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DK1730119T3 - Imidazolforbindelser til behandling af neurodegenerative forstyrrelser - Google Patents

Imidazolforbindelser til behandling af neurodegenerative forstyrrelser

Info

Publication number
DK1730119T3
DK1730119T3 DK05708746T DK05708746T DK1730119T3 DK 1730119 T3 DK1730119 T3 DK 1730119T3 DK 05708746 T DK05708746 T DK 05708746T DK 05708746 T DK05708746 T DK 05708746T DK 1730119 T3 DK1730119 T3 DK 1730119T3
Authority
DK
Denmark
Prior art keywords
treatment
neurodegenerative disorders
imidazole compounds
imidazole
compounds
Prior art date
Application number
DK05708746T
Other languages
Danish (da)
English (en)
Inventor
Michael Aaron Brodney
Karen Jean Coffman
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1730119T3 publication Critical patent/DK1730119T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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DK05708746T 2004-03-23 2005-03-11 Imidazolforbindelser til behandling af neurodegenerative forstyrrelser DK1730119T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55562304P 2004-03-23 2004-03-23
PCT/IB2005/000659 WO2005092864A1 (en) 2004-03-23 2005-03-11 Imidazole compounds for the treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
DK1730119T3 true DK1730119T3 (da) 2008-08-11

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DK05708746T DK1730119T3 (da) 2004-03-23 2005-03-11 Imidazolforbindelser til behandling af neurodegenerative forstyrrelser

Country Status (42)

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US (3) US7342118B2 (sl)
EP (1) EP1730119B1 (sl)
JP (2) JP4054845B2 (sl)
KR (1) KR100814599B1 (sl)
CN (1) CN1934091B (sl)
AP (1) AP2379A (sl)
AR (1) AR049875A1 (sl)
AT (1) ATE399155T1 (sl)
AU (1) AU2005225635B2 (sl)
BR (1) BRPI0509069B8 (sl)
CA (1) CA2560580C (sl)
CR (1) CR8644A (sl)
CY (1) CY1108347T1 (sl)
DE (1) DE602005007717D1 (sl)
DK (1) DK1730119T3 (sl)
DO (1) DOP2005000040A (sl)
EA (1) EA011689B1 (sl)
EC (1) ECSP066879A (sl)
ES (1) ES2308441T3 (sl)
GE (1) GEP20084420B (sl)
GT (1) GT200500060A (sl)
HN (1) HN2005000115A (sl)
HR (1) HRP20080375T3 (sl)
IL (1) IL177594A0 (sl)
IS (1) IS8550A (sl)
MA (1) MA28481B1 (sl)
NL (1) NL1028598C2 (sl)
NO (1) NO338263B1 (sl)
NZ (1) NZ549331A (sl)
PA (1) PA8627201A1 (sl)
PE (1) PE20051155A1 (sl)
PL (1) PL1730119T3 (sl)
PT (1) PT1730119E (sl)
RS (1) RS50595B (sl)
SI (1) SI1730119T1 (sl)
SV (1) SV2006002055A (sl)
TN (1) TNSN06300A1 (sl)
TW (1) TWI372146B (sl)
UA (1) UA83899C2 (sl)
UY (1) UY28817A1 (sl)
WO (1) WO2005092864A1 (sl)
ZA (1) ZA200606957B (sl)

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