DK0991658T3 - Dolastatin 15-derivater - Google Patents

Dolastatin 15-derivater

Info

Publication number: DK0991658T3
Authority: DK; Denmark
Prior art keywords: dolastatin; derivatives
Prior art date: 1997-07-18

Application number

DK98935531T

Other languages

Danish (da)

English (en)

Inventor

Bernd Janssen

Thomas Zierke

Andreas Kling

Teresa Barlozzari

Andreas Haupt

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

1998-07-07

Publication date

2006-05-15

1998-07-07 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2006-05-15 Application granted granted Critical

2006-05-15 Publication of DK0991658T3 publication Critical patent/DK0991658T3/da

Links

LQKSHSFQQRCAFW-CCVNJFHASA-N [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxyl Chemical class C([C@@H]1N(C(=O)C=C1OC)C(=O)[C@@H](OC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)C1=CC=CC=C1 LQKSHSFQQRCAFW-CCVNJFHASA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

DK98935531T 1997-07-18 1998-07-07 Dolastatin 15-derivater DK0991658T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/896,394 US6143721A (en)	1997-07-18	1997-07-18	Dolastatin 15 derivatives

Publications (1)

Publication Number	Publication Date
DK0991658T3 true DK0991658T3 (da)	2006-05-15

Family

ID=25406130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98935531T DK0991658T3 (da)	1997-07-18	1998-07-07	Dolastatin 15-derivater

Country Status (32)

Country	Link
US (6)	US6143721A (fr)
EP (1)	EP0991658B1 (fr)
JP (4)	JP4508413B2 (fr)
KR (1)	KR100579748B1 (fr)
CN (1)	CN1268636C (fr)
AR (1)	AR018501A1 (fr)
AT (1)	ATE314387T1 (fr)
AU (1)	AU750120B2 (fr)
BG (1)	BG65212B1 (fr)
BR (1)	BR9810911A (fr)
CA (1)	CA2296036C (fr)
CO (1)	CO4990967A1 (fr)
CY (1)	CY1107047T1 (fr)
CZ (1)	CZ303045B6 (fr)
DE (1)	DE69832982T2 (fr)
DK (1)	DK0991658T3 (fr)
ES (1)	ES2258819T3 (fr)
HR (1)	HRP980397A2 (fr)
HU (1)	HU228996B1 (fr)
ID (1)	ID24669A (fr)
IL (1)	IL133784A (fr)
MY (1)	MY135057A (fr)
NO (1)	NO326827B1 (fr)
NZ (1)	NZ502296A (fr)
PL (1)	PL197884B1 (fr)
PT (1)	PT991658E (fr)
RU (1)	RU2195462C2 (fr)
SK (1)	SK286581B6 (fr)
TR (2)	TR200103545T2 (fr)
TW (1)	TW533217B (fr)
WO (1)	WO1999003879A1 (fr)
ZA (1)	ZA986358B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010009901A1 (en) *	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
AU2001227375A1 (en)	2000-02-08	2001-08-20	Herbert T. Nagasawa	N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US7256257B2 (en) *	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US6884869B2 (en) *	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
WO2003082268A2 (fr) *	2002-03-22	2003-10-09	Eisai Co. Ltd	Derives de l'hemiasterline et leurs utilisations
US7064211B2 (en) *	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
EP1545613B9 (fr)	2002-07-31	2012-01-25	Seattle Genetics, Inc.	Conjugues d'auristatine et leur utilisation dans le traitement du cancer, d'une maladie auto-immune ou d'une maladie infectieuse
DK1725249T3 (en)	2003-11-06	2014-03-17	Seattle Genetics Inc	Monomethylvaline compounds capable of conjugating to ligands.
US20060148014A1 (en) *	2004-12-09	2006-07-06	Sergei Agoulnik	Tubulin isotype screening in cancer therapy using hemiasterlin analogs
WO2006122408A1 (fr)	2005-05-18	2006-11-23	Aegera Therapeutics Inc.	Composes liants de domaine bir
SG171682A1 (en)	2006-05-16	2011-06-29	Aegera Therapeutics Inc	Iap bir domain binding compounds
KR101486615B1 (ko)	2007-07-16	2015-01-28	제넨테크, 인크.	항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
WO2009012256A1 (fr)	2007-07-16	2009-01-22	Genentech, Inc.	Anticorps anti-cd79b humanisés, immunoconjugués, et procédés d'utilisation
DE102007039706A1 (de)	2007-08-22	2009-02-26	Erhard Prof. Dr.-Ing. Kohn	Chemischer Sensor auf Diamantschichten
RU2553566C2 (ru)	2008-01-31	2015-06-20	Дженентек, Инк.	АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2013514982A (ja)	2009-12-18	2013-05-02	イデニクプハルマセウティカルス，インコーポレイテッド	５，５−縮合アリーレン又はヘテロアリーレンｃ型肝炎ウイルス阻害剤
CN102933231B (zh)	2010-02-10	2015-07-29	伊缪诺金公司	Cd20抗体及其用途
MX340870B (es)	2010-02-12	2016-07-27	Pharmascience Inc	Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
ES2701076T3 (es)	2012-11-24	2019-02-20	Hangzhou Dac Biotech Co Ltd	Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
CA2938919C (fr)	2014-02-28	2020-12-29	Hangzhou Dac Biotech Co., Ltd	Lieurs charges et leurs utilisations pour la conjugaison
WO2016049214A1 (fr)	2014-09-23	2016-03-31	Genentech, Inc.	Procédé d'utilisation d'immunoconjugués anti-cd79b
CN108026123B (zh)	2015-06-15	2021-02-05	杭州多禧生物科技有限公司	用于偶联的亲水链接体
NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147719A (ko)	2016-11-14	2022-11-03	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
WO2023033129A1 (fr)	2021-09-03	2023-03-09	東レ株式会社	Composition pharmaceutique pour le traitement et/ou la prévention du cancer
WO2022078524A2 (fr)	2021-11-03	2022-04-21	Hangzhou Dac Biotech Co., Ltd.	Conjugaison spécifique d'un anticorps

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
ES2144421T3 (es) *	1991-08-09	2000-06-16	Teikoku Hormone Mfg Co Ltd	Nuevo derivado tetrapeptidico.
US5448045A (en)	1992-02-26	1995-09-05	Clark; Paul C.	System for protecting computers via intelligent tokens or smart cards
US5533097A (en) *	1992-02-26	1996-07-02	Motorola, Inc.	Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
UA45304C2 (uk) *	1992-05-20	2002-04-15	Басф Аг	Похідні пептиду або їх солі, фармацевтична композиція
HUT72067A (en) *	1992-12-16	1996-03-28	Basf Ag	Dolostatin analog
US5554993A (en)	1994-01-04	1996-09-10	Panasonic Technologies, Inc.	Global position determining system and method
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides
US5554725A (en) *	1994-09-14	1996-09-10	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Synthesis of dolastatin 15
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en)	1995-03-23	1997-04-08	Martin; John R.	Dual mode gaming device methods and systems
US5970143A (en)	1995-11-22	1999-10-19	Walker Asset Management Lp	Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
TW474946B (en) *	1995-12-15	2002-02-01	Basf Ag	Novel compounds, the preparation and use thereof
CA2287379C (fr)	1997-01-10	2005-10-04	Silicon Gaming-Nevada	Procede et dispositif pour assurer une communication en ligne protegee et authentifiee entre des lieux eloignes
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6554705B1 (en)	1997-08-22	2003-04-29	Blake Cumbers	Passive biometric customer identification and tracking system
US6629591B1 (en)	2001-01-12	2003-10-07	Igt	Smart token
US6438382B1 (en)	2001-02-14	2002-08-20	Telefonaktiebolaget Lm Ericsson (Publ.)	Expedited location determination in analog service areas

