DK1119571T3 - Tricykliske Delta 3 piperidiner som alpha 2 antagonister. - Google Patents

Tricykliske Delta 3 piperidiner som alpha 2 antagonister.

Info

Publication number: DK1119571T3
Authority: DK; Denmark
Prior art keywords: piperidines; antagonists; alpha; tricyclic; delta
Prior art date: 1998-10-06

Application number

DK99950627T

Other languages

English (en)

Inventor

Ludo Edmond J Kennis

Den Keybus F M A Janssen P Van

Josephus C Mertens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-06

Filing date

1999-10-01

Publication date

2003-05-26

1999-10-01 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1119571T3 publication Critical patent/DK1119571T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)

DK99950627T 1998-10-06 1999-10-01 Tricykliske Delta 3 piperidiner som alpha 2 antagonister. DK1119571T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203370		1998-10-06
PCT/EP1999/007419 WO2000020421A2 (en)	1998-10-06	1999-10-01	TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS

Publications (1)

Publication Number	Publication Date
DK1119571T3 true DK1119571T3 (da)	2003-05-26

Family

ID=8234191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99950627T DK1119571T3 (da)	1998-10-06	1999-10-01	Tricykliske Delta 3 piperidiner som alpha 2 antagonister.

Country Status (30)

Country	Link
US (1)	US6495555B1 (da)
EP (1)	EP1119571B1 (da)
JP (1)	JP4590101B2 (da)
KR (1)	KR20010071843A (da)
CN (1)	CN1131230C (da)
AR (1)	AR024216A1 (da)
AT (1)	ATE232869T1 (da)
AU (1)	AU760502B2 (da)
BG (1)	BG64872B1 (da)
BR (1)	BR9913507A (da)
CA (1)	CA2345622C (da)
CZ (1)	CZ20011104A3 (da)
DE (1)	DE69905478T2 (da)
DK (1)	DK1119571T3 (da)
EE (1)	EE04770B1 (da)
ES (1)	ES2193751T3 (da)
HU (1)	HUP0104002A3 (da)
ID (1)	ID28032A (da)
IL (1)	IL142443A0 (da)
NO (1)	NO20011270L (da)
NZ (1)	NZ510115A (da)
PL (1)	PL347894A1 (da)
PT (1)	PT1119571E (da)
RU (1)	RU2230744C2 (da)
SI (1)	SI1119571T1 (da)
SK (1)	SK285585B6 (da)
TR (1)	TR200100952T2 (da)
TW (1)	TWI248441B (da)
UA (1)	UA69420C2 (da)
WO (1)	WO2000020421A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ510116A (en) *	1998-10-06	2002-10-25	Janssen Pharmaceutica Nv	Tricyclic delta-3-piperidines as pharmaceuticals
WO2003082825A1 (en) *	2002-04-03	2003-10-09	Orion Corporation	Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
MXPA06011777A (es)	2004-04-12	2007-01-16	Taisho Pharma Co Ltd	Compuesto de amina ciclico.
WO2006006740A1 (ja) *	2004-07-14	2006-01-19	Japan Tobacco Inc.	３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤
MX2007000480A (es) *	2004-07-15	2007-03-29	Japan Tobacco Inc	Compuesto de benzamida fusionado e inhibidor de actividad de receptor de vainilloide 1.
US7906508B2 (en) *	2005-12-28	2011-03-15	Japan Tobacco Inc.	3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
WO2010132599A1 (en)	2009-05-14	2010-11-18	Janssen Pharmaceutica Nv	Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
JOP20200052A1 (ar) *	2013-12-19	2017-06-16	Bayer Pharma AG	بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
PE20160842A1 (es) *	2013-12-19	2016-09-24	Bayer Pharma AG	Piperidiniltetrahidroquinolinas sustituidas
CN106029657A (zh)	2013-12-19	2016-10-12	拜耳制药股份公司	作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物
CN114276359B (zh) *	2022-01-05	2023-05-05	浙江大学	一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU926914A1 (ru) *	1980-05-26	1992-04-23	Научно-исследовательский институт фармакологии АМН СССР	Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
DE3522959A1 (de)	1985-06-27	1987-01-08	Merck Patent Gmbh	Indolderivate
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
JPH0256485A (ja) *	1988-04-27	1990-02-26	Glaxo Group Ltd	ラクタム誘導体
US4971974A (en) *	1988-06-16	1990-11-20	Neurex Corporation	Benzothiophenes as appetite suppressants
US5100891A (en) *	1991-01-18	1992-03-31	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
ES2168682T3 (es) *	1996-12-06	2002-06-16	Abbott Lab	Compuestos alfa-1 adrenergicos a base de benzopiranopirrol y de benzopiranopiridina.
WO1999033804A1 (en) *	1997-12-25	1999-07-08	Meiji Seika Kaisha, Ltd.	Tetrahydrobenzindole derivatives
NZ510116A (en) *	1998-10-06	2002-10-25	Janssen Pharmaceutica Nv	Tricyclic delta-3-piperidines as pharmaceuticals

1999
- 1999-01-10 UA UA2001031999A patent/UA69420C2/uk unknown
- 1999-10-01 CN CN99811682A patent/CN1131230C/zh not_active Expired - Fee Related
- 1999-10-01 AT AT99950627T patent/ATE232869T1/de not_active IP Right Cessation
- 1999-10-01 SI SI9930264T patent/SI1119571T1/xx unknown
- 1999-10-01 AU AU63341/99A patent/AU760502B2/en not_active Ceased
- 1999-10-01 JP JP2000574533A patent/JP4590101B2/ja not_active Expired - Fee Related
- 1999-10-01 DK DK99950627T patent/DK1119571T3/da active
- 1999-10-01 CZ CZ20011104A patent/CZ20011104A3/cs unknown
- 1999-10-01 NZ NZ510115A patent/NZ510115A/xx unknown
- 1999-10-01 EE EEP200100209A patent/EE04770B1/xx not_active IP Right Cessation
- 1999-10-01 PL PL99347894A patent/PL347894A1/xx not_active Application Discontinuation
- 1999-10-01 CA CA002345622A patent/CA2345622C/en not_active Expired - Fee Related
- 1999-10-01 ID IDW20010780A patent/ID28032A/id unknown
- 1999-10-01 US US09/806,547 patent/US6495555B1/en not_active Expired - Lifetime
- 1999-10-01 HU HU0104002A patent/HUP0104002A3/hu unknown
- 1999-10-01 ES ES99950627T patent/ES2193751T3/es not_active Expired - Lifetime
- 1999-10-01 IL IL14244399A patent/IL142443A0/xx not_active IP Right Cessation
- 1999-10-01 RU RU2001111812/04A patent/RU2230744C2/ru not_active IP Right Cessation
- 1999-10-01 TW TW088116898A patent/TWI248441B/zh not_active IP Right Cessation
- 1999-10-01 SK SK432-2001A patent/SK285585B6/sk unknown
- 1999-10-01 TR TR2001/00952T patent/TR200100952T2/xx unknown
- 1999-10-01 KR KR1020017000442A patent/KR20010071843A/ko not_active Ceased
- 1999-10-01 PT PT99950627T patent/PT1119571E/pt unknown
- 1999-10-01 DE DE69905478T patent/DE69905478T2/de not_active Expired - Lifetime
- 1999-10-01 EP EP99950627A patent/EP1119571B1/en not_active Expired - Lifetime
- 1999-10-01 BR BR9913507-8A patent/BR9913507A/pt not_active IP Right Cessation
- 1999-10-01 WO PCT/EP1999/007419 patent/WO2000020421A2/en not_active Ceased
- 1999-10-05 AR ARP990105038A patent/AR024216A1/es not_active Application Discontinuation
2001
- 2001-03-12 BG BG105332A patent/BG64872B1/bg unknown
- 2001-03-13 NO NO20011270A patent/NO20011270L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
SK4322001A3 (en)	2002-01-07
IL142443A0 (en)	2002-03-10
EP1119571A2 (en)	2001-08-01
HUP0104002A2 (hu)	2002-03-28
TWI248441B (en)	2006-02-01
CA2345622C (en)	2007-12-04
SK285585B6 (sk)	2007-04-05
BR9913507A (pt)	2001-06-05
HUP0104002A3 (en)	2003-12-29
CN1332744A (zh)	2002-01-23
HK1038010A1 (en)	2002-03-01
CN1131230C (zh)	2003-12-17
DE69905478D1 (de)	2003-03-27
AR024216A1 (es)	2002-09-25
PT1119571E (pt)	2003-06-30
WO2000020421A3 (en)	2000-08-03
CA2345622A1 (en)	2000-04-13
NO20011270D0 (no)	2001-03-13
EP1119571B1 (en)	2003-02-19
ID28032A (id)	2001-05-03
JP2002526545A (ja)	2002-08-20
DE69905478T2 (de)	2004-03-18
JP4590101B2 (ja)	2010-12-01
ATE232869T1 (de)	2003-03-15
US6495555B1 (en)	2002-12-17
RU2230744C2 (ru)	2004-06-20
BG64872B1 (bg)	2006-07-31
WO2000020421A2 (en)	2000-04-13
NO20011270L (no)	2001-03-13
KR20010071843A (ko)	2001-07-31
PL347894A1 (en)	2002-04-22
EE200100209A (et)	2002-06-17
EE04770B1 (et)	2007-02-15
BG105332A (en)	2001-11-30
AU6334199A (en)	2000-04-26
ES2193751T3 (es)	2003-11-01
UA69420C2 (uk)	2004-09-15
TR200100952T2 (tr)	2001-10-22
AU760502B2 (en)	2003-05-15
SI1119571T1 (en)	2003-08-31
NZ510115A (en)	2002-11-26
CZ20011104A3 (cs)	2001-12-12

Publication	Publication Date	Title
ID29241A (id)	2001-08-16	Turunan-turunan kinolin teranelasi-1,2
ATE435861T1 (de)	2009-07-15	12,13-cyclopropan-epothilonderivate
ID30132A (id)	2001-11-08	Turunan-turunan pirazol trisiklik
ID17259A (id)	1997-12-11	Fluorina mengandung turunan piperidina 1,4-disubtitusikan
FI981011L (fi)	1999-11-07	Uudet koostumukset
DK1218359T3 (da)	2004-10-18	Piperazinforbindelser som tachykininantagonister
NO20001609D0 (no)	2000-03-28	Aminoterminert trunkerte RANTES som kjemokinantagonister
NO982651L (no)	1998-06-09	3-Azetidinylalkylpiperidiner eller -pyrrolidiner som takykininantagonister
ID28874A (id)	2001-07-12	Inhibitor fosfodiesterase 4 turunan ftalazina.
DE69938258D1 (de)	2008-04-10	4,5-pyrazinoxindole als proteinkinasehemmer
NO20010873D0 (no)	2001-02-21	Mikropartikkel-blanding
DK0964863T3 (da)	2003-08-04	Oxazolidinoner som 5-HT2A-antagonister
DK1119571T3 (da)	2003-05-26	Tricykliske Delta 3 piperidiner som alpha 2 antagonister.
DE50107988D1 (de)	2005-12-15	Substituierte 1,2,3,4-tetrahydrochinolin-2-carbonsäurederivate
ID26909A (id)	2001-02-15	Turunan-turunan 1,3,4-oksadiazolon
DE60025958D1 (de)	2006-04-20	14,15-beta-methylen substituierte androgene
DK1075471T3 (da)	2005-01-17	Idolylderivater som serotonerge midler
NO20000434D0 (no)	2000-01-27	Lyksofuranosyl benzimidazoler som antivirale midler
ATE234839T1 (de)	2003-04-15	4,5-azolo-oxindole
ITTO970975A0 (it)	1997-11-07	Composizioni organiche.
NO20034529D0 (no)	2003-10-09	3,7-diazabicyklo(3,3,1) formuleringer samt antiarytmiforbindelser
NO20011402L (no)	2001-03-20	Tricykliske <delta>3-piperidiner som farmasöytiske midler
DK1315700T3 (da)	2007-02-19	Substituerede 4-phenyl-1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridiner
NO20002575D0 (no)	2000-05-19	Substituerte oksimer som neurokininantagonister
DK0882044T3 (da)	2002-09-02	1,4-dihydropyridinforbindelser som bradykinin-antagonister