DE60106599D1 - Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren - Google Patents

Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren

Info

Publication number: DE60106599D1
Authority: DE; Germany
Prior art keywords: glucocinase; activators; substituted phenylacetamides; phenylacetamides; substituted
Prior art date: 2000-05-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60106599T

Other languages

English (en)

Other versions

DE60106599T2 (de

Inventor

Wendy Lea Corbett

Nancy-Ellen Haynes

Ramakanth Sarabu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-04-27

Publication date

2004-11-25

2001-04-27 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2004-11-25 Publication of DE60106599D1 publication Critical patent/DE60106599D1/de

2006-02-09 Application granted granted Critical

2006-02-09 Publication of DE60106599T2 publication Critical patent/DE60106599T2/de

2021-04-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60106599T 2000-05-08 2001-04-27 Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren Expired - Lifetime DE60106599T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20238700P	2000-05-08	2000-05-08
US202387P		2000-05-08
PCT/EP2001/004777 WO2001085706A1 (en)	2000-05-08	2001-04-27	Substituted phenylacetamides and their use as glucokinase activators

Publications (2)

Publication Number	Publication Date
DE60106599D1 true DE60106599D1 (de)	2004-11-25
DE60106599T2 DE60106599T2 (de)	2006-02-09

Family

ID=22749667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60106599T Expired - Lifetime DE60106599T2 (de)	2000-05-08	2001-04-27	Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren

Country Status (20)

Country	Link
US (1)	US6384220B2 (de)
EP (1)	EP1282611B1 (de)
JP (1)	JP3839723B2 (de)
KR (1)	KR100548901B1 (de)
CN (1)	CN1245394C (de)
AR (1)	AR035639A1 (de)
AT (1)	ATE280163T1 (de)
AU (1)	AU778036B2 (de)
BR (1)	BR0110704A (de)
CA (1)	CA2407759C (de)
DE (1)	DE60106599T2 (de)
DK (1)	DK1282611T3 (de)
EC (1)	ECSP014067A (de)
ES (1)	ES2230309T3 (de)
MX (1)	MXPA02010796A (de)
PE (1)	PE20020056A1 (de)
PT (1)	PT1282611E (de)
UY (1)	UY26694A1 (de)
WO (1)	WO2001085706A1 (de)
ZA (1)	ZA200208367B (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6610846B1 (en)	1999-03-29	2003-08-26	Hoffman-La Roche Inc.	Heteroaromatic glucokinase activators
US6482951B2 (en) *	2000-12-13	2002-11-19	Hoffmann-La Roche Inc.	Isoindolin-1-one glucokinase activators
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
EP1336607A1 (de) *	2002-02-19	2003-08-20	Novo Nordisk A/S	Amidderivate als Glucokinase-Aktivatoren
US6911545B2 (en)	2001-12-19	2005-06-28	Hoffman-La Roche Inc.	Crystals of glucokinase and methods of growing them
PL370989A1 (en) *	2001-12-21	2005-06-13	Novo Nordisk A/S	Amide derivatives as gk activators
MXPA05000130A (es)	2002-06-27	2005-02-17	Novo Nordisk As	Derivados de aril-carbonilo como agentes terapeuticos.
CN1678311A (zh)	2002-06-27	2005-10-05	诺沃挪第克公司	用作治疗剂的芳基羰基衍生物
JP2006509774A (ja) *	2002-10-03	2006-03-23	ノバルティスアクチエンゲゼルシャフト	２型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換（チアゾール−２−イル）−アミドまたはスルホンアミド
GB0226931D0 (en)	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
US7132425B2 (en)	2002-12-12	2006-11-07	Hoffmann-La Roche Inc.	5-substituted-six-membered heteroaromatic glucokinase activators
CA2509086C (en) *	2003-01-06	2012-08-21	Eli Lilly And Company	Substituted arylcyclopropylacetamides as glucokinase activators
PL378117A1 (pl) *	2003-02-11	2006-03-06	Prosidion Limited	Tricyklopodstawione związki amidowe
PL1723128T3 (pl) *	2004-01-06	2013-04-30	Novo Nordisk As	Pochodne heteroarylowe mocznika oraz ich zastosowanie jako aktywatory glukokinazy
BRPI0509543A (pt) *	2004-04-02	2007-09-18	Novartis Ag	derivados de tiazolopiridina, condições farmacêuticas que contêm os mesmos e métodos para tratar condições mediadas por glucocinase
BRPI0509573A (pt)	2004-04-02	2007-09-25	Novartis Ag	derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2
AU2005235798A1 (en) *	2004-04-21	2005-11-03	Prosidion Limited	Tri(cyclo) substituted amide compounds
UA90264C2 (ru) *	2004-04-21	2010-04-26	Прозидион Лтд.	Три(цикло)замещенные амиды, фармацевтическая композиция, способы лечения и профилактики, способ получения соединения
WO2006016194A1 (en) *	2004-08-12	2006-02-16	Prosidion Limited	Substituted phenylacetamides and their use as glucokinase activators
US8148412B2 (en) *	2004-12-03	2012-04-03	Novo Nordisk A/S	Heteroaromatic glucokinase activators
ATE547396T1 (de) *	2005-07-08	2012-03-15	Novo Nordisk As	Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren
KR20080024211A (ko)	2005-07-08	2008-03-17	노보 노르디스크 에이/에스	디시클로알킬 우레아 글루코키나제 활성제
JP4651714B2 (ja)	2005-07-09	2011-03-16	アストラゼネカアクチボラグ	糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
US7884210B2 (en) *	2005-07-14	2011-02-08	Novo Nordisk A/S	Ureido-thiazole glucokinase activators
ES2426345T3 (es)	2005-07-20	2013-10-22	Eli Lilly And Company	Compuesto unidos en posición 1-amino
RU2008112184A (ru)	2005-08-31	2009-10-10	Астеллас Фарма Инк. (Jp)	Производное тиазола
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
RU2008112198A (ru)	2005-09-29	2009-10-10	Санофи-Авентис (Fr)	Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств
GT200600428A (es)	2005-09-30	2007-05-21		Compuestos organicos
GT200600429A (es)	2005-09-30	2007-04-30		Compuestos organicos
BRPI0618062A2 (pt) *	2005-11-03	2011-08-16	Prosidion Ltd	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
BRPI0618649A2 (pt)	2005-11-17	2011-09-06	Lilly Co Eli	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto
JP2009515997A (ja) *	2005-11-18	2009-04-16	タケダサンディエゴインコーポレイテッド	グルコキナーゼ活性剤
US8034822B2 (en)	2006-03-08	2011-10-11	Takeda San Diego, Inc.	Glucokinase activators
US8211925B2 (en)	2006-04-28	2012-07-03	Transtech Pharma, Inc.	Benzamide glucokinase activators
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
US8008332B2 (en)	2006-05-31	2011-08-30	Takeda San Diego, Inc.	Substituted indazoles as glucokinase activators
KR20090025358A (ko)	2006-07-24	2009-03-10	에프. 호프만-라 로슈 아게	글루코키나제 활성화제로서의 피라졸
JP5419706B2 (ja)	2006-12-20	2014-02-19	タケダカリフォルニアインコーポレイテッド	グルコキナーゼアクチベーター
TW200831081A (en)	2006-12-25	2008-08-01	Kyorin Seiyaku Kk	Glucokinase activator
US8138185B2 (en) *	2007-01-09	2012-03-20	Novo Nordisk A/S	Urea glucokinase activators
EP2099777B1 (de)	2007-01-11	2015-08-12	Novo Nordisk A/S	Harnstoff-glucokinase-aktivatoren
WO2008104994A2 (en)	2007-02-28	2008-09-04	Advinus Therapeutics Private Limited	2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
JP5248477B2 (ja) *	2007-03-07	2013-07-31	杏林製薬株式会社	グルコキナーゼ活性化物質
WO2008116107A2 (en)	2007-03-21	2008-09-25	Takeda San Diego, Inc.	Piperazine derivatives as glucokinase activators
ES2446932T3 (es) *	2007-10-08	2014-03-10	Advinus Therapeutics Private Limited	Derivados de acetamida como activadores de glucoquinasa, su procedimiento y aplicaciones en medicina
PE20091313A1 (es) *	2008-01-15	2009-09-03	Lilly Co Eli	(r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
KR20100113518A (ko)	2008-01-18	2010-10-21	아스텔라스세이야쿠 가부시키가이샤	페닐아세트아미드 유도체
US7741327B2 (en)	2008-04-16	2010-06-22	Hoffmann-La Roche Inc.	Pyrrolidinone glucokinase activators
US8258134B2 (en)	2008-04-16	2012-09-04	Hoffmann-La Roche Inc.	Pyridazinone glucokinase activators
CN105315224B (zh)	2008-04-28	2018-04-10	杏林制药株式会社	环戊基丙烯酰胺衍生物
UA104742C2 (uk)	2008-12-19	2014-03-11	Эли Лилли Энд Компани	Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази
US8222416B2 (en)	2009-12-14	2012-07-17	Hoffmann-La Roche Inc.	Azaindole glucokinase activators
AU2011235212B2 (en)	2010-03-31	2014-07-31	The Scripps Research Institute	Reprogramming cells
US8178689B2 (en)	2010-06-17	2012-05-15	Hoffman-La Roche Inc.	Tricyclic compounds
EP4487909A3 (de)	2018-06-12	2025-03-19	vTv Therapeutics LLC	Therapeutische verwendungen von glucokinaseaktivatoren in kombination mit insulin oder insulinanaloga
CN109021035B (zh) *	2018-09-18	2021-04-06	云南中烟工业有限责任公司	一种苯乙酰胺类化合物、其制备方法和用途
US12391658B2 (en)	2020-02-18	2025-08-19	Vtv Therapeutics Llc	Sulfoxide and sulfone glucokinase activators and methods of use thereof
KR20230048502A (ko)	2020-06-08	2023-04-11	브이티브이 테라퓨틱스 엘엘씨	｛2-[3-사이클로헥실-3-(트랜스-4-프로폭시-사이클로헥실)-우레이도]-티아졸-5-일설파닐｝-아세트산의 염 또는 공결정 및 그의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3776917A (en) *	1972-06-05	1973-12-04	Schering Corp	2-amino-6-phenalkyl-aminopyridines and derivatives thereof
DE4139750A1 (de) *	1991-12-03	1993-06-09	Bayer Ag, 5090 Leverkusen, De	Chinolylmethoxyphenylessigsaeure-acylamide und -harnstoffe
DE4443892A1 (de) *	1994-12-09	1996-06-13	Bayer Ag	4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
HUP0200396A3 (en) *	1999-03-29	2003-04-28	Hoffmann La Roche	Gluckokinase activators, process for their preparation, pharmaceutical compositions containing them and their use

