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DK0770059T3 - Substituerede benzamidiner, deres fremstilling og deres anvendelse som lægemidler - Google Patents

Substituerede benzamidiner, deres fremstilling og deres anvendelse som lægemidler

Info

Publication number
DK0770059T3
DK0770059T3 DK95921824T DK95921824T DK0770059T3 DK 0770059 T3 DK0770059 T3 DK 0770059T3 DK 95921824 T DK95921824 T DK 95921824T DK 95921824 T DK95921824 T DK 95921824T DK 0770059 T3 DK0770059 T3 DK 0770059T3
Authority
DK
Denmark
Prior art keywords
drugs
preparation
substituted benzamidines
benzamidines
substituted
Prior art date
Application number
DK95921824T
Other languages
English (en)
Inventor
Ernst-Otto Renth
Ralf Anderskewitz
Gner Armin F
Christopher Meade
Kurt Schromm
Franz Birke
Hubert Heuer
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0770059T3 publication Critical patent/DK0770059T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK95921824T 1994-07-13 1995-06-03 Substituerede benzamidiner, deres fremstilling og deres anvendelse som lægemidler DK0770059T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4424713A DE4424713A1 (de) 1994-07-13 1994-07-13 Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
PCT/EP1995/002112 WO1996002497A1 (de) 1994-07-13 1995-06-03 Substituierte benzamidine, ihre herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK0770059T3 true DK0770059T3 (da) 1999-10-18

Family

ID=6523047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95921824T DK0770059T3 (da) 1994-07-13 1995-06-03 Substituerede benzamidiner, deres fremstilling og deres anvendelse som lægemidler

Country Status (36)

Country Link
US (1) US5731332A (da)
EP (1) EP0770059B1 (da)
JP (1) JP2931410B2 (da)
KR (1) KR100421580B1 (da)
CN (1) CN1083830C (da)
AT (1) ATE178590T1 (da)
AU (1) AU700585B2 (da)
BG (1) BG62090B1 (da)
BR (1) BR9508374A (da)
CA (1) CA2194885C (da)
CO (1) CO4410184A1 (da)
CZ (1) CZ289376B6 (da)
DE (2) DE4424713A1 (da)
DK (1) DK0770059T3 (da)
EE (1) EE03311B1 (da)
ES (1) ES2131830T3 (da)
FI (1) FI970094A0 (da)
GR (1) GR3030043T3 (da)
HR (1) HRP950365B1 (da)
HU (1) HU224823B1 (da)
IL (1) IL114571A (da)
MX (1) MX9700273A (da)
MY (1) MY117090A (da)
NO (1) NO307373B1 (da)
NZ (1) NZ287883A (da)
PE (1) PE32496A1 (da)
PL (1) PL179595B1 (da)
RO (1) RO118653B1 (da)
RU (1) RU2159228C2 (da)
SA (1) SA95160355B1 (da)
SK (1) SK281744B6 (da)
TW (1) TW555738B (da)
UA (1) UA45351C2 (da)
WO (1) WO1996002497A1 (da)
YU (1) YU48934B (da)
ZA (1) ZA955780B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486181B1 (en) 1992-08-28 2002-11-26 City Of Hope Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
US6191169B1 (en) 1992-08-28 2001-02-20 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
DK0813525T3 (da) * 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
EP0743064A1 (en) * 1995-05-17 1996-11-20 Eli Lilly And Company Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19718334A1 (de) 1997-04-30 1998-11-05 Boehringer Ingelheim Pharma Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
TW513402B (en) * 1997-05-30 2002-12-11 Daiichi Seiyaku Co Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives
US6046224A (en) * 1997-10-15 2000-04-04 City Of Hope 12 (S)--hete receptor blockers
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
DE19834713A1 (de) * 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6291531B1 (en) * 1999-10-07 2001-09-18 Boehringer Ingelheim Pharma Kg LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
DE10000907A1 (de) * 2000-01-12 2001-07-19 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aryl-iminomethyl-carbaminsäureestern
US6417382B2 (en) 2000-01-12 2002-07-09 Boehringer Ingelheim Pharma Kg Process for preparing aryl-iminomethyl-carbamino acid esters
US6528491B2 (en) * 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
JP2004523512A (ja) * 2001-01-16 2004-08-05 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト ムチン遺伝子の増大された発現により生じる疾患の治療及び／又は予防のためのｌｔｂ４アンタゴニストの使用
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
AU2002333235B2 (en) * 2001-07-14 2007-07-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical formulation containing an LTB4 antagonist
US20040006092A1 (en) * 2001-08-31 2004-01-08 Neurochem, Inc. Amidine derivatives for treating amyloidosis
RS20050390A (sr) * 2002-11-26 2008-04-04 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Farmaceutska kompozicija koja obuhvata ltb4 antagonist i koks-2 inhibitor ili kombinovani koks1/2 inhibitor
DE10350528A1 (de) * 2003-10-29 2005-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittelformulierung, enthaltend einen LTB4-Antagonisten, sowie Verfahren zu deren Herstellung und deren Verwendung
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
JP4773456B2 (ja) * 2004-11-23 2011-09-14 ドン ファ ファーマシューティカル カンパニー リミテッド 生体利用率を向上させた経口用製剤
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
AU2018266393A1 (en) 2017-05-12 2019-12-19 Riken Class A GPCR-binding compound modifier

