DE60316698D1 - Verfahren zur herstellung von n-monosubstituierten -aminoalkoholen - Google Patents

Verfahren zur herstellung von n-monosubstituierten -aminoalkoholen

Info

Publication number: DE60316698D1
Authority: DE; Germany
Prior art keywords: producing; amino alcohols; monosubstituted amino; aralkyl; aryl
Prior art date: 2002-07-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60316698T

Other languages

English (en)

Other versions

DE60316698T2 (de

Inventor

Dominique Michel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lonza AG

Original Assignee

Lonza AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-09

Filing date

2003-07-09

Publication date

2007-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60316698(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-07-09 Application filed by Lonza AG filed Critical Lonza AG

2007-11-15 Publication of DE60316698D1 publication Critical patent/DE60316698D1/de

2008-07-17 Application granted granted Critical

2008-07-17 Publication of DE60316698T2 publication Critical patent/DE60316698T2/de

2023-07-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

DE2003616698 2002-07-09 2003-07-09 VERFAHREN ZUR HERSTELLUNG VON N-MONOSUBSTITUIERTEN ß-AMINOALKOHOLEN Expired - Lifetime DE60316698T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02015229		2002-07-09
EP02015229		2002-07-09
PCT/EP2003/007411 WO2004005239A1 (en)	2002-07-09	2003-07-09	PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS

Publications (2)

Publication Number	Publication Date
DE60316698D1 true DE60316698D1 (de)	2007-11-15
DE60316698T2 DE60316698T2 (de)	2008-07-17

Family

ID=30011063

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE2003616698 Expired - Lifetime DE60316698T2 (de)	2002-07-09	2003-07-09	VERFAHREN ZUR HERSTELLUNG VON N-MONOSUBSTITUIERTEN ß-AMINOALKOHOLEN
DE60329640T Expired - Lifetime DE60329640D1 (de)	2002-07-09	2003-07-09	Verfahren zur Herstellung von N-Monoalkyl-Beta-Aminoalkoholen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60329640T Expired - Lifetime DE60329640D1 (de)	2002-07-09	2003-07-09	Verfahren zur Herstellung von N-Monoalkyl-Beta-Aminoalkoholen

Country Status (19)

Country	Link
US (7)	US20080119661A1 (de)
JP (1)	JP4546242B2 (de)
KR (2)	KR101021460B1 (de)
CN (4)	CN1891683A (de)
AT (2)	ATE444949T1 (de)
AU (1)	AU2010201850B2 (de)
BR (1)	BR0312651B1 (de)
CA (1)	CA2491472C (de)
CY (1)	CY1109691T1 (de)
DE (2)	DE60316698T2 (de)
DK (1)	DK1539673T3 (de)
EA (1)	EA009394B1 (de)
ES (2)	ES2334397T3 (de)
IL (1)	IL166107A (de)
NO (2)	NO329267B1 (de)
NZ (1)	NZ537567A (de)
PT (2)	PT1852415E (de)
SI (1)	SI1852415T1 (de)
WO (1)	WO2004005239A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10240026A1 (de) *	2002-08-27	2004-03-11	Merck Patent Gmbh	Verfahren zur Herstellung von Monoalkylaminoketonen
DE10302595A1 (de) *	2003-01-22	2004-07-29	Basf Ag	3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
EP1566383A1 (de) *	2004-02-19	2005-08-24	Lonza AG	Verfahren zur Herstellung von enantiomerenreinen 1-substituierten 3-Aminoalkoholen
KR101160502B1 (ko) *	2004-02-19	2012-06-28	론자 아게	거울상 이성질체적으로 순수한 1-치환된-3-아미노알콜의제조 방법
DE102004021434A1 (de)	2004-04-30	2005-11-24	Basf Ag	Schnelle schaumarme Netzer für hydrophobe Oberflächen
EA200701613A1 (ru)	2005-02-21	2008-02-28	Лонца Аг	Способ получения энантиомерно чистых 1-замещенных 3-аминоспиртов
CZ299270B6 (cs)	2006-01-04	2008-06-04	Zentiva, A. S.	Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
US20100280093A1 (en)	2006-07-03	2010-11-04	Ranbaxy Laboratories Limited	Process for the preparation enantiomerically pure salts of n-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine
ATE552250T1 (de)	2006-12-22	2012-04-15	Synthon Bv	Verfahren zur herstellung von duloxetin und verwandten verbindungen
US8288141B2 (en)	2008-08-27	2012-10-16	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (de)	2008-08-27	2015-10-28	Codexis, Inc.	Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin
CZ304602B6 (cs)	2009-09-02	2014-07-30	Zentiva, K. S.	Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
CN108707096B (zh) *	2018-05-07	2021-03-19	上海科技大学	一种制备氨基醇衍生物的方法
CN108947798B (zh) *	2018-05-30	2021-03-02	上海科技大学	一种降解聚合物的方法
CN109134427B (zh) *	2018-10-24	2020-06-30	浙江乐普药业股份有限公司	一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法
CN115677512A (zh) *	2022-10-27	2023-02-03	大连万福制药有限公司	一种合成乐卡地平中间体n-甲基-3，3-二苯基丙胺盐酸盐的方法
CN116640115A (zh) *	2023-05-16	2023-08-25	浙江工业大学	一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3031248A1 (de) *	1980-08-19	1982-04-01	Ruhrchemie Ag, 4200 Oberhausen	Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US5362866A (en) *	1983-09-02	1994-11-08	Molecular Biosystems, Inc.	Oligonucleotide polymeric support system with an oxidation cleavable link
FI912280L (fi) *	1990-05-17	1991-11-18	Lilly Co Eli	Kiral syntes av 1-aryl-3-aminopropan-1 -oler.
US5362886A (en) *	1993-10-12	1994-11-08	Eli Lilly And Company	Asymmetric synthesis
DE10240026A1 (de)	2002-08-27	2004-03-11	Merck Patent Gmbh	Verfahren zur Herstellung von Monoalkylaminoketonen
EP1510517A1 (de) *	2003-09-01	2005-03-02	Lonza AG	Verfahren zur asymmetrischen Hydrierung von Beta-Aminoketonen

