DE60129753D1 - ET-743 Analoga als Antitumoralverbindungen - Google Patents

ET-743 Analoga als Antitumoralverbindungen

Info

Publication number: DE60129753D1
Authority: DE; Germany
Prior art keywords: hydroxy; spiroamine; analogues; protecting group; bridge
Prior art date: 2000-05-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60129753T

Other languages

English (en)

Other versions

DE60129753T2 (de

Inventor

Ignacio Manzanares

Maria Jesus Martin

Alberto Rodrigues

Simon Munt

Carmen Cuevas

Marta Perez

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmamar SA

Original Assignee

Pharmamar SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-15

Filing date

2001-05-15

Publication date

2007-09-13

2000-05-15 Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en

2001-05-15 Application filed by Pharmamar SA filed Critical Pharmamar SA

2007-09-13 Application granted granted Critical

2007-09-13 Publication of DE60129753D1 publication Critical patent/DE60129753D1/de

2008-04-30 Publication of DE60129753T2 publication Critical patent/DE60129753T2/de

2021-05-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Discharging, Photosensitive Material Shape In Electrophotography (AREA)
Instruments For Viewing The Inside Of Hollow Bodies (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

DE60129753T 2000-05-15 2001-05-15 ET-743 Analoga als Antitumoralverbindungen Expired - Lifetime DE60129753T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/GB2000/001852 WO2000069862A2 (en)	1999-05-14	2000-05-15	Hemisynthetic method and intermediates thereof
WOPCT/GB00/01852		2000-05-15

Publications (2)

Publication Number	Publication Date
DE60129753D1 true DE60129753D1 (de)	2007-09-13
DE60129753T2 DE60129753T2 (de)	2008-04-30

Family

ID=34855248

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE60129753T Expired - Lifetime DE60129753T2 (de)	2000-05-15	2001-05-15	ET-743 Analoga als Antitumoralverbindungen
DE60112286T Expired - Lifetime DE60112286T2 (de)	2000-05-15	2001-05-15	Synthetisches verfahren zur herstellung von ecteinascidin-derivaten
DE60107241T Expired - Lifetime DE60107241T2 (de)	2000-05-15	2001-05-15	Et-743 analoga als antitumoralverbindungen

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE60112286T Expired - Lifetime DE60112286T2 (de)	2000-05-15	2001-05-15	Synthetisches verfahren zur herstellung von ecteinascidin-derivaten
DE60107241T Expired - Lifetime DE60107241T2 (de)	2000-05-15	2001-05-15	Et-743 analoga als antitumoralverbindungen

Country Status (16)

Country	Link
EP (3)	EP1289999B1 (de)
KR (2)	KR100830717B1 (de)
AT (2)	ATE368671T1 (de)
AU (2)	AU2001256496C1 (de)
DE (3)	DE60129753T2 (de)
DK (3)	DK1496060T3 (de)
EA (2)	EA006369B1 (de)
ES (2)	ES2248319T3 (de)
GB (1)	GB9918178D0 (de)
HU (1)	HU228789B1 (de)
MX (1)	MXPA02010701A (de)
NZ (2)	NZ532793A (de)
PL (2)	PL215769B1 (de)
PT (3)	PT1289999E (de)
SI (2)	SI1289999T1 (de)
UA (1)	UA75597C2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101188691B1 (ko)	2004-10-29	2012-10-09	파르마 마르 에스.에이.	엑티나시딘 및 디사카라이드를 포함하는 제제
KR100676324B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100676325B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100712667B1 (ko) *	2006-04-11	2007-05-02	재단법인서울대학교산학협력재단	신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
EP2576569B1 (de) *	2010-05-25	2015-01-14	Pharma Mar S.A.	Synthetisches verfahren zur herstellung von ecteinascidinverbindungen und zwischenverbindungen
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2020105068A1 (en) *	2018-11-24	2020-05-28	Natco Pharma Limited	Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JP2562162B2 (ja) *	1986-06-09	1996-12-11	ユニバーシティ・オブ・イリノイ	エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
2001
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 EP EP01929813A patent/EP1289999B1/de not_active Expired - Lifetime
- 2001-05-15 EP EP01929816A patent/EP1287004B1/de not_active Expired - Lifetime
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 EP EP04010399A patent/EP1496060B1/de not_active Expired - Lifetime
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko not_active Expired - Fee Related
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko not_active Expired - Lifetime
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
- 2001-05-15 PL PL358258A patent/PL215769B1/pl unknown
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown

Also Published As

Publication number	Publication date
EP1289999A1 (de)	2003-03-12
DE60129753T2 (de)	2008-04-30
DK1496060T3 (da)	2007-12-03
DK1289999T3 (da)	2005-03-14
ATE300547T1 (de)	2005-08-15
KR20030005308A (ko)	2003-01-17
AU5649301A (en)	2001-11-26
DE60112286T2 (de)	2006-06-01
KR100777464B1 (ko)	2007-11-27
PL358143A1 (en)	2004-08-09
SI1496060T1 (sl)	2008-06-30
KR20030031481A (ko)	2003-04-21
DE60107241D1 (de)	2004-12-23
EA200201209A1 (ru)	2003-04-24
AU2001256496C1 (en)	2006-08-03
DK1287004T3 (da)	2005-11-28
HUP0300648A3 (en)	2006-05-29
DE60107241T2 (de)	2006-08-03
GB9918178D0 (en)	1999-10-06
PT1289999E (pt)	2005-03-31
ATE368671T1 (de)	2007-08-15
EP1496060A1 (de)	2005-01-12
HUP0300648A2 (hu)	2003-07-28
SI1289999T1 (en)	2005-06-30
NZ532793A (en)	2004-10-29
ES2248319T3 (es)	2006-03-16
HU228789B1 (en)	2013-05-28
PL203745B1 (pl)	2009-11-30
EP1496060B1 (de)	2007-08-01
AU2001256496B2 (en)	2006-02-16
EP1287004A1 (de)	2003-03-05
AU783563B2 (en)	2005-11-10
PT1496060E (pt)	2007-10-30
UA75597C2 (en)	2006-05-15
ES2290583T3 (es)	2008-02-16
KR100830717B1 (ko)	2008-05-20
EA006070B1 (ru)	2005-08-25
PT1287004E (pt)	2005-11-30
HK1050193A1 (en)	2003-06-13
EP1287004B1 (de)	2005-07-27
PL215769B1 (pl)	2014-01-31
DE60112286D1 (de)	2005-09-01
EP1289999B1 (de)	2004-11-17
EA006369B1 (ru)	2005-12-29
MXPA02010701A (es)	2003-05-14
EA200201210A1 (ru)	2003-04-24
NZ521807A (en)	2004-06-25
PL358258A1 (en)	2004-08-09

Publication	Publication Date	Title
BR9915961A (pt)	2001-08-21	Análogos de glp-1
BR9916027A (pt)	2001-08-28	Análogos de glp-1
BR9815166A (pt)	2000-10-10	"método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"
LU91206I2 (fr)	2006-05-30	Ceftiofur sous forme d'acide libre cristallin et ses dérivés pharmaceutiquement acceptables (naxcel)
ATE527247T1 (de)	2011-10-15	Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
AU2001234521A1 (en)	2001-07-31	Methods of using a beverage composition
ES2141957T3 (es)	2000-04-01	Uso de raloxifeno y sus analogos para la produccion de un medicamento para el tratamiento de enfermedades virales.
DE60129753D1 (de)	2007-09-13	ET-743 Analoga als Antitumoralverbindungen
IS3189A7 (is)	1987-07-31	Ný díhýdróbenzófúran- og króman-karboxamíð efni, aðferð við framleiðslu þeirra og notkun þeirra sem lyf
HUP0204354A2 (hu)	2003-04-28	Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE3762860D1 (de)	1990-06-28	2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DE69227583D1 (de)	1998-12-17	Arylmorpholine, herstellung und verwendung
ATE152707T1 (de)	1997-05-15	Neue naphthalin-amide und sulfonamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
EP0291269A3 (de)	1990-06-20	Antitumor-Sulfonylharnstoff-Derivate
SE0004462D0 (sv)	2000-12-04	Novel method and use
FI950209A0 (fi)	1995-01-18	Farmakologisesti aktiiviset alfa-(tertiaarinen-amino-metyyli)-bentseenimetanolijohdannaiset
BR9611572A (pt)	1999-03-30	Produção de um sal de ácido clavulânico
DK0690855T3 (da)	1997-06-02	Benzopyraner som kaliumkanalåbnere
DK0650363T3 (da)	1998-09-21	Antivirale kombinationer
ES2188189T3 (es)	2003-06-16	Composiciones que comprenden derivados de acido fenil-amino-tiofeno-acetico para el tratamiento del sindrome de angustia respiratoria aguda o de adultos (ards) y del sindrome de angustia respiratoria de niños (irds).
DE69411380D1 (de)	1998-08-06	Neue heterocyclische acyldipeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung

Legal Events

Date	Code	Title	Description
2008-08-21	8364	No opposition during term of opposition