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550192B1 (fr) * 1983-08-03 1986-04-04 Sanofi Sa Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
ES2075672T3 (es) * 1991-06-11 1995-10-01 Ciba Geigy Ag Amidinocompuestos, su fabricacion y uso como medicamento.
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
AU673343B2 (en) * 1992-02-05 1996-11-07 Boehringer Ingelheim International Gmbh Novel amidine derivatives, their preparation and their use as mediaments with LTB4 antagonistic effect
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives

Also Published As

Publication number Publication date
JP2931410B2 (ja) 1999-08-09
HK1011966A1 (en) 1999-07-23
ZA955780B (en) 1996-01-15
HRP950365B1 (en) 2000-04-30
ES2131830T3 (es) 1999-08-01
HRP950365A2 (en) 1997-08-31
SA95160355B1 (ar) 2005-06-13
PL179595B1 (pl) 2000-09-29
TW555738B (en) 2003-10-01
NO970122D0 (no) 1997-01-10
SK1997A3 (en) 1997-08-06
HU9700059D0 (en) 1997-02-28
WO1996002497A1 (de) 1996-02-01
CA2194885A1 (en) 1996-02-01
EP0770059B1 (de) 1999-04-07
YU48934B (sh) 2002-12-10
DE59505600D1 (de) 1999-05-12
BG62090B1 (bg) 1999-02-26
MY117090A (en) 2004-05-31
PE32496A1 (es) 1996-08-12
IL114571A (en) 2003-09-17
KR970704675A (ko) 1997-09-06
NZ287883A (en) 1999-02-25
HUT77220A (hu) 1998-03-02
SK281744B6 (sk) 2001-07-10
RO118653B1 (ro) 2003-08-29
NO307373B1 (no) 2000-03-27
FI970094A7 (fi) 1997-01-10
BR9508374A (pt) 1998-05-26
CZ6697A3 (cs) 1998-02-18
HU224823B1 (en) 2006-02-28
GR3030043T3 (en) 1999-07-30
KR100421580B1 (ko) 2004-07-31
JPH10502645A (ja) 1998-03-10
EE03311B1 (et) 2000-12-15
IL114571A0 (en) 1995-11-27
CO4410184A1 (es) 1997-01-09
ATE178590T1 (de) 1999-04-15
NO970122L (no) 1997-01-10
BG101105A (bg) 1998-04-30
CN1083830C (zh) 2002-05-01
CN1152304A (zh) 1997-06-18
MX9700273A (es) 1997-05-31
DE4424713A1 (de) 1996-01-18
RU2159228C2 (ru) 2000-11-20
AU2674295A (en) 1996-02-16
CA2194885C (en) 2006-04-25
EP0770059A1 (de) 1997-05-02
YU45295A (sh) 1997-12-05
FI970094L (fi) 1997-01-10
AU700585B2 (en) 1999-01-07
UA45351C2 (uk) 2002-04-15
PL318115A1 (en) 1997-05-12
US5731332A (en) 1998-03-24
CZ289376B6 (cs) 2002-01-16
FI970094A0 (fi) 1997-01-10

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