FI934144L - Morfinanderivat och medicinsk anvaendning - Google Patents
Morfinanderivat och medicinsk anvaendning Download PDFInfo
- Publication number
- FI934144L FI934144L FI934144A FI934144A FI934144L FI 934144 L FI934144 L FI 934144L FI 934144 A FI934144 A FI 934144A FI 934144 A FI934144 A FI 934144A FI 934144 L FI934144 L FI 934144L
- Authority
- FI
- Finland
- Prior art keywords
- morfinanderivat
- medicinsk
- anvaendning
- och
- och medicinsk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (en) | 1992-01-23 | 1993-01-22 | Morphinan derivative and medicinal use |
| JP9300080 | 1993-01-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI934144A0 FI934144A0 (fi) | 1993-09-22 |
| FI934144L true FI934144L (fi) | 1993-09-22 |
| FI106126B FI106126B (fi) | 2000-11-30 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI934144A FI106126B (fi) | 1992-01-23 | 1993-09-22 | Menetelmä farmaseuttisten 6-typpisubstituoitujen 4,5-epoksimorfinaanijohdannaisten valmistamiseksi |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (fi) |
| EP (2) | EP0846694A1 (fi) |
| JP (1) | JP2525552B2 (fi) |
| KR (1) | KR970011390B1 (fi) |
| AT (1) | ATE172201T1 (fi) |
| AU (2) | AU666702B2 (fi) |
| CA (1) | CA2105072C (fi) |
| DE (1) | DE69321525T2 (fi) |
| DK (1) | DK0577847T3 (fi) |
| ES (1) | ES2121988T3 (fi) |
| FI (1) | FI106126B (fi) |
| NO (1) | NO302755B1 (fi) |
| NZ (1) | NZ246687A (fi) |
| TW (1) | TW332814B (fi) |
| WO (1) | WO1993015081A1 (fi) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323212B1 (en) * | 1992-01-23 | 2001-11-27 | Toray Industries, Inc. | Morphinan derivative and its pharmaceutical applications |
| EP0657163B1 (en) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussive |
| JP3948026B2 (ja) * | 1993-07-19 | 2007-07-25 | 東レ株式会社 | 脳細胞保護剤 |
| AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602959A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (en) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
| EP1310251A1 (en) * | 1996-11-25 | 2003-05-14 | Toray Industries, Inc. | Antipruritic agent |
| ES2297882T3 (es) | 1997-03-27 | 2008-05-01 | Toray Industries, Inc. | Derivados de morfinano y usos medicos de los mismos. |
| ES2217563T3 (es) * | 1997-07-11 | 2004-11-01 | Toray Industries, Inc. | Compuestos medicinales estables que contienen derivados de 4,5-epoximorfinado. |
| CA2288828A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| WO1999005146A1 (en) * | 1997-07-25 | 1999-02-04 | Toray Industries, Inc. | Hyponatremia remedies |
| US6583151B2 (en) | 1997-09-02 | 2003-06-24 | Toray Industries, Inc. | Remedies for drug addiction |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| WO2001014383A1 (en) * | 1999-08-24 | 2001-03-01 | Toray Industries, Inc. | Remedies for neuropathic pain and model animals of neuropathic pain |
| WO2001039659A1 (en) * | 1999-12-03 | 2001-06-07 | Iouri Malov | Field testing using spread spectrum technique |
| WO2001074819A1 (en) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Analgesics containing morphinan n-oxide derivatives as the active ingredient |
| JP4453254B2 (ja) | 2001-03-30 | 2010-04-21 | 東レ株式会社 | レストレス・レッグズ症候群治療薬 |
| WO2002080918A1 (en) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Remedial or prophylactic agent for frequent urination or urinary incontinence |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| WO2003097608A2 (en) | 2002-05-17 | 2003-11-27 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| NZ539199A (en) | 2002-10-09 | 2008-09-26 | Toray Industries | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7279579B2 (en) * | 2003-06-04 | 2007-10-09 | Alkermes, Inc. | Polymorphic forms of naltrexone |
| ES2623362T3 (es) * | 2004-05-28 | 2017-07-11 | Human Biomolecular Research Institute | Analgésicos metabólicamente estables y medicaciones para el dolor |
| AR053098A1 (es) * | 2004-11-04 | 2007-04-25 | Toray Industries | Analgesico derivado de morfinano |
| AU2006234257B2 (en) * | 2005-04-06 | 2011-03-10 | Toray Industries, Inc. | Crystals of morphinan derivative and process for producing the same |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| CN101466381B (zh) * | 2006-04-21 | 2012-11-14 | 尼克塔治疗公司 | 吗啡酮的立体选择性还原 |
| PL2151240T3 (pl) | 2007-04-24 | 2014-01-31 | Toray Industries | Środek terapeutyczny lub profilaktyczny przeciw dyskinezie |
| ES2381056T3 (es) | 2007-04-26 | 2012-05-22 | Toray Industries, Inc. | Preparación sólida estable que contiene un derivado de 4,5-epoximorfinano |
| ES2555785T3 (es) | 2007-06-22 | 2016-01-08 | Toray Industries, Inc. | Remedio o preventivo para esquizofrenia |
| CA2702032C (en) | 2007-10-05 | 2013-04-02 | Shinji Ona | Skin property-improving therapeutic agent comprising a morphinan derivative or any of its pharmacologically permissible acid addition salts as an active ingredient |
| JP2011512360A (ja) * | 2008-02-14 | 2011-04-21 | アルカーメス，インコーポレイテッド | 選択的オピオイド化合物 |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| MX2011004307A (es) | 2008-10-24 | 2011-07-28 | Toray Industries | Tableta estable conteniendo derivado de 4,5-epoximorfinano. |
| CN102325775A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-6-羟基-吗啡喃或(+)-6-氨基-吗啡喃衍生物 |
| EP2398806A1 (en) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-morphinanium n-oxides and processes for their production |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
| CN102459274B (zh) * | 2009-06-11 | 2015-07-15 | 马林克罗特有限公司 | 6-酮基去甲吗啡喃通过催化氢转移的还原胺化 |
| US8519133B2 (en) * | 2009-06-11 | 2013-08-27 | Mallinckrodt Llc | Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| EP2529739B1 (en) | 2010-01-29 | 2016-07-13 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
| WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| PL2593095T3 (pl) * | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| WO2012054566A2 (en) | 2010-10-19 | 2012-04-26 | Memorial Sloan-Kettering Cancer Center | 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| CN103327977B (zh) | 2011-01-31 | 2016-05-04 | 东丽株式会社 | 恶液质的治疗或预防剂 |
| CN103717601A (zh) | 2011-06-09 | 2014-04-09 | 马林克罗特有限公司 | 通过催化氢转移对6-酮基吗啡喃的还原胺化 |
| PL2753622T3 (pl) | 2011-09-08 | 2016-07-29 | SpecGx LLC | Wytwarzanie alkaloidów bez oddzielania związków pośrednich |
| DK2884978T3 (da) | 2012-08-16 | 2019-09-30 | Scripps Research Inst | Nye Kappa-opioidligander |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (ja) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | モルヒナン誘導体及びその医薬用途 |
| EP3291676B1 (en) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Mitragynine analogs and uses thereof |
| JP6885560B2 (ja) | 2015-10-29 | 2021-06-16 | 国立大学法人 筑波大学 | モルヒナン誘導体及びその医薬用途 |
| US11529340B2 (en) | 2016-03-22 | 2022-12-20 | Regents Of The University Of Minnesota | Combination for treating pain |
