DE69630604D1 - Heterocyclycarboxamid-derivate und ihre verwendung als therapeutische mittel - Google Patents
Heterocyclycarboxamid-derivate und ihre verwendung als therapeutische mittelInfo
- Publication number
- DE69630604D1 DE69630604D1 DE69630604T DE69630604T DE69630604D1 DE 69630604 D1 DE69630604 D1 DE 69630604D1 DE 69630604 T DE69630604 T DE 69630604T DE 69630604 T DE69630604 T DE 69630604T DE 69630604 D1 DE69630604 D1 DE 69630604D1
- Authority
- DE
- Germany
- Prior art keywords
- disorders
- pct
- date jan
- methylene
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 210000000607 neurosecretory system Anatomy 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 201000004240 prostatic hypertrophy Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9514380 | 1995-07-13 | ||
| GBGB9514380.6A GB9514380D0 (en) | 1995-07-13 | 1995-07-13 | Therapeutic agents |
| PCT/EP1996/002890 WO1997003071A1 (en) | 1995-07-13 | 1996-07-02 | Heterocyclylcarboxamide derivatives and their use as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69630604D1 true DE69630604D1 (de) | 2003-12-11 |
| DE69630604T2 DE69630604T2 (de) | 2004-09-23 |
Family
ID=10777626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69630604T Expired - Fee Related DE69630604T2 (de) | 1995-07-13 | 1996-07-02 | Heterocyclylcarboxamid-derivate und ihre verwendung als therapeutische mittel |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5935973A (de) |
| EP (1) | EP0839145B1 (de) |
| JP (1) | JPH11508599A (de) |
| KR (1) | KR19990028918A (de) |
| CN (1) | CN1071755C (de) |
| AT (1) | ATE253573T1 (de) |
| AU (1) | AU708890B2 (de) |
| BG (1) | BG62771B1 (de) |
| BR (1) | BR9609506A (de) |
| CA (1) | CA2223472A1 (de) |
| CZ (1) | CZ388497A3 (de) |
| DE (1) | DE69630604T2 (de) |
| GB (1) | GB9514380D0 (de) |
| HR (1) | HRP960348A2 (de) |
| HU (1) | HUP9901485A3 (de) |
| IL (1) | IL122540A (de) |
| MX (1) | MX9800084A (de) |
| NO (1) | NO980129D0 (de) |
| NZ (1) | NZ313164A (de) |
| PL (1) | PL324529A1 (de) |
| RU (1) | RU2169147C2 (de) |
| SK (1) | SK2498A3 (de) |
| TR (1) | TR199800041T1 (de) |
| TW (1) | TW454006B (de) |
| WO (1) | WO1997003071A1 (de) |
| ZA (1) | ZA965921B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9811879D0 (en) * | 1998-06-03 | 1998-07-29 | Knoll Ag | Therapeutic agents |
| GB9915616D0 (en) * | 1999-07-05 | 1999-09-01 | Knoll Ag | Therapeutic agents |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| AU4890301A (en) * | 2000-04-17 | 2001-10-30 | Dong Wha Pharmaceutical Industrial Co., Ltd. | 6-methylnicotinamide derivatives as antiviral agents |
| CZ20031434A3 (cs) * | 2000-11-14 | 2003-09-17 | Merck Patent Gmbh | Použití kombinovaných selektivních dopamin D2 receptorových antagonistů a 5-HT1A receptorových agonistů |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| US8106074B2 (en) | 2001-07-13 | 2012-01-31 | Pierre Fabre Medicament | Pyridin-2-yl-methylamine derivatives for treating opiate dependence |
| WO2003009835A2 (en) * | 2001-07-26 | 2003-02-06 | Merck Patent Gmbh | Novel use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts |
| BRPI0412259B1 (pt) | 2003-07-22 | 2019-08-20 | Astex Therapeutics Limited | Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica |
| CA2556589A1 (en) * | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
| JP4604583B2 (ja) * | 2004-07-20 | 2011-01-05 | ダイソー株式会社 | １−アミド−３−（２−ヒドロキシフェノキシ）−２−プロパノール誘導体、ならびに２−アミドメチル−１，４−ベンゾジオキサン誘導体の製造法 |
| JP5475234B2 (ja) | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| AU2006207325B2 (en) | 2005-01-21 | 2012-08-16 | Astex Therapeutics Limited | Pharmaceutical compounds |
| TWI457122B (zh) * | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物 |
