DK0577847T3 - Morphinanderivat og medicinsk anvendelse deraf - Google Patents
Morphinanderivat og medicinsk anvendelse derafInfo
- Publication number
- DK0577847T3 DK0577847T3 DK93902520T DK93902520T DK0577847T3 DK 0577847 T3 DK0577847 T3 DK 0577847T3 DK 93902520 T DK93902520 T DK 93902520T DK 93902520 T DK93902520 T DK 93902520T DK 0577847 T3 DK0577847 T3 DK 0577847T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical use
- nch3
- morphine derivative
- xso2
- alkylene
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (fr) | 1992-01-23 | 1993-01-22 | Derive de morphinane et utilisation en medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0577847T3 true DK0577847T3 (da) | 1999-06-23 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93902520T DK0577847T3 (da) | 1992-01-23 | 1993-01-22 | Morphinanderivat og medicinsk anvendelse deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (fr) |
| EP (2) | EP0846694A1 (fr) |
| JP (1) | JP2525552B2 (fr) |
| KR (1) | KR970011390B1 (fr) |
| AT (1) | ATE172201T1 (fr) |
| AU (2) | AU666702B2 (fr) |
| CA (1) | CA2105072C (fr) |
| DE (1) | DE69321525T2 (fr) |
| DK (1) | DK0577847T3 (fr) |
| ES (1) | ES2121988T3 (fr) |
| FI (1) | FI106126B (fr) |
| NO (1) | NO302755B1 (fr) |
| NZ (1) | NZ246687A (fr) |
| TW (1) | TW332814B (fr) |
| WO (1) | WO1993015081A1 (fr) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69321525T2 (de) | 1992-01-23 | 1999-03-04 | Toray Industries, Inc., Tokio/Tokyo | Morphinan-derivate und medizinische verwendung |
| EP0657163B1 (fr) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussif |
| WO1995003307A1 (fr) * | 1993-07-19 | 1995-02-02 | Toray Industries, Inc. | Agent de protection de cellules cerebrales |
| CA2143864C (fr) * | 1993-07-23 | 2006-01-24 | Hiroshi Nagase | Derives de la morphine et leurs utilisations pharmaceutiques |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602963A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (fr) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Dérivés de l'acide morphinane hydroxamique |
| ATE359076T1 (de) * | 1996-11-25 | 2007-05-15 | Toray Industries | Mittel gegen juckreiz |
| DE69838662T2 (de) | 1997-03-27 | 2008-08-28 | Toray Industries, Inc. | Morphinanderivate und ihre medizinische Anwendung |
| DE69824277T2 (de) * | 1997-07-11 | 2004-09-23 | Toray Industries, Inc. | Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| IL132363A (en) * | 1997-07-14 | 2004-02-19 | Adolor Corp | Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them |
| AU6117298A (en) * | 1997-07-25 | 1999-02-16 | Toray Industries, Inc. | Hyponatremia remedies |
| JP4359711B2 (ja) * | 1997-09-02 | 2009-11-04 | 東レ株式会社 | 薬物依存症治療薬 |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| CN1204139C (zh) | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
| JP2003515375A (ja) * | 1999-12-03 | 2003-05-07 | イオウリ マロヴ， | 拡散スペクトル技術による現場試験 |
| WO2001074819A1 (fr) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
| DE60231388D1 (de) * | 2001-03-30 | 2009-04-16 | Toray Industries | Mittel zur behandlung des syndroms der unruhigen beine |
| WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| EP1506174B1 (fr) | 2002-05-17 | 2015-09-30 | Taiwanj Pharmaceuticals Co., Ltd. | Utilisation de la naltrexone pour le traitement de lésions hépatiques et rénales |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| NZ539199A (en) * | 2002-10-09 | 2008-09-26 | Toray Industries | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group |
| US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP1628664A4 (fr) * | 2003-06-04 | 2008-11-05 | Alkermes Inc | Formes polymorphes de naltrexone |
| AU2005249508A1 (en) * | 2004-05-28 | 2005-12-15 | Human Biomolecular Research Institute | Synthesis of metabolically stable analgesics, pain medications and other agents |
| TW200621785A (en) * | 2004-11-04 | 2006-07-01 | Toray Industries | Analgesic |
| EP1873158B1 (fr) * | 2005-04-06 | 2016-04-06 | Toray Industries, Inc. | Cristaux d'un derive de morphinane et procede de fabrication de ces cristaux |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| AU2007240680B2 (en) | 2006-04-21 | 2013-05-02 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
| CA2685126C (fr) | 2007-04-24 | 2015-04-14 | Toray Industries, Inc. | Agent therapeutique ou prophylactique de la dyskinesie |
| ATE550023T1 (de) | 2007-04-26 | 2012-04-15 | Toray Industries | Stabile feste zubereitung mit 4,5- epoxymorphinanderivat |
| EP2168580B1 (fr) * | 2007-06-22 | 2015-12-02 | Toray Industries, Inc. | Traitement ou prevention de la schizophrénie |
| KR101173509B1 (ko) | 2007-10-05 | 2012-08-14 | 도레이 카부시키가이샤 | 모르피난 유도체 또는 그 약리학적으로 허용되는 산부가염을 유효 성분으로 하는 피부 성상 개선 치료약 |
| AU2009214500B2 (en) * | 2008-02-14 | 2014-10-23 | Alkermes, Inc. | Selective opioid compounds |
| WO2010006299A1 (fr) * | 2008-07-11 | 2010-01-14 | Regents Of The University Of Minnesota | Agents analgésiques |
| JP5648480B2 (ja) | 2008-10-24 | 2015-01-07 | 東レ株式会社 | ４，５−エポキシモルヒナン誘導体を含有する安定な錠剤 |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| JP2012518651A (ja) * | 2009-02-23 | 2012-08-16 | マリンクロッド インコーポレイテッド | （＋）−モルフィナニウムｎ−オキシドおよびそれらの生成方法 |
| US8436174B2 (en) * | 2009-02-23 | 2013-05-07 | Mallinckrodt Llc | (+)-morphinanium quaternary salts and processes for their production |
| EP2398807A1 (fr) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | Dérivés de (+)-6-hydroxy-morphinane ou de (+)-6-amino-morphinane |
| CN102803267A (zh) * | 2009-06-11 | 2012-11-28 | 马林克罗特有限公司 | 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备 |
| ES2465066T3 (es) * | 2009-06-11 | 2014-06-05 | Mallinckrodt Llc | Aminación reductora de 6-ceto-normorfinanos por transferencia de hidrógeno catalítica |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| CA2787323C (fr) | 2010-01-29 | 2017-08-29 | Toray Industries, Inc. | Agent therapeutique ou prophylactique pour les maladies du tractus biliaire |
| EP2580218B1 (fr) | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Traitement de n-désalkylation d'amines tertiaires |
| ES2666404T3 (es) | 2010-06-11 | 2018-05-04 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| US20130289060A1 (en) * | 2010-10-19 | 2013-10-31 | Memorial Sloan-Kettering Cancer Center | 6-AMIDO DERIVATIVES OF 4, 5-a EPOXYMORPHINANS FOR THE TREATMENT OF PAIN |
| CA2825165C (fr) | 2011-01-31 | 2018-07-03 | Toray Industries, Inc. | Agent therapeutique ou prophylactique pour la cachexie |
| KR20140036215A (ko) | 2011-06-09 | 2014-03-25 | 말린크로트 엘엘씨 | 촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화 |
| CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
| CA2882132C (fr) | 2012-08-16 | 2021-07-06 | The Scripps Research Institute | Ligands d'opioides kappa |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| US9969746B2 (en) | 2013-12-05 | 2018-05-15 | The University Of Bath | Opioid compounds and their uses |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (fr) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | Dérivé de morphinane et son usage médical |
| EP3291676B1 (fr) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
| JP6885560B2 (ja) | 2015-10-29 | 2021-06-16 | 国立大学法人 筑波大学 | モルヒナン誘導体及びその医薬用途 |
| US11529340B2 (en) | 2016-03-22 | 2022-12-20 | Regents Of The University Of Minnesota | Combination for treating pain |
| EP3458061B1 (fr) * | 2016-05-19 | 2023-01-18 | Virginia Commonwealth University | Modulateurs puissants et sélectifs des récepteurs opioïdes mu |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| WO2019168985A1 (fr) * | 2018-02-27 | 2019-09-06 | Delpor, Inc. | Compositions pour composés agents thérapeutiques à petites molécules |
| AU2019229892B2 (en) | 2018-03-08 | 2025-01-30 | University Of Kansas | Treatment of demyelinating diseases |
| CN113614089B (zh) * | 2019-03-29 | 2024-08-20 | 人福医药美国公司 | 可用于治疗医学病症的新型吗啡喃 |
| US11613547B2 (en) * | 2019-07-08 | 2023-03-28 | University Of Health Sciences & Pharmacy In St. Louis | G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment |
| US20230087342A1 (en) | 2019-09-30 | 2023-03-23 | Nippon Chemiphar Co., Ltd. | Azepane derivative |
| TW202128165A (zh) | 2019-10-24 | 2021-08-01 | 日商東麗股份有限公司 | 惡病質之治療劑或預防劑 |
| EP4173624A4 (fr) | 2020-06-30 | 2024-08-14 | Toray Industries, Inc. | Agent d'amélioration ou agent prophylactique pour symptôme de faiblesse musculaire dans une maladie ou un syndrome associé à un trouble métabolique |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| WO2022225045A1 (fr) | 2021-04-23 | 2022-10-27 | 東レ株式会社 | Agent thérapeutique ou prophylactique pour la cachexie associée à une résistance à la ghréline |
| MX2023014819A (es) | 2021-06-14 | 2024-03-21 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer. |
| CN115960108A (zh) * | 2021-10-09 | 2023-04-14 | 山东新时代药业有限公司 | 一种无定型盐酸纳呋拉啡及其制备方法 |
| WO2023190665A1 (fr) * | 2022-03-29 | 2023-10-05 | 東レ株式会社 | Dérivé de morphinane et son utilisation médicale |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL290054A (fr) * | ||||
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) * | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| US4362870A (en) | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) * | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (fr) * | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH01149788A (ja) * | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| FR2636330B1 (fr) * | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| US5219861A (en) * | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| EP0374919A1 (fr) * | 1988-12-21 | 1990-06-27 | Chugai Seiyaku Kabushiki Kaisha | Dérivé de morphine |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| DE69321525T2 (de) * | 1992-01-23 | 1999-03-04 | Toray Industries, Inc., Tokio/Tokyo | Morphinan-derivate und medizinische verwendung |
| EP0657163B1 (fr) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussif |
-
1993
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 EP EP98100805A patent/EP0846694A1/fr not_active Withdrawn
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/fr not_active Ceased
- 1993-01-22 CA CA002105072A patent/CA2105072C/fr not_active Expired - Lifetime
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 EP EP93902520A patent/EP0577847B1/fr not_active Expired - Lifetime
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2525552B2 (ja) | 1996-08-21 |
| US6323212B1 (en) | 2001-11-27 |
| EP0577847A1 (fr) | 1994-01-12 |
| FI106126B (fi) | 2000-11-30 |
| EP0846694A1 (fr) | 1998-06-10 |
| CA2105072C (fr) | 1998-07-28 |
| EP0577847B1 (fr) | 1998-10-14 |
| KR970011390B1 (ko) | 1997-07-10 |
| AU4067195A (en) | 1996-03-07 |
| DE69321525T2 (de) | 1999-03-04 |
| FI934144A0 (fi) | 1993-09-22 |
| JPH08502275A (ja) | 1996-03-12 |
| AU686483B2 (en) | 1998-02-05 |
| AU3367193A (en) | 1993-09-01 |
| ES2121988T3 (es) | 1998-12-16 |
| US6277859B1 (en) | 2001-08-21 |
| NO302755B1 (no) | 1998-04-20 |
| NO933376D0 (no) | 1993-09-22 |
| FI934144L (fi) | 1993-09-22 |
| CA2105072A1 (fr) | 1993-07-24 |
| EP0577847A4 (fr) | 1994-12-07 |
| DE69321525D1 (de) | 1998-11-19 |
| TW332814B (en) | 1998-06-01 |
| NZ246687A (en) | 1996-12-20 |
| WO1993015081A1 (fr) | 1993-08-05 |
| NO933376L (no) | 1993-09-23 |
| ATE172201T1 (de) | 1998-10-15 |
| AU666702B2 (en) | 1996-02-22 |
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