DK1701698T3 - Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779 - Google Patents

Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779

Info

Publication number: DK1701698T3
Authority: DK; Denmark
Prior art keywords: cci; pharmaceutical composition; oral administration; directly compressible; compressible pharmaceutical
Prior art date: 2004-01-08

Application number

DK04814371T

Other languages

English (en)

Inventor

Muhammad Ashraf

Eric J Benjamin

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-08

Filing date

2004-12-14

Publication date

2008-05-05

2004-12-14 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-05-05 Application granted granted Critical

2008-05-05 Publication of DK1701698T3 publication Critical patent/DK1701698T3/da

Links

CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229960000235 temsirolimus Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK04814371T 2004-01-08 2004-12-14 Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779 DK1701698T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53495104P	2004-01-08	2004-01-08
PCT/US2004/042178 WO2005070393A2 (en)	2004-01-08	2004-12-14	Directly compressible pharmaceutical composition of the rapamycin ester cci-779

Publications (1)

Publication Number	Publication Date
DK1701698T3 true DK1701698T3 (da)	2008-05-05

Family

ID=34806893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04814371T DK1701698T3 (da)	2004-01-08	2004-12-14	Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779

Country Status (30)

Country	Link
US (1)	US20050152983A1 (da)
EP (1)	EP1701698B1 (da)
JP (1)	JP2007517879A (da)
KR (1)	KR20060130162A (da)
CN (1)	CN1921861A (da)
AR (1)	AR047180A1 (da)
AT (1)	ATE383859T1 (da)
AU (1)	AU2004314213A1 (da)
BR (1)	BRPI0418373A (da)
CA (1)	CA2552595A1 (da)
CR (1)	CR8491A (da)
CY (1)	CY1107373T1 (da)
DE (1)	DE602004011398T2 (da)
DK (1)	DK1701698T3 (da)
EC (1)	ECSP066757A (da)
ES (1)	ES2298861T3 (da)
GT (1)	GT200500003A (da)
HN (1)	HN2005000005A (da)
IL (1)	IL176519A0 (da)
MX (1)	MXPA06007829A (da)
NO (1)	NO20062930L (da)
PA (1)	PA8621201A1 (da)
PE (1)	PE20050683A1 (da)
PL (1)	PL1701698T3 (da)
PT (1)	PT1701698E (da)
RU (1)	RU2006122517A (da)
TW (1)	TW200526213A (da)
UA (1)	UA84903C2 (da)
WO (1)	WO2005070393A2 (da)
ZA (1)	ZA200605631B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005023254A1 (en)	2003-09-03	2005-03-17	Wyeth	Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
BRPI0509852A (pt) *	2004-04-14	2007-10-23	Wyeth Corp	método para a preparação regioespecìfica dos derivados de 42-éster de rapamicina, preparação regioespecìfica do 42-éster de rapamicina, composição, produto, e, kit farmacêutico
BRPI0510277A (pt) *	2004-04-27	2007-10-30	Wyeth Corp	método para marcar especificamente uma rapamicina, rapamicina especificamente marcada, composição, e, kit
RU2007127499A (ru) *	2005-02-15	2009-03-27	Вайет (Us)	Таблетированные композиции, содержащие cci-779 в биодоступной при пероральном введении форме
EA015922B1 (ru)	2005-11-14	2011-12-30	Ариад Фармасьютикалз, Инк.	ВВЕДЕНИЕ ИНГИБИТОРА mTOR ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛЬЮ
WO2008003050A2 (en) *	2006-06-28	2008-01-03	Emisphere Technologies, Inc.	Gallium nitrate formulations
US8414909B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8425459B2 (en)	2006-11-20	2013-04-23	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8998846B2 (en)	2006-11-20	2015-04-07	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US8414525B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US9700704B2 (en)	2006-11-20	2017-07-11	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US9737640B2 (en)	2006-11-20	2017-08-22	Lutonix, Inc.	Drug releasing coatings for medical devices
US20080276935A1 (en)	2006-11-20	2008-11-13	Lixiao Wang	Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414910B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8414526B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
WO2010024898A2 (en)	2008-08-29	2010-03-04	Lutonix, Inc.	Methods and apparatuses for coating balloon catheters
JP2013527223A (ja)	2010-06-02	2013-06-27	フレゼニウス・カビ・オンコロジー・リミテッド	ラパマイシンエステルの安定な医薬組成物
MX342405B (es)	2010-06-03	2016-09-28	Pharmacyclics Inc	El uso de inhibidores de la tirosina quinasa de bruton (btk).
MX387669B (es)	2012-06-04	2025-03-18	Pharmacyclics Llc	Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
BR112015001690A2 (pt)	2012-07-24	2017-11-07	Pharmacyclics Inc	mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
US10682415B2 (en)	2013-07-22	2020-06-16	Wisconsin Alumni Research Foundation	Thermogel formulation for combination drug delivery
CN104721158B (zh) *	2013-12-24	2018-01-30	正大天晴药业集团股份有限公司	一种稳定的依维莫司片剂
IL315294A (en)	2015-03-03	2024-10-01	Pharmacyclics Llc	Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
WO2017038925A1 (ja) *	2015-09-03	2017-03-09	日本化薬株式会社	ラパマイシン又はその誘導体を含有する医薬組成物
WO2017129772A1 (en)	2016-01-29	2017-08-03	Xellia Phamaceuticals Aps	Stable pharmaceutical compositions of temsirolimus

Family Cites Families (19)

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ZA737247B (en) *	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
JP2642486B2 (ja) *	1989-08-04	1997-08-20	田辺製薬株式会社	難溶性薬物の超微粒子化法
US5536729A (en) *	1993-09-30	1996-07-16	American Home Products Corporation	Rapamycin formulations for oral administration
US5928668A (en) *	1993-12-21	1999-07-27	Applied Analytical Industries, Inc.	Method for dry blend compression of medicaments
US5362718A (en) *	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
BE1009856A5 (fr) *	1995-07-14	1997-10-07	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
RO120603B1 (ro) *	1996-08-22	2006-05-30	Research Triangle Pharmaceuticals Ltd.	Compoziţie conţinând microparticule de substanţe insolubile în apă şi procedeu de preparare
US5989591A (en) *	1997-03-14	1999-11-23	American Home Products Corporation	Rapamycin formulations for oral administration
US5985325A (en) *	1997-06-13	1999-11-16	American Home Products Corporation	Rapamycin formulations for oral administration
US6277983B1 (en) *	2000-09-27	2001-08-21	American Home Products Corporation	Regioselective synthesis of rapamycin derivatives
TWI286074B (en) *	2000-11-15	2007-09-01	Wyeth Corp	Pharmaceutical composition containing CCI-779 as an antineoplastic agent
UA77200C2 (en) *	2001-08-07	2006-11-15	Wyeth Corp	Antineoplastic combination of cci-779 and bkb-569
US20040077677A1 (en) *	2002-09-17	2004-04-22	Wyeth	Oral formulations
UA83484C2 (uk) *	2003-03-05	2008-07-25	Уайт	Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
RU2345772C2 (ru) *	2003-07-25	2009-02-10	Уайт	Лиофилизированные композиции cci-779
DK1658295T3 (da) *	2003-08-07	2007-09-24	Wyeth Corp	Regioselektiv syntese af CCI-779
WO2005023254A1 (en) *	2003-09-03	2005-03-17	Wyeth	Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
US20060142422A1 (en) *	2004-12-07	2006-06-29	Toshikazu Kobayashi	Hydrolysis resistant polyester compositions and articles made therefrom
RU2007127499A (ru) *	2005-02-15	2009-03-27	Вайет (Us)	Таблетированные композиции, содержащие cci-779 в биодоступной при пероральном введении форме

