DK156398C - N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives - Google Patents

N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Info

Publication number: DK156398C
Authority: DK; Denmark
Prior art keywords: diheteroaryl; butenyl; substituted; carboxylic acid; acid derivatives
Prior art date: 1985-06-26

Application number

DK100887A

Other languages

English (en)

Other versions

DK100887A (da

DK100887D0 (da

DK156398B (da

Inventor

Frederik Christian Groenvald

Claus Braestrup

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-26

Filing date

1987-02-26

Publication date

1990-01-08

1987-02-26 Application filed by Novo Industri As filed Critical Novo Industri As

1987-02-26 Priority to DK100887A priority Critical patent/DK156398C/da

1987-02-26 Publication of DK100887A publication Critical patent/DK100887A/da

1987-02-26 Publication of DK100887D0 publication Critical patent/DK100887D0/da

1989-08-14 Publication of DK156398B publication Critical patent/DK156398B/da

1990-01-08 Application granted granted Critical

1990-01-08 Publication of DK156398C publication Critical patent/DK156398C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Anesthesiology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

DK100887A 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives DK156398C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK100887A DK156398C (da)	1985-06-26	1987-02-26	N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK288385		1985-06-26
DK288385A DK288385D0 (da)	1985-06-26	1985-06-26	Aminosyrederivater
PCT/DK1986/000076 WO1987000171A1 (en)	1985-06-26	1986-06-26	Amino acid derivatives
DK8600076		1986-06-26
DK100887A DK156398C (da)	1985-06-26	1987-02-26	N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives
DK100887		1987-02-26

Publications (4)

Publication Number	Publication Date
DK100887A DK100887A (da)	1987-02-26
DK100887D0 DK100887D0 (da)	1987-02-26
DK156398B DK156398B (da)	1989-08-14
DK156398C true DK156398C (da)	1990-01-08

Family

ID=8116767

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK288385A DK288385D0 (da)	1985-06-26	1985-06-26	Aminosyrederivater
DK100887A DK156398C (da)	1985-06-26	1987-02-26	N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK288385A DK288385D0 (da)	1985-06-26	1985-06-26	Aminosyrederivater

Country Status (16)

Country	Link
US (1)	US5010090A (da)
EP (1)	EP0236342B1 (da)
JP (1)	JPH07103116B2 (da)
AT (1)	ATE67196T1 (da)
AU (1)	AU599326B2 (da)
CA (1)	CA1284503C (da)
DK (2)	DK288385D0 (da)
ES (1)	ES8800927A1 (da)
FI (1)	FI89355C (da)
GR (1)	GR861650B (da)
IE (1)	IE59084B1 (da)
LU (1)	LU90130I2 (da)
NZ (1)	NZ216657A (da)
PT (1)	PT82841B (da)
WO (1)	WO1987000171A1 (da)
ZA (1)	ZA864608B (da)

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DK704488D0 (da) *	1988-12-19	1988-12-19	Novo Industri As	Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) *	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
DK588189D0 (da) *	1989-11-22	1989-11-22	Novo Nordisk As	Nye heterocykliske carboxylsyrer
DK58291D0 (da) *	1991-04-02	1991-04-02	Novo Nordisk As	Krystalinsk stof og dets fremstilling
US5750140A (en) *	1994-05-20	1998-05-12	Novo Nordisk A/S	Transdermal delivery of tiagabine
IL117295A (en) *	1995-02-28	1999-11-30	Lundbeck & Co As H	4-Aminotetrahydro-benzisoxazole or-isothiazole compounds and pharmaceutical compositions comprising them
US5962449A (en)	1995-04-07	1999-10-05	Novo Nordisk A/S	Tricyclic compounds in treating hyperalgesic conditions and NIDDM
US5866590A (en) *	1995-05-05	1999-02-02	Novo Nordisk A/S	Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
US6191165B1 (en)	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
US5958951A (en) *	1996-06-14	1999-09-28	Novo Nordiskials	Modified form of the R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride
UA52661C2 (uk) *	1996-06-14	2003-01-15	Ново Нордіск А/С	Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5914333A (en) *	1996-07-31	1999-06-22	Novo Nordisk A/S	Treatment of psychotic disorders
DK0991409T3 (da) *	1997-08-01	2002-03-25	Elan Corp Plc	Farmaceutiske tiagabinindeholdende præparater med reguleret frigivelse
IE970588A1 (en)	1997-08-01	2000-08-23	Elan Corp Plc	Controlled release pharmaceutical compositions containing tiagabine
US6288083B1 (en) *	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) *	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
DE19840611A1 (de) *	1998-09-05	2000-03-09	Klaus Wanner	GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
EP1142584A4 (en) *	1999-01-12	2003-04-16	Takeda Chemical Industries Ltd	COMPOSITIONS FOR THE TREATMENT OF COMMON URBANISM AND URINE CONTINENCE
US6872734B2 (en)	2000-10-20	2005-03-29	Abbott Laboratories	Use of tiagabine for treatment of diabetic neuropathy and migraine
AU2002215160A1 (en) *	2000-11-30	2002-06-11	Pfizer Products Inc.	Combination of gaba agonists and aldose reductase inhibitors
BR0115783A (pt)	2000-11-30	2003-09-16	Pfizer Prod Inc	Combinação de agonistas de gaba e inibidores de sorbitol desidrogenase
CA2438367A1 (en)	2001-02-16	2002-08-29	Allelix Neuroscience, Inc.	Thiophene substituted amine derivatives as glyt-1 inhibitors
CA2477088A1 (en)	2002-02-22	2003-10-02	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
CN1382441A (zh) *	2002-05-21	2002-12-04	中国科学院上海生命科学研究院	γ－氨基丁酸转运蛋白抑制剂在制备镇痛药物中的应用
WO2004100992A2 (en) *	2003-05-16	2004-11-25	Pfizer Products Inc.	Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
PL1691811T3 (pl)	2003-12-11	2014-12-31	Sunovion Pharmaceuticals Inc	Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
CN1314684C (zh) *	2003-12-24	2007-05-09	中国科学院上海有机化学研究所	噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
WO2005122698A2 (en) *	2003-12-24	2005-12-29	Sun Pharmaceutical Industries Limited	Novel stable polymorphic forms of tiagabine hydrochloride
EP1737466A1 (en) *	2004-01-29	2007-01-03	Pfizer Products Inc.	COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS
WO2005092886A1 (en) *	2004-03-29	2005-10-06	Ranbaxy Laboratories Limited	Process for the preparation of amorphous form of tiagabine
US20080269495A1 (en) *	2004-08-04	2008-10-30	Prosenjit Bose	Process for Preparation of Piperidine Carboxylic Acid
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
WO2007053596A1 (en) *	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2026813A2 (en)	2006-05-09	2009-02-25	Braincells, Inc.	5 ht receptor mediated neurogenesis
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20080051435A1 (en) *	2006-08-18	2008-02-28	Cephalon, Inc.	Crystalline and amorphous forms of tiagabine
US20080064727A1 (en) *	2006-08-18	2008-03-13	Cephalon, Inc.	Crystalline forms of tiagabine hydrochloride
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US20090082401A1 (en) *	2007-09-25	2009-03-26	Protia, Llc	Deuterium-enriched tiagabine
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
CN101857591B (zh) *	2009-04-09	2013-06-05	北京京卫燕康药物研究所有限公司	盐酸噻加宾晶型及其制备方法
CN102070624B (zh) *	2011-01-25	2013-04-10	赵学清	一种盐酸噻加宾的合成方法及无水盐酸噻加宾的制备方法
CN102827152B (zh) *	2012-09-17	2014-11-05	扬子江药业集团四川海蓉药业有限公司	噻加宾的制备方法及其前体化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4383999A (en) *	1981-05-26	1983-05-17	Smithkline Beckman Corporation	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) *	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) *	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
ES2059360T3 (es) *	1986-01-07	1994-11-16	Novo Nordisk As	Nuevos derivados de aminoacidos.

1985
- 1985-06-26 DK DK288385A patent/DK288385D0/da not_active Application Discontinuation
1986
- 1986-06-20 ZA ZA864608A patent/ZA864608B/xx unknown
- 1986-06-24 CA CA000512333A patent/CA1284503C/en not_active Expired - Lifetime
- 1986-06-25 PT PT82841A patent/PT82841B/pt unknown
- 1986-06-25 IE IE170286A patent/IE59084B1/en not_active IP Right Cessation
- 1986-06-25 ES ES556659A patent/ES8800927A1/es not_active Expired
- 1986-06-25 NZ NZ216657A patent/NZ216657A/xx unknown
- 1986-06-25 GR GR861650A patent/GR861650B/el unknown
- 1986-06-26 AT AT86904114T patent/ATE67196T1/de active
- 1986-06-26 AU AU61336/86A patent/AU599326B2/en not_active Expired
- 1986-06-26 EP EP86904114A patent/EP0236342B1/en not_active Expired - Lifetime
- 1986-06-26 WO PCT/DK1986/000076 patent/WO1987000171A1/en not_active Ceased
- 1986-06-26 JP JP61503845A patent/JPH07103116B2/ja not_active Expired - Lifetime
1987
- 1987-02-25 FI FI870810A patent/FI89355C/fi not_active IP Right Cessation
- 1987-02-26 DK DK100887A patent/DK156398C/da not_active IP Right Cessation
1988
- 1988-10-07 US US07/254,557 patent/US5010090A/en not_active Expired - Lifetime
1997
- 1997-08-29 LU LU90130C patent/LU90130I2/fr unknown

Also Published As

Publication number	Publication date
EP0236342B1 (en)	1991-09-11
EP0236342A1 (en)	1987-09-16
AU599326B2 (en)	1990-07-19
ZA864608B (en)	1987-02-25
DK100887A (da)	1987-02-26
DK100887D0 (da)	1987-02-26
FI89355C (fi)	1993-09-27
ES8800927A1 (es)	1987-12-01
DK156398B (da)	1989-08-14
AU6133686A (en)	1987-01-30
JPS62503172A (ja)	1987-12-17
NZ216657A (en)	1989-10-27
FI89355B (fi)	1993-06-15
WO1987000171A1 (en)	1987-01-15
FI870810A0 (fi)	1987-02-25
US5010090A (en)	1991-04-23
ATE67196T1 (de)	1991-09-15
LU90130I2 (fr)	1997-10-24
JPH07103116B2 (ja)	1995-11-08
PT82841B (pt)	1989-01-17
DK288385D0 (da)	1985-06-26
PT82841A (en)	1986-07-01
IE59084B1 (en)	1994-01-12
ES556659A0 (es)	1987-12-01
IE861702L (en)	1986-12-26
CA1284503C (en)	1991-05-28
FI870810L (fi)	1987-02-25
GR861650B (en)	1986-10-30

Publication	Publication Date	Title
DK156398C (da)	1990-01-08	N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives
FI894095A0 (fi)	1989-08-31	Vaermare foer anvaendning i mikrovaogsugnar.
NO881460D0 (no)	1988-04-06	Kumaapning i veibane.
DE58901663D1 (de)	1992-07-23	I.m. injektionsformen von gyrase-inhibitoren.
ES2059360T3 (es)	1994-11-16	Nuevos derivados de aminoacidos.
NO880052D0 (no)	1988-01-07	Vekselstroem-effektkrets og sikring for samme.
FI890697A7 (fi)	1989-12-14	Anordning foer att vaexla stroemningsriktning i kombination med en mellan deflektor.
DE58903780D1 (de)	1993-04-22	N-substituierte 3,4,5,6-tetrahydrophthalimid-derivate.
ES1004056Y (es)	1989-02-16	Candado perfeccionado.
ES1003934Y (es)	1989-04-01	Candado perfeccionado.
ES1017217Y (es)	1992-07-01	Tapon perfeccionado.
ES1008585Y (es)	1989-12-16	Peonza perfeccionada.
ES1007190Y (es)	1989-07-16	Nevera portatil perfeccionada.
ES1008693Y (es)	1989-12-01	Tapon perfeccionado.
ES1010376Y (es)	1990-05-01	Tapon perfeccionado.
ES1015902Y (es)	1992-07-01	Tapon perfeccionado.
ES1005271Y (es)	1989-05-01	Hidrante perfeccionado.
ES1003422Y (es)	1989-02-16	Tapon de cierre perfeccionado.
ES1019194Y (es)	1992-10-16	Tapon precinto perfeccionado.
ATE77235T1 (de)	1992-07-15	I.m. injektionsformen von gyrase-inhibitoren.
ES1007631Y (es)	1989-08-16	Expositor-display perfeccionado.
ES1004378Y (es)	1989-04-01	Calendario-agenda perfeccionado.
ES1007179Y (es)	1989-07-16	Especiero perfeccionado.
ES1008232Y (es)	1989-12-16	Chocolatina perfeccionada.
ES1007563Y (es)	1989-08-16	Futbolin-billar perfeccionado.

Legal Events

Date	Code	Title	Description
2006-07-17	PUP	Patent expired