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MX9504215A - Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica. - Google Patents

Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.

Info

Publication number
MX9504215A
MX9504215A MX9504215A MX9504215A MX9504215A MX 9504215 A MX9504215 A MX 9504215A MX 9504215 A MX9504215 A MX 9504215A MX 9504215 A MX9504215 A MX 9504215A MX 9504215 A MX9504215 A MX 9504215A
Authority
MX
Mexico
Prior art keywords
oligopeptides
daltons
improved process
purify
molecular weights
Prior art date
Application number
MX9504215A
Other languages
English (en)
Inventor
Sergio Antonio Estrada Parra
Carlos Adolfo Perez De La Mora
Original Assignee
Inst Politecnico Nacional
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Politecnico Nacional filed Critical Inst Politecnico Nacional
Priority to MX9504215A priority Critical patent/MX9504215A/es
Priority to PCT/MX1996/000018 priority patent/WO1997012915A1/es
Priority to AU70985/96A priority patent/AU7098596A/en
Publication of MX9504215A publication Critical patent/MX9504215A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a un procedimiento mejorado para el fraccionamiento con alto rendimiento, de un conjunto de oligopéptidos (de 1000 a 10000 daltones), recuperados a partir del rompimiento de leucocitos y que poseen actividad biologica para la regulacion de la respuesta inmune que comprende los siguientes pasos: a partir de paquetes leucocitarios de donadores sanos, TODO BAJO CONDICIONES ASEPTICAS, se rompen las células, se hacen suspensiones ajustando volumenes, y mediante ultracentrifugacion, se clarifica la suspension de los restos celulares (detritus celulares), se recuperan los oligopéptidos por medio de diafiltracion y se concentran por ultrafiltracion tangencial. Se formula el producto con base en su formula de producto terminado en presentacion farmacéutica.
MX9504215A 1995-10-05 1995-10-05 Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica. MX9504215A (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
MX9504215A MX9504215A (es) 1995-10-05 1995-10-05 Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.
PCT/MX1996/000018 WO1997012915A1 (es) 1995-10-05 1996-10-02 Procedimiento de purificacion del factor de transferencia a partir de leucocitos
AU70985/96A AU7098596A (en) 1995-10-05 1996-10-02 Process for purifying the transfer factor from leucocytes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX9504215A MX9504215A (es) 1995-10-05 1995-10-05 Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.

Publications (1)

Publication Number Publication Date
MX9504215A true MX9504215A (es) 1997-04-30

Family

ID=19744888

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9504215A MX9504215A (es) 1995-10-05 1995-10-05 Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.

Country Status (3)

Country Link
AU (1) AU7098596A (es)
MX (1) MX9504215A (es)
WO (1) WO1997012915A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
CA2504134C (en) * 2002-11-01 2012-03-06 Bayer Healthcare Llc Process for concentration of macromolecules
MX338863B (es) * 2011-12-16 2016-05-01 Inst Politecnico Nacional Metodo de obtencion de extracto dializable de leucocitos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56500015A (es) * 1978-10-25 1981-01-08
CH656068A5 (en) * 1983-01-06 1986-06-13 Bezirksblutspendezentrale Plau Process for the preparation of human transfer factor products
AU8107191A (en) * 1990-07-02 1992-01-23 National Jewish Center For Immunology And Respiratory Medicine Process for obtaining pure peptide transfer factor, transfer factor thus obtained and uses thereof
DD301781A7 (de) * 1990-09-12 1994-09-15 Cyto Chemia Biolog Pharmazeuti Virussichere humane Transfer-Faktor-Praeparate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
WO1997012915A1 (es) 1997-04-10
AU7098596A (en) 1997-04-28

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