[go: up one dir, main page]

DE60138127D1 - Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine - Google Patents

Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine

Info

Publication number
DE60138127D1
DE60138127D1 DE60138127T DE60138127T DE60138127D1 DE 60138127 D1 DE60138127 D1 DE 60138127D1 DE 60138127 T DE60138127 T DE 60138127T DE 60138127 T DE60138127 T DE 60138127T DE 60138127 D1 DE60138127 D1 DE 60138127D1
Authority
DE
Germany
Prior art keywords
host cells
recombinant host
polypeptide
fertilizers
recombinant proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138127T
Other languages
English (en)
Inventor
Dana Andersen
John Joly
Bradley R Snedecor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22928808&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60138127(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE60138127D1 publication Critical patent/DE60138127D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fertilizers (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60138127T 2000-11-03 2001-11-01 Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine Expired - Lifetime DE60138127D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24596200P 2000-11-03 2000-11-03
PCT/US2001/045623 WO2002040697A2 (en) 2000-11-03 2001-11-01 Metabolic rate shifts in fermentations expressing recombinant proteins

Publications (1)

Publication Number Publication Date
DE60138127D1 true DE60138127D1 (de) 2009-05-07

Family

ID=22928808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60138127T Expired - Lifetime DE60138127D1 (de) 2000-11-03 2001-11-01 Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine

Country Status (13)

Country Link
US (1) US6716602B2 (de)
EP (1) EP1332222B1 (de)
JP (1) JP4878724B2 (de)
AT (1) ATE426674T1 (de)
AU (1) AU3944002A (de)
CA (1) CA2426100A1 (de)
CY (1) CY1110494T1 (de)
DE (1) DE60138127D1 (de)
DK (1) DK1332222T3 (de)
ES (1) ES2324645T3 (de)
IL (2) IL155482A0 (de)
PT (1) PT1332222E (de)
WO (1) WO2002040697A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
CN1735691B (zh) * 2002-05-30 2010-05-26 卡吉尔道有限责任公司 利用比氧吸收率作为过程控制的发酵方法
GB0321100D0 (en) * 2003-09-09 2003-10-08 Celltech R&D Ltd Biological products
HRP20180738T1 (hr) 2008-09-15 2018-06-15 F. Hoffmann - La Roche Ag Pripravci i postupci za regulaciju stanične osmolarnosti
EA020843B1 (ru) 2009-02-03 2015-02-27 Амуникс Оперейтинг Инк. Удлиненные рекомбинантные полипептиды и содержащие их композиции
MX2012004682A (es) 2009-10-26 2012-09-07 Hoffmann La Roche Metodo para la produccion de una inmunoglobulina glicosilada.
GB2482536B (en) 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
SI2898086T1 (sl) 2012-09-19 2019-03-29 F. Hoffmann-La Roche Ag Načini in sestavki za preprečevanje napačnega vključevanja norlevcina v beljakovine
US9688977B2 (en) 2013-08-05 2017-06-27 Greenlight Biosciences, Inc. Engineered phosphoglucose isomerase proteins with a protease cleavage site
JPWO2015178466A1 (ja) * 2014-05-21 2017-04-20 味の素株式会社 フィブロイン様タンパク質の製造法
CN104164465B (zh) * 2014-07-14 2017-07-04 北京泰德制药股份有限公司 一种表达重组蛋白的发酵工艺
CN107075548B (zh) 2014-11-05 2021-08-10 基因泰克公司 在细菌中产生双链蛋白质的方法
WO2016073791A1 (en) * 2014-11-05 2016-05-12 Genentech, Inc. Methods of producing two chain proteins in bacteria
EP3303552A4 (de) * 2015-05-29 2019-01-16 Cargill, Incorporated Fermentationsverfahren zur herstellung steviolglykosiden mit mehrphasiger zuführung
EP4063513A1 (de) 2015-05-29 2022-09-28 Cargill, Incorporated Wärmebehandlung zur herstellung von glykosiden
CN107949632B (zh) 2015-05-29 2021-06-01 嘉吉公司 用于使用高pH生产甜菊醇糖苷的发酵方法和由此获得的组合物
AU2016301190A1 (en) 2015-08-06 2018-02-15 Cargill, Incorporated Fermentation methods for producing steviol glycosides
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
US11261462B2 (en) 2016-01-27 2022-03-01 Just-Evotec Biologics, Inc. Inducible expression from transposon-based vectors and uses
US11098310B2 (en) 2016-01-27 2021-08-24 Just-Evotec Biologics, Inc. Expression from transposon-based vectors and uses
JP6937309B2 (ja) 2016-01-27 2021-09-22 ジャスト−エヴォテック バイオロジックス、インコーポレイテッド ハイブリッドプロモーターおよびその使用
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
AU2019370705B2 (en) 2018-10-31 2026-01-22 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565785A (en) 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4673641A (en) 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4738921A (en) 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4795706A (en) 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5342763A (en) 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
CA2153445C (en) * 1994-09-08 2002-05-21 Ashok Raj Saxena Video optimized media streamer user interface
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5790423A (en) * 1995-06-14 1998-08-04 Audible, Inc. Interactive audio transmission receiving and playback system
AR005035A1 (es) 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
US6615192B1 (en) * 1999-03-12 2003-09-02 Matsushita Electric Industrial Co., Ltd. Contents copying system, copying method, computer-readable recording medium and disc drive copying contents but not a cipher key via a host computer
CN1187756C (zh) * 1999-05-28 2005-02-02 松下电器产业株式会社 半导体存储器卡、播放装置、记录装置、播放方法、记录方法、和计算机可读记录介质
DE19943919B4 (de) 1999-09-14 2004-05-27 Pharmacia Ab Verfahren zur Steigerung der Ausbeute von rekombinanten Proteinen in mikrobiellen Fermentationsprozessen

Also Published As

Publication number Publication date
PT1332222E (pt) 2009-06-30
US20020164700A1 (en) 2002-11-07
WO2002040697A2 (en) 2002-05-23
EP1332222B1 (de) 2009-03-25
WO2002040697A3 (en) 2003-03-13
ATE426674T1 (de) 2009-04-15
EP1332222A2 (de) 2003-08-06
IL155482A (en) 2010-12-30
ES2324645T3 (es) 2009-08-12
DK1332222T3 (da) 2009-07-06
IL155482A0 (en) 2003-11-23
HK1054765A1 (en) 2003-12-12
CY1110494T1 (el) 2015-04-29
AU3944002A (en) 2002-05-27
JP2004517614A (ja) 2004-06-17
US6716602B2 (en) 2004-04-06
JP4878724B2 (ja) 2012-02-15
CA2426100A1 (en) 2002-05-23

Similar Documents

Publication Publication Date Title
DE60138127D1 (de) Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine
SI1543106T1 (sl) Postopki in mediji za nadziranje sialilacije proteinov, ki jih proizvajajo sesalske celice
CY1117558T1 (el) Μεθοδος για καλλιεργεια κυτταρων για παραγωγη ουσιων
CA2508925A1 (en) Product quality enhancement in mammalian cell culture processes for protein production
DE69532968T2 (de) Verfahren zur sekretion thrombopoitin polypeptide
UA92157C2 (ru) Способ продуцирования гормона роста
EA200600554A1 (ru) Способ получения рекомбинантных белков
PT1200561E (pt) Clone celular recombinante estavel, sua producao e utilizacao
GB2429211A (en) Feeder independent extended culture of embryonic stem cells
Mao et al. Optimization of the fermentation parameters for the production of Ganoderma lucidum immunomodulatory protein by Pichia pastoris
Viader‐Salvadó et al. Shrimp (Litopenaeus vannamei) trypsinogen production in Pichia pastoris bioreactor cultures
Jia et al. Evaluation of the sub-optimal induction strategies for heterologous proteins production by Pichia pastoris Mut+/MutS strains and related transcriptional and metabolic analysis
DK1861504T3 (da) Glycoengineering i svampe
WO2002002591A3 (en) Peptides for use in culture media
EA199600001A3 (ru) Агент экстракции периплазматических рекомбинантных белков, способ экстракции периплазматического белка и способ культивирования прокариотического микроорганизма
Chen et al. Expression and transformation characteristics of a novel glutamic acid decarboxylase LcGAD10s and its application on Sufu processing
TW200510544A (en) Improved method for the recombinant production of polypeptides
WO2005054447A3 (en) Müller stem cells
FR2785291B1 (fr) Procede de production in vivo de proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels
AU2003277694A1 (en) Porcine uroplakin ii promoter and the production method of useful proteins using said promoter
NZ515762A (en) Method of producing a heparin-binding protein by expressing it in a mammalian cell that can be cultured in anaerobic conditions
AU2099800A (en) Production of proteins
WO2003012098A1 (en) Modified yeast showing high secretion productivity of foreign protein and process for producing foreign protein using the yeast
TNSN01128A1 (en) Process for the preparation of a neutrophil inhibitory factor
BRPI0517942B8 (pt) processo para a produção do hormônio de crescimento humano recombinante (rhgh) e usos de um meio de cultura de células isento de soro

Legal Events

Date Code Title Description
8363 Opposition against the patent