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MX2007004640A - Derivados de benzodiazepina sustituidos con halogeno. - Google Patents

Derivados de benzodiazepina sustituidos con halogeno.

Info

Publication number
MX2007004640A
MX2007004640A MX2007004640A MX2007004640A MX2007004640A MX 2007004640 A MX2007004640 A MX 2007004640A MX 2007004640 A MX2007004640 A MX 2007004640A MX 2007004640 A MX2007004640 A MX 2007004640A MX 2007004640 A MX2007004640 A MX 2007004640A
Authority
MX
Mexico
Prior art keywords
halogen substituted
benzodiazepine derivatives
substituted benzodiazepine
cognitive
sdisease
Prior art date
Application number
MX2007004640A
Other languages
English (en)
Inventor
Andrew William Thomas
Henner Knust
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35735152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007004640(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007004640A publication Critical patent/MX2007004640A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a derivados de imidazo[1,5-a] [1,2,4]triazolo[1,5-d] [1,4]benzodiazepina sustituidos con halogeno de la formula (I), y sus sales de adicion de acido farmaceuticamente aceptables. Los compuestos se pueden utilizar para el tratamiento del potenciador cognitivo, trastornos cognitivos, ansiedad, enfermedad de Alzheimer y esquizofrenia.
MX2007004640A 2004-10-20 2005-10-11 Derivados de benzodiazepina sustituidos con halogeno. MX2007004640A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04105167 2004-10-20
PCT/EP2005/010907 WO2006045429A1 (en) 2004-10-20 2005-10-11 Halogen substituted benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
MX2007004640A true MX2007004640A (es) 2007-06-08

Family

ID=35735152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004640A MX2007004640A (es) 2004-10-20 2005-10-11 Derivados de benzodiazepina sustituidos con halogeno.

Country Status (17)

Country Link
US (1) US7507728B2 (es)
EP (1) EP1807432A1 (es)
JP (1) JP4751398B2 (es)
KR (1) KR100915469B1 (es)
CN (1) CN101084220B (es)
AR (1) AR051333A1 (es)
AU (1) AU2005299031B2 (es)
BR (1) BRPI0516244A (es)
CA (1) CA2584757C (es)
IL (1) IL182697A (es)
MX (1) MX2007004640A (es)
NO (1) NO20072046L (es)
NZ (1) NZ554556A (es)
RU (1) RU2007114763A (es)
TW (1) TWI304404B (es)
WO (1) WO2006045429A1 (es)
ZA (1) ZA200703244B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007042421A1 (en) * 2005-10-11 2007-04-19 F. Hoffmann-La Roche Ag Imidazo benzodiazepine derivatives
KR20130083927A (ko) 2010-11-05 2013-07-23 에프. 호프만-라 로슈 아게 중추 신경계 질환의 치료를 위한 활성 약학 화합물의 용도
EP2457569A1 (en) 2010-11-05 2012-05-30 F. Hoffmann-La Roche AG Use of active pharmaceutical compounds for the treatment of central nervous system conditions
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
MX381561B (es) * 2013-12-20 2025-03-12 Agenebio Inc Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
CN113264939A (zh) * 2015-06-19 2021-08-17 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio, Inc. derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
CA3072740A1 (en) * 2017-09-07 2019-03-14 Eisai R&D Management Co., Ltd. Pentacyclic compound
EA202190076A1 (ru) 2018-06-19 2021-09-22 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
AU2020232044B2 (en) 2019-03-05 2025-02-20 Eisai R&D Management Co., Ltd. Pentacyclic heterocyclic compound
EP3936189A4 (en) 2019-03-05 2022-12-14 Eisai R&D Management Co., Ltd. SALT OF A PENTACYCLIC COMPOUND AND CRYSTALS THEREOF

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL49161A (en) * 1975-08-07 1982-04-30 Sparamedica Ag Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
ZW985A1 (en) * 1984-01-19 1985-08-28 Hoffmann La Roche Imidazodiazepine derivatives
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
TW201311B (es) * 1991-06-17 1993-03-01 Hoffmann La Roche
JPH078869A (ja) * 1993-06-29 1995-01-13 Mitsubishi Chem Corp 粉粒体のコーティング方法
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

Also Published As

Publication number Publication date
CA2584757A1 (en) 2006-05-04
TWI304404B (en) 2008-12-21
CA2584757C (en) 2012-07-03
IL182697A (en) 2012-02-29
BRPI0516244A (pt) 2008-08-26
JP4751398B2 (ja) 2011-08-17
IL182697A0 (en) 2007-09-20
NZ554556A (en) 2009-11-27
AU2005299031B2 (en) 2011-11-10
NO20072046L (no) 2007-04-26
US7507728B2 (en) 2009-03-24
TW200630371A (en) 2006-09-01
US20060084801A1 (en) 2006-04-20
AR051333A1 (es) 2007-01-03
AU2005299031A1 (en) 2006-05-04
CN101084220A (zh) 2007-12-05
WO2006045429A1 (en) 2006-05-04
JP2008517010A (ja) 2008-05-22
KR20070085398A (ko) 2007-08-27
ZA200703244B (en) 2008-08-27
CN101084220B (zh) 2010-12-15
RU2007114763A (ru) 2008-11-27
EP1807432A1 (en) 2007-07-18
KR100915469B1 (ko) 2009-09-03

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