DK0439030T3 - Orale lægemiddelformer af pimobendan - Google Patents

Orale lægemiddelformer af pimobendan

Info

Publication number: DK0439030T3
Authority: DK; Denmark
Prior art keywords: pimobendan; oral drug; drug forms; variations; citric acid
Prior art date: 1990-01-20

Application number

DK91100309.3T

Other languages

English (en)

Inventor

Peter Dr Dipl-Chem Gruber

Willy Dr Dipl-Chem Roth

Gottfried Dr Schepky

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-20

Filing date

1991-01-11

Publication date

1993-08-16

1991-01-11 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1993-08-16 Application granted granted Critical

1993-08-16 Publication of DK0439030T3 publication Critical patent/DK0439030T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK91100309.3T 1990-01-20 1991-01-11 Orale lægemiddelformer af pimobendan DK0439030T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4001622A DE4001622A1 (de)	1990-01-20	1990-01-20	Orale arzneimittelformen von pimobendan

Publications (1)

Publication Number	Publication Date
DK0439030T3 true DK0439030T3 (da)	1993-08-16

Family

ID=6398467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91100309.3T DK0439030T3 (da)	1990-01-20	1991-01-11	Orale lægemiddelformer af pimobendan

Country Status (18)

Country	Link
EP (1)	EP0439030B1 (da)
JP (1)	JP2608183B2 (da)
KR (1)	KR0163056B1 (da)
AT (1)	ATE87481T1 (da)
AU (1)	AU630536B2 (da)
CA (1)	CA2034569C (da)
DE (2)	DE4001622A1 (da)
DK (1)	DK0439030T3 (da)
ES (1)	ES2054379T3 (da)
FI (1)	FI96274C (da)
HK (1)	HK175796A (da)
HU (1)	HU207948B (da)
IE (1)	IE64659B1 (da)
IL (1)	IL96995A (da)
NO (1)	NO176305C (da)
NZ (1)	NZ236834A (da)
PT (1)	PT96506B (da)
ZA (1)	ZA91372B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2753904B1 (fr) *	1996-10-01	1998-10-30	Gattefosse Ets Sa	Composition pharmaceutique a liberation modifiee de principe actif, comportant une matrice, et procede de fabrication
DE102004011512B4 (de) *	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1744750A2 (en) *	2004-05-06	2007-01-24	Sandoz AG	Pharmaceutical composition comprising hydrophobic drug having improved solubility
WO2005123040A1 (ja) *	2004-06-22	2005-12-29	Shionogi & Co., Ltd.	口腔内速崩壊錠
JP4572296B2 (ja) *	2004-07-21	2010-11-04	トーアエイヨー株式会社	ピモベンダン経口投与製剤
JP2006028130A (ja) *	2004-07-21	2006-02-02	Toa Eiyo Ltd	ピモベンダン経口投与製剤
JP4572293B2 (ja) *	2004-07-21	2010-11-04	トーアエイヨー株式会社	ピモベンダン経口投与製剤
EP1937270A1 (en) *	2005-09-21	2008-07-02	Brystol-Myers Squibb Company	Oral administration of n-(2-chloro-6-methylphenyl)-2-[[6-4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof
JP4572300B2 (ja) *	2006-01-19	2010-11-04	トーアエイヨー株式会社	ピモベンダン経口投与製剤
EP1920785A1 (en)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Liquid preparation comprising a complex of pimobendan and cyclodextrin
PE20081482A1 (es) *	2006-12-20	2008-12-23	Novartis Ag	Capsulas de gelatina que contienen un acido
FR2934156B1 (fr)	2008-07-23	2010-09-24	Virbac	Medicament appetissant a administration orale sous forme solide
WO2010055119A2 (en) *	2008-11-17	2010-05-20	Novartis Ag	Pharmaceutical composition comprising pimobendan
BRPI0921868A2 (pt)	2008-11-25	2015-12-29	Boehringer Ingelheim Vetmed	inibidores de fosfodiesterase tipo iii (pde iii) ou agentes de sensibilizacao de ca2+ para o tratamento de cardiomiopatia hipertrofica
NL1037569C2 (en)	2009-12-18	2011-06-21	Eurovet Animal Health B V	Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
WO2011081118A1 (ja) *	2009-12-29	2011-07-07	興和株式会社	経口投与用医薬組成物
JPWO2011081117A1 (ja) *	2009-12-29	2013-05-09	興和株式会社	経口投与用固形医薬組成物
ES2924478T3 (es)	2012-03-15	2022-10-07	Boehringer Ingelheim Vetmedica Gmbh	Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
HUE054186T2 (hu)	2013-07-19	2021-08-30	Boehringer Ingelheim Vetmedica Gmbh	Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény
WO2015082389A1 (en)	2013-12-04	2015-06-11	Boehringer Ingelheim Vetmedica Gmbh	Improved pharmaceutical compositions of pimobendan
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106729723A (zh) *	2016-11-21	2017-05-31	青岛农业大学	一种含匹莫苯丹的药物组合物及其制备方法
KR20220006776A (ko) *	2020-07-09	2022-01-18	주식회사유한양행	다이아미노피리미딘 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물 및 이의 제조방법
EP4633607A1 (en)	2022-12-15	2025-10-22	Boehringer Ingelheim Vetmedica GmbH	Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers
JP7659339B1 (ja)	2023-11-21	2025-04-09	東海カプセル株式会社	ピモベンダンを含有する経口フィルム製剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES482789A0 (es) *	1978-08-25	1980-12-01	Thomae Gmbh Dr K	Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
DE2837161A1 (de) *	1978-08-25	1980-03-06	Thomae Gmbh Dr K	Neue benzimidazole und deren verwendung
JPS56110612A (en) *	1980-02-08	1981-09-01	Yamanouchi Pharmaceut Co Ltd	Readily disintegrable and absorbable compression molded article of slightly soluble drug
JPS60163823A (ja) *	1984-02-03	1985-08-26	Taisho Pharmaceut Co Ltd	経口投与製剤
ATE71833T1 (de) *	1986-11-03	1992-02-15	Schering Corp	Labetalol tablette mit verzoegerter wirkstoffabgabe.
DE3728244A1 (de) *	1987-08-25	1989-03-09	Thomae Gmbh Dr K	Neue (-)-benzimidazole, deren herstellung und diese verbindungen enthaltende arzneimittel
EP0306846A3 (de) *	1987-09-11	1990-05-02	Dr. Karl Thomae GmbH	Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
DE3805635A1 (de) *	1988-02-24	1989-09-07	Thomae Gmbh Dr K	Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
JPH01258621A (ja) *	1988-04-06	1989-10-16	Fujimoto Seiyaku Kk	吸収が調節されたジラゼプ錠
JPH023609A (ja) *	1988-06-21	1990-01-09	Fujimoto Seiyaku Kk	塩酸ニカルジピンを活性成分とする持効性製剤

1990
- 1990-01-20 DE DE4001622A patent/DE4001622A1/de not_active Withdrawn
1991
- 1991-01-11 AT AT91100309T patent/ATE87481T1/de not_active IP Right Cessation
- 1991-01-11 DK DK91100309.3T patent/DK0439030T3/da active
- 1991-01-11 ES ES91100309T patent/ES2054379T3/es not_active Expired - Lifetime
- 1991-01-11 EP EP91100309A patent/EP0439030B1/de not_active Expired - Lifetime
- 1991-01-11 DE DE9191100309T patent/DE59100067D1/de not_active Expired - Lifetime
- 1991-01-17 PT PT96506A patent/PT96506B/pt not_active IP Right Cessation
- 1991-01-18 CA CA002034569A patent/CA2034569C/en not_active Expired - Lifetime
- 1991-01-18 HU HU91177A patent/HU207948B/hu unknown
- 1991-01-18 FI FI910263A patent/FI96274C/fi active
- 1991-01-18 AU AU69454/91A patent/AU630536B2/en not_active Expired
- 1991-01-18 NZ NZ236834A patent/NZ236834A/en unknown
- 1991-01-18 JP JP3004069A patent/JP2608183B2/ja not_active Expired - Lifetime
- 1991-01-18 ZA ZA91372A patent/ZA91372B/xx unknown
- 1991-01-18 NO NO910213A patent/NO176305C/no not_active IP Right Cessation
- 1991-01-18 IE IE16591A patent/IE64659B1/en not_active IP Right Cessation
- 1991-01-18 KR KR1019910000822A patent/KR0163056B1/ko not_active Expired - Lifetime
- 1991-01-22 IL IL9699591A patent/IL96995A/en not_active IP Right Cessation
1996
- 1996-09-19 HK HK175796A patent/HK175796A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO910213D0 (no)	1991-01-18
IE910165A1 (en)	1991-07-31
PT96506A (pt)	1991-10-15
FI910263A0 (fi)	1991-01-18
JPH04210919A (ja)	1992-08-03
KR910014120A (ko)	1991-08-31
FI910263L (fi)	1991-07-21
DE4001622A1 (de)	1991-07-25
CA2034569C (en)	2002-03-19
NO176305C (no)	1995-03-15
AU6945491A (en)	1991-07-25
IE64659B1 (en)	1995-08-23
IL96995A (en)	1994-11-11
HU910177D0 (en)	1991-08-28
EP0439030B1 (de)	1993-03-31
NZ236834A (en)	1995-10-26
FI96274C (fi)	1996-06-10
PT96506B (pt)	1998-06-30
EP0439030A3 (en)	1991-10-16
HU207948B (en)	1993-07-28
NO910213L (no)	1991-07-22
HUT56494A (en)	1991-09-30
EP0439030A2 (de)	1991-07-31
AU630536B2 (en)	1992-10-29
HK175796A (en)	1996-09-27
JP2608183B2 (ja)	1997-05-07
CA2034569A1 (en)	1991-07-21
ATE87481T1 (de)	1993-04-15
FI96274B (fi)	1996-02-29
ZA91372B (en)	1992-09-30
NO176305B (no)	1994-12-05
KR0163056B1 (ko)	1998-12-01
DE59100067D1 (de)	1993-05-06
ES2054379T3 (es)	1994-08-01
IL96995A0 (en)	1992-03-29

