DE60331601D1 - Neue chimärische plasminogenaktivatoren und deren pharmazeutische verwendung - Google Patents
Neue chimärische plasminogenaktivatoren und deren pharmazeutische verwendungInfo
- Publication number
- DE60331601D1 DE60331601D1 DE60331601T DE60331601T DE60331601D1 DE 60331601 D1 DE60331601 D1 DE 60331601D1 DE 60331601 T DE60331601 T DE 60331601T DE 60331601 T DE60331601 T DE 60331601T DE 60331601 D1 DE60331601 D1 DE 60331601D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical use
- plasminogen activators
- terminally
- new chimeric
- plasminogen activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001938 Plasminogen Activators Human genes 0.000 title abstract 3
- 108010001014 Plasminogen Activators Proteins 0.000 title abstract 3
- 229940127126 plasminogen activator Drugs 0.000 title abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 208000029523 Interstitial Lung disease Diseases 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2003/014542 WO2005059142A1 (en) | 2003-12-18 | 2003-12-18 | Novel chimeric plasminogen activators and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60331601D1 true DE60331601D1 (de) | 2010-04-15 |
Family
ID=34684504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60331601T Expired - Lifetime DE60331601D1 (de) | 2003-12-18 | 2003-12-18 | Neue chimärische plasminogenaktivatoren und deren pharmazeutische verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8124588B2 (de) |
| EP (1) | EP1694848B1 (de) |
| JP (1) | JP4505416B2 (de) |
| AT (1) | ATE459718T1 (de) |
| AU (1) | AU2003290092B2 (de) |
| CA (1) | CA2588965C (de) |
| DE (1) | DE60331601D1 (de) |
| ES (1) | ES2342055T3 (de) |
| WO (1) | WO2005059142A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006304804B2 (en) * | 2005-10-21 | 2011-06-02 | Vertex Pharmaceuticals Incorporated | Modified proteases that inhibit complement activation |
| WO2010068754A2 (en) | 2008-12-10 | 2010-06-17 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
| MX2013001385A (es) * | 2010-08-05 | 2013-07-15 | Council Scient Ind Res | Construcciones de fusion de proteina que tienen propiedades tromboliticas y anticoagulantes. |
| WO2014056199A1 (zh) * | 2012-10-12 | 2014-04-17 | 清华大学 | 多肽的产生和纯化方法 |
| US20160264646A1 (en) * | 2013-06-24 | 2016-09-15 | Azargen Biotechnologies (Pty) Ltd | Production of human pulmonary surfactant protein b in plants |
| WO2021180068A1 (zh) * | 2020-03-09 | 2021-09-16 | 泰伦基国际有限公司 | 一种治疗2019新型冠状病毒引发疾病的方法和药物 |
| US20210322511A1 (en) * | 2020-04-17 | 2021-10-21 | President And Fellows Of Harvard College | Methods and compositions for treating a respiratory disease |
| IT202300008805A1 (it) * | 2023-05-04 | 2024-11-04 | Cerbios Pharma Sa | Metodo per la produzione di urochinasi ricombinante umana a basso peso molecolare farmaceuticamente attiva |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112755A (en) | 1982-04-15 | 1992-05-12 | Genentech, Inc. | Preparation of functional human urokinase proteins |
| GB8334498D0 (en) | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
| US4880776A (en) | 1983-12-24 | 1989-11-14 | Beecham Group P.L.C. | Plasmin A-chain urokinase B-chain hybrid protein |
| US5242819A (en) | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
| US4999194A (en) | 1988-01-14 | 1991-03-12 | Collaborative Research, Inc. | Two-chain urokinase plasminogen activators for treatment of thrombotic disease |
| US5006343A (en) | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
| US5238920A (en) | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
| US6031075A (en) | 1996-02-05 | 2000-02-29 | Children's Hospital Medical Center | Mature alveolar SP-B and a process for producing the same |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| CA2349837A1 (en) * | 1998-11-18 | 2000-05-25 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| AU5400000A (en) | 1999-06-11 | 2001-01-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c) |
-
2003
- 2003-12-18 ES ES03782451T patent/ES2342055T3/es not_active Expired - Lifetime
- 2003-12-18 AT AT03782451T patent/ATE459718T1/de not_active IP Right Cessation
- 2003-12-18 CA CA2588965A patent/CA2588965C/en not_active Expired - Fee Related
- 2003-12-18 US US10/583,785 patent/US8124588B2/en not_active Expired - Fee Related
- 2003-12-18 WO PCT/EP2003/014542 patent/WO2005059142A1/en not_active Ceased
- 2003-12-18 DE DE60331601T patent/DE60331601D1/de not_active Expired - Lifetime
- 2003-12-18 JP JP2005512170A patent/JP4505416B2/ja not_active Expired - Fee Related
- 2003-12-18 AU AU2003290092A patent/AU2003290092B2/en not_active Ceased
- 2003-12-18 EP EP03782451A patent/EP1694848B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2588965C (en) | 2013-01-22 |
| EP1694848B1 (de) | 2010-03-03 |
| ES2342055T3 (es) | 2010-07-01 |
| WO2005059142A1 (en) | 2005-06-30 |
| JP2008500001A (ja) | 2008-01-10 |
| EP1694848A1 (de) | 2006-08-30 |
| AU2003290092B2 (en) | 2009-11-19 |
| JP4505416B2 (ja) | 2010-07-21 |
| CA2588965A1 (en) | 2005-06-30 |
| US20090305961A1 (en) | 2009-12-10 |
| ATE459718T1 (de) | 2010-03-15 |
| AU2003290092A1 (en) | 2005-07-05 |
| US8124588B2 (en) | 2012-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |