DK1399448T3 - Imidazo[1,5-a]pyrimido[5,4-d]benzazepin-derivater som GABA A-receptormodulatorer - Google Patents

Imidazo[1,5-a]pyrimido[5,4-d]benzazepin-derivater som GABA A-receptormodulatorer

Info

Publication number: DK1399448T3
Authority: DK; Denmark
Prior art keywords: pyrimido; gaba; imidazo; receptor modulators; benzazepine derivatives
Prior art date: 2001-05-18

Application number

DK02771640T

Other languages

English (en)

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-08

Publication date

2005-04-11

2002-05-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-04-11 Application granted granted Critical

2005-04-11 Publication of DK1399448T3 publication Critical patent/DK1399448T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK02771640T 2001-05-18 2002-05-08 Imidazo[1,5-a]pyrimido[5,4-d]benzazepin-derivater som GABA A-receptormodulatorer DK1399448T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number	Publication Date
DK1399448T3 true DK1399448T3 (da)	2005-04-11

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02771640T DK1399448T3 (da)	2001-05-18	2002-05-08	Imidazo[1,5-a]pyrimido[5,4-d]benzazepin-derivater som GABA A-receptormodulatorer

Country Status (37)

Country	Link
US (1)	US6686352B2 (da)
EP (1)	EP1399448B1 (da)
JP (1)	JP4068466B2 (da)
KR (1)	KR100533406B1 (da)
CN (1)	CN1230436C (da)
AR (1)	AR033753A1 (da)
AT (1)	ATE283857T1 (da)
AU (1)	AU2002338898B2 (da)
BG (1)	BG108369A (da)
BR (1)	BR0209859A (da)
CA (1)	CA2446903C (da)
CZ (1)	CZ20033355A3 (da)
DE (1)	DE60202147T2 (da)
DK (1)	DK1399448T3 (da)
EC (1)	ECSP034851A (da)
ES (1)	ES2232778T3 (da)
GT (1)	GT200200087A (da)
HR (1)	HRP20030890A2 (da)
HU (1)	HUP0400743A3 (da)
IL (2)	IL158572A0 (da)
JO (1)	JO2297B1 (da)
MA (1)	MA27024A1 (da)
MX (1)	MXPA03010529A (da)
MY (1)	MY127570A (da)
NO (1)	NO20035104D0 (da)
NZ (1)	NZ529097A (da)
PA (1)	PA8545201A1 (da)
PE (1)	PE20030041A1 (da)
PL (1)	PL366846A1 (da)
PT (1)	PT1399448E (da)
RU (1)	RU2287531C2 (da)
SI (1)	SI1399448T1 (da)
SK (1)	SK15252003A3 (da)
TW (1)	TWI251489B (da)
WO (1)	WO2002094834A1 (da)
YU (1)	YU90003A (da)
ZA (1)	ZA200308544B (da)

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CN102766142A (zh) *	2004-10-04	2012-11-07	千禧药品公司	有效作为蛋白激酶抑制剂的内酰胺化合物
MX2007004640A (es) *	2004-10-20	2007-06-08	Hoffmann La Roche	Derivados de benzodiazepina sustituidos con halogeno.
BRPI0519991A2 (pt) *	2004-10-20	2009-04-07	Hoffmann La Roche	derivados de imidazo-benzodiazepina
WO2007042421A1 (en)	2005-10-11	2007-04-19	F. Hoffmann-La Roche Ag	Imidazo benzodiazepine derivatives
PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2008003749A1 (es)	2007-12-17	2010-01-15	Janssen Pharmaceutica Nv	Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
AR074487A1 (es)	2008-12-05	2011-01-19	Millennium Pharm Inc	Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer.
CA2747326C (en)	2008-12-22	2017-05-16	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-cd20 antibodies
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
BR112012020557A8 (pt)	2010-02-19	2018-01-02	Millennium Pharm Inc	formas cristalinas de 4-{[9-cloro-7-(2-flúor-6-metoifenil)-5h-pirimido[5,4-d][2]benzazepin-2-il]amino}-2-metoxibenzoato de sódio
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
CA2907726A1 (en)	2013-03-22	2014-09-25	Millennium Pharmaceuticals, Inc.	Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase
MX381561B (es) *	2013-12-20	2025-03-12	Agenebio Inc	Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
CN113264939A (zh)	2015-06-19	2021-08-17	艾吉因生物股份有限公司	用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180207173A1 (en)	2015-07-21	2018-07-26	Millennium Pharmaceuticals, Inc.	Administration of aurora kinase inhibitor and chemotherapeutic agents
BR112019012821A2 (pt)	2016-12-19	2019-11-26	Agenebio, Inc.	derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en)	2016-12-19	2018-06-21	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EA202190076A1 (ru)	2018-06-19	2021-09-22	Эйджинбайо, Инк.	Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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RU2119496C1 (ru) *	1992-04-14	1998-09-27	Научно-исследовательский институт фармакологии Российской академии медицинских наук	Производные n-ацилпролилдипептидов
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WO1999043682A1 (en) *	1998-02-26	1999-09-02	Neurogen Corporation	2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
US6177569B1 (en) *	1998-08-25	2001-01-23	Neurogen Corporation	Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
FR2783828B1 (fr)	1998-09-29	2000-11-10	Synthelabo	Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
WO2001034603A2 (en)	1999-11-12	2001-05-17	Neurogen Corporation	Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en)	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators

2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en not_active Ceased
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 EP EP02771640A patent/EP1399448B1/en not_active Expired - Lifetime
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active Expired - Fee Related
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 NO NO20035104A patent/NO20035104D0/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown

Also Published As

Publication number	Publication date
RU2003136078A (ru)	2005-05-27
BR0209859A (pt)	2004-06-15
AR033753A1 (es)	2004-01-07
KR100533406B1 (ko)	2005-12-02
YU90003A (sh)	2006-08-17
ECSP034851A (es)	2003-12-24
JP2004531563A (ja)	2004-10-14
TWI251489B (en)	2006-03-21
EP1399448A1 (en)	2004-03-24
AU2002338898B8 (en)	2002-12-03
IL158572A (en)	2010-02-17
CZ20033355A3 (en)	2004-07-14
IL158572A0 (en)	2004-05-12
HUP0400743A3 (en)	2007-09-28
JO2297B1 (en)	2005-09-12
PA8545201A1 (es)	2003-02-28
DE60202147D1 (de)	2005-01-05
HRP20030890A2 (en)	2005-08-31
WO2002094834A1 (en)	2002-11-28
MY127570A (en)	2006-12-29
DE60202147T2 (de)	2005-12-01
MA27024A1 (fr)	2004-12-20
GT200200087A (es)	2003-06-19
SI1399448T1 (en)	2005-02-28
AU2002338898B2 (en)	2007-03-15
HK1066544A1 (en)	2005-03-24
NO20035104L (no)	2003-11-17
HUP0400743A2 (hu)	2004-07-28
CN1509289A (zh)	2004-06-30
PE20030041A1 (es)	2003-02-07
PT1399448E (pt)	2005-03-31
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
US20030055042A1 (en)	2003-03-20
NO20035104D0 (no)	2003-11-17
CA2446903A1 (en)	2002-11-28
ATE283857T1 (de)	2004-12-15
KR20040002975A (ko)	2004-01-07
ES2232778T3 (es)	2005-06-01
PL366846A1 (en)	2005-02-07
CN1230436C (zh)	2005-12-07
ZA200308544B (en)	2005-01-31
RU2287531C2 (ru)	2006-11-20
BG108369A (bg)	2005-01-31
US6686352B2 (en)	2004-02-03
EP1399448B1 (en)	2004-12-01
JP4068466B2 (ja)	2008-03-26
CA2446903C (en)	2008-12-30
SK15252003A3 (sk)	2004-08-03

Publication	Publication Date	Title
DK1399448T3 (da)	2005-04-11	Imidazo[1,5-a]pyrimido[5,4-d]benzazepin-derivater som GABA A-receptormodulatorer
DK1686130T3 (da)	2009-04-06	Pyrrolo-[2,3-d]-pyrimidinforbindelser som immunsuppressive midler
TWI346664B (en)	2011-08-11	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
NO20053955D0 (no)	2005-08-25	Pyrazolo [1,5-A] pyrimidinderivater
DE60016615D1 (de)	2005-01-13	Pyrazolo[4,3-d]pyrimidinderivate
DK0996621T3 (da)	2004-02-02	Triazolo[4,5-d]pyrimidin-derivater som anti-trombotiske midler
PL370535A1 (en)	2005-05-30	Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders
IL170680A0 (en)	2009-02-11	8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES
ZA200507192B (en)	2007-03-28	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives
DK1430057T3 (da)	2006-01-16	Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater
ATE269333T1 (de)	2004-07-15	2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2- a)pyrimidin-4-on- und 7-pyridinyl-2,3- dihydroimidazo(1,2-a)pyrimidin-5 1honderivate
NO20013334D0 (no)	2001-07-05	Anvendelse av imidazo [1,5-A]-pyrido[3,2-E]-pyrazinoner som legemidler
PL370067A1 (en)	2005-05-16	8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide
AU2002228541A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002226861A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002228540A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
HK1084664A (en)	2006-08-04	Pyrazolo [1,5-a] pyrimidine derivatives
HK1068632A (en)	2005-04-29	Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
AU2002338922A1 (en)	2003-05-12	Pyrimido (4,5-b) indole derivatives
DK1330457T3 (da)	2005-02-28	Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoler som 5HT2C-antagonister