DK1676847T3 - Polymorfe former af rifaximin som antibiotika - Google Patents
Polymorfe former af rifaximin som antibiotikaInfo
- Publication number
- DK1676847T3 DK1676847T3 DK06004219T DK06004219T DK1676847T3 DK 1676847 T3 DK1676847 T3 DK 1676847T3 DK 06004219 T DK06004219 T DK 06004219T DK 06004219 T DK06004219 T DK 06004219T DK 1676847 T3 DK1676847 T3 DK 1676847T3
- Authority
- DK
- Denmark
- Prior art keywords
- rifaximin
- antibiotics
- polymorphic forms
- polymorphic
- forms
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 title 1
- 229960003040 rifaximin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1236—Cooking devices induction cooking plates or the like and devices to be used in combination with them adapted to induce current in a coil to supply power to a device and electrical heating devices powered in this way
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1245—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements
- H05B6/1263—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements using coil cooling arrangements
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002144A ITMI20032144A1 (it) | 2003-11-07 | 2003-11-07 | Forme polimorfe di rifaximina, processi per ottenerle e |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1676847T3 true DK1676847T3 (da) | 2009-05-11 |
Family
ID=33187382
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06004219T DK1676847T3 (da) | 2003-11-07 | 2004-03-09 | Polymorfe former af rifaximin som antibiotika |
| DK06004220T DK1676848T3 (da) | 2003-11-07 | 2004-03-09 | Polymorfe former af rifaximin som antibiotika |
| DK04005541T DK1557421T3 (da) | 2003-11-07 | 2004-03-09 | Polymorfe form af rifaximin som antibiotikum |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06004220T DK1676848T3 (da) | 2003-11-07 | 2004-03-09 | Polymorfe former af rifaximin som antibiotika |
| DK04005541T DK1557421T3 (da) | 2003-11-07 | 2004-03-09 | Polymorfe form af rifaximin som antibiotikum |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US7045620B2 (da) |
| EP (6) | EP1676847B1 (da) |
| JP (5) | JP2005139161A (da) |
| KR (4) | KR20050043589A (da) |
| CN (4) | CN1613858A (da) |
| AR (3) | AR043547A1 (da) |
| AT (3) | ATE421965T1 (da) |
| AU (2) | AU2004200964A1 (da) |
| BR (2) | BRPI0402382A (da) |
| CA (2) | CA2460384A1 (da) |
| CL (1) | CL2004000498A1 (da) |
| CO (1) | CO5560083A1 (da) |
| CY (3) | CY1108017T1 (da) |
| DE (4) | DE602004019296D1 (da) |
| DK (3) | DK1676847T3 (da) |
| ES (3) | ES2320161T3 (da) |
| HR (2) | HRP20040265A2 (da) |
| IL (2) | IL160798A0 (da) |
| IT (1) | ITMI20032144A1 (da) |
| JO (1) | JO2470B1 (da) |
| MA (1) | MA27069A1 (da) |
| MD (1) | MD3653G8 (da) |
| ME (1) | ME00424B (da) |
| MX (2) | MXPA04002353A (da) |
| NO (1) | NO334950B1 (da) |
| NZ (1) | NZ531622A (da) |
| PL (3) | PL1557421T3 (da) |
| PT (3) | PT1557421E (da) |
| RS (4) | RS54568B1 (da) |
| RU (1) | RU2270200C2 (da) |
| SI (3) | SI1676847T1 (da) |
| TN (2) | TNSN04044A1 (da) |
| TW (1) | TWI285107B (da) |
| UA (1) | UA86384C2 (da) |
| WO (1) | WO2005044823A2 (da) |
| YU (1) | YU24804A (da) |
| ZA (1) | ZA200401948B (da) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7906542B2 (en) * | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
| US7923553B2 (en) * | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
| ITMI20032144A1 (it) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US7902206B2 (en) * | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
| US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
| PL1698630T3 (pl) | 2005-03-03 | 2014-12-31 | Alfasigma Spa | Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych |
| ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
| PT2054066E (pt) | 2006-08-02 | 2015-07-16 | Salix Pharmaceuticals Inc | Métodos para tratamento de enterite por radiação |
| ITMI20061692A1 (it) * | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
| EP2069363B1 (en) * | 2006-09-22 | 2013-03-20 | Cipla Ltd. | Rifaximin in an amorphous form |
| US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
| US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
| ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
| JP5755878B2 (ja) * | 2007-07-06 | 2015-07-29 | ルパン リミテッドLupin Limited | リファキシミンの薬剤組成物 |
| AU2016203925B2 (en) * | 2007-07-06 | 2016-10-20 | Lupin Limited | Pharmaceutical compositions of rifaximin |
| PL2011486T5 (pl) * | 2007-07-06 | 2016-09-30 | Lupin Ltd | Farmaceutyczne kompozycje rifaksyminy |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| EP2257557A4 (en) | 2008-02-25 | 2011-06-29 | Salix Pharmaceuticals Ltd | FORMS OF RIFAXIMINE AND APPLICATIONS THEREOF |
| US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| US20110065741A1 (en) | 2009-02-26 | 2011-03-17 | Salix Pharmaceuticals, Ltd. | Methods for treating irritable bowel syndrome (ibs) |
| DK2252148T3 (da) | 2008-02-26 | 2019-05-06 | Salix Pharmaceuticals Ltd | Fremgangsmåder til behandling af irritabel tarmsyndrom |
| US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
| WO2009137672A1 (en) | 2008-05-07 | 2009-11-12 | Salix Pharmaceuticals, Ltd. | Methods of treating bowel disease by administering a bowel cleanser and an antibiotic |
| KR20110071096A (ko) | 2008-09-26 | 2011-06-28 | 아스카 세이야쿠 가부시키가이샤 | 기능성 소화관 장해의 예방 및/또는 치료제 |
| US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
| US7928115B2 (en) * | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| US20100317681A1 (en) * | 2009-06-15 | 2010-12-16 | Salix Pharmaceuticals, Ltd. | Modulation of systemic exposure to rifaximin |
| ES2770308T3 (es) | 2008-10-02 | 2020-07-01 | Salix Pharmaceuticals Ltd | Procedimientos de tratamiento de encefalopatía hepática |
| US12285414B2 (en) | 2008-10-02 | 2025-04-29 | Salix Pharmaceuticals, Inc. | Methods of treating hepatic encephalopathy |
| JP5756020B2 (ja) | 2008-12-10 | 2015-07-29 | シプラ・リミテッド | リファキシミン複合体 |
| IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
| EP3964066A1 (en) | 2009-06-02 | 2022-03-09 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
| KR20200100215A (ko) * | 2009-10-27 | 2020-08-25 | 루핀 리미티드 | 리팍시민의 고형 분산물 |
| WO2011061748A1 (en) * | 2009-11-19 | 2011-05-26 | Strides Arcolab Limited | Rifaximin premix |
| CA2781580A1 (en) | 2009-11-23 | 2011-05-26 | Cipla Limited | Topical foam composition |
| US8952159B2 (en) | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
| EP2536282A4 (en) | 2010-02-18 | 2013-07-03 | Salix Pharmaceuticals Ltd | METHOD FOR THE TREATMENT OF INFECTIONS |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| EA022490B1 (ru) * | 2010-06-03 | 2016-01-29 | Саликс Фармасьютикалс, Лтд. | Новые формы рифаксимина и их применение |
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| US8759513B2 (en) | 2010-09-13 | 2014-06-24 | Sequent Scientific Limited | Polymorphic form of rifaximin and process for its preparation |
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| WO2012060675A1 (es) * | 2010-11-05 | 2012-05-10 | Interquim, S.A. De C.V. | Proceso para la preparación de rifaximina amorfa |
| WO2012076832A1 (en) * | 2010-12-09 | 2012-06-14 | Cipla Limited | Suppositories comprising rifaximin |
| KR20140026379A (ko) | 2011-02-11 | 2014-03-05 | 샐릭스 파마슈티컬스 리미티드 | 리팍시민의 형태 및 이의 용도 |
| CA2834829A1 (en) | 2011-05-02 | 2012-11-08 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
| WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
| ITMI20110890A1 (it) | 2011-05-19 | 2012-11-20 | A M S A Anonima Materie Sint & Affini S P A | Polimorfo di rifaximina e processo per la sua preparazione |
| ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
| ES2986825T3 (es) * | 2011-11-02 | 2024-11-12 | Salix Pharmaceuticals Inc | Rifaximina para la repetición de tratamiento del síndrome del intestino irritable con predominio de diarrea |
| JP2013184902A (ja) * | 2012-03-06 | 2013-09-19 | Aska Pharmaceutical Co Ltd | リファキシミン含有結晶 |
| WO2013185211A1 (en) * | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| US9849090B2 (en) | 2012-12-12 | 2017-12-26 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of rifaximin |
| US20160038468A1 (en) | 2013-03-15 | 2016-02-11 | Alfa Wassermann S.P.A. | Rifaximin for use in the treating of vaginal infections |
| EP2971062A2 (en) | 2013-03-15 | 2016-01-20 | ALFA WASSERMANN S.p.A. | Method for diagnosing vaginal infections |
| CA2908525C (en) | 2013-04-12 | 2021-04-06 | Alfa Wassermann S.P.A. | Nsaid administration and related compositions, methods and systems |
| US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
| EP2927235B1 (en) | 2014-03-31 | 2017-02-08 | Euticals S.P.A. | Polymorphic mixture of rifaximin and its use for the preparation of solid formulations |
| CA2946101A1 (en) * | 2014-04-19 | 2015-10-22 | Granules India Limited | An improved process for the preparation of rifamycin derivatives |
| MX375805B (es) | 2014-05-04 | 2025-03-07 | Salix Pharmaceuticals Inc | Microbiota ibs y sus usos. |
| JP6576953B2 (ja) | 2014-05-12 | 2019-09-18 | アルファシグマ ソシエタ ペル アチオニ | リファキシミンの新規溶媒和物結晶形、生成物、組成物及びそれらの使用 |
| WO2016003536A1 (en) * | 2014-06-30 | 2016-01-07 | Salix Pharmaceuticals, Inc. | Methods for retreating irritable bowel syndrome (ibs) |
| CN104083324B (zh) * | 2014-07-10 | 2017-05-10 | 青岛动保国家工程技术研究中心有限公司 | 一种利福昔明的兽用悬乳剂及其制备方法和应用 |
| EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
| CN104274391B (zh) * | 2014-10-08 | 2017-02-01 | 哈尔滨坤盟医药科技有限公司 | 一种含利福昔明的药物制剂 |
| WO2017021975A1 (en) * | 2015-08-06 | 2017-02-09 | Msn Laboratories Private Limited | Process for the preparation of crystalline forms of rifaximin |
| US10842782B2 (en) | 2016-03-24 | 2020-11-24 | Sandoz Ag | Storage stable composition comprising rifaximin alpha |
| ES2700423T3 (es) | 2016-03-24 | 2019-02-15 | Sandoz Ag | Composición farmacéutica que contiene rifaximina alfa y delta |
| US9988398B2 (en) * | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
| EP3518924B1 (en) | 2016-09-30 | 2022-08-10 | Salix Pharmaceuticals, Inc. | Solid dispersion forms of rifaximin |
| CN106632396B (zh) * | 2017-01-06 | 2019-01-11 | 成都樵枫科技发展有限公司 | γ晶型利福昔明的制备方法和用途 |
| WO2018197538A1 (en) | 2017-04-26 | 2018-11-01 | Sandoz Ag | Oral dosage form comprising rifaximin in form beta |
| DK3645539T3 (da) | 2017-06-26 | 2021-05-10 | Biofer Spa | Pyrido-imidazo-rifamycin-derivater som antibakterielt middel |
| WO2020128583A1 (en) * | 2018-12-19 | 2020-06-25 | Friulchem S.P.A. | Process for the manufacture of a tablet of rifaximin and tablet of rifaximin |
| WO2020245214A1 (en) | 2019-06-03 | 2020-12-10 | Bausch Health Ireland Limited | Use of methylnaltrexone and rifaximin for treatment of increased gut permeability or associated disorders |
| EP4034091A1 (en) | 2019-09-24 | 2022-08-03 | Bausch Health Ireland Limited | Rifaximin liquid formulations |
| US20230116647A1 (en) | 2020-03-24 | 2023-04-13 | Bausch Health Ireland Limited | Methods of treating covid-19 with rifaximin |
| WO2021229480A1 (en) * | 2020-05-15 | 2021-11-18 | Atra Pharmaceuticals Limited | Polymorph of rifaximin, process for the preparation thereof and pharmaceutical composition containing rifaximin |
| JP2023531268A (ja) | 2020-06-26 | 2023-07-21 | バウシュ ヘルス アイルランド リミテッド | 標的化放出リファキシミン組成物 |
| WO2022090490A1 (en) | 2020-10-29 | 2022-05-05 | Bausch Health Ireland Limited | Rifaximin liquid formulations for use in the treatment of sickle cell disease |
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| IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| ITMI20032144A1 (it) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US20050262269A1 (en) | 2004-05-20 | 2005-11-24 | Pike Jimmy D | System and method for information handling system PCI express advanced switching |
| PL1698630T3 (pl) | 2005-03-03 | 2014-12-31 | Alfasigma Spa | Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych |
| EP2069363B1 (en) | 2006-09-22 | 2013-03-20 | Cipla Ltd. | Rifaximin in an amorphous form |
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