DK1287004T3 - Syntetisk proces til fremstilling af en ecteinascidinforbindelse - Google Patents

Syntetisk proces til fremstilling af en ecteinascidinforbindelse

Info

Publication number: DK1287004T3
Authority: DK; Denmark
Prior art keywords: ecteinascidin; hydroxy; preparing; spiroamine; synthetic process
Prior art date: 2000-05-15

Application number

DK01929816T

Other languages

English (en)

Inventor

Carmen Pharma Mar S A Cuevas

Marta Pharma Mar S A Perez

Andres Pharma Mar S Francesch

Carolina Pharma Mar Fernandez

Jose Luis Pharma Mar Chicharro

Pilar Pharma Mar S A Gallego

Maria Pharma Mar S A Zarzuelo

Ignacio Pharma Mar Manzanares

Maria Jesus Pharma Mar Martin

Simon Pharma Mar S A Munt

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-15

Filing date

2001-05-15

Publication date

2005-11-28

2000-05-15 Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en

2001-05-15 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2005-11-28 Application granted granted Critical

2005-11-28 Publication of DK1287004T3 publication Critical patent/DK1287004T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Discharging, Photosensitive Material Shape In Electrophotography (AREA)
Instruments For Viewing The Inside Of Hollow Bodies (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK01929816T 2000-05-15 2001-05-15 Syntetisk proces til fremstilling af en ecteinascidinforbindelse DK1287004T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/GB2000/001852 WO2000069862A2 (en)	1999-05-14	2000-05-15	Hemisynthetic method and intermediates thereof

Publications (1)

Publication Number	Publication Date
DK1287004T3 true DK1287004T3 (da)	2005-11-28

Family

ID=34855248

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK01929816T DK1287004T3 (da)	2000-05-15	2001-05-15	Syntetisk proces til fremstilling af en ecteinascidinforbindelse
DK01929813T DK1289999T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET-743
DK04010399T DK1496060T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET 743

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK01929813T DK1289999T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET-743
DK04010399T DK1496060T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET 743

Country Status (16)

Country	Link
EP (3)	EP1287004B1 (da)
KR (2)	KR100777464B1 (da)
AT (2)	ATE368671T1 (da)
AU (2)	AU2001256496C1 (da)
DE (3)	DE60129753T2 (da)
DK (3)	DK1287004T3 (da)
EA (2)	EA006070B1 (da)
ES (2)	ES2248319T3 (da)
GB (1)	GB9918178D0 (da)
HU (1)	HU228789B1 (da)
MX (1)	MXPA02010701A (da)
NZ (2)	NZ532793A (da)
PL (2)	PL203745B1 (da)
PT (3)	PT1287004E (da)
SI (2)	SI1289999T1 (da)
UA (1)	UA75597C2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006046079A1 (en)	2004-10-29	2006-05-04	Pharma Mar S.A., Sociedad Unipersonal	Formulations comprising ecteinascidin and a disaccharide
KR100676324B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100676325B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100712667B1 (ko) *	2006-04-11	2007-05-02	재단법인서울대학교산학협력재단	신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
CN103038240A (zh) *	2010-05-25	2013-04-10	法马马有限公司	制备海鞘素化合物的合成方法
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2020105068A1 (en) *	2018-11-24	2020-05-28	Natco Pharma Limited	Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
EP0309477B1 (en) *	1986-06-09	1991-11-06	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
2001
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 EP EP01929816A patent/EP1287004B1/en not_active Expired - Lifetime
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime
- 2001-05-15 EP EP04010399A patent/EP1496060B1/en not_active Expired - Lifetime
- 2001-05-15 EP EP01929813A patent/EP1289999B1/en not_active Expired - Lifetime
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko not_active Expired - Lifetime
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 PL PL358258A patent/PL215769B1/pl unknown
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1287004B1 (en)	2005-07-27
EA006369B1 (ru)	2005-12-29
ATE300547T1 (de)	2005-08-15
ATE368671T1 (de)	2007-08-15
PT1289999E (pt)	2005-03-31
ES2248319T3 (es)	2006-03-16
DK1289999T3 (da)	2005-03-14
DE60107241T2 (de)	2006-08-03
AU5649301A (en)	2001-11-26
PL358143A1 (en)	2004-08-09
EP1496060A1 (en)	2005-01-12
DK1496060T3 (da)	2007-12-03
PL203745B1 (pl)	2009-11-30
ES2290583T3 (es)	2008-02-16
DE60129753T2 (de)	2008-04-30
EP1289999A1 (en)	2003-03-12
DE60112286T2 (de)	2006-06-01
PT1287004E (pt)	2005-11-30
DE60107241D1 (de)	2004-12-23
KR20030005308A (ko)	2003-01-17
AU2001256496B2 (en)	2006-02-16
PL358258A1 (en)	2004-08-09
EP1289999B1 (en)	2004-11-17
KR100777464B1 (ko)	2007-11-27
PL215769B1 (pl)	2014-01-31
EP1496060B1 (en)	2007-08-01
DE60112286D1 (de)	2005-09-01
AU783563B2 (en)	2005-11-10
KR100830717B1 (ko)	2008-05-20
PT1496060E (pt)	2007-10-30
NZ521807A (en)	2004-06-25
SI1289999T1 (en)	2005-06-30
AU2001256496C1 (en)	2006-08-03
UA75597C2 (en)	2006-05-15
DE60129753D1 (de)	2007-09-13
HU228789B1 (en)	2013-05-28
HK1050193A1 (en)	2003-06-13
EA200201210A1 (ru)	2003-04-24
KR20030031481A (ko)	2003-04-21
HUP0300648A3 (en)	2006-05-29
EA200201209A1 (ru)	2003-04-24
GB9918178D0 (en)	1999-10-06
SI1496060T1 (sl)	2008-06-30
EA006070B1 (ru)	2005-08-25
EP1287004A1 (en)	2003-03-05
MXPA02010701A (es)	2003-05-14
NZ532793A (en)	2004-10-29
HUP0300648A2 (hu)	2003-07-28

Publication	Publication Date	Title
BRPI0110443B8 (pt)	2021-05-25	etapas processuais na produção de um composto de ecteinascidina
BRPI0407507A (pt)	2006-02-14	derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento
DE69114198D1 (de)	1995-12-07	O-Methylderivate von Azithromycin A, Verfahren und Zwischenverbindungen zu ihrer Herstellung und deren Verwendung zur Herstellung von Heilmitteln.
ATE527247T1 (de)	2011-10-15	Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
DK1287004T3 (da)	2005-11-28	Syntetisk proces til fremstilling af en ecteinascidinforbindelse
DE69433012D1 (de)	2003-09-11	Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
DE50301507D1 (de)	2005-12-01	17a-FLUORALKYL-11BETA-BENZALDOXIM-STEROIDE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE STEROIDE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN
PT101006A (pt)	1994-02-28	Processo de preparacao de (s)(+)-4,4-(1-metil-1,2-etanodiil)-bis-(2,6-piperazinadiona) e uso como medicamento.
DE50112449D1 (de)	2007-06-14	Verfahren zur herstellung von 3,3-diarylpropylaminen
ATA186795A (de)	1997-06-15	Verfahren zur fällung von alkalisalzen der clavulansäure
ATE205473T1 (de)	2001-09-15	Neue borneolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
ATE173259T1 (de)	1998-11-15	Verfahren zur herstellung von indolizinderivaten
DE59910589D1 (de)	2004-10-28	Neue diphenyl-substituierte 6-ring heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
DK0796256T3 (da)	2004-05-10	Fremgangsmåde til fremstilling af ranitidin
DE69104364D1 (de)	1994-11-03	Verfahren zur herstellung von streptograminderivaten.
ATE174922T1 (de)	1999-01-15	Neue phosphanoxide, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE69514512D1 (de)	2000-02-17	Verfahren zur herstellung von benzopyranderivaten
DE3764330D1 (de)	1990-09-20	2,2;6,6-diethylen-3-oxo-17alpha-pregn-4-en-21, 17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharm. praeparate.
DE69007041D1 (de)	1994-04-07	Verfahren zur Herstellung von Synergistinen.
ATE327220T1 (de)	2006-06-15	Verfahren zur herstellung von 2-hydroxymethyl- pyrolidin-3,4-diolen
DE69612413D1 (de)	2001-05-17	1-(Hetero)Arylvinyl-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems, sowie Benzopyrylium Intermediate zu ihrer Herstellung
MX9605668A (es)	1998-05-31	Sal de estilbazolio, su preparacion y uso.