DK1278540T3 - Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelsen af aterosklerose - Google Patents

Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelsen af aterosklerose

Info

Publication number: DK1278540T3
Authority: DK; Denmark
Prior art keywords: atherosclerosis; inhibitors; prevention; treatment
Prior art date: 2000-05-05

Application number

DK01945064T

Other languages

English (en)

Inventor

Yolande Chvatchko

Alain Tedgui

Ziad Mallat

Original Assignee

Serono Lab

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-05

Filing date

2001-04-30

Publication date

2008-07-21

2001-04-30 Application filed by Serono Lab, Inst Nat Sante Rech Med filed Critical Serono Lab

2008-07-21 Application granted granted Critical

2008-07-21 Publication of DK1278540T3 publication Critical patent/DK1278540T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Mycology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

DK01945064T 2000-05-05 2001-04-30 Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelsen af aterosklerose DK1278540T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00109606		2000-05-05
PCT/EP2001/004843 WO2001085201A2 (en)	2000-05-05	2001-04-30	Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis

Publications (1)

Publication Number	Publication Date
DK1278540T3 true DK1278540T3 (da)	2008-07-21

Family

ID=8168631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01945064T DK1278540T3 (da)	2000-05-05	2001-04-30	Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelsen af aterosklerose

Country Status (32)

Country	Link
US (1)	US20040076628A1 (da)
EP (1)	EP1278540B1 (da)
JP (1)	JP5122053B2 (da)
KR (2)	KR100798545B1 (da)
CN (2)	CN1250286C (da)
AR (1)	AR035640A1 (da)
AT (1)	ATE395075T1 (da)
AU (2)	AU6739001A (da)
BG (1)	BG65881B1 (da)
BR (1)	BRPI0110506B8 (da)
CA (1)	CA2407895C (da)
CY (1)	CY1110385T1 (da)
CZ (1)	CZ300792B6 (da)
DE (1)	DE60134009D1 (da)
DK (1)	DK1278540T3 (da)
EA (2)	EA005410B1 (da)
EE (1)	EE05056B1 (da)
ES (1)	ES2305082T3 (da)
HR (1)	HRP20020828A2 (da)
HU (1)	HU229375B1 (da)
IL (2)	IL152567A0 (da)
ME (1)	ME00554B (da)
MX (1)	MXPA02010895A (da)
NO (1)	NO329821B1 (da)
PL (1)	PL209371B1 (da)
PT (1)	PT1278540E (da)
RS (1)	RS50926B (da)
SI (1)	SI1278540T1 (da)
SK (1)	SK287761B6 (da)
UA (2)	UA87658C2 (da)
WO (1)	WO2001085201A2 (da)
ZA (1)	ZA200208228B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL151044A0 (en) *	2000-02-10	2003-04-10	Abbott Lab	Antibodies that bind human interleukin-18 and methods of making and using
SI1355668T1 (sl) *	2001-01-29	2008-06-30	Serono Lab	Uporaba inhibitorjev za il-18 za zdravljenje in/ali prepreäśevanje sräśne bolezni
ME00550B (me) *	2001-05-25	2011-10-10	Ares Trading Sa	Korišćenje il-18 inhibitora za lećenje ili prevenciju povreda cns
US6797727B2 (en)	2001-07-16	2004-09-28	Transition Therapeutics Inc.	Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
US8729124B2 (en)	2002-03-05	2014-05-20	Pronova Biopharma Norge As	Use of EPA and DHA in secondary prevention
GB0210212D0 (en) *	2002-05-03	2002-06-12	Univ Southampton	Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
BRPI0308663B8 (pt) *	2002-03-22	2021-05-25	Applied Res Systems Ars Holding N V	uso de inibidores de il-18 para o tratamento e/ou prevenção de doenças vasculares periféricas
MXPA05009608A (es) *	2003-03-11	2006-03-21	Applied Research Systems	Vectores de expresion que comprenden el promotor mcmv ie2.
JP5074030B2 (ja)	2003-05-13	2012-11-14	メルクセローノソシエテアノニム	Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
US7968684B2 (en)	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
PT1755642E (pt) *	2004-04-15	2010-04-20	Athera Biotechnologies Ab	Anexina v para prevenção de aterotrombose e da ruptura de placas
CN101219208B (zh) *	2005-01-04	2010-08-11	健能隆医药技术（上海）有限公司	白介素-22的医药用途
AU2006254103B2 (en)	2005-06-03	2012-09-06	Ares Trading S.A.	Production of recombinant IL-18 binding protein
ATE529433T1 (de)	2005-06-10	2011-11-15	Ares Trading Sa	Verfahren zur reinigung eines il-18-bindenden proteins
CN103080132B (zh)	2010-08-25	2016-06-08	弗·哈夫曼-拉罗切有限公司	抗il-18r1的抗体及其用途
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
MD707Z (ro) *	2013-01-18	2014-07-31	Институт Зоологии Академии Наук Молдовы	Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
PH12016500425B1 (en)	2013-09-05	2022-07-29	Ab2 Bio Sa	Il-18 binding protein (il-18bp) in inflammatory diseases
JP7274259B2 (ja)	2015-03-05	2023-05-16	エイビー２バイオソシエテアノニム	炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体
TW202233675A (zh)	2020-10-29	2022-09-01	瑞士商諾華公司	Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
CN112972655A (zh) *	2021-04-16	2021-06-18	武汉大学	白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985863A (en) *	1996-09-12	1999-11-16	Vertex Pharmaceuticals, Inc.	Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5877197A (en) *	1996-12-16	1999-03-02	Karanewsky; Donald S.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) *	1998-06-24	1999-12-24	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP0987552A3 (en) *	1998-08-31	2000-06-07	Pfizer Products Inc.	Diarylsulfonylurea binding proteins
KR100537558B1 (ko) *	1998-09-01	2005-12-19	가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조	인터류킨-18 결합 단백질

2001
- 2001-04-30 KR KR1020077014038A patent/KR100798545B1/ko not_active Expired - Lifetime
- 2001-04-30 IL IL15256701A patent/IL152567A0/xx unknown
- 2001-04-30 MX MXPA02010895A patent/MXPA02010895A/es active IP Right Grant
- 2001-04-30 WO PCT/EP2001/004843 patent/WO2001085201A2/en not_active Ceased
- 2001-04-30 ME MEP-2008-640A patent/ME00554B/me unknown
- 2001-04-30 RS YUP-826/02A patent/RS50926B/sr unknown
- 2001-04-30 HR HRP20020828 patent/HRP20020828A2/hr not_active Application Discontinuation
- 2001-04-30 EA EA200201175A patent/EA005410B1/ru not_active IP Right Cessation
- 2001-04-30 US US10/275,341 patent/US20040076628A1/en not_active Abandoned
- 2001-04-30 CN CNB018090540A patent/CN1250286C/zh not_active Expired - Lifetime
- 2001-04-30 SK SK1556-2002A patent/SK287761B6/sk not_active IP Right Cessation
- 2001-04-30 UA UAA200507913A patent/UA87658C2/uk unknown
- 2001-04-30 AT AT01945064T patent/ATE395075T1/de active
- 2001-04-30 KR KR1020027014755A patent/KR20030016254A/ko not_active Ceased
- 2001-04-30 PL PL365697A patent/PL209371B1/pl unknown
- 2001-04-30 CN CN2006100092901A patent/CN1841066B/zh not_active Expired - Lifetime
- 2001-04-30 CA CA2407895A patent/CA2407895C/en not_active Expired - Lifetime
- 2001-04-30 HU HU0301991A patent/HU229375B1/hu unknown
- 2001-04-30 AU AU6739001A patent/AU6739001A/xx active Pending
- 2001-04-30 EA EA200401183A patent/EA007014B1/ru not_active IP Right Cessation
- 2001-04-30 AU AU2001267390A patent/AU2001267390B2/en not_active Expired
- 2001-04-30 SI SI200130832T patent/SI1278540T1/sl unknown
- 2001-04-30 BR BRPI0110506A patent/BRPI0110506B8/pt not_active IP Right Cessation
- 2001-04-30 ES ES01945064T patent/ES2305082T3/es not_active Expired - Lifetime
- 2001-04-30 DK DK01945064T patent/DK1278540T3/da active
- 2001-04-30 JP JP2001581854A patent/JP5122053B2/ja not_active Expired - Lifetime
- 2001-04-30 DE DE60134009T patent/DE60134009D1/de not_active Expired - Lifetime
- 2001-04-30 EP EP01945064A patent/EP1278540B1/en not_active Expired - Lifetime
- 2001-04-30 UA UA2002129704A patent/UA78492C2/uk unknown
- 2001-04-30 EE EEP200200620A patent/EE05056B1/xx unknown
- 2001-04-30 PT PT01945064T patent/PT1278540E/pt unknown
- 2001-04-30 CZ CZ20023644A patent/CZ300792B6/cs not_active IP Right Cessation
- 2001-05-04 AR ARP010102129A patent/AR035640A1/es unknown
2002
- 2002-10-11 ZA ZA2002/08228A patent/ZA200208228B/en unknown
- 2002-10-24 BG BG107218A patent/BG65881B1/bg unknown
- 2002-10-31 IL IL152567A patent/IL152567A/en active IP Right Grant
- 2002-11-05 NO NO20025307A patent/NO329821B1/no not_active IP Right Cessation
2008
- 2008-06-30 CY CY20081100684T patent/CY1110385T1/el unknown

Also Published As

Publication number	Publication date
CY1110385T1 (el)	2015-04-29
EP1278540A2 (en)	2003-01-29
ZA200208228B (en)	2005-07-27
UA78492C2 (en)	2007-04-10
SI1278540T1 (sl)	2008-10-31
KR20030016254A (ko)	2003-02-26
SK287761B6 (en)	2011-09-05
EA200201175A1 (ru)	2003-04-24
EP1278540B1 (en)	2008-05-14
YU82602A (sh)	2006-01-16
CA2407895C (en)	2012-12-18
IL152567A (en)	2010-12-30
BRPI0110506B1 (pt)	2015-05-19
CZ20023644A3 (cs)	2003-03-12
CN1434722A (zh)	2003-08-06
EA005410B1 (ru)	2005-02-24
HRP20020828A2 (en)	2004-12-31
JP2003532685A (ja)	2003-11-05
UA87658C2 (uk)	2009-08-10
EA007014B1 (ru)	2006-06-30
BRPI0110506B8 (pt)	2021-05-25
HK1055681A1 (en)	2004-01-21
MXPA02010895A (es)	2003-03-27
CZ300792B6 (cs)	2009-08-12
ES2305082T3 (es)	2008-11-01
BG107218A (bg)	2003-06-30
BR0110506A (pt)	2003-04-01
CN1841066B (zh)	2012-08-29
KR20070073989A (ko)	2007-07-10
JP5122053B2 (ja)	2013-01-16
AU6739001A (en)	2001-11-20
AU2001267390B2 (en)	2005-09-22
DE60134009D1 (de)	2008-06-26
ME00554B (me)	2012-03-20
PL365697A1 (en)	2005-01-10
EA200401183A1 (ru)	2004-12-30
HU229375B1 (en)	2013-11-28
NO20025307D0 (no)	2002-11-05
HK1094909A1 (en)	2007-04-13
BG65881B1 (bg)	2010-04-30
HUP0301991A3 (en)	2006-11-28
EE05056B1 (et)	2008-08-15
WO2001085201A3 (en)	2002-05-10
CN1250286C (zh)	2006-04-12
MEP64008A (en)	2011-12-20
RS50926B (sr)	2010-08-31
CN1841066A (zh)	2006-10-04
SK15562002A3 (sk)	2003-05-02
CA2407895A1 (en)	2001-11-15
KR100798545B1 (ko)	2008-01-28
NO329821B1 (no)	2010-12-27
WO2001085201A2 (en)	2001-11-15
AR035640A1 (es)	2004-06-23
PT1278540E (pt)	2008-07-03
HUP0301991A2 (hu)	2003-09-29
US20040076628A1 (en)	2004-04-22
ATE395075T1 (de)	2008-05-15
IL152567A0 (en)	2003-05-29
NO20025307L (no)	2002-12-18
PL209371B1 (pl)	2011-08-31
EE200200620A (et)	2004-06-15

Publication	Publication Date	Title
DK1278540T3 (da)	2008-07-21	Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelsen af aterosklerose
NO20032668D0 (no)	2003-06-12	Gyraseinhibitorer og anvendelser derav
DK1251848T3 (da)	2004-10-18	Gyraseinhibitorer og anvendelse deraf
IS6934A (is)	2003-08-29	Nýjar spírótrísýklískar afleiður og notkun þeirrasem fosfódíesterasa-7-hindrar
DK1506041T3 (da)	2008-01-28	Inbandronsyre til behandling og forebyggelse af osteoporose
DK1487541T3 (da)	2009-01-19	Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelse af perifere vaskulære sygdomme
DK1133477T3 (da)	2004-06-21	Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
IS6700A (is)	2003-01-27	Meðferðarblanda CETP hindra og atórvastatíns
NO20020343L (no)	2002-03-21	Kaspase-inhibitorer og anvendelse derav
NO20000011D0 (no)	2000-01-03	Skumdempersammensetninger og fremgangsmåter
NO20015274L (no)	2001-12-28	ACE-2 inhiberende forbindelser og fremgangsmåter for anvendelse derav
DK1282719T3 (da)	2006-10-02	Fremgangsmåde til fremstilling af dihydroxyestere og derivater deraf
NO20033854L (no)	2003-10-28	N-but-3-enyl-norbuprenorfin og fremgangsmåter for anvendelse
NO20031806D0 (no)	2003-04-23	Anvendelse av pericytt apoptosehemmere for behandling og/eller forhindringav diabetisk retinopati
DK1601744T3 (da)	2012-08-20	Forgasningsapparat og fremgangsmåde
DK1337547T3 (da)	2014-06-10	Nuklease-baseret fremgangsmåde til detektion og kvantificering af oligonukleotider
DK1355668T3 (da)	2008-05-05	Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom
FI20011370L (fi)	2002-12-28	Biotunnistusmenetelmä ja sitä hyödyntävä laite
PT1274700E (pt)	2005-02-28	Di-hidrobenzopiranos di-hidrobenzotiopiranos e tetra-hidroquinolinas para o tratamento de afeccoes mediadas por cox-2
DE60223540D1 (de)	2007-12-27	Mundschutz und mundschutzfolie
DK1381620T3 (da)	2006-06-26	Hypersulfaterede disaccharider og fremgangsmåder til anvendelse af samme til behandling af inflammationer
EE05263B1 (et)	2010-02-15	IL-18 inhibiitorite kasutamine kesknrvissteemi kahjustuste raviks v?i ennetamiseks
NO20011176D0 (no)	2001-03-08	FremgangsmÕte og anordning ved mær
DK1307761T3 (da)	2010-04-12	Fremgangsmåde til retningsbestemmelse og bestemmelsesapparat
IT1315029B1 (it)	2003-01-27	Metodo e linea per la laminazione di rotaie o altre sezioni