DK1686113T3 - Inhibitorer af aspartylprotease - Google Patents

Inhibitorer af aspartylprotease

Info

Publication number: DK1686113T3
Authority: DK; Denmark
Prior art keywords: inhibitors; aspartyl protease; aspartyl; protease
Prior art date: 1999-06-11

Application number

DK06009072.7T

Other languages

English (en)

Inventor

Michael Robin Hale

Roger Tung

Stephen Price

Robin David Wilkes

Wayne Carl Schairer

Ashley Nicholas Jarvis

Andrew Spaltenstein

Eric Steven Furfine

Vicente Samano

Istvan Kaldor

John Franklin Miller

Michael Stephen Brieger

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-11

Filing date

2000-06-08

Publication date

2012-02-20

2000-06-08 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-02-20 Application granted granted Critical

2012-02-20 Publication of DK1686113T3 publication Critical patent/DK1686113T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK06009072.7T 1999-06-11 2000-06-08 Inhibitorer af aspartylprotease DK1686113T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13907099P	1999-06-11	1999-06-11
US19021100P	2000-03-17	2000-03-17
EP00941279A EP1194404B1 (en)	1999-06-11	2000-06-08	Inhibitors of aspartyl protease

Publications (1)

Publication Number	Publication Date
DK1686113T3 true DK1686113T3 (da)	2012-02-20

Family

ID=26836833

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK06009072.7T DK1686113T3 (da)	1999-06-11	2000-06-08	Inhibitorer af aspartylprotease
DK00941279T DK1194404T3 (da)	1999-06-11	2000-06-08	Aspartylproteaseinhibitorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK00941279T DK1194404T3 (da)	1999-06-11	2000-06-08	Aspartylproteaseinhibitorer

Country Status (31)

Country	Link
EP (2)	EP1194404B1 (da)
JP (2)	JP4503896B2 (da)
KR (1)	KR100762188B1 (da)
CN (2)	CN100516034C (da)
AR (1)	AR031520A1 (da)
AT (2)	ATE534622T1 (da)
AU (1)	AU779994B2 (da)
BR (1)	BR0011745A (da)
CA (1)	CA2380858C (da)
CO (1)	CO5160337A1 (da)
CY (1)	CY1112632T1 (da)
CZ (1)	CZ303052B6 (da)
DE (1)	DE60027722T2 (da)
DK (2)	DK1686113T3 (da)
ES (2)	ES2375823T3 (da)
HK (1)	HK1046899B (da)
HU (1)	HUP0300385A3 (da)
IL (3)	IL146918A0 (da)
MX (1)	MXPA01012808A (da)
MY (1)	MY137777A (da)
NO (1)	NO323951B1 (da)
NZ (1)	NZ516003A (da)
PE (1)	PE20010230A1 (da)
PL (1)	PL210227B1 (da)
PT (2)	PT1686113E (da)
SI (1)	SI1194404T1 (da)
TN (1)	TNSN00129A1 (da)
TR (3)	TR200200407T2 (da)
TW (3)	TWI318116B (da)
WO (1)	WO2000076961A1 (da)
ZA (1)	ZA200110177B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ508855A (en) *	1998-06-19	2003-10-31	Vertex Pharma	Sulfonamide inhibitors of HIV aspartyl protease
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100870184B1 (ko) *	2001-02-14	2008-11-24	티보텍 파마슈티칼즈 리미티드	광범위 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ프로티아제 억제제
US7285566B2 (en) *	2002-01-07	2007-10-23	Erickson John W	Resistance-repellent retroviral protease inhibitors
MY142238A (en) *	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
CN101074242A (zh) *	2002-04-26	2007-11-21	吉里德科学公司	Hiv蛋白酶抑制剂化合物的膦酸酯类似物的细胞蓄积及这类化合物
US6632816B1 (en) *	2002-12-23	2003-10-14	Pharmacor Inc.	Aromatic derivatives as HIV aspartyl protease inhibitors
US20060148865A1 (en) *	2003-06-27	2006-07-06	Martin Michael T	Preparation of chemical compounds
US7767683B2 (en)	2003-08-18	2010-08-03	H. Lundbeck A/S	Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
SG163508A1 (en) *	2003-12-15	2010-08-30	Schering Corp	Heterocyclic aspartyl protease inhibitors
WO2005087728A1 (en)	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
TWI383975B (zh)	2004-03-31	2013-02-01	悌柏泰克醫藥有限公司	製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
US7388008B2 (en)	2004-08-02	2008-06-17	Ambrilia Biopharma Inc.	Lysine based compounds
TWI453198B (zh)	2005-02-16	2014-09-21	Lundbeck & Co As H	製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
TWI376373B (en)	2005-02-16	2012-11-11	Lundbeck & Co As H	Crystalline base of a pharmaceutical compound
US20080194554A1 (en) *	2005-03-11	2008-08-14	Mclean Ed W	Hiv Protease Inhibitors
AU2006319716B2 (en)	2005-11-30	2012-02-02	Taimed Biologics, Inc.	Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
US20080070910A1 (en) *	2006-07-24	2008-03-20	Desai Manoj C	Therapeutic compounds and methods
MX2009004957A (es)	2006-11-09	2009-05-19	Tibotec Pharm Ltd	Metodos para la preparacion de hexahidrofuro[2,3-b]furan-3-ol.
US9808527B2 (en) *	2006-11-21	2017-11-07	Purdue Research Foundation	Methods and compositions for treating HIV infections
DK2152667T3 (da)	2007-04-27	2011-05-16	Tibotec Pharm Ltd	Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater
GB2452952A (en) *	2007-09-20	2009-03-25	Npil Pharmaceuticals	N-[2-Hydroxy-3-(hydroxycarbonylamino)-3-methyl]-N-methyl-sulphonamide derivatives via N-[2-oxo-3-(hydroxycarbonylamino)-3-methyl]-N-methyl-imine skeleton
US8592487B2 (en)	2007-10-26	2013-11-26	Concert Pharmaceuticals, Inc.	Deuterated darunavir
CA2774750C (en) *	2009-09-22	2017-11-28	Tibotec Pharmaceuticals	Treatment and prevention of hiv infection
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
EP3192794A4 (en) *	2014-09-11	2018-06-27	Shionogi & Co., Ltd.	Sustained hiv protease inhibitor
US11116737B1 (en)	2020-04-10	2021-09-14	University Of Georgia Research Foundation, Inc.	Methods of using probenecid for treatment of coronavirus infections
US12083099B2 (en)	2020-10-28	2024-09-10	Accencio LLC	Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3635907A1 (de) *	1986-10-22	1988-04-28	Merck Patent Gmbh	Hydroxy-aminosaeurederivate
CA2032259A1 (en) *	1989-12-18	1991-06-19	Wayne J. Thompson	Hiv protease inhibitors useful for the treatment of aids
DK0813867T3 (da) *	1990-11-19	2005-10-03	Monsanto Co	Retrovirale proteaseinhibitorer
US5475013A (en) *	1990-11-19	1995-12-12	Monsanto Company	Retroviral protease inhibitors
DK0656887T3 (da) *	1992-08-25	1999-07-05	Searle & Co	Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0666843T3 (da) *	1992-10-30	2000-03-20	Searle & Co	Sulfonylalkanoylaminohydroxyethylaminosulfaminsyrer, der kan anvendes som inhibitorer af retrovirale proteaser
ATE174587T1 (de) *	1993-08-24	1999-01-15	Searle & Co	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
AU4700896A (en) *	1995-01-20	1996-08-07	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) *	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9607625A (pt) *	1995-03-10	1999-06-15	Searle & Co	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
US5691372A (en) *	1995-04-19	1997-11-25	Vertex Pharmaceuticals Incorporated	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
EP0861249A1 (en) *	1995-11-15	1998-09-02	G.D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
GB9712504D0 (en) *	1997-06-17	1997-08-20	Dundee Teaching Hospitals Nhs	Thermal imaging method and apparatus
WO1999010373A1 (en) *	1997-08-26	1999-03-04	Wisconsin Alumni Research Foundation	Non-immunosuppressive cyclosporins and their use in the prevention and treatment of hiv infection
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion

2000
- 2000-06-07 AR ARP000102852A patent/AR031520A1/es active IP Right Grant
- 2000-06-08 PT PT06009072T patent/PT1686113E/pt unknown
- 2000-06-08 AT AT06009072T patent/ATE534622T1/de active
- 2000-06-08 DE DE60027722T patent/DE60027722T2/de not_active Expired - Lifetime
- 2000-06-08 TW TW096138754A patent/TWI318116B/zh not_active IP Right Cessation
- 2000-06-08 TW TW093114799A patent/TWI299000B/zh not_active IP Right Cessation
- 2000-06-08 EP EP00941279A patent/EP1194404B1/en not_active Expired - Lifetime
- 2000-06-08 DK DK06009072.7T patent/DK1686113T3/da active
- 2000-06-08 BR BR0011745-5A patent/BR0011745A/pt not_active Application Discontinuation
- 2000-06-08 NZ NZ516003A patent/NZ516003A/xx not_active IP Right Cessation
- 2000-06-08 AU AU56006/00A patent/AU779994B2/en not_active Ceased
- 2000-06-08 TW TW089111145A patent/TW593248B/zh not_active IP Right Cessation
- 2000-06-08 MY MYPI20002595A patent/MY137777A/en unknown
- 2000-06-08 PL PL352830A patent/PL210227B1/pl not_active IP Right Cessation
- 2000-06-08 ES ES06009072T patent/ES2375823T3/es not_active Expired - Lifetime
- 2000-06-08 ES ES00941279T patent/ES2263478T3/es not_active Expired - Lifetime
- 2000-06-08 CA CA2380858A patent/CA2380858C/en not_active Expired - Fee Related
- 2000-06-08 PE PE2000000573A patent/PE20010230A1/es not_active Application Discontinuation
- 2000-06-08 HU HU0300385A patent/HUP0300385A3/hu unknown
- 2000-06-08 PT PT00941279T patent/PT1194404E/pt unknown
- 2000-06-08 DK DK00941279T patent/DK1194404T3/da active
- 2000-06-08 JP JP2001503821A patent/JP4503896B2/ja not_active Expired - Fee Related
- 2000-06-08 CO CO00042752A patent/CO5160337A1/es unknown
- 2000-06-08 TR TR2002/00407T patent/TR200200407T2/xx unknown
- 2000-06-08 TR TR2002/02528T patent/TR200202528T2/xx unknown
- 2000-06-08 CN CNB008104395A patent/CN100516034C/zh not_active Expired - Fee Related
- 2000-06-08 TR TR2006/03871T patent/TR200603871T2/xx unknown
- 2000-06-08 TN TNTNSN00129A patent/TNSN00129A1/fr unknown
- 2000-06-08 SI SI200030872T patent/SI1194404T1/sl unknown
- 2000-06-08 AT AT00941279T patent/ATE325091T1/de active
- 2000-06-08 MX MXPA01012808A patent/MXPA01012808A/es active IP Right Grant
- 2000-06-08 EP EP06009072A patent/EP1686113B1/en not_active Expired - Lifetime
- 2000-06-08 WO PCT/US2000/015781 patent/WO2000076961A1/en not_active Ceased
- 2000-06-08 KR KR1020017016293A patent/KR100762188B1/ko not_active Expired - Fee Related
- 2000-06-08 CN CNA2008100096668A patent/CN101245058A/zh active Pending
- 2000-06-08 IL IL14691800A patent/IL146918A0/xx unknown
- 2000-06-08 CZ CZ20014431A patent/CZ303052B6/cs not_active IP Right Cessation
- 2000-06-08 HK HK02106939.9A patent/HK1046899B/en not_active IP Right Cessation
2001
- 2001-12-04 IL IL146918A patent/IL146918A/en not_active IP Right Cessation
- 2001-12-10 NO NO20016034A patent/NO323951B1/no not_active IP Right Cessation
- 2001-12-11 ZA ZA200110177A patent/ZA200110177B/en unknown
2008
- 2008-09-08 JP JP2008230351A patent/JP2009046493A/ja not_active Withdrawn
2009
- 2009-12-09 IL IL202633A patent/IL202633A/en not_active IP Right Cessation
2012
- 2012-02-22 CY CY20121100182T patent/CY1112632T1/el unknown

Also Published As

Publication number	Publication date
AU779994B2 (en)	2005-02-24
CA2380858C (en)	2011-12-06
AR031520A1 (es)	2003-09-24
PT1194404E (pt)	2006-08-31
IL202633A0 (en)	2010-06-30
EP1686113B1 (en)	2011-11-23
BR0011745A (pt)	2002-03-19
NO20016034D0 (no)	2001-12-10
HK1046899B (en)	2007-03-02
TW200804252A (en)	2008-01-16
MXPA01012808A (es)	2002-07-22
TR200603871T2 (tr)	2007-01-22
WO2000076961A1 (en)	2000-12-21
CN100516034C (zh)	2009-07-22
JP4503896B2 (ja)	2010-07-14
IL146918A (en)	2010-06-16
CN1361765A (zh)	2002-07-31
EP1194404A1 (en)	2002-04-10
ES2263478T3 (es)	2006-12-16
NO20016034L (no)	2002-01-18
DK1194404T3 (da)	2006-09-04
NO323951B1 (no)	2007-07-23
CO5160337A1 (es)	2002-05-30
AU5600600A (en)	2001-01-02
CZ303052B6 (cs)	2012-03-14
CA2380858A1 (en)	2000-12-21
PE20010230A1 (es)	2001-03-15
EP1194404B1 (en)	2006-05-03
PT1686113E (pt)	2012-02-20
JP2003502309A (ja)	2003-01-21
TWI299000B (en)	2008-07-21
CZ20014431A3 (cs)	2002-06-12
HUP0300385A3 (en)	2007-05-29
TWI318116B (en)	2009-12-11
JP2009046493A (ja)	2009-03-05
TW200425891A (en)	2004-12-01
KR100762188B1 (ko)	2007-10-04
ATE325091T1 (de)	2006-06-15
HUP0300385A2 (hu)	2003-07-28
PL352830A1 (en)	2003-09-08
EP1686113A1 (en)	2006-08-02
TW593248B (en)	2004-06-21
ES2375823T3 (es)	2012-03-06
PL210227B1 (pl)	2011-12-30
CY1112632T1 (el)	2016-02-10
TNSN00129A1 (fr)	2005-11-10
TR200202528T2 (tr)	2003-02-21
KR20020033642A (ko)	2002-05-07
NZ516003A (en)	2004-02-27
IL202633A (en)	2013-02-28
DE60027722T2 (de)	2007-04-26
CN101245058A (zh)	2008-08-20
DE60027722D1 (en)	2006-06-08
ATE534622T1 (de)	2011-12-15
IL146918A0 (en)	2002-08-14
HK1046899A1 (en)	2003-01-30
MY137777A (en)	2009-03-31
ZA200110177B (en)	2003-01-13
SI1194404T1 (sl)	2006-10-31
TR200200407T2 (tr)	2002-08-21

Publication	Publication Date	Title
DK1686113T3 (da)	2012-02-20	Inhibitorer af aspartylprotease
DK1086076T3 (da)	2005-03-29	Sulfonamidinhibitorer af aspartylprotease
CY2012007I2 (el)	2014-07-02	Πεπτιδομιμητικοι αναστολεις πρωτεασης
NO20012980L (no)	2001-08-01	Proteaseinhibitorer
EE200000386A (et)	2001-12-17	Aspartüülproteaasi inhibiitorite eelravimid
DK0936912T3 (da)	2004-06-07	Inhibitorer af cysteinprotease
DK0846110T3 (da)	2002-12-23	THF-holdige sulfonamidinhibitorer af aspartylprotease
EE04466B1 (et)	2005-04-15	Sulfoonamiidi derivaadid kui aspartüülproteaasi inhibiitorid
DK1315694T3 (da)	2005-08-08	Inhibitorer af alpha-4-medieret celleadhæsion
DE60002193D1 (de)	2003-05-22	Metalloprotease inhibitoren
DK1064298T3 (da)	2009-01-19	Inhibitorer af caspaser
NO995433D0 (no)	1999-11-05	Protease-inhibitorer
ATE264339T1 (de)	2004-04-15	Serine protease inhibitoren
DK1458447T3 (da)	2010-01-18	Kombination af cytokrom-p450-beroende proteasinhibitorer
NO20004696L (no)	2000-09-20	Kinoloner som serinproteaseinhibitorer
DK1307263T3 (da)	2005-08-22	Hidtil ukendt anvendelse af lipaseinhibitorer
NO995435D0 (no)	1999-11-05	Protease-inhibitorer
NO995268D0 (no)	1999-10-28	Proteaseinhibitorer
NO995434L (no)	1999-11-05	Proteaseinhibitorer
NO20014243D0 (no)	2001-08-31	Dihetero-substituerte metalloprotease inhibitorer
NO20025786L (no)	2003-02-12	Protaseinhibitorer
DK1066276T3 (da)	2003-10-06	Fremgangsmåde til syntese af HIV protease inhibitor
NO20025005D0 (no)	2002-10-17	Proteaseinhibitorer
NO20032328D0 (no)	2003-05-22	Proteaseinhibitorer
DE60124397D1 (de)	2006-12-21	Inhibitoren von serinproteasen