BR9607625A - Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila - Google Patents

Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila

Info

Publication number: BR9607625A
Authority: BR; Brazil
Prior art keywords: hydroxyethylamino; retroviral; amino acid; protease inhibitors; heterocyclocarbonyl
Prior art date: 1995-03-10

Application number

BR9607625A

Other languages

English (en)

Inventor

Daniel P Getman

Gary A Descrescenzo

John N Freskos

Michael L Vazquez

James A Sikorski

Balekudru Devadas

Srinivasan Nagarajan

David L Brown

Joseph J Mcdonald

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1996-03-07

Publication date

1999-06-15

1995-06-07 Priority claimed from US08/474,117 external-priority patent/US5776971A/en

1996-03-07 Application filed by Searle & Co filed Critical Searle & Co

1999-06-15 Publication of BR9607625A publication Critical patent/BR9607625A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BR9607625A 1995-03-10 1996-03-07 Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila BR9607625A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40241995A	1995-03-10	1995-03-10
US08/474,117 US5776971A (en)	1995-03-10	1995-06-07	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en)	1995-03-10	1996-03-07	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number	Publication Date
BR9607625A true BR9607625A (pt)	1999-06-15

Family

ID=27017874

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9607625A BR9607625A (pt)	1995-03-10	1996-03-07	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila

Country Status (20)

