DE69617665D1 - Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes - Google Patents

Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes

Info

Publication number: DE69617665D1
Authority: DE; Germany
Prior art keywords: phenyl; compounds; disorders; benzmidazole; modulators
Prior art date: 1995-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69617665T

Other languages

English (en)

Other versions

DE69617665T2 (de

Inventor

Lene Teuber

Frank Waetjen

Yoshimasa Fukuda

Osamu Ushiroda

Toshiro Sasaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NTG Nordic Transport Group AS

Original Assignee

Neurosearch AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-21

Filing date

1996-04-17

Publication date

2002-01-17

1996-04-17 Application filed by Neurosearch AS filed Critical Neurosearch AS

2002-01-17 Publication of DE69617665D1 publication Critical patent/DE69617665D1/de

2002-05-08 Application granted granted Critical

2002-05-08 Publication of DE69617665T2 publication Critical patent/DE69617665T2/de

2016-04-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE69617665T 1995-04-21 1996-04-17 Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes Expired - Lifetime DE69617665T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK46095		1995-04-21
PCT/EP1996/001606 WO1996033194A1 (en)	1995-04-21	1996-04-17	Benzimidazole compounds and their use as modulators of the gaba a receptor complex

Publications (2)

Publication Number	Publication Date
DE69617665D1 true DE69617665D1 (de)	2002-01-17
DE69617665T2 DE69617665T2 (de)	2002-05-08

Family

ID=8093808

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69617665T Expired - Lifetime DE69617665T2 (de)	1995-04-21	1996-04-17	Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes
DE69636670T Expired - Lifetime DE69636670T2 (de)	1995-04-21	1996-04-19	Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69636670T Expired - Lifetime DE69636670T2 (de)	1995-04-21	1996-04-19	Benzimidazolverbindungen und ihre verwendung als gaba a receptor komplex modulatoren

Country Status (22)

Country	Link
US (2)	US5922724A (de)
EP (3)	EP0821684B1 (de)
JP (2)	JP3342874B2 (de)
KR (2)	KR100297445B1 (de)
CN (2)	CN1072669C (de)
AT (2)	ATE210132T1 (de)
AU (2)	AU695957B2 (de)
BR (1)	BR9608048A (de)
CA (2)	CA2218493C (de)
CZ (1)	CZ287545B6 (de)
DE (2)	DE69617665T2 (de)
EE (1)	EE04310B1 (de)
HU (1)	HUP9801692A3 (de)
IS (1)	IS1959B (de)
NO (1)	NO314504B1 (de)
NZ (1)	NZ307521A (de)
PL (1)	PL183853B1 (de)
RU (1)	RU2135493C1 (de)
SK (1)	SK282425B6 (de)
TR (1)	TR199701218T2 (de)
UA (1)	UA54393C2 (de)
WO (2)	WO1996033194A1 (de)

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US6281237B1 (en)	1999-04-02	2001-08-28	Neurogen Corporation	N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
US6627624B1 (en)	1999-04-02	2003-09-30	Neurogen Corporation	Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6380210B1 (en)	1999-04-02	2002-04-30	Neurogen Corporation	Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6358949B1 (en)	1999-04-02	2002-03-19	Neurogen Corporation	Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors
ES2226812T3 (es) *	1999-04-02	2005-04-01	Neurogen Corporation	Derivados de aminoalquilimidazol condensados con arilo y heteroarilo:moduladores selesctivos de los preseptores gabaa.
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GB0208394D0 (en) *	2002-04-11	2002-05-22	Merck Sharp & Dohme	Therapeutic agents
US7329678B2 (en) *	2003-01-28	2008-02-12	Smithkline Beecham Corporation	Chemical compounds
WO2004087137A1 (en)	2003-04-03	2004-10-14	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
JP2006522070A (ja)	2003-04-03	2006-09-28	ニューロサーチ、アクティーゼルスカブ	ベンズイミダゾール誘導体及びこれをｇａｂａａ受容体複合体をモジュレートするために使用する方法
WO2005040131A1 (en) *	2003-10-23	2005-05-06	Akzo Nobel N.V.	1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the gabaa receptor complex
PT1877052E (pt)	2005-04-13	2009-08-25	Neurosearch As	Derivados de benzimidazole e sua utilização para modulação do complexo do receptor gabaa
US20070015782A1 (en) *	2005-04-15	2007-01-18	Eisai Co., Ltd.	Benzimidazole compound
EP1928437A2 (de)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenese mittels muscarinrezeptormodulation
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
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DK1996556T3 (da)	2005-12-05	2010-04-06	Neurosearch As	Benzimidazoiderivater og deres anvendelse til modulering af GABAA-receptorkomplekset
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EP2430921B1 (de) *	2007-04-03	2017-07-05	E. I. du Pont de Nemours and Company	Substituierte Benzenfungizide
US20100190826A1 (en)	2007-07-24	2010-07-29	Akio Kakefuda	Benzimidazole derivative
KR20090024998A (ko) *	2007-09-05	2009-03-10	제일모직주식회사	분자 내에 정공수송기와 전자수송기를 동시에 가지는바이폴라 유기화합물을 포함하는 유기광전소자용 재료 및이를 이용한 유기광전소자
WO2010055126A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
EP2383573A4 (de)	2009-01-27	2012-10-24	Astellas Pharma Inc	Screening-verfahren für eine als mittel zur behandlung von prostatakrebs verwendbare substanz
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
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EP2935253B1 (de)	2012-12-21	2018-08-01	Zenith Epigenetics Ltd.	Neuartige heterocyclische verbindungen als bromdomänenhemmer
TWI606048B (zh) *	2013-01-31	2017-11-21	帝人製藥股份有限公司	唑苯衍生物
SI3010503T1 (sl)	2013-06-21	2020-07-31	Zenith Epigenetics Ltd.	Novi biciklični inhibitorji bromodomene
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JP6542212B2 (ja)	2013-07-31	2019-07-10	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	ブロモドメイン阻害剤としての新規キナゾリノン
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CA2966298A1 (en)	2014-12-01	2016-06-09	Zenith Epigenetics Ltd.	Substituted pyridinones as bromodomain inhibitors
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1996
- 1996-04-17 WO PCT/EP1996/001606 patent/WO1996033194A1/en not_active Ceased
- 1996-04-17 SK SK1399-97A patent/SK282425B6/sk unknown
- 1996-04-17 CA CA002218493A patent/CA2218493C/en not_active Expired - Fee Related
- 1996-04-17 AT AT96914932T patent/ATE210132T1/de not_active IP Right Cessation
- 1996-04-17 JP JP53146496A patent/JP3342874B2/ja not_active Expired - Fee Related
- 1996-04-17 TR TR97/01218T patent/TR199701218T2/xx unknown
- 1996-04-17 DE DE69617665T patent/DE69617665T2/de not_active Expired - Lifetime
- 1996-04-17 EP EP96914932A patent/EP0821684B1/de not_active Expired - Lifetime
- 1996-04-17 NZ NZ307521A patent/NZ307521A/en unknown
- 1996-04-17 RU RU97119173A patent/RU2135493C1/ru not_active IP Right Cessation
- 1996-04-17 KR KR1019970707465A patent/KR100297445B1/ko not_active Expired - Fee Related
- 1996-04-17 EP EP01112476A patent/EP1164134A1/de not_active Withdrawn
- 1996-04-17 US US08/945,023 patent/US5922724A/en not_active Expired - Lifetime
- 1996-04-17 UA UA97115591A patent/UA54393C2/uk unknown
- 1996-04-17 PL PL96322892A patent/PL183853B1/pl not_active IP Right Cessation
- 1996-04-17 CN CN96193419A patent/CN1072669C/zh not_active Expired - Fee Related
- 1996-04-17 AU AU56891/96A patent/AU695957B2/en not_active Ceased
- 1996-04-17 BR BR9608048-5A patent/BR9608048A/pt not_active IP Right Cessation
- 1996-04-17 HU HU9801692A patent/HUP9801692A3/hu unknown
- 1996-04-17 CZ CZ19973292A patent/CZ287545B6/cs not_active IP Right Cessation
- 1996-04-17 EE EE9700283A patent/EE04310B1/xx not_active IP Right Cessation
- 1996-04-19 JP JP8531487A patent/JP3040485B2/ja not_active Expired - Fee Related
- 1996-04-19 US US08/930,216 patent/US5902813A/en not_active Expired - Lifetime
- 1996-04-19 AU AU55014/96A patent/AU5501496A/en not_active Abandoned
- 1996-04-19 KR KR1019970707464A patent/KR19990007941A/ko not_active Abandoned
- 1996-04-19 DE DE69636670T patent/DE69636670T2/de not_active Expired - Lifetime
- 1996-04-19 CN CN96193420A patent/CN1182426A/zh active Pending
- 1996-04-19 WO PCT/EP1996/001654 patent/WO1996033192A1/en not_active Ceased
- 1996-04-19 AT AT96912025T patent/ATE344257T1/de not_active IP Right Cessation
- 1996-04-19 EP EP96912025A patent/EP0821683B1/de not_active Expired - Lifetime
- 1996-04-19 CA CA002217601A patent/CA2217601C/en not_active Expired - Fee Related
1997
- 1997-10-13 IS IS4588A patent/IS1959B/is unknown
- 1997-10-20 NO NO19974844A patent/NO314504B1/no unknown

Also Published As

Publication number	Publication date
JPH11501321A (ja)	1999-02-02
US5902813A (en)	1999-05-11
EE04310B1 (et)	2004-06-15
DE69636670T2 (de)	2007-02-08
DE69636670D1 (de)	2006-12-14
JPH11501320A (ja)	1999-02-02
RU2135493C1 (ru)	1999-08-27
AU5689196A (en)	1996-11-07
CA2217601A1 (en)	1996-10-24
AU695957B2 (en)	1998-08-27
UA54393C2 (uk)	2003-03-17
NO974844D0 (no)	1997-10-20
EP0821683B1 (de)	2006-11-02
NO974844L (no)	1997-12-16
JP3040485B2 (ja)	2000-05-15
WO1996033194A1 (en)	1996-10-24
EP0821684B1 (de)	2001-12-05
WO1996033192A1 (en)	1996-10-24
EE9700283A (et)	1998-06-15
NZ307521A (en)	1999-04-29
PL183853B1 (pl)	2002-07-31
KR100297445B1 (ko)	2001-10-25
HUP9801692A3 (en)	2001-11-28
CZ329297A3 (cs)	1998-03-18
NO314504B1 (no)	2003-03-31
ATE210132T1 (de)	2001-12-15
CN1182426A (zh)	1998-05-20
JP3342874B2 (ja)	2002-11-11
EP0821683A1 (de)	1998-02-04
KR19990007942A (ko)	1999-01-25
CN1072669C (zh)	2001-10-10
DE69617665T2 (de)	2002-05-08
HUP9801692A2 (hu)	1999-03-29
CN1182427A (zh)	1998-05-20
EP1164134A1 (de)	2001-12-19
US5922724A (en)	1999-07-13
BR9608048A (pt)	1999-11-30
EP0821684A1 (de)	1998-02-04
SK282425B6 (sk)	2002-01-07
CA2217601C (en)	2002-04-16
TR199701218T2 (xx)	1998-08-21
KR19990007941A (ko)	1999-01-25
HK1015674A1 (en)	1999-10-22
CA2218493C (en)	2005-02-22
CA2218493A1 (en)	1996-10-24
SK139997A3 (en)	1998-05-06
ATE344257T1 (de)	2006-11-15
IS4588A (is)	1997-10-13
PL322892A1 (en)	1998-03-02
AU5501496A (en)	1996-11-07
IS1959B (is)	2004-11-15
CZ287545B6 (en)	2000-12-13

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ATE168991T1 (de)	1998-08-15	Substituierte arylalkoxybenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
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