Publication	Publication Date	Title
DK0439030T3 (da)	1993-08-16	Orale lægemiddelformer af pimobendan
ITBO910024A1 (it)	1992-07-30	Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
NO912607D0 (no)	1991-07-03	Oral, fast farmasoeytisk doseringsform med programmert frigivelse.
DE69104777D1 (de)	1994-12-01	Orale Arzneimittelformen von biologisch aktiven Eiweisstoffen.
DZ1876A1 (fr)	2002-02-17	Médicaments pour administration orale.
DK0667148T3 (da)	2002-07-22	Peroralt farmaceutisk præparat, der udløses i den nedre del af mavetarmkanalen
FI913236L (fi)	1992-01-05	9-purinylfosfonsyraderivat.
DE69007080D1 (de)	1994-04-07	Orale Hygienezusammensetzung.
DE3679920D1 (de)	1991-08-01	Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
FR2698268B1 (fr)	1995-01-20	Composition photoprotectrice administrée par voie orale.
NO911429D0 (no)	1991-04-11	Stoffbehandling.
FI910088L (fi)	1991-07-10	Oral farmaceutisk komposition.
FI910254L (fi)	1991-07-19	Oralt aktiva renininhibitorer.
FI922879A0 (fi)	1992-06-18	Etenpolymer med hoeg smaelthaollfasthet, foerfarande foer dess framstaellning och dess anvaendning.
FI913179A7 (fi)	1991-12-29	Aminosyraderivat.
DE3873011D1 (de)	1992-08-27	Pharmazeutische zusammensetzung, enthaltend piperidinalkanolderivate.
NO913019D0 (no)	1991-08-02	Faste orale preparatformer som inneholder ifosfamid som virksomt stoff.
FI914149L (fi)	1992-03-06	Foerfarande foer kontinuerlig omsaettning av kefalosporinderivat till glutaryl-7-aminokefalosporinsyraderivat.
DE3681856D1 (de)	1991-11-14	Pharmazeutische 2-oxopyrrolidinverbindungen, ihre salze und ihre herstellung.
NO894592D0 (no)	1989-11-17	Pyrrolidon-2-karboksylsyre-derivater med psykotropisk virkning.
NO911430L (no)	1991-10-14	Stoffbehandlingsmetode.
ATE145333T1 (de)	1996-12-15	Hirudin enthaltende orale arzneimittel
DE69202059D1 (de)	1995-05-18	Propensäurederivate.
ATE165239T1 (de)	1998-05-15	Orale arzeimittelzubereitung enthaltend diclofenac-natrium und eine organische säure
FI922496A0 (fi)	1992-05-29	Lineaert viskoelastisk, vattenhaltig, flytande tvaettmedelskomposition med foerbaettrad, hoeg temperatur- stabilitet, speciellt foer automatiska diskmaskiner.