[go: up one dir, main page]

DE60326012D1 - Verfahren zur Konzentration von Proteinen - Google Patents

Verfahren zur Konzentration von Proteinen

Info

Publication number
DE60326012D1
DE60326012D1 DE60326012T DE60326012T DE60326012D1 DE 60326012 D1 DE60326012 D1 DE 60326012D1 DE 60326012 T DE60326012 T DE 60326012T DE 60326012 T DE60326012 T DE 60326012T DE 60326012 D1 DE60326012 D1 DE 60326012D1
Authority
DE
Germany
Prior art keywords
proteins
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60326012T
Other languages
English (en)
Inventor
Konstantin Konstantinov
Huong T Nguyen
Jens H Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Application granted granted Critical
Publication of DE60326012D1 publication Critical patent/DE60326012D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60326012T 2002-11-01 2003-11-01 Verfahren zur Konzentration von Proteinen Expired - Lifetime DE60326012D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42299902P 2002-11-01 2002-11-01
PCT/US2003/034522 WO2004042012A2 (en) 2002-11-01 2003-11-01 Process for concentration of macromolecules

Publications (1)

Publication Number Publication Date
DE60326012D1 true DE60326012D1 (de) 2009-03-12

Family

ID=32312584

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60326012T Expired - Lifetime DE60326012D1 (de) 2002-11-01 2003-11-01 Verfahren zur Konzentration von Proteinen

Country Status (8)

Country Link
US (1) US7674885B2 (de)
EP (1) EP1596667B1 (de)
JP (1) JP4500683B2 (de)
AU (1) AU2003287299A1 (de)
CA (1) CA2504134C (de)
DE (1) DE60326012D1 (de)
ES (1) ES2318183T3 (de)
WO (1) WO2004042012A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051347A1 (en) * 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
TW200634145A (en) 2005-01-25 2006-10-01 Wyeth Res Ireland Ltd Shear protectants in harvest microfiltration
ES2776657T3 (es) 2005-06-14 2020-07-31 Amgen Inc Formulaciones de proteínas autotamponantes
HRP20131112T1 (hr) 2005-11-01 2014-01-03 Abbvie Biotechnology Ltd Postupak za odreä�ivanje uäśinkovitosti adalimumaba kod subjekata koji pate od ankilozantnog spondilitisa pomoä†u ctx-ii i mmp3 kao biomarkera
AU2008233173B2 (en) * 2007-03-29 2013-09-19 Abbvie Inc. Crystalline anti-human IL-12 antibodies
US8092998B2 (en) * 2007-05-31 2012-01-10 Abbott Laboratories Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders
KR20210049186A (ko) * 2007-11-30 2021-05-04 애브비 바이오테크놀로지 리미티드 단백질 제형 및 이의 제조방법
AU2013204044B2 (en) * 2007-11-30 2017-08-31 Abbvie Biotechnology Ltd. Protein formulations and methods of making same
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
ES2406029T3 (es) 2008-04-15 2013-06-05 Grifols Therapeutics Inc. Ultrafiltración/diafiltración en dos fases
DE102008051574A1 (de) 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
BRPI0921320A2 (pt) * 2008-11-28 2018-05-22 Abbott Laboratories composições de anticorpo estáveis e métodos para estabilizar os mesmos
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2890782A1 (de) 2012-09-02 2015-07-08 AbbVie Inc. Verfahren zur steuerung einer proteinheterogenität
PE20150964A1 (es) 2012-09-07 2015-07-25 Coherus Biosciences Inc Formulaciones acuosas estables de adalimumab
EP2830651A4 (de) 2013-03-12 2015-09-02 Abbvie Inc An humanes tnf-alpha bindende humane antikörper und verfahren zur herstellung davon
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
KR102457855B1 (ko) 2016-08-17 2022-10-25 베링거 인겔하임 인터내셔날 게엠베하 생체 분자를 함유하는 고농축 액상 제형의 제조 방법
CA3040899A1 (en) 2016-10-21 2018-04-26 Amgen Inc. Pharmaceutical formulations and methods of making the same
US20220009961A1 (en) * 2020-07-09 2022-01-13 Waters Technologies Corporation Compositions, kits and methods useful for separating proteins from surfactants
AU2021381439A1 (en) 2020-11-23 2023-06-22 Abec, Inc. Filtration systems,components and methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
US5417970A (en) 1988-10-21 1995-05-23 Sanofi Drugs containing a glycosylated interleukin-2
US5552303A (en) * 1993-03-08 1996-09-03 Immunex Corporation DNA encoding epithelium-derived T-cell factor
MX9504215A (es) * 1995-10-05 1997-04-30 Inst Politecnico Nacional Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
US5814478A (en) 1995-12-15 1998-09-29 Regeneron Pharmaceuticals, Inc. Tyrosine kinase receptors and ligands
JP2000506534A (ja) * 1996-03-15 2000-05-30 ノボ ノルディスク アクティーゼルスカブ タンパク質含有溶液からのタンパク質の精製方法
DE19622422A1 (de) * 1996-06-04 1997-12-11 Sanorell Pharma Gmbh & Co Lagerungsstabile pharmazeutische Zusammensetzung mit immun - modulierenden und antiinflammatorischen Eigenschaften sowie ein Verfahren zu dessen Herstellung
US6365395B1 (en) * 2000-11-03 2002-04-02 Millipore Corporation Process for removing protein aggregates and virus from a protein solution