| US10988481B2 (en) * | 2016-05-19 | 2021-04-27 | Virginia Commonwealth University | Potent and selective mu opioid receptor modulators |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| EP3758701A1 (en) * | 2018-02-27 | 2021-01-06 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
| AU2019229892B2 (en) | 2018-03-08 | 2025-01-30 | University Of Kansas | Treatment of demyelinating diseases |
| CN113614089B (zh) * | 2019-03-29 | 2024-08-20 | 人福医药美国公司 | 可用于治疗医学病症的新型吗啡喃 |
| US11613547B2 (en) * | 2019-07-08 | 2023-03-28 | University Of Health Sciences & Pharmacy In St. Louis | G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment |
| KR20220071223A (ko) | 2019-09-30 | 2022-05-31 | 닛뽕 케미파 가부시키가이샤 | 아제판 유도체 |
| WO2021079978A1 (ja) | 2019-10-24 | 2021-04-29 | 東レ株式会社 | 悪液質の治療剤又は予防剤 |
| JP7735862B2 (ja) | 2020-06-30 | 2025-09-09 | 東レ株式会社 | 代謝異常を伴う疾患又は症候群における筋力低下症状の改善剤又は予防剤 |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| TW202308627A (zh) | 2021-04-23 | 2023-03-01 | 日商東麗股份有限公司 | 伴隨著飢餓素抗性之惡病體質的治療劑或預防劑 |
| IL309232A (en) | 2021-06-14 | 2024-02-01 | Scorpion Therapeutics Inc | Urea derivatives which can be used to treat cancer |
| CN115960108B (zh) * | 2021-10-09 | 2026-02-03 | 山东新时代药业有限公司 | 一种无定型盐酸纳呋拉啡及其制备方法 |
| JPWO2023190665A1 (fi) * | 2022-03-29 | 2023-10-05 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL290054A (fi) | ||||
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| US4362870A (en) | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) * | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (fi) * | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH01149788A (ja) * | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| FR2636330B1 (fr) | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| CA2006311A1 (en) | 1988-12-21 | 1990-06-21 | Ken Kanematsu | Morphine derivative |
| US5219861A (en) * | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US6323212B1 (en) * | 1992-01-23 | 2001-11-27 | Toray Industries, Inc. | Morphinan derivative and its pharmaceutical applications |
| EP0657163B1 (en) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussive |
-
1993
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 EP EP98100805A patent/EP0846694A1/en not_active Withdrawn
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 EP EP93902520A patent/EP0577847B1/en not_active Expired - Lifetime
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/ja not_active Ceased
- 1993-01-22 CA CA002105072A patent/CA2105072C/en not_active Expired - Lifetime
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0577847A1 (en) | 1994-01-12 |
| ATE172201T1 (de) | 1998-10-15 |
| ES2121988T3 (es) | 1998-12-16 |
| EP0577847B1 (en) | 1998-10-14 |
| TW332814B (en) | 1998-06-01 |
| EP0577847A4 (en) | 1994-12-07 |
| NO933376D0 (no) | 1993-09-22 |
| NZ246687A (en) | 1996-12-20 |
| FI106126B (fi) | 2000-11-30 |
| WO1993015081A1 (en) | 1993-08-05 |
| KR970011390B1 (ko) | 1997-07-10 |
| DE69321525D1 (de) | 1998-11-19 |
| JP2525552B2 (ja) | 1996-08-21 |
| FI934144A0 (fi) | 1993-09-22 |
| DE69321525T2 (de) | 1999-03-04 |
| JPH08502275A (ja) | 1996-03-12 |
| AU666702B2 (en) | 1996-02-22 |
| NO302755B1 (no) | 1998-04-20 |
| DK0577847T3 (da) | 1999-06-23 |
| US6323212B1 (en) | 2001-11-27 |
| CA2105072A1 (en) | 1993-07-24 |
| AU3367193A (en) | 1993-09-01 |
| EP0846694A1 (en) | 1998-06-10 |
| NO933376L (no) | 1993-09-23 |
| CA2105072C (en) | 1998-07-28 |
| US6277859B1 (en) | 2001-08-21 |
| AU686483B2 (en) | 1998-02-05 |
| AU4067195A (en) | 1996-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |