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DE602004008668D1 - Benzoxazinderivate und deren verwendungen - Google Patents

Benzoxazinderivate und deren verwendungen

Info

Publication number
DE602004008668D1
DE602004008668D1 DE602004008668T DE602004008668T DE602004008668D1 DE 602004008668 D1 DE602004008668 D1 DE 602004008668D1 DE 602004008668 T DE602004008668 T DE 602004008668T DE 602004008668 T DE602004008668 T DE 602004008668T DE 602004008668 D1 DE602004008668 D1 DE 602004008668D1
Authority
DE
Germany
Prior art keywords
benzoxazine derivatives
benzoxazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004008668T
Other languages
English (en)
Other versions
DE602004008668T2 (de
Inventor
Jacob Berger
Robin Douglas Clark
Shu-Hai Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602004008668D1 publication Critical patent/DE602004008668D1/de
Application granted granted Critical
Publication of DE602004008668T2 publication Critical patent/DE602004008668T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004008668T 2003-12-09 2004-11-30 Benzoxazinderivate und deren verwendungen Expired - Lifetime DE602004008668T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52837803P 2003-12-09 2003-12-09
US528378P 2003-12-09
PCT/EP2004/013557 WO2005058847A1 (en) 2003-12-09 2004-11-30 Benzoxazine derivatives and uses thereof

Publications (2)

Publication Number Publication Date
DE602004008668D1 true DE602004008668D1 (de) 2007-10-11
DE602004008668T2 DE602004008668T2 (de) 2008-06-12

Family

ID=34699863

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004008668T Expired - Lifetime DE602004008668T2 (de) 2003-12-09 2004-11-30 Benzoxazinderivate und deren verwendungen

Country Status (21)

Country Link
US (1) US7202241B2 (de)
EP (1) EP1694656B1 (de)
JP (1) JP4527730B2 (de)
KR (1) KR100827915B1 (de)
CN (1) CN100532369C (de)
AR (1) AR046753A1 (de)
AT (1) ATE371653T1 (de)
AU (1) AU2004299201B2 (de)
BR (1) BRPI0416873A (de)
CA (1) CA2547764A1 (de)
CO (1) CO5700768A2 (de)
DE (1) DE602004008668T2 (de)
ES (1) ES2291984T3 (de)
IL (1) IL175817A0 (de)
MY (1) MY145576A (de)
NO (1) NO20062491L (de)
NZ (1) NZ547120A (de)
RU (1) RU2354651C2 (de)
TW (1) TW200522953A (de)
WO (1) WO2005058847A1 (de)
ZA (1) ZA200604725B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1408976B3 (de) * 2001-07-20 2010-08-25 Psychogenics Inc. Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
MX2007003545A (es) * 2004-09-30 2007-05-18 Hoffmann La Roche Composiciones y metodos para tratar trastornos cognitivos.
JP2009533325A (ja) * 2006-03-17 2009-09-17 アストラゼネカ・アクチエボラーグ ５−ｈｔ６調節剤としての新規なテトラリン
CL2007003044A1 (es) * 2006-10-24 2008-07-04 Wyeth Corp Compuestos derivados de benzoxazina; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y abuso o dependencia de sustancias entre otros.
WO2011023753A1 (en) * 2009-08-27 2011-03-03 Glaxo Group Limited Benzoxazine derivatives as glycine transport inhibitors
CN101836993B (zh) 2010-05-20 2011-06-22 山东大学 2，3-二氢-3-羟甲基-6-氨基-[1，4]-苯并噁嗪在制备诱导胚胎干细胞向血管内皮细胞分化药物中的应用
CN102060810B (zh) * 2010-12-20 2012-07-04 金坛市爱特生物科技有限公司 一种n-叔丁氧羰基-哌嗪的提纯方法
EP3110429A4 (de) 2014-02-27 2018-02-21 Lycera Corporation Adoptive zelltherapie unter verwendung eines agonisten des retinsäurenrezeptor-assoziierten orphanrezeptors gamma und dazugehörige therapeutische verfahren
WO2015171558A2 (en) 2014-05-05 2015-11-12 Lycera Corporation BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE
AU2015256190B2 (en) 2014-05-05 2019-08-15 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
AU2015286049B2 (en) 2014-07-08 2018-03-01 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
JP2018515491A (ja) 2015-05-05 2018-06-14 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物
EP3307738B1 (de) 2015-06-11 2022-04-20 The Regents of the University of Michigan Aryl-dihydro-2h-benzo[b][1,4]oxazin-sulfonamid und verwandte verbindungen zur verwendung als agonisten von rory und zur behandlung von erkrankungen
CN109568321B (zh) * 2019-01-14 2022-02-22 山东轩竹医药科技有限公司 RORγ调节剂
US20230416262A1 (en) * 2020-08-07 2023-12-28 Casma Therapeutics, Inc. Trpml modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803419D0 (en) * 1988-02-15 1988-03-16 Erba Carlo Spa 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation
GB9507203D0 (en) 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
CN1260781A (zh) 1997-04-18 2000-07-19 史密丝克莱恩比彻姆有限公司 具有综合的5ht1a、5ht1b和5ht1d受体拮抗剂活性的吲哚衍生物
HRP20010785A2 (en) * 1999-04-28 2003-02-28 Reddys Lab Ltd Dr Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
AU2001236606A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa
NZ536230A (en) * 2002-05-13 2007-05-31 Hoffmann La Roche Benzoxazine derivatives as 5-hydroxytryptamine-6 (5-HT6) modulatory neurotransmitter in the brain
WO2004041792A1 (en) * 2002-11-08 2004-05-21 F. Hoffmann-La Roche Ag Substituted benzoxazinones and uses thereof

Also Published As

Publication number Publication date
CA2547764A1 (en) 2005-06-30
KR100827915B1 (ko) 2008-05-07
DE602004008668T2 (de) 2008-06-12
CN100532369C (zh) 2009-08-26
TW200522953A (en) 2005-07-16
NO20062491L (no) 2006-09-06
AU2004299201B2 (en) 2009-12-03
ATE371653T1 (de) 2007-09-15
MY145576A (en) 2012-02-29
CN1890227A (zh) 2007-01-03
US20050124613A1 (en) 2005-06-09
EP1694656A1 (de) 2006-08-30
US7202241B2 (en) 2007-04-10
IL175817A0 (en) 2006-10-05
CO5700768A2 (es) 2006-11-30
WO2005058847A1 (en) 2005-06-30
AR046753A1 (es) 2005-12-21
KR20060097758A (ko) 2006-09-15
RU2006124513A (ru) 2008-01-27
ZA200604725B (en) 2007-12-27
RU2354651C2 (ru) 2009-05-10
EP1694656B1 (de) 2007-08-29
JP2007513904A (ja) 2007-05-31
AU2004299201A1 (en) 2005-06-30
ES2291984T3 (es) 2008-03-01
JP4527730B2 (ja) 2010-08-18
BRPI0416873A (pt) 2007-02-27
NZ547120A (en) 2009-02-28

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Legal Events

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