AR023914A1 - Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores - Google Patents
Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumoresInfo
- Publication number
- AR023914A1 AR023914A1 ARP990105796A ARP990105796A AR023914A1 AR 023914 A1 AR023914 A1 AR 023914A1 AR P990105796 A ARP990105796 A AR P990105796A AR P990105796 A ARP990105796 A AR P990105796A AR 023914 A1 AR023914 A1 AR 023914A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical compositions
- caprolactamas
- replaced
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical group O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a caprolactamas sustituidas, que comprende un compuesto de la formula (1) en donde: R1 es alquilo C1-6 o cicloalquilo C3-6; R2 eshidrogeno o alquilo C1-6; X es alquileno C1-12, alquenileno C2-12 o alquinileno C2-12; m es 0 o1; y R3 es cicloalquilo C3-8; o un sistema de anillo aromáticoseleccionado a partir de las formulas (2) a (5), en donde: R4 es hidrogeno, cloro, o metoxilo; R5 es hidrogeno, cloro, alquilo C1-18, o alcoxilo C1-18; y Z esoxígeno, azufre, N-H, oN-CH3; o una sal de adicion de ácido farmacéuticamente aceptable del mismo, cuando sea posible; caprolactama sustituida a composicionesfarmacéuticas que contienen estos compuestos, o al uso de estos compuestos para la preparacion de un medicamentosen el tra tamiento de tumores, y a un procesopara fabricar estos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19335498A | 1998-11-17 | 1998-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023914A1 true AR023914A1 (es) | 2002-09-04 |
Family
ID=22713307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105796A AR023914A1 (es) | 1998-11-17 | 1999-11-15 | Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1131297B1 (es) |
| JP (1) | JP3550545B2 (es) |
| KR (1) | KR20010080461A (es) |
| CN (1) | CN1187333C (es) |
| AR (1) | AR023914A1 (es) |
| AT (1) | ATE264309T1 (es) |
| AU (1) | AU748016B2 (es) |
| BR (1) | BR9915436A (es) |
| CA (1) | CA2347773C (es) |
| CO (1) | CO5140099A1 (es) |
| CZ (1) | CZ20011707A3 (es) |
| DE (1) | DE69916488T2 (es) |
| ES (1) | ES2221463T3 (es) |
| HU (1) | HUP0104224A3 (es) |
| ID (1) | ID28343A (es) |
| IL (1) | IL142701A0 (es) |
| NO (1) | NO20012428L (es) |
| PE (1) | PE20001241A1 (es) |
| PL (1) | PL347633A1 (es) |
| PT (1) | PT1131297E (es) |
| SK (1) | SK6692001A3 (es) |
| TR (1) | TR200101366T2 (es) |
| UY (2) | UY25807A1 (es) |
| WO (1) | WO2000029382A1 (es) |
| ZA (1) | ZA200103419B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2299515T3 (es) * | 2000-05-11 | 2008-06-01 | Novartis Ag | Carbonatos y eteres de caprolactama sustituidos y su uso como agentes antitumorales. |
| WO2002072555A1 (en) * | 2001-03-12 | 2002-09-19 | Novartis Ag | Process for preparing certain substituted caprolactams |
| AU2004263287B2 (en) * | 2003-07-25 | 2009-02-12 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
| US7153846B2 (en) | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
| DE10349669B3 (de) * | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2878525B1 (fr) * | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
| FR2878528B1 (fr) * | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
| FR2901556A1 (fr) * | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation |
| FR2901555A1 (fr) | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation |
| FR2901554B1 (fr) | 2006-05-24 | 2011-04-01 | Sanofi Aventis | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
| CN102947274A (zh) | 2010-06-17 | 2013-02-27 | 诺瓦提斯公司 | 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物 |
| JP2013532149A (ja) | 2010-06-17 | 2013-08-15 | ノバルティス アーゲー | ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411841D0 (en) * | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
-
1999
- 1999-11-04 CO CO99069674A patent/CO5140099A1/es unknown
- 1999-11-15 EP EP99957309A patent/EP1131297B1/en not_active Expired - Lifetime
- 1999-11-15 WO PCT/EP1999/008767 patent/WO2000029382A1/en not_active Ceased
- 1999-11-15 PL PL99347633A patent/PL347633A1/xx unknown
- 1999-11-15 AT AT99957309T patent/ATE264309T1/de not_active IP Right Cessation
- 1999-11-15 HU HU0104224A patent/HUP0104224A3/hu unknown
- 1999-11-15 IL IL14270199A patent/IL142701A0/xx unknown
- 1999-11-15 AR ARP990105796A patent/AR023914A1/es unknown
- 1999-11-15 SK SK669-2001A patent/SK6692001A3/sk unknown
- 1999-11-15 BR BR9915436-6A patent/BR9915436A/pt not_active Application Discontinuation
- 1999-11-15 JP JP2000582369A patent/JP3550545B2/ja not_active Expired - Fee Related
- 1999-11-15 DE DE69916488T patent/DE69916488T2/de not_active Expired - Lifetime
- 1999-11-15 PE PE1999001155A patent/PE20001241A1/es not_active Application Discontinuation
- 1999-11-15 PT PT99957309T patent/PT1131297E/pt unknown
- 1999-11-15 CN CNB998134104A patent/CN1187333C/zh not_active Expired - Fee Related
- 1999-11-15 CZ CZ20011707A patent/CZ20011707A3/cs unknown
- 1999-11-15 ES ES99957309T patent/ES2221463T3/es not_active Expired - Lifetime
- 1999-11-15 AU AU15060/00A patent/AU748016B2/en not_active Ceased
- 1999-11-15 KR KR1020017006152A patent/KR20010080461A/ko not_active Ceased
- 1999-11-15 CA CA002347773A patent/CA2347773C/en not_active Expired - Fee Related
- 1999-11-15 TR TR2001/01366T patent/TR200101366T2/xx unknown
- 1999-11-15 ID IDW00200100966A patent/ID28343A/id unknown
- 1999-11-17 UY UY25807A patent/UY25807A1/es unknown
-
2000
- 2000-02-25 UY UY26036A patent/UY26036A1/es unknown
-
2001
- 2001-04-26 ZA ZA200103419A patent/ZA200103419B/en unknown
- 2001-05-16 NO NO20012428A patent/NO20012428L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1187333C (zh) | 2005-02-02 |
| HUP0104224A2 (hu) | 2002-03-28 |
| BR9915436A (pt) | 2001-08-07 |
| WO2000029382A1 (en) | 2000-05-25 |
| DE69916488D1 (de) | 2004-05-19 |
| SK6692001A3 (en) | 2001-10-08 |
| ES2221463T3 (es) | 2004-12-16 |
| PE20001241A1 (es) | 2000-11-24 |
| NO20012428L (no) | 2001-07-17 |
| UY25807A1 (es) | 2001-08-27 |
| EP1131297B1 (en) | 2004-04-14 |
| AU1506000A (en) | 2000-06-05 |
| ID28343A (id) | 2001-05-17 |
| JP2002529536A (ja) | 2002-09-10 |
| HUP0104224A3 (en) | 2002-04-29 |
| NO20012428D0 (no) | 2001-05-16 |
| CO5140099A1 (es) | 2002-03-22 |
| CA2347773A1 (en) | 2000-05-25 |
| IL142701A0 (en) | 2002-03-10 |
| TR200101366T2 (tr) | 2001-10-22 |
| KR20010080461A (ko) | 2001-08-22 |
| CZ20011707A3 (cs) | 2001-08-15 |
| DE69916488T2 (de) | 2005-03-24 |
| JP3550545B2 (ja) | 2004-08-04 |
| ATE264309T1 (de) | 2004-04-15 |
| ZA200103419B (en) | 2002-06-26 |
| CN1326445A (zh) | 2001-12-12 |
| PL347633A1 (en) | 2002-04-22 |
| EP1131297A1 (en) | 2001-09-12 |
| AU748016B2 (en) | 2002-05-30 |
| PT1131297E (pt) | 2004-08-31 |
| CA2347773C (en) | 2009-03-10 |
| UY26036A1 (es) | 2001-06-29 |
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