BR9508374A - Benzamidinas substituídas sua preparação e aplicação como medicamento - Google Patents

Benzamidinas substituídas sua preparação e aplicação como medicamento

Info

Publication number: BR9508374A
Authority: BR; Brazil
Prior art keywords: methyl; imino; amine; pct; phenoxymethyl
Prior art date: 1994-07-13

Application number

BR9508374A

Other languages

English (en)

Inventor

Hubert Heuer

Ralf Anderskewitz

Christopher Meade

Kurt Schromm

Ernst-Otto Renth

Franz Birke

Armin Fuegner

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-13

Filing date

1995-06-03

Publication date

1998-05-26

1995-06-03 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1998-05-26 Publication of BR9508374A publication Critical patent/BR9508374A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

BR9508374A 1994-07-13 1995-06-03 Benzamidinas substituídas sua preparação e aplicação como medicamento BR9508374A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4424713A DE4424713A1 (de)	1994-07-13	1994-07-13	Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
PCT/EP1995/002112 WO1996002497A1 (de)	1994-07-13	1995-06-03	Substituierte benzamidine, ihre herstellung und verwendung als arzneimittel

Publications (1)

Publication Number	Publication Date
BR9508374A true BR9508374A (pt)	1998-05-26

Family

ID=6523047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9508374A BR9508374A (pt)	1994-07-13	1995-06-03	Benzamidinas substituídas sua preparação e aplicação como medicamento

Country Status (36)

Country	Link
US (1)	US5731332A (pt)
EP (1)	EP0770059B1 (pt)
JP (1)	JP2931410B2 (pt)
KR (1)	KR100421580B1 (pt)
CN (1)	CN1083830C (pt)
AT (1)	ATE178590T1 (pt)
AU (1)	AU700585B2 (pt)
BG (1)	BG62090B1 (pt)
BR (1)	BR9508374A (pt)
CA (1)	CA2194885C (pt)
CO (1)	CO4410184A1 (pt)
CZ (1)	CZ289376B6 (pt)
DE (2)	DE4424713A1 (pt)
DK (1)	DK0770059T3 (pt)
EE (1)	EE03311B1 (pt)
ES (1)	ES2131830T3 (pt)
FI (1)	FI970094A0 (pt)
GR (1)	GR3030043T3 (pt)
HR (1)	HRP950365B1 (pt)
HU (1)	HU224823B1 (pt)
IL (1)	IL114571A (pt)
MX (1)	MX9700273A (pt)
MY (1)	MY117090A (pt)
NO (1)	NO307373B1 (pt)
NZ (1)	NZ287883A (pt)
PE (1)	PE32496A1 (pt)
PL (1)	PL179595B1 (pt)
RO (1)	RO118653B1 (pt)
RU (1)	RU2159228C2 (pt)
SA (1)	SA95160355B1 (pt)
SK (1)	SK281744B6 (pt)
TW (1)	TW555738B (pt)
UA (1)	UA45351C2 (pt)
WO (1)	WO1996002497A1 (pt)
YU (1)	YU48934B (pt)
ZA (1)	ZA955780B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6486181B1 (en)	1992-08-28	2002-11-26	City Of Hope	Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
US6191169B1 (en)	1992-08-28	2001-02-20	City Of Hope	Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
DK0813525T3 (da) *	1995-03-10	2004-02-16	Berlex Lab	Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
EP0743064A1 (en) *	1995-05-17	1996-11-20	Eli Lilly And Company	Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
DE19636689A1 (de) *	1996-09-10	1998-03-12	Boehringer Ingelheim Kg	Neue Benzamidinderivate
DE19718334A1 (de)	1997-04-30	1998-11-05	Boehringer Ingelheim Pharma	Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
TW513402B (en) *	1997-05-30	2002-12-11	Daiichi Seiyaku Co	Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives
US6046224A (en) *	1997-10-15	2000-04-04	City Of Hope	12 (S)--hete receptor blockers
ID24720A (id)	1997-12-12	2000-08-03	Novartis Ag	Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
DE19834713A1 (de) *	1998-07-31	2000-02-03	Boehringer Ingelheim Pharma	Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6291531B1 (en) *	1999-10-07	2001-09-18	Boehringer Ingelheim Pharma Kg	LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
DE10000907A1 (de) *	2000-01-12	2001-07-19	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Aryl-iminomethyl-carbaminsäureestern
US6417382B2 (en)	2000-01-12	2002-07-09	Boehringer Ingelheim Pharma Kg	Process for preparing aryl-iminomethyl-carbamino acid esters
US6528491B2 (en) *	2000-10-24	2003-03-04	Boehringer Ingelheim Pharma Kg	Pyranoside derivatives
JP2004523512A (ja) *	2001-01-16	2004-08-05	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	ムチン遺伝子の増大された発現により生じる疾患の治療及び／又は予防のためのｌｔｂ４アンタゴニストの使用
US20030119901A1 (en) *	2001-07-14	2003-06-26	Boehringer Ingelheim Pharma Kg	Pharmaceutical formulation containing an LTB4 antagonist
AU2002333235B2 (en) *	2001-07-14	2007-07-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical formulation containing an LTB4 antagonist
US20040006092A1 (en) *	2001-08-31	2004-01-08	Neurochem, Inc.	Amidine derivatives for treating amyloidosis
RS20050390A (sr) *	2002-11-26	2008-04-04	Boehringer Ingelheim Pharma Gmbh. & Co.Kg.,	Farmaceutska kompozicija koja obuhvata ltb4 antagonist i koks-2 inhibitor ili kombinovani koks1/2 inhibitor
DE10350528A1 (de) *	2003-10-29	2005-06-09	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Arzneimittelformulierung, enthaltend einen LTB4-Antagonisten, sowie Verfahren zu deren Herstellung und deren Verwendung
US7262223B2 (en) *	2004-01-23	2007-08-28	Neurochem (International) Limited	Amidine derivatives for treating amyloidosis
JP4773456B2 (ja) *	2004-11-23	2011-09-14	ドンファファーマシューティカルカンパニーリミテッド	生体利用率を向上させた経口用製剤
CN103012200B (zh) *	2011-09-20	2014-12-17	北京大学	具有β-分泌酶抑制功能的化合物及其制备方法与应用
AU2018266393A1 (en)	2017-05-12	2019-12-19	Riken	Class A GPCR-binding compound modifier

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2550192B1 (fr) *	1983-08-03	1986-04-04	Sanofi Sa	Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
ES2075672T3 (es) *	1991-06-11	1995-10-01	Ciba Geigy Ag	Amidinocompuestos, su fabricacion y uso como medicamento.
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
AU673343B2 (en) *	1992-02-05	1996-11-07	Boehringer Ingelheim International Gmbh	Novel amidine derivatives, their preparation and their use as mediaments with LTB4 antagonistic effect
US5455274A (en) *	1992-12-09	1995-10-03	Ciba-Geigy Corporation	Hydroxyamidine derivatives

1994
- 1994-07-13 DE DE4424713A patent/DE4424713A1/de not_active Withdrawn
1995
- 1995-06-03 UA UA97020598A patent/UA45351C2/uk unknown
- 1995-06-03 SK SK19-97A patent/SK281744B6/sk not_active IP Right Cessation
- 1995-06-03 HU HU9700059A patent/HU224823B1/hu not_active IP Right Cessation
- 1995-06-03 KR KR1019970700124A patent/KR100421580B1/ko not_active Expired - Fee Related
- 1995-06-03 ES ES95921824T patent/ES2131830T3/es not_active Expired - Lifetime
- 1995-06-03 AT AT95921824T patent/ATE178590T1/de active
- 1995-06-03 US US08/765,692 patent/US5731332A/en not_active Expired - Lifetime
- 1995-06-03 WO PCT/EP1995/002112 patent/WO1996002497A1/de not_active Ceased
- 1995-06-03 AU AU26742/95A patent/AU700585B2/en not_active Ceased
- 1995-06-03 RO RO97-00018A patent/RO118653B1/ro unknown
- 1995-06-03 DK DK95921824T patent/DK0770059T3/da active
- 1995-06-03 MX MX9700273A patent/MX9700273A/es not_active IP Right Cessation
- 1995-06-03 BR BR9508374A patent/BR9508374A/pt not_active IP Right Cessation
- 1995-06-03 JP JP8504618A patent/JP2931410B2/ja not_active Expired - Lifetime
- 1995-06-03 DE DE59505600T patent/DE59505600D1/de not_active Expired - Lifetime
- 1995-06-03 RU RU97102043/04A patent/RU2159228C2/ru not_active IP Right Cessation
- 1995-06-03 CZ CZ199766A patent/CZ289376B6/cs not_active IP Right Cessation
- 1995-06-03 CN CN95194048A patent/CN1083830C/zh not_active Expired - Fee Related
- 1995-06-03 EP EP95921824A patent/EP0770059B1/de not_active Expired - Lifetime
- 1995-06-03 CA CA002194885A patent/CA2194885C/en not_active Expired - Fee Related
- 1995-06-03 NZ NZ287883A patent/NZ287883A/xx not_active IP Right Cessation
- 1995-06-03 EE EE9700066A patent/EE03311B1/xx not_active IP Right Cessation
- 1995-06-03 FI FI970094A patent/FI970094A0/fi not_active Application Discontinuation
- 1995-06-03 PL PL95318115A patent/PL179595B1/pl not_active IP Right Cessation
- 1995-06-28 HR HRP4424713.3A patent/HRP950365B1/xx not_active IP Right Cessation
- 1995-07-04 TW TW084106873A patent/TW555738B/zh active
- 1995-07-06 YU YU45295A patent/YU48934B/sh unknown
- 1995-07-11 PE PE1995273519A patent/PE32496A1/es not_active Application Discontinuation
- 1995-07-12 CO CO95030618A patent/CO4410184A1/es unknown
- 1995-07-12 ZA ZA955780A patent/ZA955780B/xx unknown
- 1995-07-12 IL IL11457195A patent/IL114571A/xx not_active IP Right Cessation
- 1995-07-13 MY MYPI95001982A patent/MY117090A/en unknown
- 1995-11-01 SA SA95160355A patent/SA95160355B1/ar unknown
1997
- 1997-01-04 BG BG101105A patent/BG62090B1/bg unknown
- 1997-01-10 NO NO970122A patent/NO307373B1/no unknown
1999
- 1999-04-23 GR GR990401120T patent/GR3030043T3/el unknown

