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DE69929544D1 - Attenuierte Pestiviren - Google Patents

Attenuierte Pestiviren

Info

Publication number
DE69929544D1
DE69929544D1 DE69929544T DE69929544T DE69929544D1 DE 69929544 D1 DE69929544 D1 DE 69929544D1 DE 69929544 T DE69929544 T DE 69929544T DE 69929544 T DE69929544 T DE 69929544T DE 69929544 D1 DE69929544 D1 DE 69929544D1
Authority
DE
Germany
Prior art keywords
attenuated pestiviruses
pestiviruses
attenuated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69929544T
Other languages
English (en)
Other versions
DE69929544T2 (de
Inventor
Gregor Meyers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of DE69929544D1 publication Critical patent/DE69929544D1/de
Application granted granted Critical
Publication of DE69929544T2 publication Critical patent/DE69929544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13Tumour cells, irrespective of tissue of origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24311Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24311Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69929544T 1998-06-05 1999-05-26 Attenuierte Pestiviren Expired - Lifetime DE69929544T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110356 1998-06-05
EP98110356A EP0965639A1 (de) 1998-06-05 1998-06-05 Attenuierte Pestiviren

Publications (2)

Publication Number Publication Date
DE69929544D1 true DE69929544D1 (de) 2006-04-13
DE69929544T2 DE69929544T2 (de) 2006-07-20

Family

ID=8232074

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69928700T Expired - Lifetime DE69928700T2 (de) 1998-06-05 1999-05-26 Attenuierte Pestiviren
DE69929544T Expired - Lifetime DE69929544T2 (de) 1998-06-05 1999-05-26 Attenuierte Pestiviren
DE69922953T Expired - Lifetime DE69922953T2 (de) 1998-06-05 1999-05-26 Attenuierte pestiviren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69928700T Expired - Lifetime DE69928700T2 (de) 1998-06-05 1999-05-26 Attenuierte Pestiviren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69922953T Expired - Lifetime DE69922953T2 (de) 1998-06-05 1999-05-26 Attenuierte pestiviren

Country Status (23)

Country Link
EP (5) EP0965639A1 (de)
JP (3) JP4632540B2 (de)
KR (1) KR100637940B1 (de)
CN (2) CN101085346A (de)
AR (3) AR020084A1 (de)
AT (3) ATE316380T1 (de)
AU (1) AU769823C (de)
BR (2) BR9911619B1 (de)
CA (1) CA2330241C (de)
CO (1) CO5050392A1 (de)
CZ (3) CZ301569B6 (de)
DE (3) DE69928700T2 (de)
DK (3) DK1203812T3 (de)
ES (3) ES2253457T3 (de)
HU (3) HU228469B1 (de)
NZ (1) NZ509228A (de)
PE (1) PE20000552A1 (de)
PL (2) PL202509B1 (de)
PT (2) PT1203813E (de)
SI (3) SI1084251T1 (de)
SK (3) SK287625B6 (de)
TR (3) TR200103666T2 (de)
WO (1) WO1999064604A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
EP1104676A1 (de) * 1999-11-30 2001-06-06 Boehringer Ingelheim Vetmedica Gmbh Sichere abgeschwächte Rinderdiarrhöeviren zur Verwendung in trächtigen Kühen
ES2261329T3 (es) 2000-04-21 2006-11-16 Akzo Nobel N.V. Mutantes de pestivirus y vacunas que los contienen.
US7135561B2 (en) 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
US20090068223A1 (en) 2005-11-15 2009-03-12 Boehringer Ingelheim Vetmedica, Inc. Combination vaccine comprising an attenuated bovine viral diarrhea virus
AR069087A1 (es) 2007-10-29 2009-12-30 Boehringer Ingelheim Vetmed Cepa bacteriana de m. bovis atenuada avirulenta obtenida por pases, vacuna de micoplasma boris y metodos de uso de la misma
UY31930A (es) 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
WO2010051210A1 (en) 2008-10-31 2010-05-06 Boehringer Ingelheim Vetmedica, Inc. Use of various antigens including antigens from mycoplasma bovis in multivalent vaccine composition
US8846054B2 (en) 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
UY32570A (es) 2009-04-24 2010-11-30 Boehringer Ingelheim Vetmed Vacuna viva modificada de mycoplasma bovis mejorada
CN101915837B (zh) * 2010-07-28 2013-07-03 中国兽医药品监察所 一种猪瘟兔化弱毒活疫苗效力检验方法
ES2606605T3 (es) 2010-09-21 2017-03-24 Intervet International B.V. Vacuna para el BVDV
CN103882051B (zh) * 2014-03-20 2016-04-06 北京市农林科学院 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒
DK3146042T3 (da) * 2014-05-23 2019-09-30 Boehringer Ingelheim Vetmedica Gmbh Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop
WO2020211801A1 (en) * 2019-04-18 2020-10-22 Boehringer Ingelheim Vetmedica (China) Co., Ltd. Recombinant classical swine fever virus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE342996T1 (de) * 1986-01-27 2006-11-15 Schering Plough Ltd Attenuierte herpesviren, herpesviren die eine aminosäuresequenz kodierende fremde dna enthalten,und diese enthaltende impfstoffe

Also Published As

Publication number Publication date
PT1084251E (pt) 2005-03-31
JP2010259445A (ja) 2010-11-18
PE20000552A1 (es) 2000-07-14
SI1203812T1 (sl) 2006-04-30
JP2013099357A (ja) 2013-05-23
TR200003622T2 (tr) 2001-06-21
BR9911619A (pt) 2001-10-02
BR9911619B1 (pt) 2013-11-12
EP1203812A3 (de) 2004-02-04
WO1999064604A2 (en) 1999-12-16
DE69928700D1 (de) 2006-01-05
EP1614423A2 (de) 2006-01-11
ES2253457T3 (es) 2006-06-01
ATE311193T1 (de) 2005-12-15
JP4632540B2 (ja) 2011-02-16
EP1084251A2 (de) 2001-03-21
EP0965639A1 (de) 1999-12-22
EP1203813B1 (de) 2006-01-25
HU228468B1 (en) 2013-03-28
JP5755265B2 (ja) 2015-07-29
JP2002517250A (ja) 2002-06-18
AR020084A1 (es) 2002-04-10
AR071881A2 (es) 2010-07-21
NZ509228A (en) 2003-12-19
SK287625B6 (sk) 2011-04-05
DE69928700T2 (de) 2006-06-22
WO1999064604A3 (en) 2000-01-27
HU228469B1 (en) 2013-03-28
AU4369299A (en) 1999-12-30
CZ301570B6 (cs) 2010-04-21
EP1084251B1 (de) 2004-12-29
DE69929544T2 (de) 2006-07-20
HU228471B1 (en) 2013-03-28
EP1203813A2 (de) 2002-05-08
DE69922953T2 (de) 2005-05-19
AR071880A2 (es) 2010-07-21
KR100637940B1 (ko) 2006-10-23
ES2257476T3 (es) 2006-08-01
CN100374563C (zh) 2008-03-12
PL348019A1 (en) 2002-05-06
JP5247770B2 (ja) 2013-07-24
ATE316380T1 (de) 2006-02-15
AU769823B2 (en) 2004-02-05
EP1614423A3 (de) 2008-01-30
CZ301569B6 (cs) 2010-04-21
SI1203813T1 (sl) 2006-06-30
AU769823C (en) 2004-11-25
TR200103664T2 (tr) 2002-06-21
KR20010071406A (ko) 2001-07-28
CZ301494B6 (cs) 2010-03-24
PL202509B1 (pl) 2009-06-30
CA2330241C (en) 2010-09-21
TR200103666T2 (tr) 2002-03-21
SK18232000A3 (sk) 2001-05-10
HUP0102707A2 (hu) 2001-11-28
SI1084251T1 (en) 2005-08-31
SK287626B6 (sk) 2011-04-05
HUP0102707A3 (en) 2008-04-28
PT1203813E (pt) 2006-06-30
DK1084251T3 (da) 2005-04-11
EP1203812A2 (de) 2002-05-08
CN101085346A (zh) 2007-12-12
CO5050392A1 (es) 2001-06-27
DK1203813T3 (da) 2006-05-22
CZ20004533A3 (cs) 2001-07-11
DE69922953D1 (de) 2005-02-03
EP1203812B1 (de) 2005-11-30
CA2330241A1 (en) 1999-12-16
DK1203812T3 (da) 2006-04-10
BRPI9917787B1 (pt) 2016-09-06
ES2235488T3 (es) 2005-07-01
CN1304452A (zh) 2001-07-18
EP1203813A3 (de) 2004-02-04
PL202161B1 (pl) 2009-06-30
SK287014B6 (sk) 2009-09-07
ATE286131T1 (de) 2005-01-15

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