DK167185B1 - 5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater - Google Patents

5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater Download PDF

Info

Publication number: DK167185B1
Authority: DK; Denmark
Prior art keywords: compound; methoxyphenyl; cis; ethyl; chloro
Prior art date: 1983-06-03

Application number

DK272884A

Other languages

Danish (da)

English (en)

Other versions

DK272884A (da

DK272884D0 (da

Inventor

Mikio Takeda

Tokuro Oh-Ishi

Hiromichi Nakajima

Taku Nagao

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-03

Filing date

1984-06-01

Publication date

1993-09-13

1983-06-03 Priority claimed from GB838315364A external-priority patent/GB8315364D0/en

1984-01-14 Priority claimed from GB848400983A external-priority patent/GB8400983D0/en

1984-06-01 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

1984-06-01 Publication of DK272884D0 publication Critical patent/DK272884D0/da

1984-12-04 Publication of DK272884A publication Critical patent/DK272884A/da

1993-09-13 Application granted granted Critical

1993-09-13 Publication of DK167185B1 publication Critical patent/DK167185B1/da

Links

238000000034 method Methods 0.000 title description 17
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125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 43
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239000011734 sodium Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
239000011135 tin Substances 0.000 description 1
229910052718 tin Inorganic materials 0.000 description 1
AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
239000004246 zinc acetate Substances 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
- C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J123/04—Homopolymers or copolymers of ethene
- C09J123/08—Copolymers of ethene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Hydrogenated Pyridines (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK272884A 1983-06-03 1984-06-01 5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater DK167185B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB838315364A GB8315364D0 (en)	1983-06-03	1983-06-03	8-chloro-1 5-benzothiazepine derivatives
GB8315364		1983-06-03
GB848400983A GB8400983D0 (en)	1984-01-14	1984-01-14	8-chloro-1,5-benzothiazepine derivatives
GB8400983		1984-01-14

Publications (3)

Publication Number	Publication Date
DK272884D0 DK272884D0 (da)	1984-06-01
DK272884A DK272884A (da)	1984-12-04
DK167185B1 true DK167185B1 (da)	1993-09-13

Family

ID=26286299

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK272884A DK167185B1 (da)	1983-06-03	1984-06-01	5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater
DK104792A DK167186B1 (da)	1983-06-03	1992-08-24	8-chlor-1,5-benzothiazepinderivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK104792A DK167186B1 (da)	1983-06-03	1992-08-24	8-chlor-1,5-benzothiazepinderivater og fremgangsmaade til fremstilling deraf

Country Status (18)

Country	Link
US (1)	US4567175A (es)
EP (1)	EP0127882B1 (es)
KR (1)	KR900005697B1 (es)
AT (1)	ATE22889T1 (es)
AU (1)	AU563093B2 (es)
BG (2)	BG41130A3 (es)
CA (2)	CA1237719A (es)
DD (1)	DD218619A5 (es)
DE (1)	DE3460972D1 (es)
DK (2)	DK167185B1 (es)
ES (2)	ES533009A0 (es)
HK (1)	HK81888A (es)
HU (2)	HU191933B (es)
MY (1)	MY101748A (es)
NO (2)	NO162518C (es)
PH (1)	PH21627A (es)
PT (1)	PT78682B (es)
SU (2)	SU1299508A3 (es)

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JPS6450872A (en) *	1987-08-21	1989-02-27	Tanabe Seiyaku Co	Production of 1,5-benzothiazepine derivative
JPS6445376A (en) *	1987-08-12	1989-02-17	Tanabe Seiyaku Co	Production of 1,5-benzothiazepine derivative
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US5002942A (en) *	1988-07-25	1991-03-26	Sankyo Company, Limited	1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1226301B (it) *	1988-07-26	1990-12-27	Zambon Spa	Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2637285B1 (fr) *	1988-10-03	1991-04-12	Synthelabo	Procede de preparation de derives de l'acide propionique et produits obtenus
US4952692A (en) *	1989-04-04	1990-08-28	E. R. Squibb & Sons, Inc.	Benzazepine derivatives
US4946840A (en) *	1989-04-06	1990-08-07	E. R. Squibb & Sons, Inc.	Benzazepine and benzothiazepine derivatives
IT1230057B (it) *	1989-04-13	1991-09-27	Zambon Spa	Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
US5128469A (en) *	1989-04-28	1992-07-07	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivatives
ES2069003T3 (es) *	1989-04-28	1995-05-01	Tanabe Seiyaku Co	Procedimiento para preparar derivados de 1,5-benzotiazepina.
US5250680A (en) *	1989-08-31	1993-10-05	Merrell Dow Pharmaceuticals Inc.	Heterogeneous synthesis of azepinones from esters
AU628217B2 (en) *	1989-08-31	1992-09-10	Marion Merrell Dow Inc.	Heterogeneous synthesis of azepinones from esters
JPH088879B2 (ja) *	1989-09-13	1996-01-31	田辺製薬株式会社	光学活性３―フェニルグリシッド酸エステル類化合物の製法
CA2030159A1 (en) *	1989-11-22	1991-05-23	Nahed K. Ahmed	Anti-cancer drug potentiators
CA2030160A1 (en) *	1989-11-22	1991-05-23	Nahed K. Ahmed	Benzothiazepine metastasis treatment
US5001236A (en) *	1989-11-22	1991-03-19	Marion Laboratories, Inc.	Benzothiazepines
US5112969A (en) *	1990-04-02	1992-05-12	Merrell Dow Pharmaceuticals Inc.	Cyano esters and azepinones
US5055575A (en) *	1990-04-12	1991-10-08	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivatives
IT1240651B (it) *	1990-05-17	1993-12-17	Zambon Spa	Processo per la risoluzione di derivati glicidici
CA2049655C (en) *	1990-09-17	1996-11-12	Akio Odawara	Pharmaceutical composition for inhibiting platelet aggregation
DK0585355T3 (da) *	1991-05-20	1995-06-06	Tanabe Seiyaku Co	Flerlagspræparat med reguleret frigivelse
US5378698A (en) *	1991-10-21	1995-01-03	Shionogi & Co., Ltd.	Benzothiazepine derivatives
CA2087743C (en) *	1992-02-06	1999-04-27	Akio Odawara	Pharmaceutical composition for inhibiting platelet aggregation
KR950003279A (ko) *	1993-07-29	1995-02-16	고사이 아끼오	플루오로알칸 카르복사미드 유도체의 제조방법
DE69601210T2 (de) *	1995-12-05	1999-05-20	Tanabe Seiyaku Co., Ltd., Osaka	Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung
US5705638A (en) *	1995-12-05	1998-01-06	Tanabe Seiyaku Co., Ltd.	Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
AU709280B2 (en) *	1996-02-23	1999-08-26	Tanabe Seiyaku Co., Ltd.	Process for preparing 1,5-benzothiazepine derivative
IT1302261B1 (it)	1998-09-24	2000-09-05	Zambon Spa	Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
KR100668539B1 (ko)	2002-08-19	2007-01-16	화이자 프로덕츠 인크.	과증식성 질환에 대한 조합요법
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
KR20070054644A (ko) *	2004-07-26	2007-05-29	액테리온 파마슈티칼 리미티드	미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
MX2007005137A (es) *	2004-11-23	2007-06-22	Warner Lambert Co	Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7893050B2 (en) *	2005-10-26	2011-02-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
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BR6915295D0 (pt) *	1969-01-25	1973-04-12	Tanabe Seiyaku Co	Indicador cronologico de evento em transmissao televisada