Also Published As

Publication number	Publication date
JP2931410B2 (ja)	1999-08-09
HK1011966A1 (en)	1999-07-23
ZA955780B (en)	1996-01-15
HRP950365B1 (en)	2000-04-30
ES2131830T3 (es)	1999-08-01
HRP950365A2 (en)	1997-08-31
SA95160355B1 (ar)	2005-06-13
PL179595B1 (pl)	2000-09-29
TW555738B (en)	2003-10-01
NO970122D0 (no)	1997-01-10
DK0770059T3 (da)	1999-10-18
SK1997A3 (en)	1997-08-06
HU9700059D0 (en)	1997-02-28
WO1996002497A1 (de)	1996-02-01
CA2194885A1 (en)	1996-02-01
EP0770059B1 (de)	1999-04-07
YU48934B (sh)	2002-12-10
DE59505600D1 (de)	1999-05-12
BG62090B1 (bg)	1999-02-26
MY117090A (en)	2004-05-31
PE32496A1 (es)	1996-08-12
IL114571A (en)	2003-09-17
KR970704675A (ko)	1997-09-06
NZ287883A (en)	1999-02-25
HUT77220A (hu)	1998-03-02
SK281744B6 (sk)	2001-07-10
RO118653B1 (ro)	2003-08-29
NO307373B1 (no)	2000-03-27
FI970094A7 (fi)	1997-01-10
CZ6697A3 (cs)	1998-02-18
HU224823B1 (en)	2006-02-28
GR3030043T3 (en)	1999-07-30
KR100421580B1 (ko)	2004-07-31
JPH10502645A (ja)	1998-03-10
EE03311B1 (et)	2000-12-15
IL114571A0 (en)	1995-11-27
CO4410184A1 (es)	1997-01-09
ATE178590T1 (de)	1999-04-15
NO970122L (no)	1997-01-10
BG101105A (bg)	1998-04-30
CN1083830C (zh)	2002-05-01
CN1152304A (zh)	1997-06-18
MX9700273A (es)	1997-05-31
DE4424713A1 (de)	1996-01-18
RU2159228C2 (ru)	2000-11-20
AU2674295A (en)	1996-02-16
CA2194885C (en)	2006-04-25
EP0770059A1 (de)	1997-05-02
YU45295A (sh)	1997-12-05
FI970094L (fi)	1997-01-10
AU700585B2 (en)	1999-01-07
UA45351C2 (uk)	2002-04-15
PL318115A1 (en)	1997-05-12
US5731332A (en)	1998-03-24
CZ289376B6 (cs)	2002-01-16
FI970094A0 (fi)	1997-01-10

Publication	Publication Date	Title
BR9508374A (pt)	1998-05-26	Benzamidinas substituídas sua preparação e aplicação como medicamento
DE69130830D1 (de)	1999-03-11	Insektizide, akarizide und fungizide aminopyrimidine
PT799209E (pt)	2003-12-31	Novas sulfonamidas
NZ507144A (en)	2002-10-25	Benzamide derivatives useful for the treatment of diseases mediated by cytokines
DE69512763D1 (de)	1999-11-18	Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung
DK0790824T3 (da)	2002-05-27	2,2-dichloralkancarboxylsyrer, fremgangsmåde til fremstilling deraf, lægemidler indeholdende disse og anvendelse af disse lægemidler til behandling af insulinresistens
ATE179698T1 (de)	1999-05-15	Pyrrolidin- und oxazolidin derivate , ihre herstellung und ihre verwendung als thrombocyten- aggregations-hemmer
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