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MA27024A1 - Derives d'imidazo [1,5-a] pyrimido [5,4-d] benzazepine en tant que modulateurs du recepteur gaba a - Google Patents

Derives d'imidazo [1,5-a] pyrimido [5,4-d] benzazepine en tant que modulateurs du recepteur gaba a

Info

Publication number
MA27024A1
MA27024A1 MA27398A MA27398A MA27024A1 MA 27024 A1 MA27024 A1 MA 27024A1 MA 27398 A MA27398 A MA 27398A MA 27398 A MA27398 A MA 27398A MA 27024 A1 MA27024 A1 MA 27024A1
Authority
MA
Morocco
Prior art keywords
pyrimido
gaba
imidazo
receptor modulators
benzazepine derivatives
Prior art date
Application number
MA27398A
Other languages
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27024A1 publication Critical patent/MA27024A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MA27398A 2001-05-18 2003-11-14 Derives d'imidazo [1,5-a] pyrimido [5,4-d] benzazepine en tant que modulateurs du recepteur gaba a MA27024A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01112222 2001-05-18

Publications (1)

Publication Number Publication Date
MA27024A1 true MA27024A1 (fr) 2004-12-20

Family

ID=8177471

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27398A MA27024A1 (fr) 2001-05-18 2003-11-14 Derives d'imidazo [1,5-a] pyrimido [5,4-d] benzazepine en tant que modulateurs du recepteur gaba a

Country Status (37)

Country Link
US (1) US6686352B2 (fr)
EP (1) EP1399448B1 (fr)
JP (1) JP4068466B2 (fr)
KR (1) KR100533406B1 (fr)
CN (1) CN1230436C (fr)
AR (1) AR033753A1 (fr)
AT (1) ATE283857T1 (fr)
AU (1) AU2002338898B2 (fr)
BG (1) BG108369A (fr)
BR (1) BR0209859A (fr)
CA (1) CA2446903C (fr)
CZ (1) CZ20033355A3 (fr)
DE (1) DE60202147T2 (fr)
DK (1) DK1399448T3 (fr)
EC (1) ECSP034851A (fr)
ES (1) ES2232778T3 (fr)
GT (1) GT200200087A (fr)
HR (1) HRP20030890A2 (fr)
HU (1) HUP0400743A3 (fr)
IL (2) IL158572A0 (fr)
JO (1) JO2297B1 (fr)
MA (1) MA27024A1 (fr)
MX (1) MXPA03010529A (fr)
MY (1) MY127570A (fr)
NO (1) NO20035104D0 (fr)
NZ (1) NZ529097A (fr)
PA (1) PA8545201A1 (fr)
PE (1) PE20030041A1 (fr)
PL (1) PL366846A1 (fr)
PT (1) PT1399448E (fr)
RU (1) RU2287531C2 (fr)
SI (1) SI1399448T1 (fr)
SK (1) SK15252003A3 (fr)
TW (1) TWI251489B (fr)
WO (1) WO2002094834A1 (fr)
YU (1) YU90003A (fr)
ZA (1) ZA200308544B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104193750B (zh) 2004-05-14 2018-04-27 千禧药品公司 通过抑制极光激酶抑制有丝分裂的化合物和方法
WO2006041773A2 (fr) * 2004-10-04 2006-04-20 Millennium Pharmaceuticals, Inc. Composes a base de lactame utiles en tant qu'inhibiteurs de la proteine kinase
WO2006045429A1 (fr) * 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Dérivés de benzodiazépine à substitution halogène
MX2007004639A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de imidazo-benzodiazepina.
ES2348356T3 (es) 2005-10-11 2010-12-03 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina.
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
PE20091102A1 (es) 2007-12-17 2009-07-25 Janssen Pharmaceutica Nv Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
WO2010065134A1 (fr) 2008-12-05 2010-06-10 Millennium Pharmaceuticals, Inc. 5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazépin-6-thiones utilisées en tant qu'inhibiteurs de plk
MX2011006725A (es) 2008-12-22 2011-09-15 Millennium Pharm Inc Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CN104031049A (zh) 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
NZ722077A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN113264939A (zh) 2015-06-19 2021-08-17 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607503B1 (fr) * 1986-12-02 1989-02-24 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
TW201311B (fr) 1991-06-17 1993-03-01 Hoffmann La Roche
RU2119496C1 (ru) * 1992-04-14 1998-09-27 Научно-исследовательский институт фармакологии Российской академии медицинских наук Производные n-ацилпролилдипептидов
FR2728902B1 (fr) * 1994-12-29 1997-01-31 Synthelabo Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique
US6166203A (en) * 1998-02-26 2000-12-26 Neurogen Corporation Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
US6177569B1 (en) * 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
US6511987B1 (en) 1999-11-12 2003-01-28 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Also Published As

Publication number Publication date
ATE283857T1 (de) 2004-12-15
HUP0400743A2 (hu) 2004-07-28
IL158572A0 (en) 2004-05-12
ES2232778T3 (es) 2005-06-01
AR033753A1 (es) 2004-01-07
PA8545201A1 (es) 2003-02-28
JP2004531563A (ja) 2004-10-14
DK1399448T3 (da) 2005-04-11
ZA200308544B (en) 2005-01-31
CA2446903A1 (fr) 2002-11-28
GT200200087A (es) 2003-06-19
JP4068466B2 (ja) 2008-03-26
PE20030041A1 (es) 2003-02-07
NO20035104L (no) 2003-11-17
US6686352B2 (en) 2004-02-03
SK15252003A3 (sk) 2004-08-03
CZ20033355A3 (en) 2004-07-14
DE60202147D1 (de) 2005-01-05
HRP20030890A2 (en) 2005-08-31
CN1230436C (zh) 2005-12-07
WO2002094834A1 (fr) 2002-11-28
ECSP034851A (es) 2003-12-24
DE60202147T2 (de) 2005-12-01
RU2287531C2 (ru) 2006-11-20
US20030055042A1 (en) 2003-03-20
CA2446903C (fr) 2008-12-30
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29
TWI251489B (en) 2006-03-21
JO2297B1 (en) 2005-09-12
EP1399448A1 (fr) 2004-03-24
IL158572A (en) 2010-02-17
PT1399448E (pt) 2005-03-31
BG108369A (bg) 2005-01-31
MY127570A (en) 2006-12-29
NO20035104D0 (no) 2003-11-17
KR20040002975A (ko) 2004-01-07
CN1509289A (zh) 2004-06-30
BR0209859A (pt) 2004-06-15
HK1066544A1 (en) 2005-03-24
AU2002338898B2 (en) 2007-03-15
EP1399448B1 (fr) 2004-12-01
SI1399448T1 (en) 2005-02-28
KR100533406B1 (ko) 2005-12-02
AU2002338898B8 (en) 2002-12-03
PL366846A1 (en) 2005-02-07
HUP0400743A3 (en) 2007-09-28
YU90003A (sh) 2006-08-17
RU2003136078A (ru) 2005-05-27

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