DK0726894T3 - Kortvarigt virkende dihydropyridiner - Google Patents
Kortvarigt virkende dihydropyridinerInfo
- Publication number
- DK0726894T3 DK0726894T3 DK95900347T DK95900347T DK0726894T3 DK 0726894 T3 DK0726894 T3 DK 0726894T3 DK 95900347 T DK95900347 T DK 95900347T DK 95900347 T DK95900347 T DK 95900347T DK 0726894 T3 DK0726894 T3 DK 0726894T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- pct
- chloro
- methyl
- nitro
- Prior art date
Links
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
| PCT/SE1994/001031 WO1995012578A1 (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0726894T3 true DK0726894T3 (da) | 2000-10-23 |
Family
ID=20391655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95900347T DK0726894T3 (da) | 1993-11-05 | 1994-11-03 | Kortvarigt virkende dihydropyridiner |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US5856346A (da) |
| EP (1) | EP0726894B1 (da) |
| JP (1) | JP3712209B2 (da) |
| KR (1) | KR100331663B1 (da) |
| CN (1) | CN1049428C (da) |
| AT (1) | ATE194330T1 (da) |
| AU (1) | AU685532B2 (da) |
| BR (1) | BR9407946A (da) |
| CA (1) | CA2174969C (da) |
| CZ (1) | CZ285691B6 (da) |
| DE (1) | DE69425152T2 (da) |
| DK (1) | DK0726894T3 (da) |
| EE (1) | EE03230B1 (da) |
| EG (1) | EG20539A (da) |
| ES (1) | ES2150544T3 (da) |
| FI (1) | FI110429B (da) |
| FR (1) | FR12C0053I2 (da) |
| GR (1) | GR3034469T3 (da) |
| HU (1) | HU215591B (da) |
| IL (1) | IL111127A (da) |
| IS (1) | IS1674B (da) |
| LU (1) | LU92209I2 (da) |
| MY (1) | MY111770A (da) |
| NO (1) | NO305656B1 (da) |
| NZ (1) | NZ275915A (da) |
| PL (1) | PL185099B1 (da) |
| PT (1) | PT726894E (da) |
| RU (1) | RU2139278C1 (da) |
| SA (1) | SA94150250B1 (da) |
| SE (1) | SE9303657D0 (da) |
| SK (1) | SK281467B6 (da) |
| TW (1) | TW279859B (da) |
| UA (1) | UA45959C2 (da) |
| WO (1) | WO1995012578A1 (da) |
| ZA (1) | ZA947570B (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9804002D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
| EP1455804A4 (en) * | 2001-12-21 | 2005-01-05 | Alcon Inc | USE OF NANOTEILES AS CARRIERS OF BIOCIDES IN OPHTHALMIC COMPOSITIONS |
| FR2922439B1 (fr) * | 2007-10-18 | 2010-12-10 | Hill Rom Ind Sa | Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre |
| US20100113534A1 (en) | 2008-08-01 | 2010-05-06 | Rajeshwar Motheram | Pharmaceutical Compositions And Methods For Producing Low Impurity Concentrations Of The Same |
| KR20120100945A (ko) * | 2009-09-30 | 2012-09-12 | 마이크로도스 테라퓨특스, 인코포레이티드 | 레이노 증후군의 치료를 위한 방법들 및 조성물들 |
| CN101780036B (zh) * | 2010-03-30 | 2011-11-16 | 武汉武药科技有限公司 | 丁酸氯维地平脂微球注射液及其制备方法 |
| CA2701087A1 (en) * | 2010-04-12 | 2011-10-12 | Alphora Research Inc. | Preparation of clevidipine butyrate ring the same |
| US8455655B2 (en) | 2010-05-07 | 2013-06-04 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
| ES2571043T3 (es) | 2010-05-07 | 2016-05-23 | Lesvi Laboratorios Sl | Preparación de dihidropiridinas |
| EA022849B1 (ru) | 2010-10-12 | 2016-03-31 | Дзе Медсинз Компани | Эмульсионные композиции клевидипина, содержащие противомикробные агенты |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| EP2694063A1 (en) * | 2011-04-01 | 2014-02-12 | The Medicines Company | Short -acting dihydropyridines (clevidipine) for use in reducing stroke damage |
| CA2846387C (en) | 2011-08-26 | 2016-02-09 | Wockhardt Limited | Methods for treating cardiovascular disorders |
| CN103420899B (zh) * | 2012-05-25 | 2016-01-27 | 四川科伦药物研究有限公司 | 一种丁酸氯维地平的纯化方法 |
