DE60326970D1 - Gegen gewebefaktor gerichtete antikörper als antikoagulantien - Google Patents

Gegen gewebefaktor gerichtete antikörper als antikoagulantien

Info

Publication number: DE60326970D1
Authority: DE; Germany
Prior art keywords: anticoagulants; antibodies; tissue facial; facial; tissue
Prior art date: 2002-05-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60326970T

Other languages

English (en)

Inventor

David Light

Kirk Mclean

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Bayer Schering Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-01

Filing date

2003-04-30

Publication date

2009-05-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60326970(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-30 Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG

2009-05-14 Application granted granted Critical

2009-05-14 Publication of DE60326970D1 publication Critical patent/DE60326970D1/de

2023-05-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Immunology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE60326970T 2002-05-01 2003-04-30 Gegen gewebefaktor gerichtete antikörper als antikoagulantien Expired - Lifetime DE60326970D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37656602P	2002-05-01	2002-05-01
PCT/US2003/013521 WO2003093422A2 (en)	2002-05-01	2003-04-30	Novel tissue factor targeted antibodies as anticoagulants

Publications (1)

Publication Number	Publication Date
DE60326970D1 true DE60326970D1 (de)	2009-05-14

Family

ID=29401364

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60334538T Expired - Lifetime DE60334538D1 (de)	2002-05-01	2003-04-30	Neue gegen den gewebefaktor gerichtete thrombomodulin-fusionsproteine als antikoagulantien
DE60326970T Expired - Lifetime DE60326970D1 (de)	2002-05-01	2003-04-30	Gegen gewebefaktor gerichtete antikörper als antikoagulantien

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60334538T Expired - Lifetime DE60334538D1 (de)	2002-05-01	2003-04-30	Neue gegen den gewebefaktor gerichtete thrombomodulin-fusionsproteine als antikoagulantien

Country Status (29)

Country	Link
US (3)	US7250168B2 (de)
EP (2)	EP1549341B1 (de)
JP (2)	JP4567437B2 (de)
KR (2)	KR101013697B1 (de)
CN (2)	CN100563709C (de)
AR (1)	AR039515A1 (de)
AT (2)	ATE427121T1 (de)
AU (2)	AU2003225255B2 (de)
BR (2)	BR0304660A (de)
CA (2)	CA2483910A1 (de)
CR (1)	CR7584A (de)
DE (2)	DE60334538D1 (de)
DK (2)	DK1503785T3 (de)
EC (2)	ECSP045468A (de)
ES (2)	ES2354419T3 (de)
HK (1)	HK1080372A1 (de)
IL (3)	IL164733A0 (de)
MX (2)	MXPA04010795A (de)
NO (2)	NO20035848L (de)
NZ (2)	NZ536242A (de)
PE (1)	PE20040597A1 (de)
PL (2)	PL210582B1 (de)
PT (2)	PT1503785E (de)
RS (2)	RS102404A (de)
RU (2)	RU2345789C2 (de)
TW (1)	TWI343388B (de)
UA (2)	UA85996C2 (de)
WO (2)	WO2003093422A2 (de)
ZA (2)	ZA200409692B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2339843T3 (es)	1999-06-02	2010-05-26	Chugai Seiyaku Kabushiki Kaisha	Proteina receptora de hematopoyetina novedosa, nr10.
EP1221482B1 (de) *	1999-09-27	2005-12-28	Chugai Seiyaku Kabushiki Kaisha	HäMOPOIETINREZEPTOR-PROTEIN, NR12
AU2001296305B2 (en)	2000-09-26	2007-12-06	Duke University	RNA aptamers and methods for identifying the same
US7579000B2 (en)	2002-05-01	2009-08-25	Bayer Schering Pharma Ag	Tissue factor targeted antibodies as anticoagulants
UA85996C2 (ru) *	2002-05-01	2009-03-25	Шеринг Акциенгезельшафт	Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору
EP1539235A2 (de) *	2002-07-01	2005-06-15	Human Genome Sciences, Inc.	Spezifisch an reg iv bindende antikörper
US7425328B2 (en)	2003-04-22	2008-09-16	Purdue Pharma L.P.	Tissue factor antibodies and uses thereof
US7833978B2 (en) *	2004-02-20	2010-11-16	Emory University	Thrombomodulin derivatives and conjugates
DK1745062T3 (da)	2004-04-22	2014-08-11	Regado Biosciences Inc	Forbedrede modulatorer af koagulationsfaktorer
JP4067557B2 (ja) *	2005-06-03	2008-03-26	持田製薬株式会社	抗ｃｄ１４抗体融合蛋白質
US20090130104A1 (en) *	2005-10-05	2009-05-21	The Trustees Of The University Of Pennsylvania	Fusion proteins for inhibition and dissolution of coagulation
ES2353084T3 (es) *	2006-04-07	2011-02-25	Novo Nordisk Health Care Ag	Complejo covalente de factor vii y factor tisular.
WO2007142325A1 (ja)	2006-06-08	2007-12-13	Chugai Seiyaku Kabushiki Kaisha	炎症性疾患の予防または治療剤
CN101522206B (zh) *	2006-10-06	2013-03-27	旭化成制药株式会社	弥散性血管内凝血综合征的治疗剂和/或改善剂
US9649499B2 (en)	2007-03-28	2017-05-16	Medtronic ATS Medical, Inc.	Method for inhibiting platelet interaction with biomaterial surfaces
US20100316563A1 (en) *	2007-09-20	2010-12-16	Bracco Imaging S.P.A.	Method For The Preparation Of New Oligoclonal Antibodies
MX2010006097A (es)	2007-12-05	2010-08-04	Chugai Pharmaceutical Co Ltd	Agentes terapeuticos para tratar el prurito.
US8333973B2 (en) *	2008-01-02	2012-12-18	The Trustees Of The University Of Pennsylvania	Targeting recombinant therapeutics to circulating red blood cells
UA112050C2 (uk) *	2008-08-04	2016-07-25	БАЄР ХЕЛСКЕР ЛЛСі	Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
SG2013061528A (en) *	2008-08-14	2015-03-30	Merck Sharp & Dohme	Methods for purifying antibodies using protein a affinity chromatography
US20110262466A1 (en) *	2008-10-16	2011-10-27	The Trustees Of The University Of Pennsylvania	Compositions containing thrombomodulin domains and uses thereof
US20120165244A1 (en) *	2008-10-30	2012-06-28	Hua-Lin Wu	Methods for binding lewis y antigen
UA109633C2 (uk)	2008-12-09	2015-09-25		Антитіло людини проти тканинного фактора
EP2230251A1 (de) *	2009-03-19	2010-09-22	Bracco Imaging S.p.A	Antikörper, die speziell im Koronarplaque aktiv sind und Verfahren zur ihrer Identifizierung
EP2470201A4 (de) *	2009-08-28	2013-01-30	Bayer Healthcare Llc	Kofaktoren zur faktor-vii-thrombinaktivierung und anwendungen davon
GB201007356D0 (en)	2010-04-30	2010-06-16	Leverton Licence Holdings Ltd	Conjugated factor VIIa
EP2576625B1 (de)	2010-06-04	2018-04-25	TiumBio Co., Ltd.	Fusionprotein mit faktor-vii wirkung
CA2802782C (en)	2010-06-15	2018-03-13	Genmab A/S	Human antibody drug conjugates against tissue factor
AR082588A1 (es)	2010-08-05	2012-12-19	Council Scient Ind Res	Construcciones de proteinas de fusion con propiedades tromboliticas y anticoagulantes
RU2445365C1 (ru) *	2010-11-03	2012-03-20	Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат")	Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
KR102514173B1 (ko)	2015-04-14	2023-03-27	추가이 세이야쿠 가부시키가이샤	Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
RU2749512C2 (ru)	2015-04-14	2021-06-11	Чугаи Сейяку Кабусики Кайся	Фармацевтическая композиция для профилактики и/или лечения атопического дерматита, включающая антагонист ил-31 в качестве активного ингредиента
WO2016176440A2 (en) *	2015-04-28	2016-11-03	Saint Louis University	Thrombin-thrombomodulin fusion proteins as protein c activators
US11085031B2 (en)	2016-04-28	2021-08-10	Saint Louis University	Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
RU2019118427A (ru) *	2016-11-16	2020-12-17	БАЙЕР ХелсКер ЛЛСи	Нацеленный на эритроциты фактор viii и способ его применения
BR102017005783A2 (pt) *	2017-03-21	2018-10-02	Fund Butantan	processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
TWI841554B (zh)	2018-03-21	2024-05-11	丹麥商珍美寶股份有限公司	以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
SG11202010993VA (en)	2018-05-07	2020-12-30	Genmab As	Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
CN112840032A (zh) *	2018-10-04	2021-05-25	血栓形成和凝血公司	用于确定蛋白水平的方法
TWI844571B (zh)	2018-10-30	2024-06-11	丹麥商珍美寶股份有限公司	使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
WO2021100794A1 (ja)	2019-11-20	2021-05-27	中外製薬株式会社	抗体含有製剤
CN114686444B (zh) *	2020-12-31	2024-05-31	广州万孚生物技术股份有限公司	杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用
CN114686443B (zh) *	2020-12-31	2023-11-03	广州万孚生物技术股份有限公司	杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4208479A (en) *	1977-07-14	1980-06-17	Syva Company	Label modified immunoassays
ZA862768B (en) *	1985-04-17	1986-12-30	Zymogenetics Inc	Expression of factor vii and ix activities in mammalian cells
US5589173A (en) *	1986-11-04	1996-12-31	Genentech, Inc.	Method and therapeutic compositions for the treatment of myocardial infarction
US5223427A (en) *	1987-03-31	1993-06-29	The Scripps Research Institute	Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US5437864A (en) *	1987-03-31	1995-08-01	The Scripps Research Institute	Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US4912207A (en) *	1987-05-06	1990-03-27	Washington University	DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da)	1987-06-12	1987-06-12	Novo Industri As	Proteins and derivatives thereof
US5298599A (en) *	1988-12-30	1994-03-29	Oklahoma Medical Research Foundation	Expression and purification of recombinant soluble tissue factor
KR920701459A (ko) *	1989-02-17	1992-08-11	코돈	트롬보모듈린의 가용성 유사체
US5256770A (en) *	1990-04-09	1993-10-26	Schering Ag	Oxidation resistant thrombomodulin analogs
US6063763A (en) *	1989-04-28	2000-05-16	Schering Aktiengesellschaft	Protease-resistant thrombomodulin analogs
US5466668A (en) *	1989-04-28	1995-11-14	Schering Aktiengesellschaft	Superior thrombomodulin analogs for pharmaceutical use
KR930008093B1 (ko) *	1990-08-03	1993-08-25	아사히가세이고오교 가부시끼가이샤	신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
US5506134A (en) *	1990-10-22	1996-04-09	Corvas International, Inc.	Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5843442A (en) *	1990-10-22	1998-12-01	Corvas International, Inc.	Blood coagulation protein antagonists and uses therefor
JPH0578397A (ja) *	1991-01-29	1993-03-30	Sumitomo Pharmaceut Co Ltd	血栓溶解タンパク質
JPH06133780A (ja) *	1992-10-23	1994-05-17	Sumitomo Pharmaceut Co Ltd	新規なｔ−ＰＡ改変体
US5916874A (en) *	1994-04-20	1999-06-29	Asahi Kasei Kogyo Kabushiki Kaisha	Method for treating liver injury
US5736364A (en) *	1995-12-04	1998-04-07	Genentech, Inc.	Factor viia inhibitors
US5986065A (en) *	1997-03-10	1999-11-16	Sunol Molecular Corporation	Antibodies for inhibiting blood coagulation and methods of use thereof
TR200101541T2 (tr) *	1998-04-03	2002-06-21	Chugai Seiyaku Kabushiki Kaisha	İnsan doku faktörüne (TF) karşı insanlaştırılmış antikor.
AU5081401A (en) *	2000-03-16	2001-10-03	Genentech Inc	Anti-tissue factor antibodies with enhanced anticoagulant potency
US6632791B1 (en) *	2000-06-21	2003-10-14	Schering Aktiengesellschaft	Thrombomodulin analogs for pharmaceutical use
TWI338009B (en) *	2001-10-29	2011-03-01	Genentech Inc	Antibodies for inhibiting blood coagulation and methods of use thereof
EP1465998A2 (de)	2002-01-08	2004-10-13	Bayer HealthCare AG	Herz-kreislauf-erkrankung und medikamentenwirkung voraussagende einzelnukleotid-polymorphismen
UA85996C2 (ru)	2002-05-01	2009-03-25	Шеринг Акциенгезельшафт	Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору
US7579000B2 (en)	2002-05-01	2009-08-25	Bayer Schering Pharma Ag	Tissue factor targeted antibodies as anticoagulants

2003
- 2003-04-30 UA UA20041109788A patent/UA85996C2/ru unknown
- 2003-04-30 US US10/427,805 patent/US7250168B2/en not_active Expired - Fee Related
- 2003-04-30 MX MXPA04010795A patent/MXPA04010795A/es active IP Right Grant
- 2003-04-30 UA UA20041109787A patent/UA81114C2/uk unknown
- 2003-04-30 CN CNB038157039A patent/CN100563709C/zh not_active Expired - Fee Related
- 2003-04-30 PL PL373960A patent/PL210582B1/pl not_active IP Right Cessation
- 2003-04-30 PT PT03721975T patent/PT1503785E/pt unknown
- 2003-04-30 EP EP03721974A patent/EP1549341B1/de not_active Expired - Lifetime
- 2003-04-30 NZ NZ536242A patent/NZ536242A/en unknown
- 2003-04-30 WO PCT/US2003/013521 patent/WO2003093422A2/en not_active Ceased
- 2003-04-30 RU RU2004135306/13A patent/RU2345789C2/ru not_active IP Right Cessation
- 2003-04-30 BR BR0304660-5A patent/BR0304660A/pt not_active IP Right Cessation
- 2003-04-30 PL PL03373945A patent/PL373945A1/xx not_active Application Discontinuation
- 2003-04-30 RU RU2004135308/15A patent/RU2320366C2/ru not_active IP Right Cessation
- 2003-04-30 DE DE60334538T patent/DE60334538D1/de not_active Expired - Lifetime
- 2003-04-30 BR BR0304659-1A patent/BR0304659A/pt not_active IP Right Cessation
- 2003-04-30 ES ES03721975T patent/ES2354419T3/es not_active Expired - Lifetime
- 2003-04-30 KR KR1020047017456A patent/KR101013697B1/ko not_active Expired - Fee Related
- 2003-04-30 HK HK06100300.9A patent/HK1080372A1/zh unknown
- 2003-04-30 AR ARP030101529A patent/AR039515A1/es active IP Right Grant
- 2003-04-30 RS YU102404A patent/RS102404A/sr unknown
- 2003-04-30 ES ES03721974T patent/ES2323056T3/es not_active Expired - Lifetime
- 2003-04-30 PE PE2003000426A patent/PE20040597A1/es not_active Application Discontinuation
- 2003-04-30 PT PT03721974T patent/PT1549341E/pt unknown
- 2003-04-30 CN CNB038157020A patent/CN100412090C/zh not_active Expired - Fee Related
- 2003-04-30 AT AT03721974T patent/ATE427121T1/de active
- 2003-04-30 CA CA002483910A patent/CA2483910A1/en not_active Abandoned
- 2003-04-30 DE DE60326970T patent/DE60326970D1/de not_active Expired - Lifetime
- 2003-04-30 DK DK03721975.5T patent/DK1503785T3/da active
- 2003-04-30 CA CA002483909A patent/CA2483909A1/en not_active Abandoned
- 2003-04-30 DK DK03721974T patent/DK1549341T3/da active
- 2003-04-30 JP JP2004500787A patent/JP4567437B2/ja not_active Expired - Fee Related
- 2003-04-30 NZ NZ536243A patent/NZ536243A/en unknown
- 2003-04-30 AT AT03721975T patent/ATE484524T1/de active
- 2003-04-30 IL IL16473303A patent/IL164733A0/xx unknown
- 2003-04-30 EP EP03721975A patent/EP1503785B1/de not_active Expired - Lifetime
- 2003-04-30 RS YUP-1045/04A patent/RS104504A/sr unknown
- 2003-04-30 AU AU2003225255A patent/AU2003225255B2/en not_active Ceased
- 2003-04-30 KR KR1020047017458A patent/KR101080587B1/ko not_active Expired - Fee Related
- 2003-04-30 WO PCT/US2003/013522 patent/WO2003092602A2/en not_active Ceased
- 2003-04-30 TW TW092110159A patent/TWI343388B/zh not_active IP Right Cessation
- 2003-04-30 JP JP2004501558A patent/JP4460443B2/ja not_active Expired - Fee Related
