BRPI0207394B8 - dna codificando uma proteína de fusão proteína codificada por um dna, plasmídeo, micro-organismo hospedeiro, processo para a produção fermentativa de uma proteína de fusão e processo para a produçao de insulina - Google Patents
dna codificando uma proteína de fusão proteína codificada por um dna, plasmídeo, micro-organismo hospedeiro, processo para a produção fermentativa de uma proteína de fusão e processo para a produçao de insulinaInfo
- Publication number
- BRPI0207394B8 BRPI0207394B8 BRPI0207394A BR0207394A BRPI0207394B8 BR PI0207394 B8 BRPI0207394 B8 BR PI0207394B8 BR PI0207394 A BRPI0207394 A BR PI0207394A BR 0207394 A BR0207394 A BR 0207394A BR PI0207394 B8 BRPI0207394 B8 BR PI0207394B8
- Authority
- BR
- Brazil
- Prior art keywords
- fusion protein
- production
- dna
- protein
- insulin
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 238000000034 method Methods 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 238000012262 fermentative production Methods 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 239000013612 plasmid Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"proteína de fusão para a secreção de uma proteína de interesse no sobrenadante da cultura bacteriana". a invenção refere-se a proteínas de fusão compreendendo uma parte de fusão e uma proteína de interesse, a combinação das duas proteínas conduzindo à proteína de fusão sendo secretada no sobrenadante de um hospedeiro bacteriano e a proteína de interesse estando presente em sua correta estrutura tridimensional.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108212A DE10108212A1 (de) | 2001-02-20 | 2001-02-20 | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
| PCT/EP2002/001307 WO2002068660A1 (en) | 2001-02-20 | 2002-02-08 | Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0207394A BR0207394A (pt) | 2004-02-10 |
| BRPI0207394B1 BRPI0207394B1 (pt) | 2015-06-16 |
| BRPI0207394B8 true BRPI0207394B8 (pt) | 2021-05-25 |
Family
ID=7674913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0207394A BRPI0207394B8 (pt) | 2001-02-20 | 2002-02-08 | dna codificando uma proteína de fusão proteína codificada por um dna, plasmídeo, micro-organismo hospedeiro, processo para a produção fermentativa de uma proteína de fusão e processo para a produçao de insulina |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1364029B1 (pt) |
| JP (1) | JP4243104B2 (pt) |
| KR (1) | KR100858009B1 (pt) |
| CN (1) | CN100500853C (pt) |
| AT (1) | ATE314480T1 (pt) |
| AU (1) | AU2002231784B2 (pt) |
| BR (1) | BRPI0207394B8 (pt) |
| CA (1) | CA2438886C (pt) |
| DE (2) | DE10108212A1 (pt) |
| DK (1) | DK1364029T3 (pt) |
| ES (1) | ES2254658T3 (pt) |
| IL (1) | IL157414A0 (pt) |
| MX (1) | MXPA03007114A (pt) |
| NO (1) | NO331271B1 (pt) |
| NZ (1) | NZ527643A (pt) |
| PE (1) | PE20020876A1 (pt) |
| WO (1) | WO2002068660A1 (pt) |
| ZA (1) | ZA200305869B (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| PL2327718T3 (pl) | 2003-11-21 | 2016-10-31 | Ulepszone systemy ekspresyjne z wykorzystaniem systemu sekrecji SEC | |
| ES2663594T3 (es) | 2004-01-16 | 2018-04-16 | Pfenex Inc | Expresión de proteínas de mamífero en Pseudomonas fluorescens |
| CA2574953A1 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technolgies Inc. | Process for improved protein expression by strain engineering |
| DE102006031955A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006050332A1 (de) | 2006-10-25 | 2008-04-30 | Wacker Chemie Ag | DNS-Konstrukt und Verfahren zur fermentativen Herstellung von Fusionsproteinen |
| AU2008210538B2 (en) | 2007-01-31 | 2013-06-06 | Pelican Technology Holdings, Inc. | Bacterial leader sequences for increased expression |
| JP5444553B2 (ja) | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法 |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| DE102008025007A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008025008A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| US9018001B2 (en) | 2008-10-02 | 2015-04-28 | Unitargeting Research As | Kit for the optimisation of protein synthesis/secretion |
| LT3228320T (lt) | 2008-10-17 | 2020-03-10 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
| PE20121362A1 (es) | 2009-11-13 | 2012-10-17 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende despro36exendina-4(1-39)-lys6-nh2, insulina gly(a21)-arg(b31)-arg(b32) y metionina |
| KR101772372B1 (ko) | 2009-11-13 | 2017-08-29 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| EP2611458B1 (en) | 2010-08-30 | 2016-09-21 | Sanofi-Aventis Deutschland GmbH | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| AU2012300978B2 (en) | 2011-08-29 | 2017-04-27 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| US11084860B2 (en) | 2013-03-12 | 2021-08-10 | The General Hospital Corporation | Modified Mullerian inhibiting substance (MIS) proteins and uses thereof for the treatment of diseases |
| EP4008339A1 (en) | 2013-12-11 | 2022-06-08 | The General Hospital Corporation | Use of mullerian inhibiting substance (mis) proteins for contraception |
| HRP20230470T1 (hr) | 2014-12-12 | 2023-07-21 | Sanofi-Aventis Deutschland Gmbh | Formulacija fiksnog omjera inzulin glargin/liksisenatid |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341414C (fr) * | 1984-03-27 | 2002-12-31 | Paul Tolstoshev | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| EP0511393B1 (en) * | 1990-11-08 | 1996-07-31 | Japan Energy Corporation | Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism |
| WO1995009125A1 (en) * | 1992-09-28 | 1995-04-06 | Pehr Harold T | Kicker latch for container closures |
| DE10033195A1 (de) * | 2000-07-07 | 2002-03-21 | Aventis Pharma Gmbh | Bifunktionale Fusionsproteine aus Hirudin und TAP |
-
2001
- 2001-02-20 DE DE10108212A patent/DE10108212A1/de not_active Withdrawn
-
2002
- 2002-02-06 PE PE2002000081A patent/PE20020876A1/es not_active Application Discontinuation
- 2002-02-08 ES ES02711847T patent/ES2254658T3/es not_active Expired - Lifetime
- 2002-02-08 CA CA2438886A patent/CA2438886C/en not_active Expired - Lifetime
- 2002-02-08 BR BRPI0207394A patent/BRPI0207394B8/pt not_active IP Right Cessation
- 2002-02-08 NZ NZ527643A patent/NZ527643A/en not_active IP Right Cessation
- 2002-02-08 KR KR1020037010943A patent/KR100858009B1/ko not_active Expired - Lifetime
- 2002-02-08 AT AT02711847T patent/ATE314480T1/de active
- 2002-02-08 DK DK02711847T patent/DK1364029T3/da active
- 2002-02-08 DE DE60208343T patent/DE60208343T2/de not_active Expired - Lifetime
- 2002-02-08 WO PCT/EP2002/001307 patent/WO2002068660A1/en not_active Ceased
- 2002-02-08 MX MXPA03007114A patent/MXPA03007114A/es active IP Right Grant
- 2002-02-08 AU AU2002231784A patent/AU2002231784B2/en not_active Expired
- 2002-02-08 CN CNB028068505A patent/CN100500853C/zh not_active Expired - Lifetime
- 2002-02-08 JP JP2002568754A patent/JP4243104B2/ja not_active Expired - Lifetime
- 2002-02-08 EP EP02711847A patent/EP1364029B1/en not_active Expired - Lifetime
- 2002-02-08 IL IL15741402A patent/IL157414A0/xx active IP Right Grant
-
2003
- 2003-07-30 ZA ZA200305869A patent/ZA200305869B/en unknown
- 2003-08-19 NO NO20033673A patent/NO331271B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20033673D0 (no) | 2003-08-19 |
| EP1364029B1 (en) | 2005-12-28 |
| ATE314480T1 (de) | 2006-01-15 |
| AU2002231784B2 (en) | 2006-10-26 |
| BR0207394A (pt) | 2004-02-10 |
| PE20020876A1 (es) | 2002-11-05 |
| DE10108212A1 (de) | 2002-08-22 |
| EP1364029A1 (en) | 2003-11-26 |
| JP2004518444A (ja) | 2004-06-24 |
| DE60208343T2 (de) | 2006-06-22 |
| NO331271B1 (no) | 2011-11-14 |
| NO20033673L (no) | 2003-10-17 |
| NZ527643A (en) | 2005-07-29 |
| IL157414A0 (en) | 2004-03-28 |
| CA2438886A1 (en) | 2002-09-06 |
| JP4243104B2 (ja) | 2009-03-25 |
| WO2002068660A1 (en) | 2002-09-06 |
| KR20030074842A (ko) | 2003-09-19 |
| CA2438886C (en) | 2013-07-23 |
| MXPA03007114A (es) | 2003-11-18 |
| BRPI0207394B1 (pt) | 2015-06-16 |
| CN100500853C (zh) | 2009-06-17 |
| HK1065335A1 (zh) | 2005-02-18 |
| DK1364029T3 (da) | 2006-05-08 |
| CN1529757A (zh) | 2004-09-15 |
| ES2254658T3 (es) | 2006-06-16 |
| ZA200305869B (en) | 2004-06-25 |
| DE60208343D1 (de) | 2006-02-02 |
| KR100858009B1 (ko) | 2008-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0207394B8 (pt) | dna codificando uma proteína de fusão proteína codificada por um dna, plasmídeo, micro-organismo hospedeiro, processo para a produção fermentativa de uma proteína de fusão e processo para a produçao de insulina | |
| IL173937A0 (en) | Novel fungal proteins and nucleic acids encoding same | |
| WO2004022697A3 (en) | Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof | |
| DE60235039D1 (de) | Egvii-endoglucanase und dafür codierende nukleinsäuren | |
| NZ595500A (en) | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them | |
| AU2002234863A1 (en) | Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses | |
| NZ591415A (en) | Haemophilus influenzae type B | |
| WO2003027306A3 (en) | Bgl3 beta-glucosidase and nucleic acids encoding the same | |
| ATE490309T1 (de) | Mutante e. coli-appa-phytaseenzyme und natürliche varianten davon, solche phytaseenzyme codierende nukleinsäuren, diese enthaltende vektoren und wirtszellen und verfahren zur herstellung und verwendung davon | |
| WO2003040681A3 (de) | Gene die für stoffwechselweg-proteine codieren | |
| BR0014519A (pt) | Sequências de sinais para a preparação de leu-herudin através da secreção por e. coli no meio de cultura | |
| WO2008073688A3 (en) | Improved expression system for recombinant human arginase i | |
| AU2002346803A1 (en) | Genes encoding for carbon metabolism and energy-producing proteins | |
| WO2021231549A3 (en) | Engineered gene-editing proteins | |
| EP1090995A3 (en) | Mycoplasma hyopneumoniae antigen MHP3, gene encoding it and uses thereof | |
| AU2002258630A1 (en) | Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof | |
| WO2002055549A3 (en) | Systems for expression of heterologous proteins in m. capsulatus | |
| ATE423205T1 (de) | Verfahren zur biologischen herstellung von l- pipekolinsäure | |
| EP1870454A4 (en) | PROCESS FOR DIPEPTIDE PRODUCTION | |
| DE602005019421D1 (de) | Grosstechnisch geeigneter mikroorganismus | |
| WO2004024769A3 (en) | Ostertagia vaccine | |
| WO2003040357A3 (de) | Gene die fuer phosphoenolpyruvat-zucker-phosphotransferase proteine codieren | |
| AU2002257075A1 (en) | Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof | |
| AU2002303137A1 (en) | Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof | |
| PL1716169T3 (pl) | Podjednostkowe szczepionki przeciwko Ornithobacterium rhinotracheale |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/06/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/02/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 08/02/2022 |