis, et supplement til oralt foder eller supplemeent til fast foder.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81234906P | 2006-06-09 | 2006-06-09 | |
| US81234906 | 2006-06-09 | ||
| US86224406P | 2006-10-20 | 2006-10-20 | |
| US86224406 | 2006-10-20 | ||
| US89718707P | 2007-01-24 | 2007-01-24 | |
| US89718707 | 2007-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK200900016A true DK200900016A (da) | 2009-01-06 |
Family
ID=38801859
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07798148.8T DK2032155T3 (da) | 2006-06-09 | 2007-06-06 | Stabiliserede insulinlignende vækstfaktor-polypeptider |
| DK200900016A DK200900016A (da) | 2006-06-09 | 2009-01-06 | Stabiliserede insulinlignende vækstfaktorpolypeptider |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07798148.8T DK2032155T3 (da) | 2006-06-09 | 2007-06-06 | Stabiliserede insulinlignende vækstfaktor-polypeptider |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US20100173839A1 (da) |
| EP (2) | EP2032154A2 (da) |
| JP (2) | JP5290966B2 (da) |
| KR (1) | KR101459789B1 (da) |
| AR (1) | AR061242A1 (da) |
| AU (2) | AU2007257936B2 (da) |
| BR (2) | BRPI0712147A2 (da) |
| CA (2) | CA2653781A1 (da) |
| CL (1) | CL2007001614A1 (da) |
| CR (2) | CR10432A (da) |
| CY (1) | CY1116117T1 (da) |
| DK (2) | DK2032155T3 (da) |
| EC (1) | ECSP088949A (da) |
| ES (1) | ES2529261T3 (da) |
| GT (1) | GT200800273A (da) |
| HR (1) | HRP20150326T1 (da) |
| IL (1) | IL195156A (da) |
| JO (1) | JO2968B1 (da) |
| MA (1) | MA30503B1 (da) |
| MX (2) | MX2008015726A (da) |
| MY (1) | MY147856A (da) |
| NO (2) | NO20085183L (da) |
| NZ (2) | NZ572708A (da) |
| PE (1) | PE20080715A1 (da) |
| PL (1) | PL2032155T3 (da) |
| PT (1) | PT2032155E (da) |
| RU (1) | RU2477287C2 (da) |
| SI (1) | SI2032155T1 (da) |
| TN (1) | TNSN08509A1 (da) |
| TW (1) | TWI427084B (da) |
| UA (1) | UA97953C2 (da) |
| WO (2) | WO2007146689A2 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090318355A1 (en) * | 2006-02-15 | 2009-12-24 | Chen Thomas T | Compositions and methods for promoting tissue repair and wound healing |
| SI2032155T1 (sl) | 2006-06-09 | 2015-04-30 | Novartis Ag | Stabilizirani polipeptidi inzulinu podobnega rastnega faktorja |
| PT2279210T (pt) | 2008-05-07 | 2017-07-10 | Biomarin Pharm Inc | Péptidos de direcionamento lisossomal e suas utilizações |
| US8753632B2 (en) * | 2008-11-10 | 2014-06-17 | Novartis Ag | Antibodies to modified human IGF-1/E peptides |
| WO2010088502A2 (en) * | 2009-01-30 | 2010-08-05 | The Regents Of The University Of California | Insulin-like growth factor signaling and integrin |
| LT2424895T (lt) | 2009-04-27 | 2017-12-27 | Novartis Ag | Kompozicijos ir būdai, skirti raumenų augimo spartinimui |
| UA103104C2 (ru) | 2009-07-22 | 2013-09-10 | Ипсен Фарма С.А.С. | Аналоги инсулиноподобного фактора роста-1 (igf-1), содержащие аминокислотную замену в положении 59 |
| EP2498796B1 (en) | 2009-11-09 | 2017-12-27 | AAL Scientifics, Inc. | Treatment of heart disease |
| JP2011160696A (ja) * | 2010-02-08 | 2011-08-25 | Novartis Ag | 修飾ヒトｉｇｆ−１／ｅペプチドに対する抗体 |
| WO2012116203A1 (en) | 2011-02-23 | 2012-08-30 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| WO2012178146A1 (en) * | 2011-06-24 | 2012-12-27 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of spinal muscular atrophy |
| HUE040276T2 (hu) | 2011-07-01 | 2019-02-28 | Novartis Ag | Eljárás metabolikus rendellenességek kezelésére |
| WO2014012025A2 (en) * | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Igf-1 proteins and therapeutic uses thereof |
| CR20200079A (es) | 2012-12-18 | 2020-03-21 | Novartis Ag | POLIPÉPTIDOS ESTABILIZADOS DEL FACTOR DE CRECIMIENTO TIPO INSULINA (Divisional 2015-0324) |
| CN104884467A (zh) | 2012-12-18 | 2015-09-02 | 诺华股份有限公司 | 在遗传修饰的哺乳动物细胞中生产治疗性蛋白质 |
| US20160200818A1 (en) | 2013-08-14 | 2016-07-14 | Novartis Ag | Methods of treating Sporadic Inclusion Body Myositis |
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