Country	Link
US (3)	US5972989A (pt)
EP (1)	EP0815124B1 (pt)
JP (1)	JP4124818B2 (pt)
CN (2)	CN1530372A (pt)
AT (1)	ATE229033T1 (pt)
AU (1)	AU717598B2 (pt)
BR (1)	BR9607625A (pt)
CA (1)	CA2215022A1 (pt)
CZ (1)	CZ297676B6 (pt)
DE (1)	DE69625183T2 (pt)
DK (1)	DK0815124T3 (pt)
ES (1)	ES2190793T3 (pt)
HU (1)	HUP9800518A3 (pt)
MX (1)	MX9706946A (pt)
NO (1)	NO974147L (pt)
NZ (1)	NZ306027A (pt)
PL (1)	PL184771B1 (pt)
PT (1)	PT815124E (pt)
RU (1)	RU2174519C2 (pt)
WO (1)	WO1996028465A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PL184771B1 (pl) *	1995-03-10	2002-12-31	Searle & Co	Związek stanowiący hydroksyetyloaminosulfonamid pirolidynokarbonyloaminokwasu, kompozycja zawierająca ten związek, jego zastosowanie do wytwarzania kompozycji do leczenia infekcji retrowirusowej i sposób zapobiegania replikacji retrowirusa in vitro
US6407134B1 (en) *	1995-03-10	2002-06-18	G. D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1255119A (zh) *	1997-05-08	2000-05-31	史密丝克莱恩比彻姆公司	蛋白酶抑制剂
US6538006B1 (en)	1998-07-08	2003-03-25	Pharmacia Corporation	Retroviral protease inhibitors
KR100650303B1 (ko)	1999-01-28	2006-11-28	아지노모토 가부시키가이샤	α-아미노케톤류의 제조방법
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
NZ527391A (en) *	2001-02-14	2005-04-29	Tibotec Pharm Ltd	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
IL158092A0 (en) *	2001-04-09	2004-03-28	Tibotec Pharm Ltd	Broadspectrum 2- (substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CZ304524B6 (cs)	2001-05-11	2014-06-18	Tibotec Pharmaceuticals Ltd.	Derivát 2-aminobenzoxazolsulfonamidu, farmaceutická kompozice s jeho obsahem a léčivo pro léčení infekce retroviry
TWI336621B (en)	2001-12-21	2011-02-01	Tibotec Pharm Ltd	Broad spectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) *	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
EP1517899B1 (en) *	2002-05-17	2007-08-29	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
AU2003262574B2 (en) *	2002-08-14	2009-07-09	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
US20040203166A1 (en) *	2003-04-11	2004-10-14	Sullivan John Timothy	Electrolysis apparatus and method utilizing at least one coiled electrode
ATE353323T1 (de) *	2003-09-30	2007-02-15	Tibotec Pharm Ltd	Verfahren zur herstellung von benzoxazolsulfonamidverbindungen und zwischenprodukten davon
BRPI0417272B8 (pt)	2003-12-23	2021-05-25	Janssen R&D Ireland	processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato
ME01059B (me)	2003-12-23	2012-10-20	Janssen Sciences Ireland Uc	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
EP1557166A1 (en) *	2004-01-21	2005-07-27	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
ES2426345T3 (es)	2005-07-20	2013-10-22	Eli Lilly And Company	Compuesto unidos en posición 1-amino
CN101674822A (zh)	2006-08-18	2010-03-17	塞阔伊亚药品公司	抑制细胞色素p450的组合物和方法
CN101965186A (zh)	2007-11-28	2011-02-02	塞阔伊亚药品公司	抑制细胞色素p450 2d6的化合物和方法
CN109824756B (zh) *	2019-03-19	2022-03-22	山东大学	含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) *	2020-02-13	2021-10-22	中国医学科学院医药生物技术研究所	一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
EP0068378B1 (en) *	1981-06-26	1986-03-05	Schering Corporation	Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4634465A (en) *	1982-07-16	1987-01-06	Ciba-Geigy Corporation	Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas
DE3377497D1 (en) *	1982-09-15	1988-09-01	Haessle Ab	Enzyme inhibitors
US4595407A (en) *	1982-11-01	1986-06-17	E. I. Du Pont De Nemours And Company	Triazinyl-amino-carbonyl-1,3-benzohetero- or -1,4-benzohetero-sulfonamides
US4668770A (en) *	1982-12-27	1987-05-26	Merck & Co., Inc.	Renin inhibitory tripeptides
EP0114993B1 (en) *	1982-12-27	1990-05-16	Merck & Co. Inc.	Renin inhibitory tripeptides
FI843837L (fi) *	1983-02-07	1984-09-28	Ferring Ab	Enzyminhibitorer.
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
US4514391A (en) *	1983-07-21	1985-04-30	E. R. Squibb & Sons, Inc.	Hydroxy substituted peptide compounds
US4477441A (en) *	1983-09-14	1984-10-16	Merck & Co., Inc.	Renin inhibitors containing a C-terminal disulfide cycle
US4645759A (en) *	1984-06-22	1987-02-24	Abbott Laboratories	Renin inhibiting compounds
US4616088A (en) *	1984-10-29	1986-10-07	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitor
US4599198A (en) *	1985-08-02	1986-07-08	Pfizer Inc.	Intermediates in polypeptide synthesis
US4668769A (en) *	1985-08-02	1987-05-26	Hoover Dennis J	Oxa- and azahomocyclostatine polypeptides
CA1282549C (en) *	1985-11-12	1991-04-02	Eric M. Gordon	Aminocarbonyl renin inhibitors
CA1297631C (en) *	1985-12-23	1992-03-17	Sesha I. Natarajan	Ureido renin inhibitors
US4757050A (en) *	1985-12-23	1988-07-12	E. R. Squibb Sons, Inc.	Ureido renin inhibitors
US4880938A (en) *	1986-06-16	1989-11-14	Merck & Co., Inc.	Amino acid analogs
DE3635907A1 (de) *	1986-10-22	1988-04-28	Merck Patent Gmbh	Hydroxy-aminosaeurederivate
NL8800100A (nl) *	1987-01-21	1988-08-16	Sandoz Ag	Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.
USH725H (en) *	1987-02-26	1990-01-02	E. R. Squibb & Sons, Inc.	Ureido amino and imino acids, compositions and methods for use
GB8707412D0 (en) *	1987-03-27	1987-04-29	Fujisawa Pharmaceutical Co	Peptide compounds
DE3830825A1 (de) *	1987-09-15	1989-03-23	Sandoz Ag	Hydrophile reninhemmer, ihre herstellung und verwendung
IL89900A0 (en) *	1988-04-12	1989-12-15	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
US4977277A (en) *	1988-05-09	1990-12-11	Abbott Laboratories	Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof
IL90218A0 (en) *	1988-05-13	1989-12-15	Abbott Lab	Retroviral protease inhibitors
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IL90872A0 (en) *	1988-07-08	1990-02-09	Smithkline Beckman Corp	Retroviral protease binding peptides
IL91307A0 (en) *	1988-08-24	1990-03-19	Merck & Co Inc	Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
CA2012306A1 (en) *	1989-03-28	1990-09-28	Werner Neidhart	Amino acid derivatives
JP2701932B2 (ja) *	1989-04-10	1998-01-21	サントリー株式会社	タンパク質分解酵素阻害剤
DE3912829A1 (de) *	1989-04-19	1990-10-25	Bayer Ag	Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
TW225540B (pt) *	1990-06-28	1994-06-21	Shionogi & Co
US5289728A (en) *	1990-11-08	1994-03-01	Jr Johanson, Inc.	Flow-no-flow tester
DE69118907T2 (de) *	1990-11-19	1996-11-14	Monsanto Co	Retrovirale proteaseinhibitoren
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
AU2267992A (en) *	1991-08-27	1993-03-16	Upjohn Company, The	Compounds used for the inhibition of hiv-protease
ZA929869B (en) *	1991-12-20	1994-06-20	Syntex Inc	Hiv protease inhibitors
US5463104A (en) *	1992-08-25	1995-10-31	G. D. Searle & Co.	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
KR100296463B1 (ko) *	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69307726T2 (de) *	1992-10-30	1997-06-05	Monsanto Co	Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer
ATE167669T1 (de) *	1992-10-30	1998-07-15	Searle & Co	Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen
DE69415326T2 (de) *	1993-08-24	1999-06-02	G.D. Searle & Co., Chicago, Ill.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PL184771B1 (pl) *	1995-03-10	2002-12-31	Searle & Co	Związek stanowiący hydroksyetyloaminosulfonamid pirolidynokarbonyloaminokwasu, kompozycja zawierająca ten związek, jego zastosowanie do wytwarzania kompozycji do leczenia infekcji retrowirusowej i sposób zapobiegania replikacji retrowirusa in vitro