Also Published As

Publication number Publication date
AU2003287299A8 (en) 2004-06-07
US7674885B2 (en) 2010-03-09
AU2003287299A1 (en) 2004-06-07
US20060149042A1 (en) 2006-07-06
CA2504134C (en) 2012-03-06
CA2504134A1 (en) 2004-05-21
EP1596667B1 (de) 2009-01-21
WO2004042012A3 (en) 2004-11-04
JP4500683B2 (ja) 2010-07-14
EP1596667A4 (de) 2006-04-05
WO2004042012A2 (en) 2004-05-21
JP2006504525A (ja) 2006-02-09
EP1596667A2 (de) 2005-11-23
ES2318183T3 (es) 2009-05-01

Similar Documents

Publication Publication Date Title
DE60326012D1 (de) Verfahren zur Konzentration von Proteinen
DE60335733D1 (de) Verfahren zur solubilisierung von protein
DE60313283D1 (de) Verfahren zur zusammenfassung von unbekanntem videoinhalt
DE60306819D1 (de) Verfahren und System zur Bestimmung von Gaskomponenten
DE60223299D1 (de) Verfahren zur Sequenzierung von Nukleinsäuren
DE60320101D1 (de) Verfahren für regressionsanalyse von formationsparametern
ATE441300T1 (de) Verfahren und system zur ablieferung von hilfsdaten
EP1532516A4 (de) Verfahren zur bestimmung von gen-knockout-strategien
DE60234425D1 (de) Verfahren zur optimaliserung von verkerhrsinformationsinhalt
DE112004001806D2 (de) Verfahren zur Selbstjustierenden Verkleinerung von Strukturen
ATE437486T1 (de) Verfahren zur konfiguration von physischen kanälen
DE50205653D1 (de) Verfahren zur festlegung von zeitpunkt und umfang von wartungsvorgängen
DE502004003630D1 (de) System und verfahren zur identifizierung von automatisierungskomponenten
ATE505811T1 (de) Verfahren zur nassbehandlung von scheibenförmigen gegenständen
DE60307617D1 (de) Verfahren zur gewinnung von gold
ATE416619T1 (de) Verfahren zur dearomatisierung von molkeprotein
DE50303241D1 (de) Verfahren zur bereitstellung von abwesenheitsinformation
DE60301283D1 (de) Verfahren zur Bestimmung von Biopolymeren
DE50301044D1 (de) Verfahren zur auswahl von transpondern
DE50204680D1 (de) Verfahren zur detektion von nukleinsäuremolekülen
DE10393421D2 (de) Verfahren zur Anreicherung und zum Nachweis von pathologisch veränderten Prion-Proteinen (PRPSC)
ATA16992003A (de) Verfahren zur qualitätssicherung von langholz
DE60322483D1 (de) Vorrichtung und Verfahren zur Feststellung von Vortragsstil
EP1392444A4 (de) Verfahren zur sulfidkonzentration
DE60328693D1 (de) Verfahren zur oxadimierung von carbonylverbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition