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DK1000027T3 - Termodynamisk stabil modifikation af 1-(4-carbazolyloxy)-3-[2-(methoxyphenoxy)ethylamino]-2-propanol, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende denne - Google Patents

Termodynamisk stabil modifikation af 1-(4-carbazolyloxy)-3-[2-(methoxyphenoxy)ethylamino]-2-propanol, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende denne

Info

Publication number
DK1000027T3
DK1000027T3 DK98937576T DK98937576T DK1000027T3 DK 1000027 T3 DK1000027 T3 DK 1000027T3 DK 98937576 T DK98937576 T DK 98937576T DK 98937576 T DK98937576 T DK 98937576T DK 1000027 T3 DK1000027 T3 DK 1000027T3
Authority
DK
Denmark
Prior art keywords
carbazolyloxy
methoxyphenoxy
ethylamino
propanol
preparation
Prior art date
Application number
DK98937576T
Other languages
English (en)
Inventor
Erhard Reinholz
Peter Beyer
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of DK1000027T3 publication Critical patent/DK1000027T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK98937576T 1997-07-22 1998-07-18 Termodynamisk stabil modifikation af 1-(4-carbazolyloxy)-3-[2-(methoxyphenoxy)ethylamino]-2-propanol, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende denne DK1000027T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97112491A EP0893440A1 (en) 1997-07-22 1997-07-22 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
PCT/EP1998/004475 WO1999005105A1 (en) 1997-07-22 1998-07-18 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it

Publications (1)

Publication Number Publication Date
DK1000027T3 true DK1000027T3 (da) 2003-07-21

Family

ID=8227094

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98937576T DK1000027T3 (da) 1997-07-22 1998-07-18 Termodynamisk stabil modifikation af 1-(4-carbazolyloxy)-3-[2-(methoxyphenoxy)ethylamino]-2-propanol, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende denne

Country Status (31)

Country Link
EP (2) EP0893440A1 (da)
JP (1) JP2001510824A (da)
KR (1) KR100336229B1 (da)
CN (1) CN1125047C (da)
AR (1) AR015133A1 (da)
AT (1) ATE236123T1 (da)
AU (1) AU740453B2 (da)
BR (1) BR9810776A (da)
CA (1) CA2296637C (da)
CZ (1) CZ296947B6 (da)
DE (1) DE69812964T2 (da)
DK (1) DK1000027T3 (da)
ES (1) ES2195366T3 (da)
HR (1) HRP980406A2 (da)
HU (1) HUP0003198A3 (da)
IL (1) IL133677A (da)
MA (1) MA26523A1 (da)
MY (1) MY117734A (da)
NO (1) NO313588B1 (da)
NZ (1) NZ502136A (da)
PE (1) PE96999A1 (da)
PL (1) PL191602B1 (da)
PT (1) PT1000027E (da)
RU (1) RU2202542C2 (da)
SI (1) SI1000027T1 (da)
TR (1) TR200000148T2 (da)
TW (1) TW505631B (da)
UY (1) UY25108A1 (da)
WO (1) WO1999005105A1 (da)
YU (1) YU2200A (da)
ZA (1) ZA986475B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001263813A1 (en) * 2000-04-03 2001-10-15 F.Hoffmann-La Roche Ag Concentrated solutions of carvedilol
AU2001271639A1 (en) 2000-06-28 2002-01-08 Teva Pharmaceutical Industries Ltd. Carvedilol
EP1655285A1 (en) * 2000-06-28 2006-05-10 Teva Pharmaceutical Industries Ltd. Method for preparation of a crystalline form of carvedilol (form II)
JP2004534840A (ja) * 2001-07-13 2004-11-18 スミスクライン・ビーチャム・コーポレイション カルベジロール多型体
ES2298401T3 (es) 2001-09-21 2008-05-16 Egalet A/S Dispersiones solidas de liberacion controlada de carvedilol.
WO2003029214A1 (en) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
CA2472377A1 (en) 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
AU2003231283A1 (en) * 2002-04-30 2003-11-17 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
US20050261355A1 (en) 2002-06-27 2005-11-24 Sb Pharmco Puerto Rico Inc., Carvedilol hydobromide
CN103254114A (zh) 2002-06-27 2013-08-21 史密斯克莱.比奇曼（科克）有限公司 卡维地洛磷酸盐和/或其溶剂合物相应的组合物和/或治疗方法
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
EP1610767B1 (en) 2003-03-26 2011-01-19 Egalet A/S Morphine controlled release system
WO2004094378A1 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
US7750036B2 (en) 2003-11-25 2010-07-06 Sb Pharmco Puerto Rico Inc. Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
ATE445601T1 (de) * 2004-12-09 2009-10-15 Zach System Spa Verfahren zur herstellung von carvedilol und seinen enantiomeren
KR20070088507A (ko) * 2005-06-09 2007-08-29 테바 파마슈티컬 인더스트리즈 리미티드 카베딜올의 결정질 형태 및 이것의 제조 방법
WO2008002683A2 (en) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
RU2366653C2 (ru) * 2006-07-03 2009-09-10 Ооо "Нанокриохимия" Способ получения рентгеноаморфной модификации карведилола
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
CA2751667C (en) 2009-02-06 2016-12-13 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

Also Published As

Publication number Publication date
KR100336229B1 (ko) 2002-05-09
HRP980406A2 (en) 1999-04-30
SI1000027T1 (en) 2003-10-31
ZA986475B (en) 2000-01-21
CA2296637C (en) 2005-11-15
DE69812964T2 (de) 2004-03-04
CZ2000221A3 (cs) 2000-05-17
AU740453B2 (en) 2001-11-01
NO20000301L (no) 2000-01-21
KR20010022097A (ko) 2001-03-15
MY117734A (en) 2004-07-31
AR015133A1 (es) 2001-04-18
CN1125047C (zh) 2003-10-22
CZ296947B6 (cs) 2006-08-16
ATE236123T1 (de) 2003-04-15
MA26523A1 (fr) 2004-12-20
EP1000027B1 (en) 2003-04-02
NO313588B1 (no) 2002-10-28
WO1999005105A1 (en) 1999-02-04
RU2202542C2 (ru) 2003-04-20
CN1264366A (zh) 2000-08-23
HUP0003198A3 (en) 2002-10-28
PL338432A1 (en) 2000-11-06
YU2200A (sh) 2002-03-18
HK1029339A1 (en) 2001-03-30
PL191602B1 (pl) 2006-06-30
TW505631B (en) 2002-10-11
IL133677A (en) 2004-06-01
UY25108A1 (es) 2000-12-29
HUP0003198A2 (en) 2001-03-28
DE69812964D1 (de) 2003-05-08
ES2195366T3 (es) 2003-12-01
PE96999A1 (es) 1999-10-12
AU8631998A (en) 1999-02-16
IL133677A0 (en) 2001-04-30
TR200000148T2 (tr) 2000-07-21
BR9810776A (pt) 2000-09-19
JP2001510824A (ja) 2001-08-07
EP1000027A1 (en) 2000-05-17
PT1000027E (pt) 2003-07-31
NZ502136A (en) 2002-05-31
NO20000301D0 (no) 2000-01-21
CA2296637A1 (en) 1999-02-04
EP0893440A1 (en) 1999-01-27

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