1996
- 1996-03-07 PL PL96322179A patent/PL184771B1/pl not_active IP Right Cessation
- 1996-03-07 CZ CZ0282397A patent/CZ297676B6/cs not_active IP Right Cessation
- 1996-03-07 AT AT96911230T patent/ATE229033T1/de not_active IP Right Cessation
- 1996-03-07 RU RU97116523/04A patent/RU2174519C2/ru not_active IP Right Cessation
- 1996-03-07 DE DE69625183T patent/DE69625183T2/de not_active Expired - Fee Related
- 1996-03-07 EP EP96911230A patent/EP0815124B1/en not_active Expired - Lifetime
- 1996-03-07 BR BR9607625A patent/BR9607625A/pt not_active IP Right Cessation
- 1996-03-07 NZ NZ306027A patent/NZ306027A/xx unknown
- 1996-03-07 HU HU9800518A patent/HUP9800518A3/hu unknown
- 1996-03-07 MX MX9706946A patent/MX9706946A/es not_active IP Right Cessation
- 1996-03-07 DK DK96911230T patent/DK0815124T3/da active
- 1996-03-07 WO PCT/US1996/002683 patent/WO1996028465A1/en not_active Ceased
- 1996-03-07 JP JP52764796A patent/JP4124818B2/ja not_active Expired - Fee Related
- 1996-03-07 ES ES96911230T patent/ES2190793T3/es not_active Expired - Lifetime
- 1996-03-07 CN CNA2004100396931A patent/CN1530372A/zh active Pending
- 1996-03-07 AU AU54178/96A patent/AU717598B2/en not_active Ceased
- 1996-03-07 CN CNB961936193A patent/CN1149223C/zh not_active Expired - Fee Related
- 1996-03-07 PT PT96911230T patent/PT815124E/pt unknown
- 1996-03-07 CA CA002215022A patent/CA2215022A1/en not_active Abandoned
1997
- 1997-09-09 NO NO974147A patent/NO974147L/no not_active Application Discontinuation
1998
- 1998-02-24 US US09/028,272 patent/US5972989A/en not_active Expired - Fee Related
1999
- 1999-05-10 US US09/307,711 patent/US6063795A/en not_active Expired - Fee Related
2000
- 2000-02-09 US US09/501,265 patent/US6214861B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0815124A1 (en)	1998-01-07
JPH11501920A (ja)	1999-02-16
RU2174519C2 (ru)	2001-10-10
ATE229033T1 (de)	2002-12-15
PL322179A1 (en)	1998-01-19
MX9706946A (es)	1997-11-29
CN1183102A (zh)	1998-05-27
DK0815124T3 (da)	2003-03-17
AU5417896A (en)	1996-10-02
ES2190793T3 (es)	2003-08-16
NO974147D0 (no)	1997-09-09
DE69625183T2 (de)	2003-10-09
CN1530372A (zh)	2004-09-22
WO1996028465A1 (en)	1996-09-19
US5972989A (en)	1999-10-26
US6063795A (en)	2000-05-16
CZ297676B6 (cs)	2007-03-07
CA2215022A1 (en)	1996-09-19
DE69625183D1 (en)	2003-01-16
CZ282397A3 (cs)	1998-02-18
CN1149223C (zh)	2004-05-12
EP0815124B1 (en)	2002-12-04
JP4124818B2 (ja)	2008-07-23
NZ306027A (en)	1999-03-29
US6214861B1 (en)	2001-04-10
HUP9800518A2 (hu)	1998-06-29
PL184771B1 (pl)	2002-12-31
AU717598B2 (en)	2000-03-30
PT815124E (pt)	2003-04-30
NO974147L (no)	1997-11-04
HUP9800518A3 (en)	1998-09-28

Publication	Publication Date	Title
BR9607625A (pt)	1999-06-15	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
PT813542E (pt)	2003-01-31	Inibidores de proteases retrovirais hidroxietilamino sulfonamoda aminoacido
MX9706913A (es)	1997-11-29	Compuestos de bis-aminacido-hidroxietilamina-sulfonamida inhibidoresde proteasan retroviral, composiciones que los contienen y ek uso de los mismos.
MX9706947A (es)	1997-11-29	Inhibidores de proteasa retroviral de sulfonilalcanoilamino-hidroxietilamino-sulfonamida y uso de los mismos.
MX9706912A (es)	1998-01-31	Inhibidores de protesa retroviral de sulfonamida de hidroxietilamino de amino acido y uso de los mismos.

Legal Events

Date	Code	Title	Description
2005-12-13	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-10-24	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2007-04-27	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2007-10-23	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2007, OBSERVADAS AS CONDICOES LEGAIS.
2011-07-12	B24C	Patent annual fee: request for for restoration	Free format text: REFERENTE A 14A E 15A ANUIDADE(S).
2013-04-24	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE AO DESPACHO 24.3 PUBLICADO NA RPI 2114 DE 12/07/2011.