| MX359768B (es) | 2012-10-26 | 2018-10-10 | Chiesi Farm Spa | Métodos para controlar la presión arterial y para reducir la disnea durante una insuficiencia cardiaca. |
| CN103073485B (zh) * | 2013-01-17 | 2015-09-02 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平的制备方法 |
| CN103086956B (zh) * | 2013-01-17 | 2015-11-04 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平中间体的纯化方法 |
| KR102380701B1 (ko) | 2014-05-19 | 2022-03-31 | 치에시 파마슈티시 에스.피.아. | 클레비디핀 나노입자 및 그의 제약적 조성물 |
| CN105367487A (zh) * | 2014-08-23 | 2016-03-02 | 南京海纳医药科技有限公司 | 一种丁酸氯维地平重要中间体新的合成方法 |
| CN104370802A (zh) * | 2014-09-24 | 2015-02-25 | 北京蓝丹医药科技有限公司 | 氯维地平衍生物及其制备方法 |
| BR112017024773A2 (pt) | 2015-05-20 | 2018-11-06 | Merial, Inc. | compostos depsipeptídeos anti-helmínticos |
| WO2017116702A1 (en) | 2015-12-28 | 2017-07-06 | Merial, Inc. | Anthelmintic depsipeptide compounds |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| KR940003492B1 (ko) * | 1988-10-27 | 1994-04-23 | 주식회사 유한양행 | 1,4-디하이드로피리딘유도체 및 그의 제조방법 |
| US5134139A (en) * | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
-
1993
- 1993-11-05 SE SE9303657A patent/SE9303657D0/xx unknown
-
1994
- 1994-09-28 ZA ZA947570A patent/ZA947570B/xx unknown
- 1994-09-29 TW TW083108995A patent/TW279859B/zh not_active IP Right Cessation
- 1994-09-30 IS IS4218A patent/IS1674B/is unknown
- 1994-10-03 IL IL11112794A patent/IL111127A/xx not_active IP Right Cessation
- 1994-10-19 SA SA94150250A patent/SA94150250B1/ar unknown
- 1994-11-02 EG EG68994A patent/EG20539A/xx active
- 1994-11-03 ES ES95900347T patent/ES2150544T3/es not_active Expired - Lifetime
- 1994-11-03 RU RU96112152A patent/RU2139278C1/ru active
- 1994-11-03 BR BR9407946A patent/BR9407946A/pt not_active Application Discontinuation
- 1994-11-03 JP JP51317095A patent/JP3712209B2/ja not_active Expired - Lifetime
- 1994-11-03 US US08/356,224 patent/US5856346A/en not_active Expired - Lifetime
- 1994-11-03 CA CA002174969A patent/CA2174969C/en not_active Expired - Lifetime
- 1994-11-03 CZ CZ961273A patent/CZ285691B6/cs not_active IP Right Cessation
- 1994-11-03 PL PL94314128A patent/PL185099B1/pl unknown
- 1994-11-03 AT AT95900347T patent/ATE194330T1/de active
- 1994-11-03 WO PCT/SE1994/001031 patent/WO1995012578A1/en not_active Ceased
- 1994-11-03 EE EE9600051A patent/EE03230B1/xx unknown
- 1994-11-03 KR KR1019960702346A patent/KR100331663B1/ko not_active Expired - Lifetime
- 1994-11-03 CN CN94194500A patent/CN1049428C/zh not_active Expired - Lifetime
- 1994-11-03 DE DE69425152T patent/DE69425152T2/de not_active Expired - Lifetime
- 1994-11-03 HU HU9601187A patent/HU215591B/hu unknown
- 1994-11-03 NZ NZ275915A patent/NZ275915A/en not_active IP Right Cessation
- 1994-11-03 EP EP95900347A patent/EP0726894B1/en not_active Expired - Lifetime
- 1994-11-03 AU AU81196/94A patent/AU685532B2/en not_active Expired
- 1994-11-03 UA UA96041753A patent/UA45959C2/uk unknown
- 1994-11-03 DK DK95900347T patent/DK0726894T3/da active
- 1994-11-03 PT PT95900347T patent/PT726894E/pt unknown
- 1994-11-03 SK SK559-96A patent/SK281467B6/sk not_active IP Right Cessation
- 1994-11-04 MY MYPI94002934A patent/MY111770A/en unknown
-
1996
- 1996-05-02 NO NO961776A patent/NO305656B1/no not_active IP Right Cessation
- 1996-05-06 FI FI961914A patent/FI110429B/fi not_active IP Right Cessation
-
2000
- 2000-09-21 GR GR20000402158T patent/GR3034469T3/el unknown
-
2012
- 2012-09-18 FR FR12C0053C patent/FR12C0053I2/fr active Active
-
2013
- 2013-06-10 LU LU92209C patent/LU92209I2/fr unknown
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