2003
- 2003-07-09 CN CNA2006101007056A patent/CN1891683A/zh active Pending
- 2003-07-09 KR KR1020107027492A patent/KR101021460B1/ko not_active Expired - Lifetime
- 2003-07-09 DK DK03762669T patent/DK1539673T3/da active
- 2003-07-09 CN CN2012105072295A patent/CN103058986A/zh active Pending
- 2003-07-09 NZ NZ537567A patent/NZ537567A/en not_active IP Right Cessation
- 2003-07-09 AT AT07015051T patent/ATE444949T1/de active
- 2003-07-09 DE DE2003616698 patent/DE60316698T2/de not_active Expired - Lifetime
- 2003-07-09 ES ES07015051T patent/ES2334397T3/es not_active Expired - Lifetime
- 2003-07-09 ES ES03762669T patent/ES2293029T3/es not_active Expired - Lifetime
- 2003-07-09 CA CA2491472A patent/CA2491472C/en not_active Expired - Lifetime
- 2003-07-09 PT PT07015051T patent/PT1852415E/pt unknown
- 2003-07-09 BR BRPI0312651A patent/BR0312651B1/pt not_active IP Right Cessation
- 2003-07-09 JP JP2004518758A patent/JP4546242B2/ja not_active Expired - Lifetime
- 2003-07-09 WO PCT/EP2003/007411 patent/WO2004005239A1/en not_active Ceased
- 2003-07-09 KR KR20057000338A patent/KR101027358B1/ko not_active Expired - Lifetime
- 2003-07-09 PT PT03762669T patent/PT1539673E/pt unknown
- 2003-07-09 CN CN2009102668505A patent/CN101851168B/zh not_active Expired - Fee Related
- 2003-07-09 DE DE60329640T patent/DE60329640D1/de not_active Expired - Lifetime
- 2003-07-09 SI SI200331714T patent/SI1852415T1/sl unknown
- 2003-07-09 EA EA200500137A patent/EA009394B1/ru not_active IP Right Cessation
- 2003-07-09 AT AT03762669T patent/ATE374744T1/de active
- 2003-07-09 CN CNB038162237A patent/CN100497295C/zh not_active Expired - Lifetime
2005
- 2005-01-03 IL IL166107A patent/IL166107A/en active IP Right Grant
- 2005-01-06 NO NO20050079A patent/NO329267B1/no not_active IP Right Cessation
2007
- 2007-12-31 US US12/003,752 patent/US20080119661A1/en not_active Abandoned
2009
- 2009-12-30 CY CY091101353T patent/CY1109691T1/el unknown
2010
- 2010-05-07 AU AU2010201850A patent/AU2010201850B2/en not_active Ceased
- 2010-05-19 NO NO20100728A patent/NO20100728L/no not_active Application Discontinuation
- 2010-05-28 US US12/801,231 patent/US20100240911A1/en not_active Abandoned
- 2010-08-25 US US12/868,419 patent/US8558014B2/en not_active Expired - Fee Related
2013
- 2013-07-25 US US13/950,412 patent/US8962865B2/en not_active Expired - Lifetime
2014
- 2014-12-23 US US14/580,577 patent/US20150112086A1/en not_active Abandoned
2015
- 2015-08-26 US US14/836,357 patent/US20150361064A1/en not_active Abandoned
2017
- 2017-09-08 US US15/698,935 patent/US20170369467A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK1539673T3 (da)	2008-01-21
CN100497295C (zh)	2009-06-10
AU2010201850B2 (en)	2011-08-25
KR20100135331A (ko)	2010-12-24
US20150361064A1 (en)	2015-12-17
US20170369467A1 (en)	2017-12-28
CA2491472A1 (en)	2004-01-15
CN101851168B (zh)	2013-07-03
JP2005532383A (ja)	2005-10-27
KR20050017092A (ko)	2005-02-21
US20080119661A1 (en)	2008-05-22
KR101027358B1 (ko)	2011-04-11
IL166107A0 (en)	2006-01-15
US20150112086A1 (en)	2015-04-23
PT1539673E (pt)	2007-11-14
BR0312651A (pt)	2005-04-26
NZ537567A (en)	2006-11-30
CA2491472C (en)	2011-09-27
US8962865B2 (en)	2015-02-24
AU2010201850A1 (en)	2010-05-27
US20130310574A1 (en)	2013-11-21
NO20100728L (no)	2005-03-11
US8558014B2 (en)	2013-10-15
EA009394B1 (ru)	2007-12-28
WO2004005239A1 (en)	2004-01-15
SI1852415T1 (sl)	2010-01-29
IL166107A (en)	2012-06-28
BR0312651B1 (pt)	2017-10-31
AU2003250924A1 (en)	2004-01-23
NO20050079L (no)	2005-03-11
DE60316698T2 (de)	2008-07-17
ES2334397T3 (es)	2010-03-09
HK1079765A1 (en)	2006-04-13
NO329267B1 (no)	2010-09-20
ATE444949T1 (de)	2009-10-15
ES2293029T3 (es)	2008-03-16
JP4546242B2 (ja)	2010-09-15
US20110004007A1 (en)	2011-01-06
CY1109691T1 (el)	2014-08-13
KR101021460B1 (ko)	2011-03-16
CN1891683A (zh)	2007-01-10
CN101851168A (zh)	2010-10-06
US20100240911A1 (en)	2010-09-23
DE60329640D1 (de)	2009-11-19
CN1665773A (zh)	2005-09-07
ATE374744T1 (de)	2007-10-15
HK1145317A1 (en)	2011-04-15
PT1852415E (pt)	2009-12-18
EA200500137A1 (ru)	2005-08-25
CN103058986A (zh)	2013-04-24

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