1997
- 1997-07-18 US US08/896,394 patent/US6143721A/en not_active Expired - Lifetime
1998
- 1998-07-07 CA CA002296036A patent/CA2296036C/fr not_active Expired - Fee Related
- 1998-07-07 WO PCT/US1998/013901 patent/WO1999003879A1/fr not_active Ceased
- 1998-07-07 PT PT98935531T patent/PT991658E/pt unknown
- 1998-07-07 HU HU0004234A patent/HU228996B1/hu not_active IP Right Cessation
- 1998-07-07 IL IL13378498A patent/IL133784A/xx not_active IP Right Cessation
- 1998-07-07 TR TR2001/03545T patent/TR200103545T2/xx unknown
- 1998-07-07 ES ES98935531T patent/ES2258819T3/es not_active Expired - Lifetime
- 1998-07-07 AT AT98935531T patent/ATE314387T1/de active
- 1998-07-07 CZ CZ20000176A patent/CZ303045B6/cs not_active IP Right Cessation
- 1998-07-07 BR BR9810911-1A patent/BR9810911A/pt not_active Application Discontinuation
- 1998-07-07 RU RU2000103960/04A patent/RU2195462C2/ru not_active IP Right Cessation
- 1998-07-07 AU AU84758/98A patent/AU750120B2/en not_active Ceased
- 1998-07-07 TR TR2000/00132T patent/TR200000132T2/xx unknown
- 1998-07-07 EP EP98935531A patent/EP0991658B1/fr not_active Expired - Lifetime
- 1998-07-07 KR KR1020007000565A patent/KR100579748B1/ko not_active Expired - Fee Related
- 1998-07-07 NZ NZ502296A patent/NZ502296A/en not_active IP Right Cessation
- 1998-07-07 PL PL338144A patent/PL197884B1/pl unknown
- 1998-07-07 SK SK1879-99A patent/SK286581B6/sk not_active IP Right Cessation
- 1998-07-07 DE DE69832982T patent/DE69832982T2/de not_active Expired - Lifetime
- 1998-07-07 CN CNB988073595A patent/CN1268636C/zh not_active Expired - Fee Related
- 1998-07-07 DK DK98935531T patent/DK0991658T3/da active
- 1998-07-07 JP JP2000503101A patent/JP4508413B2/ja not_active Expired - Fee Related
- 1998-07-07 ID IDW20000322A patent/ID24669A/id unknown
- 1998-07-15 AR ARP980103445A patent/AR018501A1/es active IP Right Grant
- 1998-07-16 HR HR08/896,394A patent/HRP980397A2/hr not_active Application Discontinuation
- 1998-07-17 CO CO98040961A patent/CO4990967A1/es unknown
- 1998-07-17 ZA ZA9806358A patent/ZA986358B/xx unknown
- 1998-07-18 TW TW087111729A patent/TW533217B/zh active
- 1998-07-18 MY MYPI98003298A patent/MY135057A/en unknown
2000
- 2000-01-17 NO NO20000231A patent/NO326827B1/no not_active IP Right Cessation
- 2000-01-17 BG BG104089A patent/BG65212B1/bg unknown
- 2000-07-18 US US09/618,694 patent/US6458765B1/en not_active Expired - Lifetime
2002
- 2002-09-25 US US10/255,118 patent/US7084110B2/en not_active Expired - Lifetime
2006
- 2006-03-13 CY CY20061100348T patent/CY1107047T1/el unknown
- 2006-04-18 US US11/406,512 patent/US7662786B2/en not_active Expired - Fee Related
2008
- 2008-12-11 JP JP2008315263A patent/JP5122429B2/ja not_active Expired - Fee Related
- 2008-12-11 JP JP2008315269A patent/JP5047935B2/ja not_active Expired - Fee Related
2009
- 2009-12-29 US US12/648,446 patent/US8163698B2/en not_active Expired - Fee Related
2012
- 2012-04-16 US US13/447,529 patent/US20130046077A1/en not_active Abandoned
- 2012-06-20 JP JP2012138485A patent/JP2012211164A/ja active Pending

