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NO20071685L - Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer - Google Patents

Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer

Info

Publication number
NO20071685L
NO20071685L NO20071685A NO20071685A NO20071685L NO 20071685 L NO20071685 L NO 20071685L NO 20071685 A NO20071685 A NO 20071685A NO 20071685 A NO20071685 A NO 20071685A NO 20071685 L NO20071685 L NO 20071685L
Authority
NO
Norway
Prior art keywords
tricyclic
hydroxysteroid dehydrogenase
dehydrogenase inhibitors
beta hydroxysteroid
adamantylamide
Prior art date
Application number
NO20071685A
Other languages
English (en)
Inventor
Louis Jozef Elisabeth Va Veken
Joannes Theodorus Mari Linders
Gustaaf Henri Maria Willemsens
Libuse Jaroskova
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2005/054198 external-priority patent/WO2006024628A1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20071685L publication Critical patent/NO20071685L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelser med formel (I) og (I '^) er nyttige som 1 IBETA-HSDl-inhibitorer for behandling av obesitet.
NO20071685A 2004-08-30 2007-03-30 Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer NO20071685L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04104147 2004-08-30
US60784004P 2004-09-08 2004-09-08
PCT/EP2005/054198 WO2006024628A1 (en) 2004-08-30 2005-08-26 Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Publications (1)

Publication Number Publication Date
NO20071685L true NO20071685L (no) 2007-03-30

Family

ID=35432565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071685A NO20071685L (no) 2004-08-30 2007-03-30 Tricykliske adamantylamidderivater som 11-beta hydroksysteroid-dehydrogenaseinhibitorer

Country Status (3)

Country Link
US (3) US9150512B2 (no)
DE (1) DE602005017159D1 (no)
NO (1) NO20071685L (no)

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PT94121A (pt) 1989-05-23 1991-02-08 Sankyo Co Processo para a preparacao de derivados fenol para promover o factor de crescimento do nervo humano
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FR2653123B1 (fr) 1989-10-17 1992-01-17 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CA2053340C (en) 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9312893D0 (en) 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
FR2714291B1 (fr) 1993-12-24 1996-03-01 Roussel Uclaf Application des dérivés de la pyridone à titre de médicaments anesthésiques.
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US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
DE69626321T2 (de) 1995-11-17 2003-08-14 Aventis Pharmaceuticals Inc., Bridgewater Substituierte 4-(1h-benzimidazol-2-yl-amino)piperidine zur behandlung allergischer erkrankungen
DE69620241T2 (de) 1995-12-14 2002-10-02 MERCK & CO., INC. (A NEW JERSEY CORP.) Gonadotropin releasing hormon- antagonisten
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BR9612074A (pt) 1995-12-20 1999-03-30 Hoechst Marion Roussel Inc Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
JP2002505660A (ja) 1996-09-10 2002-02-19 ファルマシア・アンド・アップジョン・カンパニー 抗ウィルス剤としての８―ヒドロキシ―７―置換キノリン
NZ505207A (en) 1997-11-21 2003-10-31 Nps Pharma Inc Metabotropic glutamate receptor antagonists for treating central nervous system diseases
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6867299B2 (en) 2000-02-24 2005-03-15 Hoffmann-La Roche Inc. Oxamide IMPDH inhibitors
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
WO2002026706A2 (en) 2000-09-29 2002-04-04 Bayer Pharmaceuticals Corporation 17-beta-hydroxysteroid dehydrogenase-ii inhibitors
AU2003207717B9 (en) 2002-02-01 2009-05-07 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
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WO2004075847A2 (en) 2003-02-21 2004-09-10 Message Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR THE TREATMENT OF Aß­ ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS
ATE482747T1 (de) 2003-04-11 2010-10-15 High Point Pharmaceuticals Llc Neue amide derivate und deren pharmazeutische verwendungen
WO2004089416A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
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CA2565632C (en) 2004-05-07 2013-04-23 Janssen Pharmaceutica N.V. Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
EP1747199B1 (en) 2004-05-07 2014-09-17 Janssen Pharmaceutica NV Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
MY146435A (en) 2004-08-30 2012-08-15 Janssen Pharmaceutica Nv N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CN101039908B (zh) 2004-08-30 2010-06-23 詹森药业有限公司 作为11-β羟甾类脱氢酶抑制剂的三环内酰胺衍生物

Also Published As

Publication number Publication date
US20160002229A1 (en) 2016-01-07
US9630921B2 (en) 2017-04-25
DE602005017159D1 (de) 2009-11-26
US20160318865A1 (en) 2016-11-03
US20140179732A1 (en) 2014-06-26
US9422284B2 (en) 2016-08-23
US9150512B2 (en) 2015-10-06

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