2004
- 2004-12-14 BR BRPI0418373-8A patent/BRPI0418373A/pt not_active IP Right Cessation
- 2004-12-14 DK DK04814371T patent/DK1701698T3/da active
- 2004-12-14 EP EP04814371A patent/EP1701698B1/en not_active Expired - Lifetime
- 2004-12-14 PT PT04814371T patent/PT1701698E/pt unknown
- 2004-12-14 PL PL04814371T patent/PL1701698T3/pl unknown
- 2004-12-14 AT AT04814371T patent/ATE383859T1/de not_active IP Right Cessation
- 2004-12-14 RU RU2006122517/15A patent/RU2006122517A/ru not_active Application Discontinuation
- 2004-12-14 MX MXPA06007829A patent/MXPA06007829A/es active IP Right Grant
- 2004-12-14 DE DE602004011398T patent/DE602004011398T2/de not_active Expired - Lifetime
- 2004-12-14 KR KR1020067015655A patent/KR20060130162A/ko not_active Ceased
- 2004-12-14 CA CA002552595A patent/CA2552595A1/en not_active Abandoned
- 2004-12-14 ES ES04814371T patent/ES2298861T3/es not_active Expired - Lifetime
- 2004-12-14 WO PCT/US2004/042178 patent/WO2005070393A2/en not_active Ceased
- 2004-12-14 CN CNA2004800399872A patent/CN1921861A/zh active Pending
- 2004-12-14 JP JP2006549291A patent/JP2007517879A/ja not_active Withdrawn
- 2004-12-14 UA UAA200608870A patent/UA84903C2/ru unknown
- 2004-12-14 AU AU2004314213A patent/AU2004314213A1/en not_active Abandoned
- 2004-12-27 TW TW093140750A patent/TW200526213A/zh unknown
2005
- 2005-01-04 AR ARP050100016A patent/AR047180A1/es not_active Application Discontinuation
- 2005-01-05 GT GT200500003A patent/GT200500003A/es unknown
- 2005-01-06 US US11/030,685 patent/US20050152983A1/en not_active Abandoned
- 2005-01-06 PE PE2005000043A patent/PE20050683A1/es not_active Application Discontinuation
- 2005-01-06 HN HN2005000005A patent/HN2005000005A/es unknown
- 2005-01-07 PA PA20058621201A patent/PA8621201A1/es unknown
2006
- 2006-06-22 IL IL176519A patent/IL176519A0/en unknown
- 2006-06-22 NO NO20062930A patent/NO20062930L/no not_active Application Discontinuation
- 2006-06-28 CR CR8491A patent/CR8491A/es not_active Application Discontinuation
- 2006-07-07 ZA ZA200605631A patent/ZA200605631B/xx unknown
- 2006-08-08 EC EC2006006757A patent/ECSP066757A/es unknown
2008
- 2008-03-31 CY CY20081100359T patent/CY1107373T1/el unknown

Also Published As

Publication number	Publication date
DE602004011398D1 (de)	2008-03-06
MXPA06007829A (es)	2006-09-01
AR047180A1 (es)	2006-01-11
CR8491A (es)	2008-08-21
TW200526213A (en)	2005-08-16
ATE383859T1 (de)	2008-02-15
WO2005070393A3 (en)	2006-09-28
JP2007517879A (ja)	2007-07-05
ES2298861T3 (es)	2008-05-16
GT200500003A (es)	2005-08-18
HN2005000005A (es)	2009-04-17
PA8621201A1 (es)	2005-12-23
ZA200605631B (en)	2010-01-27
CA2552595A1 (en)	2005-08-04
IL176519A0 (en)	2006-10-05
CN1921861A (zh)	2007-02-28
DE602004011398T2 (de)	2009-01-15
RU2006122517A (ru)	2008-02-20
BRPI0418373A (pt)	2007-05-22
WO2005070393A2 (en)	2005-08-04
UA84903C2 (ru)	2008-12-10
PL1701698T3 (pl)	2008-03-31
US20050152983A1 (en)	2005-07-14
EP1701698A2 (en)	2006-09-20
PE20050683A1 (es)	2005-11-04
EP1701698B1 (en)	2008-01-16
AU2004314213A1 (en)	2005-08-04
CY1107373T1 (el)	2012-12-19
ECSP066757A (es)	2006-11-16
NO20062930L (no)	2006-10-02
PT1701698E (pt)	2008-03-27
KR20060130162A (ko)	2006-12-18
HK1090308A1 (en)	2006-12-22

Publication	Publication Date	Title
DK1701698T3 (da)	2008-05-05	Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779
DK2172205T3 (da)	2014-07-14	Farmaceutisk formulering bestående af lanthan-forbindelser
DK2058020T3 (da)	2013-01-07	Indretning til indgivelse af lægemiddel
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DK2361609T3 (da)	2013-08-26	Formulering af småmolekylære lægemidler med forsinket frigivelse
DK1928405T3 (da)	2014-12-15	Farmaceutiske sammensætninger til behandling af indre øreforstyrrelser
DK1656347T3 (da)	2011-01-10	Substituerede indolderivater til farmaceutisk sammensætning til behandling af luftvejssygdomme
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DK1587478T3 (da)	2013-10-21	Farmaceutisk sammensætning
BRPI0716698A2 (pt)	2014-02-25	Composto, composição farmacêutica e uso de um composto
SK4325U (sk)	2005-12-01	Farmaceutická kompozícia s postupným uvoľňovaním
DE60317803D1 (de)	2008-01-10	Pharmazeutische zusammensetzungen enthaltend cyclosporin zur oralen verabreichung
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