DK1392643T3 - (1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3 - Google Patents

(1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3

Info

Publication number: DK1392643T3
Authority: DK; Denmark
Prior art keywords: naphthalenylbenzamides; trisubstituted; tetrahydro; receptors containing; inhibit receptors
Prior art date: 2001-05-18

Application number

DK02739257T

Other languages

Danish (da)

English (en)

Inventor

Chih-Hung Lee

Richard J Perner

Daniel P Larson

John R Koenig

Arthur R Gomtsyan

Guo Zhu Zheng

Stanley Didomenico

Erol K Bayburt

Andrew O Stewart

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-14

Publication date

2006-01-30

2001-05-18 Priority claimed from US09/860,254 external-priority patent/US20020173665A1/en

2002-05-10 Priority claimed from US10/141,989 external-priority patent/US6831193B2/en

2002-05-14 Application filed by Abbott Lab filed Critical Abbott Lab

2006-01-30 Application granted granted Critical

2006-01-30 Publication of DK1392643T3 publication Critical patent/DK1392643T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyridine Compounds (AREA)
Pyrane Compounds (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)

DK02739257T 2001-05-18 2002-05-14 (1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3 DK1392643T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/860,254 US20020173665A1 (en)	2001-05-18	2001-05-18	Trisubstituted-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit P2X3 and P2X2/3 containing receptors
US10/141,989 US6831193B2 (en)	2001-05-18	2002-05-10	Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors

Publications (1)

Publication Number	Publication Date
DK1392643T3 true DK1392643T3 (da)	2006-01-30

Family

ID=26839642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02739257T DK1392643T3 (da)	2001-05-18	2002-05-14	(1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3

Country Status (9)

Country	Link
EP (1)	EP1392643B1 (ja)
JP (1)	JP2005508288A (ja)
AT (1)	ATE304523T1 (ja)
CA (1)	CA2447671C (ja)
DE (1)	DE60206164T2 (ja)
DK (1)	DK1392643T3 (ja)
ES (1)	ES2249589T3 (ja)
MX (1)	MXPA03010586A (ja)
WO (1)	WO2002094767A2 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2396565T3 (es)	2003-05-12	2013-02-22	Pah Usa 15 Llc	Inhibidores benzamida del receptor P2X7
EP1837330B1 (en) *	2003-05-12	2012-10-24	Pfizer Products Inc.	Benzamide inhibitors of the P2X7 receptor
RU2422441C2 (ru)	2004-03-05	2011-06-27	Ф.Хоффманн-Ля Рош Аг	Диаминопиримидины в качестве антагонистов рецепторов р2х3
AU2005266887B2 (en) *	2004-07-22	2011-08-18	Duska Scientific Co.	Method of diagnosing, monitoring and treating pulmonary diseases
ATE537169T1 (de) *	2005-08-15	2011-12-15	Hoffmann La Roche	Piperidin- und piperazinderivate als p2x3- antagonisten
CN101300235B (zh)	2005-09-01	2011-12-07	弗·哈夫曼-拉罗切有限公司	作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
JP4850912B2 (ja) *	2005-09-01	2012-01-11	エフ．ホフマン−ラロシュアーゲー	Ｐ２ｘ３およびｐ３ｘ２／３モジュレーターとしてのジアミノピリミジン
CA2619919C (en)	2005-09-01	2014-04-01	F. Hoffmann-La Roche Ag	Diaminopyrimidines as p2x3 and p2x2/3 modulators
US8101644B2 (en)	2007-03-30	2012-01-24	Shionogi & Co., Ltd.	Pyrrolinone derivative and pharmaceutical composition comprising the same
AU2008256937A1 (en) *	2007-05-25	2008-12-04	Vertex Pharmaceuticals Incorporated	Ion channel modulators and methods of use
WO2009110985A2 (en) *	2008-02-29	2009-09-11	Renovis, Inc.	Amide compounds, compositions and uses thereof
US20110237578A1 (en)	2008-09-18	2011-09-29	Zhi-Liang Wei	Amide compounds, compositions and uses thereof
EP2336109A4 (en) *	2008-09-25	2012-05-02	Shionogi & Co	NOVEL PYRROLINONE DERIVATIVE AND DRUG COMPOSITION CONTAINING THE SAME
CA2752269C (en)	2009-02-13	2016-08-30	Hiroyuki Kai	Novel triazine derivative and pharmaceutical composition comprising the same
MX346367B (es)	2010-08-10	2017-03-16	Shionogi & Co Ltd *	Derivado de triazina y composicion farmaceutica que tiene actividad analgesica que comprende el mismo.
EP2604260B1 (en)	2010-08-10	2017-05-10	Shionogi&Co., Ltd.	Novel heterocyclic derivatives and pharmaceutical composition containing same
WO2013118855A1 (ja)	2012-02-09	2013-08-15	塩野義製薬株式会社	複素環および炭素環誘導体
TWI637949B (zh)	2013-06-14	2018-10-11	塩野義製藥股份有限公司	胺基三衍生物及含有其等之醫藥組合物
WO2016084922A1 (ja) *	2014-11-28	2016-06-02	塩野義製薬株式会社	１，２，４－トリアジン誘導体およびその医薬組成物
WO2017049177A1 (en)	2015-09-16	2017-03-23	Metacrine, Inc.	Farnesoid x receptor agonists and uses thereof
EP4032884A4 (en)	2019-09-19	2023-09-13	Shionogi & Co., Ltd.	CRYSTAL OF 1,3,5-TRIAZINE DERIVATIVES OR SOLVATE THEREOF AND METHOD FOR THE PRODUCTION THEREOF
TW202203929A (zh)	2020-04-03	2022-02-01	日商塩野義製藥股份有限公司	疼痛治療用醫藥
JP2024025570A (ja) *	2022-08-12	2024-02-26	シーシーアイホールディングス株式会社	リソソーム局在性鉄イオンキレート化剤、リソソーム局在性フェロトーシス阻害剤、抗酸化剤細胞保護方法

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US5783593A (en) *	1993-11-04	1998-07-21	Abbott Laboratories	Inhibitors of squalene synthetase and protein farnesyltransferase
CA2287255A1 (en) *	1997-04-22	1998-10-29	Cocensys, Inc.	Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof

2002
- 2002-05-14 ES ES02739257T patent/ES2249589T3/es not_active Expired - Lifetime
- 2002-05-14 CA CA2447671A patent/CA2447671C/en not_active Expired - Fee Related
- 2002-05-14 MX MXPA03010586A patent/MXPA03010586A/es active IP Right Grant
- 2002-05-14 DK DK02739257T patent/DK1392643T3/da active
- 2002-05-14 DE DE60206164T patent/DE60206164T2/de not_active Expired - Lifetime
- 2002-05-14 WO PCT/US2002/015174 patent/WO2002094767A2/en not_active Ceased
- 2002-05-14 EP EP02739257A patent/EP1392643B1/en not_active Expired - Lifetime
- 2002-05-14 JP JP2002591440A patent/JP2005508288A/ja active Pending
- 2002-05-14 AT AT02739257T patent/ATE304523T1/de active

Also Published As

Publication number	Publication date
WO2002094767A2 (en)	2002-11-28
EP1392643A2 (en)	2004-03-03
CA2447671C (en)	2013-01-08
MXPA03010586A (es)	2004-04-02
DE60206164D1 (de)	2005-10-20
CA2447671A1 (en)	2002-11-28
JP2005508288A (ja)	2005-03-31
ATE304523T1 (de)	2005-09-15
ES2249589T3 (es)	2006-04-01
EP1392643B1 (en)	2005-09-14
WO2002094767A3 (en)	2003-07-31
DE60206164T2 (de)	2006-06-22

Publication	Publication Date	Title
DK1392643T3 (da)	2006-01-30	(1S)-1,2,3,4-tetrahydro-1-naphthalenylbenzamider, der er trisubstituerede ved N, og som inhiberer receptorer indeholdende P2X3 og P2X2/3
CY1105386T1 (el)	2010-04-28	Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
NO20025821L (no)	2003-02-04	2-aminokarbonyl-9H-purinderivater
ATE420644T1 (de)	2009-01-15	Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
DK1379239T3 (da)	2008-01-07	N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren
BRPI0413305A (pt)	2006-10-10	compostos azabicìclicos fundidos que inibem o receptor de subtipo de receptor de vanilóide 1 (vr1)
GB0124933D0 (en)	2001-12-05	Chemical compounds
MXPA03009750A (es)	2004-06-30	Compuestos quimicos.
CY1106247T1 (el)	2011-06-08	Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
DK1313721T3 (da)	2006-06-26	Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander
EA200301100A1 (ru)	2004-06-24	Новые фталазиноны
NO20025811L (no)	2003-02-04	Forbindelser som er effektive som beta-2-adrenoreseptor- agonister så vel som PDE4-inhibitorer
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
MXPA03007142A (es)	2004-05-24	Derivados de carbolina.
MXPA02012659A (es)	2003-09-22	Derivados de pirazindiona condensados.
BR0315644A (pt)	2005-08-30	Piperazinil e diazapanil benzamidas e benzotioamidas
DE50208918D1 (de)	2007-01-18	6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung
DK1373220T3 (da)	2007-10-08	Benzimidazoler, som er nyttige ved behandling af seksuel dysfunktion
ATE303384T1 (de)	2005-09-15	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
ATE297903T1 (de)	2005-07-15	Substituierte phenyluracile
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60202669D1 (de)	2005-02-24	6-phenylbenzonaphthyidine
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
ATE293111T1 (de)	2005-04-15	Kondensierte pyrazindionderivate als pde inhibitoren
NO20033921L (no)	2003-11-05	Inhibitor av monoaminopptak