| JP5514804B2 (ja) * | 2008-04-29 | 2014-06-04 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
| NZ703632A (en) * | 2012-06-11 | 2016-01-29 | Bristol Myers Squibb Co | Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8302622D0 (en) * | 1983-01-31 | 1983-03-02 | Celltech Ltd | Immunoassay |
| EP0200960A1 (de) * | 1985-05-08 | 1986-11-12 | Abbott Laboratories | Fluoreszenzpolarisationsimmunoassay auf Gesamtöstriol |
| CA2075057A1 (en) * | 1990-03-15 | 1991-09-16 | Pharmacia & Upjohn Company Llc | Therapeutically useful heterocyclic indole compounds |
| US5240943A (en) * | 1991-12-19 | 1993-08-31 | G. D. Searle & Co. | Benzopyran class iii antiarrhythmic agents |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
-
1995
- 1995-07-13 GB GBGB9514380.6A patent/GB9514380D0/en active Pending
-
1996
- 1996-07-02 EP EP96924847A patent/EP0839145B1/de not_active Expired - Lifetime
- 1996-07-02 IL IL12254096A patent/IL122540A/en not_active IP Right Cessation
- 1996-07-02 SK SK24-98A patent/SK2498A3/sk unknown
- 1996-07-02 MX MX9800084A patent/MX9800084A/es not_active Application Discontinuation
- 1996-07-02 AU AU65172/96A patent/AU708890B2/en not_active Ceased
- 1996-07-02 KR KR1019980700220A patent/KR19990028918A/ko not_active Ceased
- 1996-07-02 TR TR1998/00041T patent/TR199800041T1/xx unknown
- 1996-07-02 HU HU9901485A patent/HUP9901485A3/hu unknown
- 1996-07-02 PL PL96324529A patent/PL324529A1/xx unknown
- 1996-07-02 WO PCT/EP1996/002890 patent/WO1997003071A1/en not_active Ceased
- 1996-07-02 CA CA002223472A patent/CA2223472A1/en not_active Abandoned
- 1996-07-02 JP JP9505471A patent/JPH11508599A/ja not_active Withdrawn
- 1996-07-02 BR BR9609506A patent/BR9609506A/pt unknown
- 1996-07-02 RU RU98102441/04A patent/RU2169147C2/ru active
- 1996-07-02 CZ CZ973884A patent/CZ388497A3/cs unknown
- 1996-07-02 AT AT96924847T patent/ATE253573T1/de not_active IP Right Cessation
- 1996-07-02 NZ NZ313164A patent/NZ313164A/xx unknown
- 1996-07-02 US US08/981,671 patent/US5935973A/en not_active Expired - Lifetime
- 1996-07-02 DE DE69630604T patent/DE69630604T2/de not_active Expired - Fee Related
- 1996-07-02 CN CN96195477A patent/CN1071755C/zh not_active Expired - Fee Related
- 1996-07-12 ZA ZA9605921A patent/ZA965921B/xx unknown
- 1996-07-12 HR HR9514380.6A patent/HRP960348A2/hr not_active Application Discontinuation
- 1996-12-19 TW TW085115692A patent/TW454006B/zh not_active IP Right Cessation
-
1997
- 1997-12-23 BG BG102145A patent/BG62771B1/bg unknown
-
1998
- 1998-01-12 NO NO980129A patent/NO980129D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2169147C2 (ru) | 2001-06-20 |
| ATE253573T1 (de) | 2003-11-15 |
| KR19990028918A (ko) | 1999-04-15 |
| NO980129L (no) | 1998-01-12 |
| AU6517296A (en) | 1997-02-10 |
| TR199800041T1 (xx) | 1998-05-21 |
| TW454006B (en) | 2001-09-11 |
| HUP9901485A3 (en) | 2001-03-28 |
| GB9514380D0 (en) | 1995-09-13 |
| EP0839145A1 (de) | 1998-05-06 |
| MX9800084A (es) | 1998-03-29 |
| EP0839145B1 (de) | 2003-11-05 |
| NO980129D0 (no) | 1998-01-12 |
| ZA965921B (en) | 1998-01-12 |
| AU708890B2 (en) | 1999-08-12 |
| BG62771B1 (bg) | 2000-07-31 |
| HUP9901485A2 (en) | 2000-07-28 |
| BR9609506A (pt) | 1999-06-01 |
| JPH11508599A (ja) | 1999-07-27 |
| DE69630604T2 (de) | 2004-09-23 |
| CN1071755C (zh) | 2001-09-26 |
| CZ388497A3 (cs) | 1998-06-17 |
| NZ313164A (en) | 1999-07-29 |
| BG102145A (en) | 1998-11-30 |
| PL324529A1 (en) | 1998-06-08 |
| HRP960348A2 (en) | 1998-04-30 |
| CN1190967A (zh) | 1998-08-19 |
| IL122540A0 (en) | 1998-06-15 |
| CA2223472A1 (en) | 1997-01-30 |
| SK2498A3 (en) | 1998-09-09 |
| WO1997003071A1 (en) | 1997-01-30 |
| US5935973A (en) | 1999-08-10 |
| IL122540A (en) | 2001-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |