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BR9911619A - Pestivìrus atenuados - Google Patents

Pestivìrus atenuados

Info

Publication number
BR9911619A
BR9911619A BR9911619-7A BR9911619A BR9911619A BR 9911619 A BR9911619 A BR 9911619A BR 9911619 A BR9911619 A BR 9911619A BR 9911619 A BR9911619 A BR 9911619A
Authority
BR
Brazil
Prior art keywords
pestiviruses
mitigated
pestivírus
attenued
rns
Prior art date
Application number
BR9911619-7A
Other languages
English (en)
Other versions
BR9911619B1 (pt
Inventor
Gregor Meyers
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Priority to BRPI9917787A priority Critical patent/BRPI9917787B1/pt
Publication of BR9911619A publication Critical patent/BR9911619A/pt
Publication of BR9911619B1 publication Critical patent/BR9911619B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"PESTIVìRUS ATENUADOS"<D>. Esta invenção refere-se a pestivírus atenuados caracterizados pelo fato de que sua atividade enzimática presente na glicoproteína E^ RNS^ é inativada, processos para preparar, usar e deletar os mesmos.
BRPI9911619-7B1A 1998-06-05 1999-05-26 VAClNA VIVA DE PESTlVÍRUS ATENUADA, SEU USO, COMPOSIÇÃO FARMACÊUTICA, BEM COMO PROCESSO PARA ATENUAR PESTIVÍRUS BR9911619B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BRPI9917787A BRPI9917787B1 (pt) 1998-06-05 1999-05-26 pestivírus csfv atenuado

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110356A EP0965639A1 (en) 1998-06-05 1998-06-05 Attenuated pestiviruses
PCT/EP1999/003642 WO1999064604A2 (en) 1998-06-05 1999-05-26 Attenuated pestiviruses

Publications (2)

Publication Number Publication Date
BR9911619A true BR9911619A (pt) 2001-10-02
BR9911619B1 BR9911619B1 (pt) 2013-11-12

Family

ID=8232074

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9917787A BRPI9917787B1 (pt) 1998-06-05 1999-05-26 pestivírus csfv atenuado
BRPI9911619-7B1A BR9911619B1 (pt) 1998-06-05 1999-05-26 VAClNA VIVA DE PESTlVÍRUS ATENUADA, SEU USO, COMPOSIÇÃO FARMACÊUTICA, BEM COMO PROCESSO PARA ATENUAR PESTIVÍRUS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9917787A BRPI9917787B1 (pt) 1998-06-05 1999-05-26 pestivírus csfv atenuado

Country Status (23)

Country Link
EP (5) EP0965639A1 (pt)
JP (3) JP4632540B2 (pt)
KR (1) KR100637940B1 (pt)
CN (2) CN101085346A (pt)
AR (3) AR020084A1 (pt)
AT (3) ATE286131T1 (pt)
AU (1) AU769823C (pt)
BR (2) BRPI9917787B1 (pt)
CA (1) CA2330241C (pt)
CO (1) CO5050392A1 (pt)
CZ (3) CZ301569B6 (pt)
DE (3) DE69928700T2 (pt)
DK (3) DK1203813T3 (pt)
ES (3) ES2235488T3 (pt)
HU (3) HU228468B1 (pt)
NZ (1) NZ509228A (pt)
PE (1) PE20000552A1 (pt)
PL (2) PL202509B1 (pt)
PT (2) PT1203813E (pt)
SI (3) SI1203812T1 (pt)
SK (3) SK287014B6 (pt)
TR (3) TR200103666T2 (pt)
WO (1) WO1999064604A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
EP1104676A1 (en) * 1999-11-30 2001-06-06 Boehringer Ingelheim Vetmedica Gmbh Safe attenuated bovine viral diarrhea viruses for use in pregnant cows
PT1149901E (pt) 2000-04-21 2006-08-31 Akzo Nobel Nv Mutantes de pestivirus e vacinas contendo os mesmos
US7135561B2 (en) 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
UY29915A1 (es) * 2005-11-15 2007-06-29 Boehringer Ingelheim Vetmed Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina
CL2008003202A1 (es) 2007-10-29 2009-11-27 Boehringer Ingelheim Vetmedica Inc Composicion inmunogenica que comprende bacterias vivas de mycoplasma bovis atenuada avirulenta.
UY31930A (es) 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
WO2010051210A1 (en) 2008-10-31 2010-05-06 Boehringer Ingelheim Vetmedica, Inc. Use of various antigens including antigens from mycoplasma bovis in multivalent vaccine composition
US8846054B2 (en) 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
UY32570A (es) 2009-04-24 2010-11-30 Boehringer Ingelheim Vetmed Vacuna viva modificada de mycoplasma bovis mejorada
CN101915837B (zh) * 2010-07-28 2013-07-03 中国兽医药品监察所 一种猪瘟兔化弱毒活疫苗效力检验方法
ES2606605T3 (es) 2010-09-21 2017-03-24 Intervet International B.V. Vacuna para el BVDV
CN103882051B (zh) * 2014-03-20 2016-04-06 北京市农林科学院 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒
US9993544B2 (en) * 2014-05-23 2018-06-12 Boehringer Ingelheim Vetmedica Gmbh Recombinant classical swine fever virus (CSFV) comprising substitution in the TAV epitope of the E2 protein
KR20220009960A (ko) * 2019-04-18 2022-01-25 베링거 잉겔하임 베트메디카 (차이나) 코포레이션 리미티드 재조합 고전적 돼지 열병 바이러스

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3752389T2 (de) * 1986-01-27 2007-06-14 Schering-Plough Ltd. Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, und diese enthaltende Impfstoffe

Also Published As

Publication number Publication date
CN101085346A (zh) 2007-12-12
CO5050392A1 (es) 2001-06-27
DK1084251T3 (da) 2005-04-11
NZ509228A (en) 2003-12-19
WO1999064604A3 (en) 2000-01-27
ATE286131T1 (de) 2005-01-15
SK18232000A3 (sk) 2001-05-10
HU228468B1 (en) 2013-03-28
JP2002517250A (ja) 2002-06-18
EP1203813A2 (en) 2002-05-08
PL202161B1 (pl) 2009-06-30
AU4369299A (en) 1999-12-30
JP2013099357A (ja) 2013-05-23
EP0965639A1 (en) 1999-12-22
EP1614423A2 (en) 2006-01-11
CZ301570B6 (cs) 2010-04-21
CA2330241A1 (en) 1999-12-16
BR9911619B1 (pt) 2013-11-12
BRPI9917787B1 (pt) 2016-09-06
SI1203813T1 (sl) 2006-06-30
AU769823B2 (en) 2004-02-05
DE69929544D1 (de) 2006-04-13
PT1203813E (pt) 2006-06-30
ES2257476T3 (es) 2006-08-01
PT1084251E (pt) 2005-03-31
TR200103664T2 (tr) 2002-06-21
WO1999064604A2 (en) 1999-12-16
JP2010259445A (ja) 2010-11-18
EP1614423A3 (en) 2008-01-30
DE69922953D1 (de) 2005-02-03
AR020084A1 (es) 2002-04-10
KR100637940B1 (ko) 2006-10-23
SK287626B6 (sk) 2011-04-05
ES2235488T3 (es) 2005-07-01
ATE311193T1 (de) 2005-12-15
DE69922953T2 (de) 2005-05-19
AU769823C (en) 2004-11-25
HU228471B1 (en) 2013-03-28
DE69928700D1 (de) 2006-01-05
DK1203813T3 (da) 2006-05-22
CN100374563C (zh) 2008-03-12
EP1084251B1 (en) 2004-12-29
JP5755265B2 (ja) 2015-07-29
SI1203812T1 (sl) 2006-04-30
DE69929544T2 (de) 2006-07-20
AR071881A2 (es) 2010-07-21
CN1304452A (zh) 2001-07-18
TR200103666T2 (tr) 2002-03-21
CA2330241C (en) 2010-09-21
TR200003622T2 (tr) 2001-06-21
ES2253457T3 (es) 2006-06-01
HU228469B1 (en) 2013-03-28
JP5247770B2 (ja) 2013-07-24
PL202509B1 (pl) 2009-06-30
EP1203813A3 (en) 2004-02-04
EP1203812B1 (en) 2005-11-30
EP1084251A2 (en) 2001-03-21
PL348019A1 (en) 2002-05-06
DE69928700T2 (de) 2006-06-22
AR071880A2 (es) 2010-07-21
EP1203812A2 (en) 2002-05-08
SK287625B6 (sk) 2011-04-05
SK287014B6 (sk) 2009-09-07
ATE316380T1 (de) 2006-02-15
SI1084251T1 (en) 2005-08-31
HUP0102707A2 (hu) 2001-11-28
EP1203812A3 (en) 2004-02-04
CZ301569B6 (cs) 2010-04-21
EP1203813B1 (en) 2006-01-25
CZ301494B6 (cs) 2010-03-24
CZ20004533A3 (cs) 2001-07-11
JP4632540B2 (ja) 2011-02-16
HUP0102707A3 (en) 2008-04-28
PE20000552A1 (es) 2000-07-14
DK1203812T3 (da) 2006-04-10
KR20010071406A (ko) 2001-07-28

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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