Also Published As

Publication number	Publication date
CO4990967A1 (es)	2000-12-26
SK286581B6 (sk)	2009-01-07
HUP0004234A2 (hu)	2001-05-28
ES2258819T3 (es)	2006-09-01
ZA986358B (en)	2000-01-17
CN1268636C (zh)	2006-08-09
SK187999A3 (en)	2000-09-12
KR100579748B1 (ko)	2006-05-15
NO326827B1 (no)	2009-02-23
HRP980397A2 (en)	1999-04-30
US7662786B2 (en)	2010-02-16
CA2296036C (fr)	2007-05-01
CN1264388A (zh)	2000-08-23
WO1999003879A1 (fr)	1999-01-28
PT991658E (pt)	2006-05-31
EP0991658A1 (fr)	2000-04-12
TR200000132T2 (tr)	2000-05-22
PL197884B1 (pl)	2008-05-30
IL133784A (en)	2005-09-25
NO20000231D0 (no)	2000-01-17
US20060270606A1 (en)	2006-11-30
ID24669A (id)	2000-07-27
AU750120B2 (en)	2002-07-11
US20030153505A1 (en)	2003-08-14
JP2001515010A (ja)	2001-09-18
MY135057A (en)	2008-01-31
PL338144A1 (en)	2000-09-25
JP2009137968A (ja)	2009-06-25
HUP0004234A3 (en)	2001-08-28
CZ303045B6 (cs)	2012-03-07
AU8475898A (en)	1999-02-10
EP0991658B1 (fr)	2005-12-28
JP5122429B2 (ja)	2013-01-16
CY1107047T1 (el)	2012-09-26
BR9810911A (pt)	2000-08-01
BG65212B1 (bg)	2007-07-31
IL133784A0 (en)	2001-04-30
NO20000231L (no)	2000-01-17
TR200103545T2 (tr)	2002-06-21
RU2195462C2 (ru)	2002-12-27
HU228996B1 (hu)	2013-07-29
AR018501A1 (es)	2001-11-28
US8163698B2 (en)	2012-04-24
CA2296036A1 (fr)	1999-01-28
US6458765B1 (en)	2002-10-01
KR20010021998A (ko)	2001-03-15
BG104089A (en)	2000-12-29
ATE314387T1 (de)	2006-01-15
US6143721A (en)	2000-11-07
JP2009137967A (ja)	2009-06-25
CZ2000176A3 (en)	2001-06-13
TW533217B (en)	2003-05-21
JP5047935B2 (ja)	2012-10-10
NZ502296A (en)	2002-02-01
US7084110B2 (en)	2006-08-01
US20130046077A1 (en)	2013-02-21
DE69832982T2 (de)	2006-08-24
HK1029125A1 (en)	2001-03-23
US20100099843A1 (en)	2010-04-22
JP2012211164A (ja)	2012-11-01
JP4508413B2 (ja)	2010-07-21
DE69832982D1 (de)	2006-02-02

Publication	Publication Date	Title
DK0991658T3 (da)	2006-05-15	Dolastatin 15-derivater
NO983169L (no)	1998-09-09	Hetrosykel-kondenserte morfinoidderivater (31)
DE59605821D1 (de)	2000-10-05	l/4-SCALLABSORBER
DE69621528D1 (de)	2002-07-11	Anti-inflamatorische agenzien
NO996108D0 (no)	1999-12-10	9-oksinerytromycinderivater
PT828506E (pt)	2002-08-30	Agentes endoparasiticidas
FR2763953B1 (fr)	2005-01-07	Derives de 5'-desoxy-cytidine
ATE196152T1 (de)	2000-09-15	Peptidderivate
NO992059D0 (no)	1999-04-29	2-metoksyfenylpiperazinderivater
EP1046648A4 (fr)	2002-09-11	Derives de 3'-desoxyribonucleotide
NO961404D0 (no)	1996-04-09	4-indolylpiperazinyl-derivater
PT1060183E (pt)	2003-08-29	Derivados de 5'-desoxicitidina
NO960353L (no)	1996-07-29	4-aminobenzoylguanidinderivater
DE69926606D1 (de)	2005-09-15	Plazentaprotein 13
FI963568L (fi)	1996-11-07	Peptidijohdannaisia
BR9709521A (pt)	1999-08-10	"3-Cianoaril-pirazóis"
EP0850950A4 (fr)	1999-05-19	Derives peptidiques
NO960392D0 (no)	1996-01-30	4-merkaptobenzoylguanidinderivater
DK1077984T3 (da)	2003-09-15	2'-Deoxyhygromycin derivater
DE69709802D1 (de)	2002-02-28	Amythiamicin Amid-Derivate
MA26481A1 (fr)	2004-12-20	Derives d'arylsecocholadiene
NO972978D0 (no)	1997-06-26	Tomrock 5000
SE9601982D0 (sv)	1996-05-24	Tifaret 6
SI0991658T1 (sl)	2006-06-30	Derivati dolastatina 15
KR970014100U (ko)	1997-04-28	무한 증폭기