2001
- 2001-04-27 EP EP01933901A patent/EP1282611B1/de not_active Expired - Lifetime
- 2001-04-27 ES ES01933901T patent/ES2230309T3/es not_active Expired - Lifetime
- 2001-04-27 PT PT01933901T patent/PT1282611E/pt unknown
- 2001-04-27 MX MXPA02010796A patent/MXPA02010796A/es active IP Right Grant
- 2001-04-27 KR KR1020027014933A patent/KR100548901B1/ko not_active Expired - Fee Related
- 2001-04-27 CA CA002407759A patent/CA2407759C/en not_active Expired - Fee Related
- 2001-04-27 JP JP2001582307A patent/JP3839723B2/ja not_active Expired - Fee Related
- 2001-04-27 BR BR0110704-6A patent/BR0110704A/pt not_active Application Discontinuation
- 2001-04-27 DE DE60106599T patent/DE60106599T2/de not_active Expired - Lifetime
- 2001-04-27 CN CNB018091326A patent/CN1245394C/zh not_active Expired - Fee Related
- 2001-04-27 DK DK01933901T patent/DK1282611T3/da active
- 2001-04-27 AT AT01933901T patent/ATE280163T1/de not_active IP Right Cessation
- 2001-04-27 WO PCT/EP2001/004777 patent/WO2001085706A1/en not_active Ceased
- 2001-04-27 AU AU60259/01A patent/AU778036B2/en not_active Ceased
- 2001-05-01 US US09/846,821 patent/US6384220B2/en not_active Expired - Fee Related
- 2001-05-02 PE PE2001000394A patent/PE20020056A1/es not_active Application Discontinuation
- 2001-05-04 AR ARP010102125A patent/AR035639A1/es active IP Right Grant
- 2001-05-07 UY UY26694A patent/UY26694A1/es not_active Application Discontinuation
- 2001-05-08 EC EC2001004067A patent/ECSP014067A/es unknown
2002
- 2002-10-17 ZA ZA200208367A patent/ZA200208367B/en unknown

Also Published As

Publication number	Publication date
EP1282611A1 (de)	2003-02-12
ZA200208367B (en)	2004-01-26
CA2407759A1 (en)	2001-11-15
ES2230309T3 (es)	2005-05-01
UY26694A1 (es)	2001-11-30
PE20020056A1 (es)	2002-02-02
US6384220B2 (en)	2002-05-07
JP3839723B2 (ja)	2006-11-01
WO2001085706A1 (en)	2001-11-15
DE60106599T2 (de)	2006-02-09
US20020002190A1 (en)	2002-01-03
AU6025901A (en)	2001-11-20
JP2003532718A (ja)	2003-11-05
CN1245394C (zh)	2006-03-15
EP1282611B1 (de)	2004-10-20
KR100548901B1 (ko)	2006-02-02
AU778036B2 (en)	2004-11-11
DK1282611T3 (da)	2005-02-14
ATE280163T1 (de)	2004-11-15
PT1282611E (pt)	2005-02-28
CA2407759C (en)	2007-04-17
BR0110704A (pt)	2003-01-28
ECSP014067A (es)	2002-02-25
CN1427829A (zh)	2003-07-02
KR20020094022A (ko)	2002-12-16
MXPA02010796A (es)	2003-03-27
AR035639A1 (es)	2004-06-23

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