- 2003-04-30 AU AU2003225256A patent/AU2003225256B2/en not_active Ceased
- 2003-04-30 MX MXPA04010851A patent/MXPA04010851A/es active IP Right Grant
- 2003-12-30 NO NO20035848A patent/NO20035848L/no not_active Application Discontinuation
- 2003-12-30 NO NO20035849A patent/NO20035849L/no not_active Application Discontinuation
2004
- 2004-10-20 IL IL16473204A patent/IL164732A0/xx unknown
- 2004-10-20 IL IL164733A patent/IL164733A/en not_active IP Right Cessation
- 2004-11-24 CR CR7584A patent/CR7584A/es not_active Application Discontinuation
- 2004-11-30 ZA ZA200409692A patent/ZA200409692B/xx unknown
- 2004-11-30 ZA ZA200409694A patent/ZA200409694B/en unknown
- 2004-11-30 EC EC2004005468A patent/ECSP045468A/es unknown
- 2004-11-30 EC EC2004005467A patent/ECSP045467A/es unknown
2007
- 2007-06-21 US US11/766,155 patent/US7622457B2/en not_active Expired - Fee Related
- 2007-06-21 US US11/766,160 patent/US7622122B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2003093422A3 (en)	2004-07-15
RS104504A (sr)	2007-02-05
KR101013697B1 (ko)	2011-02-10
WO2003092602A2 (en)	2003-11-13
HK1080372A1 (zh)	2006-04-28
ES2354419T3 (es)	2011-03-14
EP1549341A4 (de)	2006-10-18
UA85996C2 (ru)	2009-03-25
PE20040597A1 (es)	2004-10-06
JP4567437B2 (ja)	2010-10-20
PL373945A1 (en)	2005-09-19
RU2320366C2 (ru)	2008-03-27
CR7584A (es)	2006-05-30
CN1665526A (zh)	2005-09-07
EP1503785B1 (de)	2010-10-13
CN100563709C (zh)	2009-12-02
CA2483909A1 (en)	2003-11-13
RU2004135308A (ru)	2005-08-10
KR20050045944A (ko)	2005-05-17
DK1549341T3 (da)	2009-07-06
KR20050045945A (ko)	2005-05-17
MXPA04010795A (es)	2005-03-07
AU2003225255A1 (en)	2003-11-17
EP1549341B1 (de)	2009-04-01
JP4460443B2 (ja)	2010-05-12
NZ536243A (en)	2006-06-30
NO20035848L (no)	2004-02-27
EP1503785A4 (de)	2007-02-14
AU2003225255B2 (en)	2008-07-31
TWI343388B (en)	2011-06-11
ES2323056T3 (es)	2009-07-06
PL210582B1 (pl)	2012-02-29
KR101080587B1 (ko)	2011-11-04
AR039515A1 (es)	2005-02-23
US20080019985A1 (en)	2008-01-24
ZA200409692B (en)	2006-07-26
BR0304660A (pt)	2005-06-07
NZ536242A (en)	2006-04-28
AU2003225256A1 (en)	2003-11-17
AU2003225256B2 (en)	2009-06-04
US7622457B2 (en)	2009-11-24
EP1549341A2 (de)	2005-07-06
TW200307043A (en)	2003-12-01
ZA200409694B (en)	2006-02-22
BR0304659A (pt)	2004-09-21
RU2345789C2 (ru)	2009-02-10
NO20035849L (no)	2004-02-27
RU2004135306A (ru)	2005-07-10
IL164732A0 (en)	2005-12-18
EP1503785A2 (de)	2005-02-09
CN1665534A (zh)	2005-09-07
PT1503785E (pt)	2011-01-17
ECSP045467A (es)	2005-01-28
ECSP045468A (es)	2005-01-28
US20080020965A1 (en)	2008-01-24
RS102404A (sr)	2006-12-15
DE60334538D1 (de)	2010-11-25
CN100412090C (zh)	2008-08-20
DK1503785T3 (da)	2011-02-07
UA81114C2 (en)	2007-12-10
WO2003092602A3 (en)	2004-08-26
US7622122B2 (en)	2009-11-24
US7250168B2 (en)	2007-07-31
CA2483910A1 (en)	2003-11-13
PT1549341E (pt)	2009-05-29
ATE427121T1 (de)	2009-04-15
PL373960A1 (en)	2005-09-19
IL164733A (en)	2011-05-31
JP2005538046A (ja)	2005-12-15
JP2005532045A (ja)	2005-10-27
MXPA04010851A (es)	2005-02-14
IL164733A0 (en)	2005-12-18
WO2003093422A2 (en)	2003-11-13
US20040063632A1 (en)	2004-04-01
ATE484524T1 (de)	2010-10-15

Publication	Publication Date	Title
DE60326970D1 (de)	2009-05-14	Gegen gewebefaktor gerichtete antikörper als antikoagulantien
DE50304983D1 (de)	2006-10-19	Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren
DE60330694D1 (de)	2010-02-04	Pyrimidopyrimidone als kinaseinhibitoren
EP1539252A4 (de)	2008-03-12	Gegen blutgerinnsel gerichtete nanoteilchen
ATE515515T1 (de)	2011-07-15	Immunglobuline gegen menschlisches osm
DE60317997D1 (de)	2008-01-24	Lanzette
DE60305603D1 (de)	2006-07-06	Bankautomat
DE60336213D1 (de)	2011-04-14	Chirurgisches klammergerät
PT1484995E (pt)	2006-10-31	Guarda-chuva inclinavel
ATE490756T1 (de)	2010-12-15	Kosmetisches unterarm-verfahren
DE60329138D1 (de)	2009-10-22	Geldautomat
DE60318132D1 (de)	2008-01-31	Haarwaschmittel
DE60329874D1 (de)	2009-12-17	Haarwaschmittel
DE60319547D1 (de)	2008-04-17	Haarwaschmittel
DE602004015227D1 (de)	2008-09-04	Bankautomat
DE60309952D1 (de)	2007-01-11	Geldautomat
DE602004004736D1 (de)	2007-03-29	Haarwaschmittel
DE50302584D1 (de)	2006-05-04	Stereomikroskop
DE50302514D1 (de)	2006-04-27	Stereomikroskop
DE60335978D1 (de)	2011-03-24	Haarwaschmittel
EP1579918A4 (de)	2008-07-23	Schleudermaschine
DE10393352D2 (de)	2005-06-16	Skalpell
DE60328937D1 (de)	2009-10-08	Objektivdiagnostik
FI20021817A7 (fi)	2004-04-15	Kanyyli
ATA12882003A (de)	2005-09-15	Osteosynthesevorrichtung

Legal Events

Date	Code	Title	Description
2010-04-22	8364	No opposition during term of opposition