1984
- 1984-05-16 US US06/610,856 patent/US4567175A/en not_active Expired - Lifetime
- 1984-05-29 CA CA000455370A patent/CA1237719A/en not_active Expired
- 1984-05-30 BG BG069785A patent/BG41130A3/xx unknown
- 1984-05-30 DE DE8484106187T patent/DE3460972D1/de not_active Expired
- 1984-05-30 BG BG065689A patent/BG40964A3/xx unknown
- 1984-05-30 EP EP84106187A patent/EP0127882B1/en not_active Expired
- 1984-05-30 AT AT84106187T patent/ATE22889T1/de active
- 1984-05-31 PH PH30744A patent/PH21627A/en unknown
- 1984-05-31 AU AU28873/84A patent/AU563093B2/en not_active Ceased
- 1984-05-31 ES ES533009A patent/ES533009A0/es active Granted
- 1984-06-01 PT PT78682A patent/PT78682B/pt not_active IP Right Cessation
- 1984-06-01 SU SU843749937A patent/SU1299508A3/ru active
- 1984-06-01 HU HU842144A patent/HU191933B/hu not_active IP Right Cessation
- 1984-06-01 DD DD84263713A patent/DD218619A5/de not_active IP Right Cessation
- 1984-06-01 NO NO842203A patent/NO162518C/no unknown
- 1984-06-01 HU HU863905A patent/HU193865B/hu unknown
- 1984-06-01 DK DK272884A patent/DK167185B1/da active
- 1984-06-02 KR KR1019840003088A patent/KR900005697B1/ko not_active Expired
1985
- 1985-02-25 SU SU853856852A patent/SU1362401A3/ru active
- 1985-03-25 ES ES541557A patent/ES8602720A1/es not_active Expired
1986
- 1986-09-25 NO NO863823A patent/NO163566C/no unknown
- 1986-11-27 CA CA000524033A patent/CA1231097A/en not_active Expired
1987
- 1987-06-24 MY MYPI87000877A patent/MY101748A/en unknown
1988
- 1988-10-06 HK HK818/88A patent/HK81888A/en not_active IP Right Cessation
1992
- 1992-08-24 DK DK104792A patent/DK167186B1/da active

Also Published As

Publication number	Publication date
CA1237719A (en)	1988-06-07
ES541557A0 (es)	1985-12-01
HK81888A (en)	1988-10-14
PT78682A (pt)	1985-01-01
DK104792D0 (da)	1992-08-24
ES8602720A1 (es)	1985-12-01
NO163566B (no)	1990-03-12
SU1362401A3 (ru)	1987-12-23
DE3460972D1 (en)	1986-11-20
CA1231097A (en)	1988-01-05
EP0127882A1 (en)	1984-12-12
PH21627A (en)	1987-12-11
ES8506677A1 (es)	1985-08-01
MY101748A (en)	1992-01-17
DK272884A (da)	1984-12-04
BG40964A3 (en)	1987-03-14
HU193865B (en)	1987-12-28
SU1299508A3 (ru)	1987-03-23
HU191933B (en)	1987-04-28
US4567175A (en)	1986-01-28
DK272884D0 (da)	1984-06-01
NO163566C (no)	1990-06-27
DK104792A (da)	1992-08-24
HUT37929A (en)	1986-03-28
AU563093B2 (en)	1987-06-25
DK167186B1 (da)	1993-09-13
AU2887384A (en)	1984-12-06
KR850000033A (ko)	1985-02-25
PT78682B (en)	1986-07-11
NO863823L (no)	1984-12-04
NO162518B (no)	1989-10-02
ES533009A0 (es)	1985-08-01
NO863823D0 (no)	1986-09-25
ATE22889T1 (de)	1986-11-15
DD218619A5 (de)	1985-02-13
BG41130A3 (en)	1987-04-15
NO842203L (no)	1984-12-04
KR900005697B1 (ko)	1990-08-06
NO162518C (no)	1990-01-10
EP0127882B1 (en)	1986-10-15

Publication	Publication Date	Title
DK167185B1 (da)	1993-09-13	5-alkyl-8-chlor-1,5-benzothiazepinderivater, fremgangsmaader til fremstilling deraf samt et farmaceutisk praeparat indeholdende disse derivater
EP0154838B1 (en)	1988-07-06	Novel 1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
FI80881C (fi)	1990-08-10	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,5-bentsotiazepinderivat.
JPH0374659B2 (es)	1991-11-27
US4665068A (en)	1987-05-12	Novel 9-chloro-1,5-benzothiazepine derivatives and their pharmaceutical use
JPH0228594B2 (ja)	1990-06-25	1*55benzochiazepinjudotai
JPS6313994B2 (es)	1988-03-29
KR900005680B1 (ko)	1990-08-06	1,5-벤조티아제핀 유도체의 제조방법
DK172192B1 (da)	1997-12-22	Nye benzothiazepinderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater
KR940003290B1 (ko)	1994-04-20	나프토티아제핀 유도체 및 이의 제조방법
US4640930A (en)	1987-02-03	Naphtho(1,8-bc)-1,5-thiazocinones
JPH0374661B2 (es)	1991-11-27
JPH0421667B2 (es)	1992-04-13
JP2954962B2 (ja)	1999-09-27	８位置換１，５―ベンゾチアゼピン誘導体
JPS6313966B2 (es)	1988-03-29
JPH0421668B2 (es)	1992-04-13